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TOP3B (DNA topoisomerase III beta)

Identity

Alias (NCBI)TOP3B1
HGNC (Hugo) TOP3B
LocusID (NCBI) 8940
Atlas_Id 42661
Location 22q11.22  [Link to chromosome band 22q11]
Location_base_pair Starts at 21957025 and ends at 21982787 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAPK1 (22q11.21) / TOP3B (22q11.22)MAPK1 22q11.21 / TOP3B 22q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOP3B   11993
Cards
Entrez_Gene (NCBI)TOP3B    DNA topoisomerase III beta
AliasesTOP3B1
GeneCards (Weizmann)TOP3B
Ensembl hg19 (Hinxton)ENSG00000100038 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100038 [Gene_View]  ENSG00000100038 [Sequence]  chr22:21957025-21982787 [Contig_View]  TOP3B [Vega]
ICGC DataPortalENSG00000100038
TCGA cBioPortalTOP3B
AceView (NCBI)TOP3B
Genatlas (Paris)TOP3B
SOURCE (Princeton)TOP3B
Genetics Home Reference (NIH)TOP3B
Genomic and cartography
GoldenPath hg38 (UCSC)TOP3B  -     chr22:21957025-21982787 -  22q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOP3B  -     22q11.22   [Description]    (hg19-Feb_2009)
GoldenPathTOP3B - 22q11.22 [CytoView hg19]  TOP3B - 22q11.22 [CytoView hg38]
ImmunoBaseENSG00000100038
Genome Data Viewer NCBITOP3B [Mapview hg19]  
OMIM603582   
Gene and transcription
Genbank (Entrez)AF017146 AF053082 AF125216 AI361851 AK096695
RefSeq transcript (Entrez)NM_001282112 NM_001282113 NM_001349845 NM_001349847 NM_001349848 NM_001349850 NM_001349851 NM_001349852 NM_003935
Consensus coding sequences : CCDS (NCBI)TOP3B
Gene ExpressionTOP3B [ NCBI-GEO ]   TOP3B [ EBI - ARRAY_EXPRESS ]   TOP3B [ SEEK ]   TOP3B [ MEM ]
Gene Expression Viewer (FireBrowse)TOP3B [ Firebrowse - Broad ]
GenevisibleExpression of TOP3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8940
GTEX Portal (Tissue expression)TOP3B
Human Protein AtlasENSG00000100038-TOP3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95985   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95985  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95985
PhosPhoSitePlusO95985
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_I_PROK (PS00396)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Topo_IA    Topo_IA_2    Topo_IA_AS    Topo_IA_cen    Topo_IA_cen_sub1    Topo_IA_cen_sub2    Topo_IA_cen_sub3    Topo_IA_core_domain    Topo_IA_DNA-bd_dom    TOPRIM_domain    TOPRIM_TopoIII   
Domain families : Pfam (Sanger)Topoisom_bac (PF01131)    Toprim (PF01751)   
Domain families : Pfam (NCBI)pfam01131    pfam01751   
Domain families : Smart (EMBL)TOP1Ac (SM00437)  TOP1Bc (SM00436)  TOPRIM (SM00493)  
Conserved Domain (NCBI)TOP3B
PDB (RSDB)5GVC    5GVE   
PDB Europe5GVC    5GVE   
PDB (PDBSum)5GVC    5GVE   
PDB (IMB)5GVC    5GVE   
Structural Biology KnowledgeBase5GVC    5GVE   
SCOP (Structural Classification of Proteins)5GVC    5GVE   
CATH (Classification of proteins structures)5GVC    5GVE   
SuperfamilyO95985
AlphaFold pdb e-kbO95985   
Human Protein Atlas [tissue]ENSG00000100038-TOP3B [tissue]
HPRD04662
Protein Interaction databases
DIP (DOE-UCLA)O95985
IntAct (EBI)O95985
BioGRIDTOP3B
STRING (EMBL)TOP3B
ZODIACTOP3B
Ontologies - Pathways
QuickGOO95985
Ontology : AmiGOcondensed chromosome  DNA binding  RNA binding  DNA topoisomerase activity  DNA topoisomerase type I (single strand cut, ATP-independent) activity  protein binding  nucleus  DNA topological change  chromosome segregation  
Ontology : EGO-EBIcondensed chromosome  DNA binding  RNA binding  DNA topoisomerase activity  DNA topoisomerase type I (single strand cut, ATP-independent) activity  protein binding  nucleus  DNA topological change  chromosome segregation  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
NDEx NetworkTOP3B
Atlas of Cancer Signalling NetworkTOP3B
Wikipedia pathwaysTOP3B
Orthology - Evolution
OrthoDB8940
GeneTree (enSembl)ENSG00000100038
Phylogenetic Trees/Animal Genes : TreeFamTOP3B
Homologs : HomoloGeneTOP3B
Homology/Alignments : Family Browser (UCSC)TOP3B
Gene fusions - Rearrangements
Fusion : MitelmanMAPK1/TOP3B [22q11.21/22q11.22]  
Fusion : QuiverTOP3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOP3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP3B
dbVarTOP3B
ClinVarTOP3B
MonarchTOP3B
1000_GenomesTOP3B 
Exome Variant ServerTOP3B
GNOMAD BrowserENSG00000100038
Varsome BrowserTOP3B
ACMGTOP3B variants
VarityO95985
Genomic Variants (DGV)TOP3B [DGVbeta]
DECIPHERTOP3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOP3B 
Mutations
ICGC Data PortalTOP3B 
TCGA Data PortalTOP3B 
Broad Tumor PortalTOP3B
OASIS PortalTOP3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOP3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOP3B
Mutations and Diseases : HGMDTOP3B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOP3B
DgiDB (Drug Gene Interaction Database)TOP3B
DoCM (Curated mutations)TOP3B
CIViC (Clinical Interpretations of Variants in Cancer)TOP3B
Cancer3DTOP3B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603582   
Orphanet
DisGeNETTOP3B
MedgenTOP3B
Genetic Testing Registry TOP3B
NextProtO95985 [Medical]
GENETestsTOP3B
Target ValidationTOP3B
Huge Navigator TOP3B [HugePedia]
ClinGenTOP3B
Clinical trials, drugs, therapy
MyCancerGenomeTOP3B
Protein Interactions : CTDTOP3B
Pharm GKB GenePA36674
PharosO95985
Clinical trialTOP3B
Miscellaneous
canSAR (ICR)TOP3B
HarmonizomeTOP3B
DataMed IndexTOP3B
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOP3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:55 CEST 2021

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