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TOP3A (topoisomerase (DNA) III alpha)

Identity

Other namesTOP3
ZGRF7
HGNC (Hugo) TOP3A
LocusID (NCBI) 7156
Atlas_Id 43536
Location 17p11.2
Location_base_pair Starts at 18177235 and ends at 18218321 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TOP3A   11992
Cards
Entrez_Gene (NCBI)TOP3A  7156  topoisomerase (DNA) III alpha
GeneCards (Weizmann)TOP3A
Ensembl hg19 (Hinxton)ENSG00000177302 [Gene_View]  chr17:18177235-18218321 [Contig_View]  TOP3A [Vega]
Ensembl hg38 (Hinxton)ENSG00000177302 [Gene_View]  chr17:18177235-18218321 [Contig_View]  TOP3A [Vega]
ICGC DataPortalENSG00000177302
TCGA cBioPortalTOP3A
AceView (NCBI)TOP3A
Genatlas (Paris)TOP3A
WikiGenes7156
SOURCE (Princeton)TOP3A
Genomic and cartography
GoldenPath hg19 (UCSC)TOP3A  -     chr17:18177235-18218321 -  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOP3A  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblTOP3A - 17p11.2 [CytoView hg19]  TOP3A - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBITOP3A [Mapview hg19]  TOP3A [Mapview hg38]
OMIM601243   
Gene and transcription
Genbank (Entrez)AF086042 AK126869 AK290513 AK292926 AK296437
RefSeq transcript (Entrez)NM_004618
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)TOP3A
Cluster EST : UnigeneHs.592115 [ NCBI ]
CGAP (NCI)Hs.592115
Alternative Splicing : Fast-db (Paris)GSHG0013163
Alternative Splicing GalleryENSG00000177302
Gene ExpressionTOP3A [ NCBI-GEO ]     TOP3A [ SEEK ]   TOP3A [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13472 (Uniprot)
NextProtQ13472  [Medical]  [Publications]
With graphics : InterProQ13472
Splice isoforms : SwissVarQ13472 (Swissvar)
Catalytic activity : Enzyme5.99.1.2 [ Enzyme-Expasy ]   5.99.1.25.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_I_PROK (PS00396)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Topo_IA    Topo_IA_2    Topo_IA_AS    Topo_IA_cen    Topo_IA_cen_sub1    Topo_IA_cen_sub2    Topo_IA_core_domain    Topo_IA_DNA-bd_dom    Topo_IA_Znf    Toprim_domain    Znf_CCHC    Znf_GRF   
Related proteins : CluSTrQ13472
Domain families : Pfam (Sanger)Topoisom_bac (PF01131)    Toprim (PF01751)    zf-C4_Topoisom (PF01396)    zf-GRF (PF06839)   
Domain families : Pfam (NCBI)pfam01131    pfam01751    pfam01396    pfam06839   
Domain families : Smart (EMBL)TOP1Ac (SM00437)  TOP1Bc (SM00436)  TOPRIM (SM00493)  ZnF_C2HC (SM00343)  
DMDM Disease mutations7156
Blocks (Seattle)Q13472
PDB (SRS)4CGY    4CHT   
PDB (PDBSum)4CGY    4CHT   
PDB (IMB)4CGY    4CHT   
PDB (RSDB)4CGY    4CHT   
Human Protein AtlasENSG00000177302
Peptide AtlasQ13472
HPRD03145
IPIIPI00013378   IPI00221295   IPI01011812   IPI01012294   IPI00798083   
Protein Interaction databases
DIP (DOE-UCLA)Q13472
IntAct (EBI)Q13472
FunCoupENSG00000177302
BioGRIDTOP3A
IntegromeDBTOP3A
STRING (EMBL)TOP3A
Ontologies - Pathways
QuickGOQ13472
Ontology : AmiGODNA binding  DNA topoisomerase type I activity  protein binding  nucleus  chromosome  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  
Ontology : EGO-EBIDNA binding  DNA topoisomerase type I activity  protein binding  nucleus  chromosome  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
Protein Interaction DatabaseTOP3A
DoCM (Curated mutations)TOP3A
Wikipedia pathwaysTOP3A
Gene fusion - Rearrangements
Gene fusion: TCGATOP3A HEATR6  TOP3A TEKT1  TOP3A MYO18A  
Polymorphisms : SNP, variants
NCBI Variation ViewerTOP3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP3A
dbVarTOP3A
ClinVarTOP3A
1000_GenomesTOP3A 
Exome Variant ServerTOP3A
SNP (GeneSNP Utah)TOP3A
SNP : HGBaseTOP3A
Genetic variants : HAPMAPTOP3A
Genomic Variants (DGV)TOP3A [DGVbeta]
Mutations
ICGC Data PortalTOP3A 
TCGA Data PortalTOP3A 
Tumor PortalTOP3A
Somatic Mutations in Cancer : COSMICTOP3A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:18177235-18218321
CONAN: Copy Number AnalysisTOP3A 
Mutations and Diseases : HGMDTOP3A
OMIM601243   
MedgenTOP3A
NextProtQ13472 [Medical]
GENETestsTOP3A
Disease Genetic AssociationTOP3A
Huge Navigator TOP3A [HugePedia]  TOP3A [HugeCancerGEM]
snp3D : Map Gene to Disease7156
DGIdb (Drug Gene Interaction db)TOP3A
BioCentury BCIQTOP3A
General knowledge
Homologs : HomoloGeneTOP3A
Homology/Alignments : Family Browser (UCSC)TOP3A
Phylogenetic Trees/Animal Genes : TreeFamTOP3A
Chemical/Protein Interactions : CTD7156
Chemical/Pharm GKB GenePA36673
Clinical trialTOP3A
Cancer Resource (Charite)ENSG00000177302
Other databases
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
CoreMineTOP3A
GoPubMedTOP3A
iHOPTOP3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:25:57 CEST 2015

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