TOX3 (TOX high mobility group box family member 3)

2009-08-01  

Identity

HGNC
TOX3
LOCATION
16q12.1
LOCUSID
27324
ALIAS
CAGF9,TNRC9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27324
MIM: 611416
HGNC: 11972
Ensembl: ENSG00000103460

Variants:

dbSNP: 27324
ClinVar: 27324
TCGA: ENSG00000103460
COSMIC: TOX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103460ENST00000219746O15405
ENSG00000103460ENST00000407228O15405
ENSG00000103460ENST00000563091H3BTZ9
ENSG00000103460ENST00000568436J3QQQ6

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202373442010Performance of common genetic variants in breast-cancer risk models.191
230011242012Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression.180
184372042008Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.167
183557722008Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.99
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
206052012010Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.59
206640432010Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci.59
197893662009Evaluation of 11 breast cancer susceptibility loci in African-American women.56
203321012010Fine scale mapping of the breast cancer 16q12 locus.35
179978232007Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.31

Citation

Dessen P

TOX3 (TOX high mobility group box family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/50991/tox3