Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TOX2 (TOX high mobility group box family member 2)

Identity

Alias_namesC20orf100
chromosome 20 open reading frame 100
Alias_symbol (synonym)dJ1108D11.2
GCX-1
Other aliasGCX1
dJ495O3.1
HGNC (Hugo) TOX2
LocusID (NCBI) 84969
Atlas_Id 52854
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 43916142 and ends at 44069614 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
B4GALT5 (20q13.13) / TOX2 (20q13.12)EEF1G (11q12.3) / TOX2 (20q13.12)TRPC4AP (20q11.22) / TOX2 (20q13.12)
B4GALT5 20q13.13 / TOX2 20q13.12TRPC4AP 20q11.22 / TOX2 20q13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOX2   16095
Cards
Entrez_Gene (NCBI)TOX2  84969  TOX high mobility group box family member 2
AliasesC20orf100; GCX-1; GCX1; dJ1108D11.2; 
dJ495O3.1
GeneCards (Weizmann)TOX2
Ensembl hg19 (Hinxton)ENSG00000124191 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124191 [Gene_View]  chr20:43916142-44069614 [Contig_View]  TOX2 [Vega]
ICGC DataPortalENSG00000124191
TCGA cBioPortalTOX2
AceView (NCBI)TOX2
Genatlas (Paris)TOX2
WikiGenes84969
SOURCE (Princeton)TOX2
Genetics Home Reference (NIH)TOX2
Genomic and cartography
GoldenPath hg38 (UCSC)TOX2  -     chr20:43916142-44069614 +  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOX2  -     20q13.12   [Description]    (hg19-Feb_2009)
EnsemblTOX2 - 20q13.12 [CytoView hg19]  TOX2 - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBITOX2 [Mapview hg19]  TOX2 [Mapview hg38]
OMIM611163   
Gene and transcription
Genbank (Entrez)AK055135 AK289906 AK298976 BC007636 BM545579
RefSeq transcript (Entrez)NM_001098796 NM_001098797 NM_001098798 NM_032883
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOX2
Cluster EST : UnigeneHs.26608 [ NCBI ]
CGAP (NCI)Hs.26608
Alternative Splicing GalleryENSG00000124191
Gene ExpressionTOX2 [ NCBI-GEO ]   TOX2 [ EBI - ARRAY_EXPRESS ]   TOX2 [ SEEK ]   TOX2 [ MEM ]
Gene Expression Viewer (FireBrowse)TOX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84969
GTEX Portal (Tissue expression)TOX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96NM4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96NM4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96NM4
Splice isoforms : SwissVarQ96NM4
PhosPhoSitePlusQ96NM4
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TOX2
DMDM Disease mutations84969
Blocks (Seattle)TOX2
SuperfamilyQ96NM4
Human Protein AtlasENSG00000124191
Peptide AtlasQ96NM4
HPRD12734
IPIIPI00043748   IPI00219264   IPI00940106   IPI00412463   IPI00646911   IPI00552402   
Protein Interaction databases
DIP (DOE-UCLA)Q96NM4
IntAct (EBI)Q96NM4
FunCoupENSG00000124191
BioGRIDTOX2
STRING (EMBL)TOX2
ZODIACTOX2
Ontologies - Pathways
QuickGOQ96NM4
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleoplasm  transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  nucleoplasm  transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  
NDEx NetworkTOX2
Atlas of Cancer Signalling NetworkTOX2
Wikipedia pathwaysTOX2
Orthology - Evolution
OrthoDB84969
GeneTree (enSembl)ENSG00000124191
Phylogenetic Trees/Animal Genes : TreeFamTOX2
HOVERGENQ96NM4
HOGENOMQ96NM4
Homologs : HomoloGeneTOX2
Homology/Alignments : Family Browser (UCSC)TOX2
Gene fusions - Rearrangements
Fusion : MitelmanB4GALT5/TOX2 [20q13.13/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanTRPC4AP/TOX2 [20q11.22/20q13.12]  [t(20;20)(q11;q13)]  
Fusion: TCGAB4GALT5 20q13.13 TOX2 20q13.12 LUAD
Fusion: TCGATRPC4AP 20q11.22 TOX2 20q13.12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOX2
dbVarTOX2
ClinVarTOX2
1000_GenomesTOX2 
Exome Variant ServerTOX2
ExAC (Exome Aggregation Consortium)TOX2 (select the gene name)
Genetic variants : HAPMAP84969
Genomic Variants (DGV)TOX2 [DGVbeta]
DECIPHERTOX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOX2 
Mutations
ICGC Data PortalTOX2 
TCGA Data PortalTOX2 
Broad Tumor PortalTOX2
OASIS PortalTOX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOX2
DgiDB (Drug Gene Interaction Database)TOX2
DoCM (Curated mutations)TOX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOX2 (select a term)
intoGenTOX2
Cancer3DTOX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611163   
Orphanet
MedgenTOX2
Genetic Testing Registry TOX2
NextProtQ96NM4 [Medical]
TSGene84969
GENETestsTOX2
Target ValidationTOX2
Huge Navigator TOX2 [HugePedia]
snp3D : Map Gene to Disease84969
BioCentury BCIQTOX2
ClinGenTOX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84969
Chemical/Pharm GKB GenePA162406727
Clinical trialTOX2
Miscellaneous
canSAR (ICR)TOX2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOX2
EVEXTOX2
GoPubMedTOX2
iHOPTOX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:00:21 CEST 2017

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