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TOX3 (TOX high mobility group box family member 3)

Identity

Alias_namesTNRC9
trinucleotide repeat containing 9
Alias_symbol (synonym)CAGF9
HGNC (Hugo) TOX3
LocusID (NCBI) 27324
Atlas_Id 50991
Location 16q12.1  [Link to chromosome band 16q12]
Location_base_pair Starts at 52471918 and ends at 52580806 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARIH2 (3p21.31) / TOX3 (16q12.1)SCAI (9q33.3) / TOX3 (16q12.1)TOX3 (16q12.1) / ARIH2 (3p21.31)
TOX3 (16q12.1) / CNTN5 (11q22.1)TOX3 (16q12.1) / GNAO1 (16q12.2)TOX3 (16q12.1) / HEYL (1p34.3)
TOX3 (16q12.1) / ITFG1 (16q12.1)TOX3 (16q12.1) / LRP6 (12p13.2)TOX3 (16q12.1) / PHKB (16q12.1)
SCAI 9q33.3 / TOX3 16q12.1TOX3 16q12.1 / CNTN5 11q22.1TOX3 16q12.1 / HEYL 1p34.3
TOX3 16q12.1 / ITFG1 16q12.1TOX3 16q12.1 / PHKB 16q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOX3   11972
Cards
Entrez_Gene (NCBI)TOX3  27324  TOX high mobility group box family member 3
AliasesCAGF9; TNRC9
GeneCards (Weizmann)TOX3
Ensembl hg19 (Hinxton)ENSG00000103460 [Gene_View]  chr16:52471918-52580806 [Contig_View]  TOX3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000103460 [Gene_View]  chr16:52471918-52580806 [Contig_View]  TOX3 [Vega]
ICGC DataPortalENSG00000103460
TCGA cBioPortalTOX3
AceView (NCBI)TOX3
Genatlas (Paris)TOX3
WikiGenes27324
SOURCE (Princeton)TOX3
Genetics Home Reference (NIH)TOX3
Genomic and cartography
GoldenPath hg19 (UCSC)TOX3  -     chr16:52471918-52580806 -  16q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOX3  -     16q12.1   [Description]    (hg38-Dec_2013)
EnsemblTOX3 - 16q12.1 [CytoView hg19]  TOX3 - 16q12.1 [CytoView hg38]
Mapping of homologs : NCBITOX3 [Mapview hg19]  TOX3 [Mapview hg38]
OMIM611416   
Gene and transcription
Genbank (Entrez)AI733227 AK025084 AK027006 AK095095 AK299202
RefSeq transcript (Entrez)NM_001080430 NM_001146188
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_012623 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)TOX3
Cluster EST : UnigeneHs.460789 [ NCBI ]
CGAP (NCI)Hs.460789
Alternative Splicing GalleryENSG00000103460
Gene ExpressionTOX3 [ NCBI-GEO ]   TOX3 [ EBI - ARRAY_EXPRESS ]   TOX3 [ SEEK ]   TOX3 [ MEM ]
Gene Expression Viewer (FireBrowse)TOX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27324
GTEX Portal (Tissue expression)TOX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15405
Splice isoforms : SwissVarO15405
PhosPhoSitePlusO15405
Domaine pattern : Prosite (Expaxy)HMG_BOX_2 (PS50118)   
Domains : Interpro (EBI)HMG_box_dom   
Domain families : Pfam (Sanger)HMG_box (PF00505)   
Domain families : Pfam (NCBI)pfam00505   
Domain families : Smart (EMBL)HMG (SM00398)  
Conserved Domain (NCBI)TOX3
DMDM Disease mutations27324
Blocks (Seattle)TOX3
SuperfamilyO15405
Human Protein AtlasENSG00000103460
Peptide AtlasO15405
IPIIPI00903025   IPI00929129   
Protein Interaction databases
DIP (DOE-UCLA)O15405
IntAct (EBI)O15405
FunCoupENSG00000103460
BioGRIDTOX3
STRING (EMBL)TOX3
ZODIACTOX3
Ontologies - Pathways
QuickGOO15405
Ontology : AmiGOchromatin binding  protein binding  nucleus  transcription, DNA-templated  apoptotic process  estrogen response element binding  protein homodimerization activity  negative regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  phosphoprotein binding  
Ontology : EGO-EBIchromatin binding  protein binding  nucleus  transcription, DNA-templated  apoptotic process  estrogen response element binding  protein homodimerization activity  negative regulation of neuron apoptotic process  positive regulation of transcription, DNA-templated  phosphoprotein binding  
NDEx NetworkTOX3
Atlas of Cancer Signalling NetworkTOX3
Wikipedia pathwaysTOX3
Orthology - Evolution
OrthoDB27324
GeneTree (enSembl)ENSG00000103460
Phylogenetic Trees/Animal Genes : TreeFamTOX3
HOVERGENO15405
HOGENOMO15405
Homologs : HomoloGeneTOX3
Homology/Alignments : Family Browser (UCSC)TOX3
Gene fusions - Rearrangements
Fusion : MitelmanSCAI/TOX3 [9q33.3/16q12.1]  [t(9;16)(q33;q12)]  
Fusion : MitelmanTOX3/CNTN5 [16q12.1/11q22.1]  [t(11;16)(q22;q12)]  
Fusion : MitelmanTOX3/GNAO1 [16q12.1/16q12.2]  [t(16;16)(q12;q12)]  
Fusion : MitelmanTOX3/HEYL [16q12.1/1p34.3]  [t(1;16)(p34;q12)]  
Fusion : MitelmanTOX3/ITFG1 [16q12.1/16q12.1]  [t(16;16)(q12;q12)]  
Fusion : MitelmanTOX3/PHKB [16q12.1/16q12.1]  [t(16;16)(q12;q12)]  
Fusion: TCGASCAI 9q33.3 TOX3 16q12.1 BRCA
Fusion: TCGATOX3 16q12.1 CNTN5 11q22.1 PRAD
Fusion: TCGATOX3 16q12.1 HEYL 1p34.3 LUAD
Fusion: TCGATOX3 16q12.1 ITFG1 16q12.1 BRCA
Fusion: TCGATOX3 16q12.1 PHKB 16q12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOX3
dbVarTOX3
ClinVarTOX3
1000_GenomesTOX3 
Exome Variant ServerTOX3
ExAC (Exome Aggregation Consortium)TOX3 (select the gene name)
Genetic variants : HAPMAP27324
Genomic Variants (DGV)TOX3 [DGVbeta]
DECIPHER (Syndromes)16:52471918-52580806  ENSG00000103460
CONAN: Copy Number AnalysisTOX3 
Mutations
ICGC Data PortalTOX3 
TCGA Data PortalTOX3 
Broad Tumor PortalTOX3
OASIS PortalTOX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOX3
DgiDB (Drug Gene Interaction Database)TOX3
DoCM (Curated mutations)TOX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOX3 (select a term)
intoGenTOX3
Cancer3DTOX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611416   
Orphanet
MedgenTOX3
Genetic Testing Registry TOX3
NextProtO15405 [Medical]
TSGene27324
GENETestsTOX3
Huge Navigator TOX3 [HugePedia]
snp3D : Map Gene to Disease27324
BioCentury BCIQTOX3
ClinGenTOX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27324
Chemical/Pharm GKB GenePA162406752
Clinical trialTOX3
Miscellaneous
canSAR (ICR)TOX3 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOX3
EVEXTOX3
GoPubMedTOX3
iHOPTOX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:54:18 CET 2016

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