TP53INP2 (tumor protein p53 inducible nuclear protein 2)

2004-08-01  

Identity

HGNC
TP53INP2
LOCATION
20q11.22
LOCUSID
58476
ALIAS
C20orf110,DOR,PIG-U,PIGU,PINH,dJ1181N3.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 58476
MIM: 617549
HGNC: 16104
Ensembl: ENSG00000078804

Variants:

dbSNP: 58476
ClinVar: 58476
TCGA: ENSG00000078804
COSMIC: TP53INP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078804ENST00000374809Q8IXH6
ENSG00000078804ENST00000374810Q8IXH6
ENSG00000078804ENST00000414082Q5JX66
ENSG00000078804ENST00000451665Q5JX65

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140

References

Pubmed IDYearTitleCitations
190566832009The TP53INP2 protein is required for autophagy in mammalian cells.44
199343092009hnRNP A2 regulates alternative mRNA splicing of TP53INP2 to control invasive cell migration.22
224705102012DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.21
295933292018TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β.8
227501422012DOR undergoes nucleo-cytoplasmic shuttling, which involves passage through the nucleolus.7
308532982019Regulation of NGF Signaling by an Axonal Untranslated mRNA.6
214673002011Role of diabetes- and obesity-related protein in the regulation of osteoblast differentiation.5
271720022016TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.4
281310962017TP53INP2-related basal autophagy is involved in the growth and malignant progression in human liposarcoma cells.2
309797792019Regulation of death receptor signaling by the autophagy protein TP53INP2.2

Citation

Dessen P

TP53INP2 (tumor protein p53 inducible nuclear protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-08-01

Online version: http://atlasgeneticsoncology.org/gene/42920/tp53inp2