TOP3A (DNA topoisomerase III alpha)

2006-10-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
MGRISCE2,PEOB5,TOP3,ZGRF7
FUSION GENES

Other Information

Locus ID:

NCBI: 7156
MIM: 601243
HGNC: 11992
Ensembl: ENSG00000177302

Variants:

dbSNP: 7156
ClinVar: 7156
TCGA: ENSG00000177302
COSMIC: TOP3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177302ENST00000321105Q13472
ENSG00000177302ENST00000461127J3QR18
ENSG00000177302ENST00000489131K7EL07
ENSG00000177302ENST00000493648K7EJ41
ENSG00000177302ENST00000542570Q13472
ENSG00000177302ENST00000580095Q13472
ENSG00000177302ENST00000581536K7EMT6
ENSG00000177302ENST00000582122K7ELI7
ENSG00000177302ENST00000582981J3KS96
ENSG00000177302ENST00000584582J3KRR9
ENSG00000177302ENST00000585031J3QS25

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
Fanconi anemia pathwayKEGGko03460
Fanconi anemia pathwayKEGGhsa03460
Bloom's syndrome complexKEGGhsa_M00414
Bloom's syndrome complexKEGGM00414
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554
HDR through Single Strand Annealing (SSA)REACTOMER-HSA-5685938
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165956952006A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.123
177282552007Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.56
183905472008Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.40
122090142002Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.34
204452072010Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1.33
184183892008Topoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.30
252000812014Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.29
124339842002The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.25
292906142018Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.23
165469982006Involvement of topoisomerase III in telomere-telomere recombination.21

Citation

Dessen P

TOP3A (DNA topoisomerase III alpha)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43536/top3a