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TOPBP1 (topoisomerase (DNA) II binding protein 1)

Identity

Alias_symbol (synonym)KIAA0259
TOP2BP1
Other alias
HGNC (Hugo) TOPBP1
LocusID (NCBI) 11073
Atlas_Id 43070
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 133600605 and ends at 133661893 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TOPBP1 (3q22.1) / CEP135 (4q12)TOPBP1 (3q22.1) / NEK11 (3q22.1)TOPBP1 (3q22.1) / TOPBP1 (3q22.1)
TOPBP1 (3q22.1) / VWA7 (6p21.33)TOPBP1 3q22.1 / NEK11 3q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOPBP1   17008
Cards
Entrez_Gene (NCBI)TOPBP1  11073  topoisomerase (DNA) II binding protein 1
AliasesTOP2BP1
GeneCards (Weizmann)TOPBP1
Ensembl hg19 (Hinxton)ENSG00000163781 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163781 [Gene_View]  chr3:133600605-133661893 [Contig_View]  TOPBP1 [Vega]
ICGC DataPortalENSG00000163781
TCGA cBioPortalTOPBP1
AceView (NCBI)TOPBP1
Genatlas (Paris)TOPBP1
WikiGenes11073
SOURCE (Princeton)TOPBP1
Genetics Home Reference (NIH)TOPBP1
Genomic and cartography
GoldenPath hg38 (UCSC)TOPBP1  -     chr3:133600605-133661893 -  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOPBP1  -     3q22.1   [Description]    (hg19-Feb_2009)
EnsemblTOPBP1 - 3q22.1 [CytoView hg19]  TOPBP1 - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBITOPBP1 [Mapview hg19]  TOPBP1 [Mapview hg38]
OMIM607760   
Gene and transcription
Genbank (Entrez)AB019397 AK026229 AK302584 BC017552 BC032633
RefSeq transcript (Entrez)NM_007027
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOPBP1
Cluster EST : UnigeneHs.593379 [ NCBI ]
CGAP (NCI)Hs.593379
Alternative Splicing GalleryENSG00000163781
Gene ExpressionTOPBP1 [ NCBI-GEO ]   TOPBP1 [ EBI - ARRAY_EXPRESS ]   TOPBP1 [ SEEK ]   TOPBP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOPBP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11073
GTEX Portal (Tissue expression)TOPBP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92547   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92547  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92547
Splice isoforms : SwissVarQ92547
PhosPhoSitePlusQ92547
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (EBI)BRCT_dom    Secretoglobin   
Domain families : Pfam (Sanger)BRCT (PF00533)    PTCB-BRCT (PF12738)   
Domain families : Pfam (NCBI)pfam00533    pfam12738   
Domain families : Smart (EMBL)BRCT (SM00292)  
Conserved Domain (NCBI)TOPBP1
DMDM Disease mutations11073
Blocks (Seattle)TOPBP1
PDB (SRS)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
PDB (PDBSum)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
PDB (IMB)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
PDB (RSDB)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
Structural Biology KnowledgeBase1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
SCOP (Structural Classification of Proteins)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
CATH (Classification of proteins structures)1WF6    2XNH    2XNK    3AL2    3AL3    3JVE    3OLC    3PD7    3UEN    3UEO   
SuperfamilyQ92547
Human Protein AtlasENSG00000163781
Peptide AtlasQ92547
HPRD09678
IPIIPI00293921   IPI00964527   
Protein Interaction databases
DIP (DOE-UCLA)Q92547
IntAct (EBI)Q92547
FunCoupENSG00000163781
BioGRIDTOPBP1
STRING (EMBL)TOPBP1
ZODIACTOPBP1
Ontologies - Pathways
QuickGOQ92547
Ontology : AmiGOcondensed nuclear chromosome  spindle pole  male germ cell nucleus  DNA binding  protein binding  nucleus  nucleoplasm  chromosome  cytoplasm  microtubule organizing center  DNA metabolic process  DNA replication  DNA replication initiation  DNA repair  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint  protein C-terminus binding  response to ionizing radiation  actin cytoskeleton  nuclear body  PML body  mitotic DNA replication checkpoint  identical protein binding  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIcondensed nuclear chromosome  spindle pole  male germ cell nucleus  DNA binding  protein binding  nucleus  nucleoplasm  chromosome  cytoplasm  microtubule organizing center  DNA metabolic process  DNA replication  DNA replication initiation  DNA repair  cellular response to DNA damage stimulus  mitotic G2 DNA damage checkpoint  protein C-terminus binding  response to ionizing radiation  actin cytoskeleton  nuclear body  PML body  mitotic DNA replication checkpoint  identical protein binding  regulation of signal transduction by p53 class mediator  
NDEx NetworkTOPBP1
Atlas of Cancer Signalling NetworkTOPBP1
Wikipedia pathwaysTOPBP1
Orthology - Evolution
OrthoDB11073
GeneTree (enSembl)ENSG00000163781
Phylogenetic Trees/Animal Genes : TreeFamTOPBP1
HOVERGENQ92547
HOGENOMQ92547
Homologs : HomoloGeneTOPBP1
Homology/Alignments : Family Browser (UCSC)TOPBP1
Gene fusions - Rearrangements
Fusion : MitelmanTOPBP1/NEK11 [3q22.1/3q22.1]  
Fusion: TCGATOPBP1 3q22.1 NEK11 3q22.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOPBP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOPBP1
dbVarTOPBP1
ClinVarTOPBP1
1000_GenomesTOPBP1 
Exome Variant ServerTOPBP1
ExAC (Exome Aggregation Consortium)TOPBP1 (select the gene name)
Genetic variants : HAPMAP11073
Genomic Variants (DGV)TOPBP1 [DGVbeta]
DECIPHERTOPBP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOPBP1 
Mutations
ICGC Data PortalTOPBP1 
TCGA Data PortalTOPBP1 
Broad Tumor PortalTOPBP1
OASIS PortalTOPBP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOPBP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOPBP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOPBP1
DgiDB (Drug Gene Interaction Database)TOPBP1
DoCM (Curated mutations)TOPBP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOPBP1 (select a term)
intoGenTOPBP1
Cancer3DTOPBP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607760   
Orphanet
MedgenTOPBP1
Genetic Testing Registry TOPBP1
NextProtQ92547 [Medical]
TSGene11073
GENETestsTOPBP1
Target ValidationTOPBP1
Huge Navigator TOPBP1 [HugePedia]
snp3D : Map Gene to Disease11073
BioCentury BCIQTOPBP1
ClinGenTOPBP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11073
Chemical/Pharm GKB GenePA134934073
Clinical trialTOPBP1
Miscellaneous
canSAR (ICR)TOPBP1 (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOPBP1
EVEXTOPBP1
GoPubMedTOPBP1
iHOPTOPBP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:17:26 CEST 2017

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