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TOP3A (topoisomerase (DNA) III alpha)

Identity

Other namesTOP3
ZGRF7
HGNC (Hugo) TOP3A
LocusID (NCBI) 7156
Location 17p11.2
Location_base_pair Starts at 18177235 and ends at 18218321 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TOP3A   11992
Cards
Entrez_Gene (NCBI)TOP3A  7156  topoisomerase (DNA) III alpha
GeneCards (Weizmann)TOP3A
Ensembl (Hinxton)ENSG00000177302 [Gene_View]  chr17:18177235-18218321 [Contig_View]  TOP3A [Vega]
ICGC DataPortalENSG00000177302
cBioPortalTOP3A
AceView (NCBI)TOP3A
Genatlas (Paris)TOP3A
WikiGenes7156
SOURCE (Princeton)NM_004618
Genomic and cartography
GoldenPath (UCSC)TOP3A  -  17p11.2   chr17:18177235-18218321 -  17p11.2   [Description]    (hg19-Feb_2009)
EnsemblTOP3A - 17p11.2 [CytoView]
Mapping of homologs : NCBITOP3A [Mapview]
OMIM601243   
Gene and transcription
Genbank (Entrez)AF086042 AK126869 AK290513 AK292926 AK296437
RefSeq transcript (Entrez)NM_004618
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NT_010718 NW_001838410 NW_004929405
Consensus coding sequences : CCDS (NCBI)TOP3A
Cluster EST : UnigeneHs.592115 [ NCBI ]
CGAP (NCI)Hs.592115
Alternative Splicing : Fast-db (Paris)GSHG0013163
Alternative Splicing GalleryENSG00000177302
Gene ExpressionTOP3A [ NCBI-GEO ]     TOP3A [ SEEK ]   TOP3A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13472 (Uniprot)
NextProtQ13472  [Medical]
With graphics : InterProQ13472
Splice isoforms : SwissVarQ13472 (Swissvar)
Catalytic activity : Enzyme5.99.1.2 [ Enzyme-Expasy ]   5.99.1.25.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_I_PROK (PS00396)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Topo_IA [organisation]   Topo_IA_2 [organisation]   Topo_IA_AS [organisation]   Topo_IA_cen [organisation]   Topo_IA_cen_sub1 [organisation]   Topo_IA_cen_sub2 [organisation]   Topo_IA_core_domain [organisation]   Topo_IA_DNA-bd [organisation]   Topo_IA_Znf [organisation]   Toprim_domain [organisation]   Znf_CCHC [organisation]   Znf_GRF [organisation]  
Related proteins : CluSTrQ13472
Domain families : Pfam (Sanger)Topoisom_bac (PF01131)    Toprim (PF01751)    zf-C4_Topoisom (PF01396)    zf-GRF (PF06839)   
Domain families : Pfam (NCBI)pfam01131    pfam01751    pfam01396    pfam06839   
Domain families : Smart (EMBL)TOP1Ac (SM00437)  TOP1Bc (SM00436)  TOPRIM (SM00493)  ZnF_C2HC (SM00343)  
DMDM Disease mutations7156
Blocks (Seattle)Q13472
PDB (SRS)4CGY    4CHT   
PDB (PDBSum)4CGY    4CHT   
PDB (IMB)4CGY    4CHT   
PDB (RSDB)4CGY    4CHT   
Human Protein AtlasENSG00000177302 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ13472
HPRD03145
IPIIPI00013378   IPI00221295   IPI01011812   IPI01012294   IPI00798083   
Protein Interaction databases
DIP (DOE-UCLA)Q13472
IntAct (EBI)Q13472
FunCoupENSG00000177302
BioGRIDTOP3A
InParanoidQ13472
Interologous Interaction database Q13472
IntegromeDBTOP3A
STRING (EMBL)TOP3A
Ontologies - Pathways
Ontology : AmiGODNA binding  DNA topoisomerase type I activity  protein binding  nucleus  chromosome  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  
Ontology : EGO-EBIDNA binding  DNA topoisomerase type I activity  protein binding  nucleus  chromosome  DNA topological change  meiotic nuclear division  zinc ion binding  PML body  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
Protein Interaction DatabaseTOP3A
Wikipedia pathwaysTOP3A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TOP3A
snp3D : Map Gene to Disease7156
SNP (GeneSNP Utah)TOP3A
SNP : HGBaseTOP3A
Genetic variants : HAPMAPTOP3A
Exome VariantTOP3A
1000_GenomesTOP3A 
ICGC programENSG00000177302 
Somatic Mutations in Cancer : COSMICTOP3A 
CONAN: Copy Number AnalysisTOP3A 
Mutations and Diseases : HGMDTOP3A
Mutations and Diseases : intOGenTOP3A
Genomic VariantsTOP3A  TOP3A [DGVbeta]
dbVarTOP3A
ClinVarTOP3A
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601243   
MedgenTOP3A
GENETestsTOP3A
Disease Genetic AssociationTOP3A
Huge Navigator TOP3A [HugePedia]  TOP3A [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTOP3A
Homology/Alignments : Family Browser (UCSC)TOP3A
Phylogenetic Trees/Animal Genes : TreeFamTOP3A
Chemical/Protein Interactions : CTD7156
Chemical/Pharm GKB GenePA36673
Clinical trialTOP3A
Cancer Resource (Charite)ENSG00000177302
Other databases
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
CoreMineTOP3A
iHOPTOP3A
OncoSearchTOP3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:23:05 CEST 2014

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