Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TOX (thymocyte selection associated high mobility group box)

Identity

Alias (NCBI)TOX1
HGNC (Hugo) TOX
HGNC Alias symbKIAA0808
TOX1
LocusID (NCBI) 9760
Atlas_Id 47116
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 58805412 and ends at 59119147 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CHD7 (8q12.2) / TOX (8q12.1)TOX (8q12.1) / CHD7 (8q12.2)TOX (8q12.1) / PGBD2 (1q44)
TOX (8q12.1) / ZNF543 (19q13.43)CHD7 8q12.1 / TOX 8q12.1TOX 8q12.1 / PGBD2 1q44

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOX   18988
Cards
Entrez_Gene (NCBI)TOX    thymocyte selection associated high mobility group box
AliasesTOX1
GeneCards (Weizmann)TOX
Ensembl hg19 (Hinxton)ENSG00000198846 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198846 [Gene_View]  ENSG00000198846 [Sequence]  chr8:58805412-59119147 [Contig_View]  TOX [Vega]
ICGC DataPortalENSG00000198846
TCGA cBioPortalTOX
AceView (NCBI)TOX
Genatlas (Paris)TOX
SOURCE (Princeton)TOX
Genetics Home Reference (NIH)TOX
Genomic and cartography
GoldenPath hg38 (UCSC)TOX  -     chr8:58805412-59119147 -  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOX  -     8q12.1   [Description]    (hg19-Feb_2009)
GoldenPathTOX - 8q12.1 [CytoView hg19]  TOX - 8q12.1 [CytoView hg38]
ImmunoBaseENSG00000198846
Genome Data Viewer NCBITOX [Mapview hg19]  
OMIM606863   
Gene and transcription
Genbank (Entrez)AB018351 AK000971 AK302331 BC016665 BX647462
RefSeq transcript (Entrez)NM_014729
Consensus coding sequences : CCDS (NCBI)TOX
Gene ExpressionTOX [ NCBI-GEO ]   TOX [ EBI - ARRAY_EXPRESS ]   TOX [ SEEK ]   TOX [ MEM ]
Gene Expression Viewer (FireBrowse)TOX [ Firebrowse - Broad ]
GenevisibleExpression of TOX in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9760
GTEX Portal (Tissue expression)TOX
Human Protein AtlasENSG00000198846-TOX [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94900   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94900  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94900
PhosPhoSitePlusO94900
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom    HMG_box_dom_sf   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TOX
SuperfamilyO94900
AlphaFold pdb e-kbO94900   
Human Protein Atlas [tissue]ENSG00000198846-TOX [tissue]
HPRD12113
Protein Interaction databases
DIP (DOE-UCLA)O94900
IntAct (EBI)O94900
BioGRIDTOX
STRING (EMBL)TOX
ZODIACTOX
Ontologies - Pathways
QuickGOO94900
Ontology : AmiGOnatural killer cell differentiation  CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment  NK T cell lineage commitment  leukocyte differentiation  protein binding  nucleus  nucleus  chromatin organization  regulation of transcription by RNA polymerase II  positive regulation of neuron projection development  cerebral cortex neuron differentiation  chromatin DNA binding  chromatin DNA binding  positive regulation of natural killer cell differentiation  CD4-positive, alpha-beta T cell lineage commitment  CD8-positive, alpha-beta T cell lineage commitment  lymph node development  Peyer's patch development  positive regulation of DNA demethylation  regulation of positive thymic T cell selection  positive regulation of neural precursor cell proliferation  
Ontology : EGO-EBInatural killer cell differentiation  CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment  NK T cell lineage commitment  leukocyte differentiation  protein binding  nucleus  nucleus  chromatin organization  regulation of transcription by RNA polymerase II  positive regulation of neuron projection development  cerebral cortex neuron differentiation  chromatin DNA binding  chromatin DNA binding  positive regulation of natural killer cell differentiation  CD4-positive, alpha-beta T cell lineage commitment  CD8-positive, alpha-beta T cell lineage commitment  lymph node development  Peyer's patch development  positive regulation of DNA demethylation  regulation of positive thymic T cell selection  positive regulation of neural precursor cell proliferation  
NDEx NetworkTOX
Atlas of Cancer Signalling NetworkTOX
Wikipedia pathwaysTOX
Orthology - Evolution
OrthoDB9760
GeneTree (enSembl)ENSG00000198846
Phylogenetic Trees/Animal Genes : TreeFamTOX
Homologs : HomoloGeneTOX
Homology/Alignments : Family Browser (UCSC)TOX
Gene fusions - Rearrangements
Fusion : MitelmanCHD7/TOX [8q12.1/8q12.1]  
Fusion : MitelmanTOX/PGBD2 [8q12.1/1q44]  
Fusion : QuiverTOX
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOX [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOX
dbVarTOX
ClinVarTOX
MonarchTOX
1000_GenomesTOX 
Exome Variant ServerTOX
GNOMAD BrowserENSG00000198846
Varsome BrowserTOX
ACMGTOX variants
VarityO94900
Genomic Variants (DGV)TOX [DGVbeta]
DECIPHERTOX [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOX 
Mutations
ICGC Data PortalTOX 
TCGA Data PortalTOX 
Broad Tumor PortalTOX
OASIS PortalTOX [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOX  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOX
Mutations and Diseases : HGMDTOX
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOX
DgiDB (Drug Gene Interaction Database)TOX
DoCM (Curated mutations)TOX
CIViC (Clinical Interpretations of Variants in Cancer)TOX
Cancer3DTOX
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606863   
Orphanet
DisGeNETTOX
MedgenTOX
Genetic Testing Registry TOX
NextProtO94900 [Medical]
GENETestsTOX
Target ValidationTOX
Huge Navigator TOX [HugePedia]
ClinGenTOX
Clinical trials, drugs, therapy
MyCancerGenomeTOX
Protein Interactions : CTDTOX
Pharm GKB GenePA162406704
PharosO94900
Clinical trialTOX
Miscellaneous
canSAR (ICR)TOX
HarmonizomeTOX
DataMed IndexTOX
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOX
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:56 CEST 2021

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