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TOP3A (topoisomerase (DNA) III alpha)

Identity

Other namesTOP3
ZGRF7
HGNC (Hugo) TOP3A
LocusID (NCBI) 7156
Atlas_Id 43536
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 18177235 and ends at 18218321 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KMT2A (11q23.3) / TOP3A (17p11.2)MYO15A (17p11.2) / TOP3A (17p11.2)TOP3A (17p11.2) / HEATR6 (17q23.1)
TOP3A (17p11.2) / KMT2A (11q23.3)TOP3A (17p11.2) / MYO18A (17q11.2)TOP3A (17p11.2) / TEKT1 (17p13.1)
TOP3A 17p11.2 / KMT2A 11q23.3MYO15A 17p11.2 / TOP3A 17p11.2TOP3A 17p11.2 / HEATR6 17q23.1
TOP3A 17p11.2 / MYO18A 17q11.2TOP3A 17p11.2 / TEKT1 17p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOP3A   11992
Cards
Entrez_Gene (NCBI)TOP3A  7156  topoisomerase (DNA) III alpha
AliasesTOP3; ZGRF7
GeneCards (Weizmann)TOP3A
Ensembl hg19 (Hinxton)ENSG00000177302 [Gene_View]  chr17:18177235-18218321 [Contig_View]  TOP3A [Vega]
Ensembl hg38 (Hinxton)ENSG00000177302 [Gene_View]  chr17:18177235-18218321 [Contig_View]  TOP3A [Vega]
ICGC DataPortalENSG00000177302
TCGA cBioPortalTOP3A
AceView (NCBI)TOP3A
Genatlas (Paris)TOP3A
WikiGenes7156
SOURCE (Princeton)TOP3A
Genomic and cartography
GoldenPath hg19 (UCSC)TOP3A  -     chr17:18177235-18218321 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOP3A  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblTOP3A - 17p11.2 [CytoView hg19]  TOP3A - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBITOP3A [Mapview hg19]  TOP3A [Mapview hg38]
OMIM601243   
Gene and transcription
Genbank (Entrez)AF086042 AK126869 AK290513 AK292926 AK296437
RefSeq transcript (Entrez)NM_001320759 NM_004618
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)TOP3A
Cluster EST : UnigeneHs.713037 [ NCBI ]
CGAP (NCI)Hs.713037
Alternative Splicing GalleryENSG00000177302
Gene ExpressionTOP3A [ NCBI-GEO ]   TOP3A [ EBI - ARRAY_EXPRESS ]   TOP3A [ SEEK ]   TOP3A [ MEM ]
Gene Expression Viewer (FireBrowse)TOP3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7156
GTEX Portal (Tissue expression)TOP3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13472 (Uniprot)
NextProtQ13472  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13472
Splice isoforms : SwissVarQ13472 (Swissvar)
Catalytic activity : Enzyme5.99.1.2 [ Enzyme-Expasy ]   5.99.1.25.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   
PhosPhoSitePlusQ13472
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_I_PROK (PS00396)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Topo_IA    Topo_IA_2    Topo_IA_AS    Topo_IA_cen    Topo_IA_cen_sub1    Topo_IA_cen_sub2    Topo_IA_core_domain    Topo_IA_DNA-bd_dom    Topo_IA_Znf    Toprim_domain    Znf_CCHC    Znf_GRF   
Domain families : Pfam (Sanger)Topoisom_bac (PF01131)    Toprim (PF01751)    zf-C4_Topoisom (PF01396)    zf-GRF (PF06839)   
Domain families : Pfam (NCBI)pfam01131    pfam01751    pfam01396    pfam06839   
Domain families : Smart (EMBL)TOP1Ac (SM00437)  TOP1Bc (SM00436)  TOPRIM (SM00493)  ZnF_C2HC (SM00343)  
DMDM Disease mutations7156
Blocks (Seattle)TOP3A
PDB (SRS)4CGY    4CHT   
PDB (PDBSum)4CGY    4CHT   
PDB (IMB)4CGY    4CHT   
PDB (RSDB)4CGY    4CHT   
Structural Biology KnowledgeBase4CGY    4CHT   
SCOP (Structural Classification of Proteins)4CGY    4CHT   
CATH (Classification of proteins structures)4CGY    4CHT   
SuperfamilyQ13472
Human Protein AtlasENSG00000177302
Peptide AtlasQ13472
HPRD03145
IPIIPI00013378   IPI00221295   IPI01011812   IPI01012294   IPI00798083   
Protein Interaction databases
DIP (DOE-UCLA)Q13472
IntAct (EBI)Q13472
FunCoupENSG00000177302
BioGRIDTOP3A
STRING (EMBL)TOP3A
ZODIACTOP3A
Ontologies - Pathways
QuickGOQ13472
Ontology : AmiGODNA synthesis involved in DNA repair  strand displacement  DNA binding  DNA topoisomerase type I activity  protein binding  nucleus  nucleoplasm  chromosome  DNA replication  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA synthesis involved in DNA repair  strand displacement  DNA binding  DNA topoisomerase type I activity  protein binding  nucleus  nucleoplasm  chromosome  DNA replication  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  regulation of signal transduction by p53 class mediator  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
NDEx Network
Atlas of Cancer Signalling NetworkTOP3A
Wikipedia pathwaysTOP3A
Orthology - Evolution
OrthoDB7156
GeneTree (enSembl)ENSG00000177302
Phylogenetic Trees/Animal Genes : TreeFamTOP3A
Homologs : HomoloGeneTOP3A
Homology/Alignments : Family Browser (UCSC)TOP3A
Gene fusions - Rearrangements
Fusion: TCGAMYO15A 17p11.2 TOP3A 17p11.2 BRCA
Fusion: TCGATOP3A 17p11.2 HEATR6 17q23.1 BRCA
Fusion: TCGATOP3A 17p11.2 MYO18A 17q11.2 LUAD
Fusion: TCGATOP3A 17p11.2 TEKT1 17p13.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerTOP3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP3A
dbVarTOP3A
ClinVarTOP3A
1000_GenomesTOP3A 
Exome Variant ServerTOP3A
ExAC (Exome Aggregation Consortium)TOP3A (select the gene name)
Genetic variants : HAPMAP7156
Genomic Variants (DGV)TOP3A [DGVbeta]
Mutations
ICGC Data PortalTOP3A 
TCGA Data PortalTOP3A 
Broad Tumor PortalTOP3A
OASIS PortalTOP3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOP3A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOP3A
DgiDB (Drug Gene Interaction Database)TOP3A
DoCM (Curated mutations)TOP3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOP3A (select a term)
intoGenTOP3A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:18177235-18218321  ENSG00000177302
CONAN: Copy Number AnalysisTOP3A 
Mutations and Diseases : HGMDTOP3A
OMIM601243   
MedgenTOP3A
Genetic Testing Registry TOP3A
NextProtQ13472 [Medical]
TSGene7156
GENETestsTOP3A
Huge Navigator TOP3A [HugePedia]
snp3D : Map Gene to Disease7156
BioCentury BCIQTOP3A
ClinGenTOP3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7156
Chemical/Pharm GKB GenePA36673
Clinical trialTOP3A
Miscellaneous
canSAR (ICR)TOP3A (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOP3A
EVEXTOP3A
GoPubMedTOP3A
iHOPTOP3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:10:39 CEST 2016

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