TOX3 (TOX high mobility group box family member 3)

2009-08-01

Identity

HGNC

TOX3

LOCATION

16q12.1

LOCUSID

27324

ALIAS

CAGF9,TNRC9

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 27324
MIM: 611416
HGNC: 11972
Ensembl: ENSG00000103460

Variants:

dbSNP: 27324
ClinVar: 27324
TCGA: ENSG00000103460
COSMIC: TOX3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103460	ENST00000219746	O15405
ENSG00000103460	ENST00000407228	O15405
ENSG00000103460	ENST00000563091	H3BTZ9
ENSG00000103460	ENST00000568436	J3QQQ6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
30515698	2019	Significant association of TOX3/LOC643714 locus-rs3803662 and breast cancer risk in a cohort of Iranian population.	5
30772441	2019	TOX3 inhibits cancer cell migration and invasion via transcriptional regulation of SNAI1 and SNAI2 in clear cell renal cell carcinoma.	15
30924295	2019	Two novel genes TOX3 and COL21A1 in large extended Malay families with nonsyndromic cleft lip and/or palate.	6
31706190	2020	TOX3 gene variant could be associated with painful restless legs.	3
31706190	2020	TOX3 gene variant could be associated with painful restless legs.	3
33716953	2020	TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study.	6
33716953	2020	TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study.	6
33740609	2021	Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma.	1
33740609	2021	Genetic polymorphism of fibroblast growth factor receptor 2 and trinucleotide repeat-containing 9 influence the susceptibility to HCV-induced hepatocellular carcinoma.	1
34260521	2021	Association between CASC16 rs4784227 polymorphism and breast cancer susceptibility: A meta-analysis.	3

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Citation

Dessen P

TOX3 (TOX high mobility group box family member 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/50991/tox3