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TOP3B (topoisomerase (DNA) III beta)

Identity

Other aliasTOP3B1
HGNC (Hugo) TOP3B
LocusID (NCBI) 8940
Atlas_Id 42661
Location 22q11.22  [Link to chromosome band 22q11]
Location_base_pair Starts at 22311397 and ends at 22337240 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAPK1 (22q11.21) / TOP3B (22q11.22)MAPK1 22q11.21 / TOP3B 22q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOP3B   11993
Cards
Entrez_Gene (NCBI)TOP3B  8940  topoisomerase (DNA) III beta
AliasesTOP3B1
GeneCards (Weizmann)TOP3B
Ensembl hg19 (Hinxton)ENSG00000100038 [Gene_View]  chr22:22311397-22337240 [Contig_View]  TOP3B [Vega]
Ensembl hg38 (Hinxton)ENSG00000100038 [Gene_View]  chr22:22311397-22337240 [Contig_View]  TOP3B [Vega]
ICGC DataPortalENSG00000100038
TCGA cBioPortalTOP3B
AceView (NCBI)TOP3B
Genatlas (Paris)TOP3B
WikiGenes8940
SOURCE (Princeton)TOP3B
Genetics Home Reference (NIH)TOP3B
Genomic and cartography
GoldenPath hg19 (UCSC)TOP3B  -     chr22:22311397-22337240 -  22q11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOP3B  -     22q11.22   [Description]    (hg38-Dec_2013)
EnsemblTOP3B - 22q11.22 [CytoView hg19]  TOP3B - 22q11.22 [CytoView hg38]
Mapping of homologs : NCBITOP3B [Mapview hg19]  TOP3B [Mapview hg38]
OMIM603582   
Gene and transcription
Genbank (Entrez)AF017146 AF053082 AF125216 AK096695 AK290997
RefSeq transcript (Entrez)NM_001282112 NM_001282113 NM_003935
RefSeq genomic (Entrez)NC_000022 NC_018933 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)TOP3B
Cluster EST : UnigeneHs.436401 [ NCBI ]
CGAP (NCI)Hs.436401
Alternative Splicing GalleryENSG00000100038
Gene ExpressionTOP3B [ NCBI-GEO ]   TOP3B [ EBI - ARRAY_EXPRESS ]   TOP3B [ SEEK ]   TOP3B [ MEM ]
Gene Expression Viewer (FireBrowse)TOP3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8940
GTEX Portal (Tissue expression)TOP3B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95985   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95985  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95985
Splice isoforms : SwissVarO95985
Catalytic activity : Enzyme5.99.1.2 [ Enzyme-Expasy ]   5.99.1.25.99.1.2 [ IntEnz-EBI ]   5.99.1.2 [ BRENDA ]   5.99.1.2 [ KEGG ]   
PhosPhoSitePlusO95985
Domaine pattern : Prosite (Expaxy)TOPOISOMERASE_I_PROK (PS00396)    TOPRIM (PS50880)   
Domains : Interpro (EBI)Topo_IA    Topo_IA_2    Topo_IA_AS    Topo_IA_cen    Topo_IA_cen_sub1    Topo_IA_cen_sub2    Topo_IA_core_domain    Topo_IA_DNA-bd_dom    Toprim_domain   
Domain families : Pfam (Sanger)Topoisom_bac (PF01131)    Toprim (PF01751)   
Domain families : Pfam (NCBI)pfam01131    pfam01751   
Domain families : Smart (EMBL)TOP1Ac (SM00437)  TOP1Bc (SM00436)  TOPRIM (SM00493)  
Conserved Domain (NCBI)TOP3B
DMDM Disease mutations8940
Blocks (Seattle)TOP3B
SuperfamilyO95985
Human Protein AtlasENSG00000100038
Peptide AtlasO95985
HPRD04662
IPIIPI00292671   IPI00216815   IPI00216816   IPI00879706   IPI00908525   IPI00878002   IPI00879091   IPI00879445   IPI00878904   IPI00879269   IPI00880050   IPI01014062   IPI00877734   IPI00877908   
Protein Interaction databases
DIP (DOE-UCLA)O95985
IntAct (EBI)O95985
FunCoupENSG00000100038
BioGRIDTOP3B
STRING (EMBL)TOP3B
ZODIACTOP3B
Ontologies - Pathways
QuickGOO95985
Ontology : AmiGOcondensed chromosome  DNA binding  DNA topoisomerase activity  DNA topoisomerase type I activity  protein binding  nucleus  DNA topological change  chromosome segregation  poly(A) RNA binding  
Ontology : EGO-EBIcondensed chromosome  DNA binding  DNA topoisomerase activity  DNA topoisomerase type I activity  protein binding  nucleus  DNA topological change  chromosome segregation  poly(A) RNA binding  
Pathways : KEGGHomologous recombination    Fanconi anemia pathway   
NDEx NetworkTOP3B
Atlas of Cancer Signalling NetworkTOP3B
Wikipedia pathwaysTOP3B
Orthology - Evolution
OrthoDB8940
GeneTree (enSembl)ENSG00000100038
Phylogenetic Trees/Animal Genes : TreeFamTOP3B
HOVERGENO95985
HOGENOMO95985
Homologs : HomoloGeneTOP3B
Homology/Alignments : Family Browser (UCSC)TOP3B
Gene fusions - Rearrangements
Fusion : MitelmanMAPK1/TOP3B [22q11.21/22q11.22]  [t(22;22)(q11;q11)]  
Fusion: TCGAMAPK1 22q11.21 TOP3B 22q11.22 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOP3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOP3B
dbVarTOP3B
ClinVarTOP3B
1000_GenomesTOP3B 
Exome Variant ServerTOP3B
ExAC (Exome Aggregation Consortium)TOP3B (select the gene name)
Genetic variants : HAPMAP8940
Genomic Variants (DGV)TOP3B [DGVbeta]
DECIPHER (Syndromes)22:22311397-22337240  ENSG00000100038
CONAN: Copy Number AnalysisTOP3B 
Mutations
ICGC Data PortalTOP3B 
TCGA Data PortalTOP3B 
Broad Tumor PortalTOP3B
OASIS PortalTOP3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOP3B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOP3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOP3B
DgiDB (Drug Gene Interaction Database)TOP3B
DoCM (Curated mutations)TOP3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOP3B (select a term)
intoGenTOP3B
Cancer3DTOP3B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603582   
Orphanet
MedgenTOP3B
Genetic Testing Registry TOP3B
NextProtO95985 [Medical]
TSGene8940
GENETestsTOP3B
Huge Navigator TOP3B [HugePedia]
snp3D : Map Gene to Disease8940
BioCentury BCIQTOP3B
ClinGenTOP3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8940
Chemical/Pharm GKB GenePA36674
Clinical trialTOP3B
Miscellaneous
canSAR (ICR)TOP3B (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOP3B
EVEXTOP3B
GoPubMedTOP3B
iHOPTOP3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:53 CET 2017

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