TP53RK (TP53 regulating kinase)

2006-10-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
BUD32,C20orf64,GAMOS4,Nori-2,Nori-2p,PRPK,TPRKB,dJ101A2
FUSION GENES

Other Information

Locus ID:

NCBI: 112858
MIM: 608679
HGNC: 16197
Ensembl: ENSG00000172315

Variants:

dbSNP: 112858
ClinVar: 112858
TCGA: ENSG00000172315
COSMIC: TP53RK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172315ENST00000372102Q5JZ02
ENSG00000172315ENST00000372114Q96S44

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Activity through PhosphorylationREACTOMER-HSA-6804756

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243518562014An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.25
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
177125282007Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB.12
166001822006A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK.9
280824452017p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma.8
294832192018Targeting PRPK Function Blocks Colon Cancer Metastasis.5
300538622018A familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case report.3

Citation

Dessen P

TP53RK (TP53 regulating kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43537/tp53rk