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TP53BP1 (tumor protein p53 binding protein 1)

Identity

Other names53BP1
FLJ41424
MGC138366
p202
HGNC (Hugo) TP53BP1
Location 15q15.3
Location_base_pair Starts at 41486706 and ends at 41572646 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TP53BP1   11999
Entrez_Gene (NCBI)TP53BP1  7158  tumor protein p53 binding protein 1
Cards
GeneCards (Weizmann)TP53BP1
Ensembl (Hinxton)ENSG00000067369 [Gene_View]  TP53BP1 [Vega]
AceView (NCBI)TP53BP1
Genatlas (Paris)TP53BP1
euGene (Indiana)7158
SOURCE (Stanford)NM_001141979 NM_001141980 NM_005657
Gene Expression (Array Express) ENSG00000067369
Genomic and cartography
GoldenPath (UCSC)TP53BP1  -  15q15.3   chr15:41486706-41572646 -  15q15.3   [Description]    (hg18-March_2006)
EnsemblTP53BP1 - 15q15.3 [CytoView]
Mapping of homologs : NCBITP53BP1 [Mapview]
OMIM605230   
Gene and transcription
Gene : Genbank (Entrez)AB210025 AF078776 AK123418 AK292915 AK295764
Reference sequence (RefSeq transcript) :SRSNM_001141979 NM_001141980 NM_005657
Reference transcript : EntrezNM_001141979 NM_001141980 NM_005657
RefSeq genomic : SRSAC_000058 AC_000147 NC_000015 NT_010194 NW_001838214 NW_925840
RefSeq genomic : EntrezAC_000058 AC_000147 NC_000015 NT_010194 NW_001838214 NW_925840
Consensus coding sequences : CCDS NCBITP53BP1
Cluster EST : UnigeneHs.440968 [ SRS ] Hs.440968 [ NCBI ]
Alternative Splicing : Fast-db (Paris)3537
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ12888 (SRS) Q12888 (Expasy) Q12888 (Uniprot)
With graphics : InterProQ12888
Splice isoforms : VarSplice FASTAQ12888(VarSplice FASTA)
Domaine pattern : Prosite (SRS)BRCT (PS50172)   
Domain pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (SRS)53-BP1_Tudor    BRCT    Transl_SH3-like_sub   
Domains : Interpro (EBI)53-BP1_Tudor    BRCT    Transl_SH3-like_sub   
Related proteins : CluSTrQ12888
Domain families : Pfam SRS53-BP1_Tudor (PF09038)   
Domain families : Pfam Sanger53-BP1_Tudor (PF09038)   
Domain families : Pfam NCBIpfam09038   
Domain families : Smart EMBLBRCT (SM00292)  
Blocks (Seattle)Q12888
Crystal structure of protein : PDB SRS1GZH    1KZY    1XNI    2G3R    2IG0   
Crystal structure of protein : PDBSum1GZH    1KZY    1XNI    2G3R    2IG0   
Crystal structure of protein : IMB1GZH    1KZY    1XNI    2G3R    2IG0   
Crystal structure of protein : PDB RSDB1GZH    1KZY    1XNI    2G3R    2IG0   
HPRD05569
Protein Interaction databases
DIP (DOE-UCLA)Q12888
IntAct (EBI)Q12888
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITP53BP1
SNP : GeneSNP UtahTP53BP1
SNP : HGBaseTP53BP1
Genetic variants : HAPMAPTP53BP1
Somatic Mutations in Cancer : COSMICTP53BP1 
Translocation Breakpoints in Cancer : TICdbcondensed 
Mutations and Diseases : HGMDTP53BP1
Hereditary diseases : OMIM605230   
Hereditary diseases : GENETests605230   
Diseases : Genetic AssociationTP53BP1
General knowledge
Homologs : HomoloGeneTP53BP1
Homology/Alignments : Family Browser UCSCTP53BP1
Phylogenetic Trees/Animal Genes : TreeFamTP53BP1
Chemical/Protein Interactions : CTD7158
Keywords Ontology : AmiGOcondensed chromosome kinetochore  chromosome, telomeric region  damaged DNA binding  protein binding  intracellular  nucleus  nucleoplasm  replication fork  cytoplasm  DNA repair  response to DNA damage stimulus  transcription activator activity  telomeric DNA binding  regulation of transcription  positive regulation of transcription, DNA-dependent  
Keywords Ontology : EGO-EBIcondensed chromosome kinetochore  chromosome, telomeric region  damaged DNA binding  protein binding  intracellular  nucleus  nucleoplasm  replication fork  cytoplasm  DNA repair  response to DNA damage stimulus  transcription activator activity  telomeric DNA binding  regulation of transcription  positive regulation of transcription, DNA-dependent  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTP53BP1 Related clones (RZPD - Berlin)
Literature
PubMed90 Pubmed reference(s) in Entrez
PubGeneTP53BP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:38:51 CET 2010
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