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TP53RK (TP53 regulating kinase)

Identity

Alias_namesC20orf64
chromosome 20 open reading frame 64
Alias_symbol (synonym)dJ101A2.2
prpk
Nori-2p
BUD32
Other aliasNori-2
PRPK
dJ101A2
HGNC (Hugo) TP53RK
LocusID (NCBI) 112858
Atlas_Id 43537
Location 20q13.12  [Link to chromosome band 20q13]
Location_base_pair Starts at 46684365 and ends at 46689637 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GREM1 (15q13.3) / TP53RK (20q13.12)TP53RK (20q13.12) / SLC13A3 (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TP53RK   16197
Cards
Entrez_Gene (NCBI)TP53RK  112858  TP53 regulating kinase
AliasesBUD32; C20orf64; Nori-2; Nori-2p; 
PRPK; dJ101A2
GeneCards (Weizmann)TP53RK
Ensembl hg19 (Hinxton)ENSG00000172315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172315 [Gene_View]  chr20:46684365-46689637 [Contig_View]  TP53RK [Vega]
ICGC DataPortalENSG00000172315
TCGA cBioPortalTP53RK
AceView (NCBI)TP53RK
Genatlas (Paris)TP53RK
WikiGenes112858
SOURCE (Princeton)TP53RK
Genetics Home Reference (NIH)TP53RK
Genomic and cartography
GoldenPath hg38 (UCSC)TP53RK  -     chr20:46684365-46689637 -  20q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TP53RK  -     20q13.12   [Description]    (hg19-Feb_2009)
EnsemblTP53RK - 20q13.12 [CytoView hg19]  TP53RK - 20q13.12 [CytoView hg38]
Mapping of homologs : NCBITP53RK [Mapview hg19]  TP53RK [Mapview hg38]
OMIM608679   
Gene and transcription
Genbank (Entrez)AB017505 AB065434 AK096502 AK315182 BC009727
RefSeq transcript (Entrez)NM_033550
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TP53RK
Cluster EST : UnigeneHs.440263 [ NCBI ]
CGAP (NCI)Hs.440263
Alternative Splicing GalleryENSG00000172315
Gene ExpressionTP53RK [ NCBI-GEO ]   TP53RK [ EBI - ARRAY_EXPRESS ]   TP53RK [ SEEK ]   TP53RK [ MEM ]
Gene Expression Viewer (FireBrowse)TP53RK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112858
GTEX Portal (Tissue expression)TP53RK
Human Protein AtlasENSG00000172315-TP53RK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96S44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96S44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96S44
Splice isoforms : SwissVarQ96S44
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ96S44
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Bud32    Kinase-like_dom    LipoPS_kinase    Prot_kinase_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Kdo (PF06293)   
Domain families : Pfam (NCBI)pfam06293   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TP53RK
DMDM Disease mutations112858
Blocks (Seattle)TP53RK
SuperfamilyQ96S44
Human Protein Atlas [tissue]ENSG00000172315-TP53RK [tissue]
Peptide AtlasQ96S44
HPRD12276
IPIIPI00290305   IPI00552208   
Protein Interaction databases
DIP (DOE-UCLA)Q96S44
IntAct (EBI)Q96S44
FunCoupENSG00000172315
BioGRIDTP53RK
STRING (EMBL)TP53RK
ZODIACTP53RK
Ontologies - Pathways
QuickGOQ96S44
Ontology : AmiGOEKC/KEOPS complex  EKC/KEOPS complex  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  protein phosphorylation  tRNA processing  membrane  hydrolase activity  tRNA threonylcarbamoyladenosine metabolic process  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIEKC/KEOPS complex  EKC/KEOPS complex  p53 binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytosol  protein phosphorylation  tRNA processing  membrane  hydrolase activity  tRNA threonylcarbamoyladenosine metabolic process  regulation of signal transduction by p53 class mediator  
NDEx NetworkTP53RK
Atlas of Cancer Signalling NetworkTP53RK
Wikipedia pathwaysTP53RK
Orthology - Evolution
OrthoDB112858
GeneTree (enSembl)ENSG00000172315
Phylogenetic Trees/Animal Genes : TreeFamTP53RK
HOVERGENQ96S44
HOGENOMQ96S44
Homologs : HomoloGeneTP53RK
Homology/Alignments : Family Browser (UCSC)TP53RK
Gene fusions - Rearrangements
Tumor Fusion PortalTP53RK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTP53RK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TP53RK
dbVarTP53RK
ClinVarTP53RK
1000_GenomesTP53RK 
Exome Variant ServerTP53RK
ExAC (Exome Aggregation Consortium)ENSG00000172315
GNOMAD BrowserENSG00000172315
Genetic variants : HAPMAP112858
Genomic Variants (DGV)TP53RK [DGVbeta]
DECIPHERTP53RK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTP53RK 
Mutations
ICGC Data PortalTP53RK 
TCGA Data PortalTP53RK 
Broad Tumor PortalTP53RK
OASIS PortalTP53RK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTP53RK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTP53RK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TP53RK
DgiDB (Drug Gene Interaction Database)TP53RK
DoCM (Curated mutations)TP53RK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TP53RK (select a term)
intoGenTP53RK
Cancer3DTP53RK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608679   
Orphanet
DisGeNETTP53RK
MedgenTP53RK
Genetic Testing Registry TP53RK
NextProtQ96S44 [Medical]
TSGene112858
GENETestsTP53RK
Target ValidationTP53RK
Huge Navigator TP53RK [HugePedia]
snp3D : Map Gene to Disease112858
BioCentury BCIQTP53RK
ClinGenTP53RK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD112858
Chemical/Pharm GKB GenePA25774
Clinical trialTP53RK
Miscellaneous
canSAR (ICR)TP53RK (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTP53RK
EVEXTP53RK
GoPubMedTP53RK
iHOPTP53RK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 21 14:39:20 CET 2017

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