TOX (thymocyte selection associated high mobility group box)

2007-04-01  

Identity

HGNC
LOCATION
8q12.1
LOCUSID
ALIAS
TOX1
FUSION GENES

Other Information

Locus ID:

NCBI: 9760
MIM: 606863
HGNC: 18988
Ensembl: ENSG00000198846

Variants:

dbSNP: 9760
ClinVar: 9760
TCGA: ENSG00000198846
COSMIC: TOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198846ENST00000361421O94900

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175299742007Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer.343
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
312076042019TOX is a critical regulator of tumour-specific T cell differentiation.38
312076052019TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.38
150788952004TOX provides a link between calcineurin activation and CD8 lineage commitment.26
224968702012Differential epigenetic regulation of TOX subfamily high mobility group box genes in lung and breast cancers.25
234156682013Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.25
211265362011TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro.22
255483212015Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma.17

Citation

Dessen P

TOX (thymocyte selection associated high mobility group box)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47116/tox