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TP73 (tumor protein p73)

Identity

Alias_symbol (synonym)P73
Other alias
HGNC (Hugo) TP73
LocusID (NCBI) 7161
Atlas_Id 205
Location 1p36.32  [Link to chromosome band 1p36]
Location_base_pair Starts at 3690672 and ends at 3736201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFT80 (3q25.33) / TP73 (1p36.32)TP73 (1p36.32) / CEP104 (1p36.32)TP73 (1p36.32) / PACSIN2 (22q13.2)
TP73 (1p36.32) / TP73 (1p36.32)TP73 1p36.32 / CEP104 1p36.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  Follicular lymphoma (FL)
Nasal T cell lymphoma
NK cell neoplasias
t(1;1)(p36;q21) in Non Hodgkin Lymphoma


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Bladder: Urothelial carcinomas


External links

Nomenclature
HGNC (Hugo)TP73   12003
Cards
Entrez_Gene (NCBI)TP73  7161  tumor protein p73
AliasesP73
GeneCards (Weizmann)TP73
Ensembl hg19 (Hinxton)ENSG00000078900 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078900 [Gene_View]  chr1:3690672-3736201 [Contig_View]  TP73 [Vega]
ICGC DataPortalENSG00000078900
TCGA cBioPortalTP73
AceView (NCBI)TP73
Genatlas (Paris)TP73
WikiGenes7161
SOURCE (Princeton)TP73
Genetics Home Reference (NIH)TP73
Genomic and cartography
GoldenPath hg38 (UCSC)TP73  -     chr1:3690672-3736201 +  1p36.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TP73  -     1p36.32   [Description]    (hg18-Feā_2409)
EnsemblTP73 - 1p36.32 [CytoView hg19]  TP73 - 1p36.32 [CytoView hg38]
Mapping of homologs : NCBITP73 [Mapview hg19]  TP73 [Mapview hg38]
OMIM601990   
Gene and transcription
Genbank (Entrez)AB055065 AB055066 AI094238 AK295669 AK302118
RefSeq transcript (Entrez)NM_001126240 NM_001126241 NM_001126242 NM_001204184 NM_001204185 NM_001204186 NM_001204187 NM_001204188 NM_001204189 NM_001204190 NM_001204191 NM_001204192 NM_005427
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TP73
Cluster EST : UnigeneHs.192132 [ NCBI ]
CGAP (NCI)Hs.192132
Alternative Splicing GalleryENSG00000078900
Gene ExpressionTP73 [ NCBI-GEO ]   TP73 [ EBI - ARRAY_EXPRESS ]   TP73 [ SEEK ]   TP73 [ MEM ]
Gene Expression Viewer (FireBrowse)TP73 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7161
GTEX Portal (Tissue expression)TP73
Human Protein AtlasENSG00000078900-TP73 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15350   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15350  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15350
Splice isoforms : SwissVarO15350
PhosPhoSitePlusO15350
Domaine pattern : Prosite (Expaxy)P53 (PS00348)   
Domains : Interpro (EBI)p53-like_TF_DNA-bd    p53/RUNT-type_TF_DNA-bd    p53_DNA-bd    p53_tetrameristn    p53_tumour_suppressor    SAM    SAM/pointed    Tp73   
Domain families : Pfam (Sanger)P53 (PF00870)    P53_tetramer (PF07710)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00870    pfam07710    pfam07647   
Domain families : Smart (EMBL)SAM (SM00454)  
Conserved Domain (NCBI)TP73
DMDM Disease mutations7161
Blocks (Seattle)TP73
PDB (SRS)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
PDB (PDBSum)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
PDB (IMB)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
PDB (RSDB)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
Structural Biology KnowledgeBase1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
SCOP (Structural Classification of Proteins)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
CATH (Classification of proteins structures)1COK    1DXS    2KBY    2MPS    2NB1    2WQI    2WQJ    2WTT    2XWC    3VD0    3VD1    3VD2    4A63    4G82    4G83    4GUO    4GUQ    5HOB    5HOC    5KBD   
SuperfamilyO15350
Human Protein Atlas [tissue]ENSG00000078900-TP73 [tissue]
Peptide AtlasO15350
HPRD03587
IPIIPI00006160   IPI00607588   IPI00215708   IPI00215709   IPI00215710   IPI00215711   IPI00215712   IPI00607886   IPI00607833   IPI00975840   IPI00953220   IPI00983586   IPI00982509   IPI00983009   IPI00981217   IPI00953682   
Protein Interaction databases
DIP (DOE-UCLA)O15350
IntAct (EBI)O15350
FunCoupENSG00000078900
BioGRIDTP73
STRING (EMBL)TP73
ZODIACTP73
Ontologies - Pathways
QuickGOO15350
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  kidney development  p53 binding  p53 binding  chromatin binding  damaged DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  mitochondrion  Golgi apparatus  cytosol  mismatch repair  transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  cell cycle arrest  regulation of mitotic cell cycle  transcription factor binding  intrinsic apoptotic signaling pathway in response to DNA damage  response to X-ray  response to organonitrogen compound  response to gamma radiation  regulation of gene expression  viral process  protein kinase binding  cell junction  mitotic G1 DNA damage checkpoint  cellular response to UV  response to drug  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  identical protein binding  regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of JUN kinase activity  negative regulation of neuron apoptotic process  transcription regulatory region DNA binding  negative regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of oligodendrocyte differentiation  protein tetramerization  negative regulation of cardiac muscle cell proliferation  positive regulation of cell cycle arrest  MDM2/MDM4 family protein binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  kidney development  p53 binding  p53 binding  chromatin binding  damaged DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  mitochondrion  Golgi apparatus  cytosol  mismatch repair  transcription from RNA polymerase II promoter  cellular response to DNA damage stimulus  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  cell cycle arrest  regulation of mitotic cell cycle  transcription factor binding  intrinsic apoptotic signaling pathway in response to DNA damage  response to X-ray  response to organonitrogen compound  response to gamma radiation  regulation of gene expression  viral process  protein kinase binding  cell junction  mitotic G1 DNA damage checkpoint  cellular response to UV  response to drug  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  identical protein binding  regulation of apoptotic process  intracellular membrane-bounded organelle  negative regulation of JUN kinase activity  negative regulation of neuron apoptotic process  transcription regulatory region DNA binding  negative regulation of neuron differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of oligodendrocyte differentiation  protein tetramerization  negative regulation of cardiac muscle cell proliferation  positive regulation of cell cycle arrest  MDM2/MDM4 family protein binding  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAATM Signaling Pathway [Genes]   
Pathways : KEGGp53 signaling pathway    Hippo signaling pathway    Neurotrophin signaling pathway    Measles   
NDEx NetworkTP73
Atlas of Cancer Signalling NetworkTP73
Wikipedia pathwaysTP73
Orthology - Evolution
OrthoDB7161
GeneTree (enSembl)ENSG00000078900
Phylogenetic Trees/Animal Genes : TreeFamTP73
HOVERGENO15350
HOGENOMO15350
Homologs : HomoloGeneTP73
Homology/Alignments : Family Browser (UCSC)TP73
Gene fusions - Rearrangements
Fusion : MitelmanTP73/CEP104 [1p36.32/1p36.32]  
Fusion: TCGA_MDACCTP73 1p36.32 CEP104 1p36.32 LGG
Tumor Fusion PortalTP73
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTP73 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TP73
dbVarTP73
ClinVarTP73
1000_GenomesTP73 
Exome Variant ServerTP73
ExAC (Exome Aggregation Consortium)ENSG00000078900
GNOMAD BrowserENSG00000078900
Genetic variants : HAPMAP7161
Genomic Variants (DGV)TP73 [DGVbeta]
DECIPHERTP73 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTP73 
Mutations
ICGC Data PortalTP73 
TCGA Data PortalTP73 
Broad Tumor PortalTP73
OASIS PortalTP73 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTP73  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTP73
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TP73
DgiDB (Drug Gene Interaction Database)TP73
DoCM (Curated mutations)TP73 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TP73 (select a term)
intoGenTP73
Cancer3DTP73(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601990   
Orphanet10953   
DisGeNETTP73
MedgenTP73
Genetic Testing Registry TP73
NextProtO15350 [Medical]
TSGene7161
GENETestsTP73
Target ValidationTP73
Huge Navigator TP73 [HugePedia]
snp3D : Map Gene to Disease7161
BioCentury BCIQTP73
ClinGenTP73 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7161
Chemical/Pharm GKB GenePA36684
Clinical trialTP73
Miscellaneous
canSAR (ICR)TP73 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTP73
EVEXTP73
GoPubMedTP73
iHOPTP73
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:39:21 CET 2017

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