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TOPBP1 (DNA topoisomerase II binding protein 1)

Identity

Alias (NCBI)Dpb11
TOP2BP1
HGNC (Hugo) TOPBP1
HGNC Alias symbKIAA0259
TOP2BP1
Dpb11
HGNC Previous nametopoisomerase (DNA) II binding protein 1
LocusID (NCBI) 11073
Atlas_Id 43070
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133600253 and ends at 133661941 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TOPBP1 (3q22.1) / CEP135 (4q12)TOPBP1 (3q22.1) / NEK11 (3q22.1)TOPBP1 (3q22.1) / TOPBP1 (3q22.1)
TOPBP1 (3q22.1) / VWA7 (6p21.33)TOPBP1 3q22.1 / NEK11 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOPBP1   17008
Cards
Entrez_Gene (NCBI)TOPBP1    DNA topoisomerase II binding protein 1
AliasesDpb11; TOP2BP1
GeneCards (Weizmann)TOPBP1
Ensembl hg19 (Hinxton)ENSG00000163781 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163781 [Gene_View]  ENSG00000163781 [Sequence]  chr3:133600253-133661941 [Contig_View]  TOPBP1 [Vega]
ICGC DataPortalENSG00000163781
TCGA cBioPortalTOPBP1
AceView (NCBI)TOPBP1
Genatlas (Paris)TOPBP1
SOURCE (Princeton)TOPBP1
Genetics Home Reference (NIH)TOPBP1
Genomic and cartography
GoldenPath hg38 (UCSC)TOPBP1  -     chr3:133600253-133661941 -  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOPBP1  -     3q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTOPBP1 - 3q22.1 [CytoView hg19]  TOPBP1 - 3q22.1 [CytoView hg38]
ImmunoBaseENSG00000163781
Genome Data Viewer NCBITOPBP1 [Mapview hg19]  
OMIM607760   
Gene and transcription
Genbank (Entrez)AB019397 AK026229 AK302584 BC017552 BC032633
RefSeq transcript (Entrez)NM_001363889 NM_007027
Consensus coding sequences : CCDS (NCBI)TOPBP1
Gene ExpressionTOPBP1 [ NCBI-GEO ]   TOPBP1 [ EBI - ARRAY_EXPRESS ]   TOPBP1 [ SEEK ]   TOPBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOPBP1 [ Firebrowse - Broad ]
GenevisibleExpression of TOPBP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11073
GTEX Portal (Tissue expression)TOPBP1
Human Protein AtlasENSG00000163781-TOPBP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92547   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92547  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92547
PhosPhoSitePlusQ92547
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (EBI)BRCT_dom    BRCT_dom_sf    Secretoglobin_sf   
Domain families : Pfam (Sanger)BRCT (PF00533)    PTCB-BRCT (PF12738)   
Domain families : Pfam (NCBI)pfam00533    pfam12738   
Domain families : Smart (EMBL)BRCT (SM00292)  
Conserved Domain (NCBI)TOPBP1
PDB (RSDB)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
PDB Europe1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
PDB (PDBSum)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
PDB (IMB)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
Structural Biology KnowledgeBase1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
SCOP (Structural Classification of Proteins)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
CATH (Classification of proteins structures)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO    6RML    6RMM   
SuperfamilyQ92547
AlphaFold pdb e-kbQ92547   
Human Protein Atlas [tissue]ENSG00000163781-TOPBP1 [tissue]
HPRD09678
Protein Interaction databases
DIP (DOE-UCLA)Q92547
IntAct (EBI)Q92547
BioGRIDTOPBP1
STRING (EMBL)TOPBP1
ZODIACTOPBP1
Ontologies - Pathways
QuickGOQ92547
Ontology : AmiGOcondensed nuclear chromosome  spindle pole  male germ cell nucleus  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytoplasm  microtubule organizing center  plasma membrane  DNA metabolic process  DNA replication  DNA replication initiation  DNA repair  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint signaling  protein C-terminus binding  response to ionizing radiation  actin cytoskeleton  nuclear body  PML body  mitotic DNA replication checkpoint signaling  identical protein binding  intracellular membrane-bounded organelle  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIcondensed nuclear chromosome  spindle pole  male germ cell nucleus  DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromosome  cytoplasm  microtubule organizing center  plasma membrane  DNA metabolic process  DNA replication  DNA replication initiation  DNA repair  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint signaling  protein C-terminus binding  response to ionizing radiation  actin cytoskeleton  nuclear body  PML body  mitotic DNA replication checkpoint signaling  identical protein binding  intracellular membrane-bounded organelle  regulation of signal transduction by p53 class mediator  
NDEx NetworkTOPBP1
Atlas of Cancer Signalling NetworkTOPBP1
Wikipedia pathwaysTOPBP1
Orthology - Evolution
OrthoDB11073
GeneTree (enSembl)ENSG00000163781
Phylogenetic Trees/Animal Genes : TreeFamTOPBP1
Homologs : HomoloGeneTOPBP1
Homology/Alignments : Family Browser (UCSC)TOPBP1
Gene fusions - Rearrangements
Fusion : MitelmanTOPBP1/NEK11 [3q22.1/3q22.1]  
Fusion : QuiverTOPBP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOPBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOPBP1
dbVarTOPBP1
ClinVarTOPBP1
MonarchTOPBP1
1000_GenomesTOPBP1 
Exome Variant ServerTOPBP1
GNOMAD BrowserENSG00000163781
Varsome BrowserTOPBP1
ACMGTOPBP1 variants
VarityQ92547
Genomic Variants (DGV)TOPBP1 [DGVbeta]
DECIPHERTOPBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOPBP1 
Mutations
ICGC Data PortalTOPBP1 
TCGA Data PortalTOPBP1 
Broad Tumor PortalTOPBP1
OASIS PortalTOPBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOPBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOPBP1
Mutations and Diseases : HGMDTOPBP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOPBP1
DgiDB (Drug Gene Interaction Database)TOPBP1
DoCM (Curated mutations)TOPBP1
CIViC (Clinical Interpretations of Variants in Cancer)TOPBP1
Cancer3DTOPBP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607760   
Orphanet
DisGeNETTOPBP1
MedgenTOPBP1
Genetic Testing Registry TOPBP1
NextProtQ92547 [Medical]
GENETestsTOPBP1
Target ValidationTOPBP1
Huge Navigator TOPBP1 [HugePedia]
ClinGenTOPBP1
Clinical trials, drugs, therapy
MyCancerGenomeTOPBP1
Protein Interactions : CTDTOPBP1
Pharm GKB GenePA134934073
PharosQ92547
Clinical trialTOPBP1
Miscellaneous
canSAR (ICR)TOPBP1
HarmonizomeTOPBP1
DataMed IndexTOPBP1
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOPBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:55 CEST 2021

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