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TPBG (trophoblast glycoprotein)

Written2013-11Swetha Yadav, Robert J Amato, Virginia Mohlere
Department of Internal Medicine/Division of Oncology, The University of Texas Health Science Center at Houston, Houston, TX, USA

(Note : for Links provided by Atlas : click)


Alias (NCBI)5T4
HGNC Alias symb5T4-AG
LocusID (NCBI) 7162
Atlas_Id 42675
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 82362983 and ends at 82367416 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TPBG.png]
Local_order Size: 7623 bp; orientation: plus strand.
  Figure 1. Adapted from Ensembl.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


  Figure 2. Adapted from NCBI.
Description The gene has 8 distinct introns.
Transcription Transcription results in the production of 9 different mRNA, 8 alternatively spliced forms and 1 unspliced form.
The mRNA differ by truncation of the 5 prime end, presence or absence of 2 cassette exons, overlapping exons with different boundaries, splicing versus retention of 3 introns.
The mRNA aAug10 variant has 2590 bp and the premessenger has a single exon. bAug10 has 3395 bp and the premessenger has 3 exons, cAug10 has 3446 bp and the premessenger has 2 exons, dAug10 has 817 bp and the premessenger has 3 exons, eAug10 has 687 bp and the premessenger has 3 exons, fAug10 has 607 bp and the premessenger has 3 exons, gAug10 has 591 bp and the premessenger has 2 exons, hAug10 has 564 bp and the premessenger has 2 exons, iAug10 has 568 bp and the premessenger has 2 exons.
The gene has 3 transcripts or 3 splice variants as per Ensembl. These 3 variants are subsets of the 8 spliced variants as per GenBAnk, bdEST, Trace and SRA databases supervised by the AceView program.


Note There is evidence at the protein level.
Description This is a 420-amino acid protein that contains an N-terminal putative signal sequence, a 310-residue extracellular region, a membrane anchorage domain, and a 44-amino acid cytoplasmic tail with a potential phosphorylation site. The extracellular region has 7 potential N-glycosylation sites and 7 leucine-rich repeats, which are located in 2 regions separated by a hydrophilic stretch (Myers et al., 1994).
Genomic sequence analysis reveals that the gene has 2 exons, the second of which encodes the protein (King et al., 1999).

The sequence has 420 amino acids and a molecular weight of 46032 (UniProt).

There are 9 different isoforms (NCBI AceView).
Of the 9 different isoforms, 6 are considered to be very good quality proteins and 3 are good quality proteins.
The 9 isoforms are:
- aAug 10, predicted protein is 593 aa long and 65,1 kDa, and it has one leucine rich repeat N terminal domain, 3 leucine rich repeat domains, one leucine rich repeat C terminal domian and a transmembrane domain;
- bAug10, predicted protein is 588 aa long and 64,3 kDa and it has has one leucine rich repeat N terminal domain, 3 leucine rich repeat domains, one leucine rich repeat C terminal domain and a transmembrane domain;
- cAug10 518 aa and 56,6 kDa and has one leucine rich repeat N terminal domain, 3 leucine rich repeat domains, one leucine rich repeat C terminal domain and a transmembrane domain;
- dAug10 272 aa and 30,2 kDa and contains 3 leucine rich repeat domains;
- eAug10 229 aa and 23 kDa and contains no protein domain;
- faug10 201 aa and 22,6 kDa and has 2 leucine rich repeat domains;
- gAug10 161 aa and 17 kDa and contains no protein domain;
- hAug10 117 aa and 13,2 kDa and contains no protein domain;
- iAug10 105aa and 11,9 kDa and contains no protein domain.
There are 2 phosphorylation sites that have been identified based on information summarized in Phosphosite Plus.
The first is threonine 99 which was identified by mass spectrometry in the HeLa cervical cancer cell lines (Chen et al., 2009).
The second site of phosphorylation is Serine 418 identified via mass spectrometry in cervical cancer and identified in HeLa cervical cancer cell lines (Olsen et al., 2010).

  Table 1. Reactivity of monoclonal antibody 5T4 with normal human tissues. Immunohistological analysis of frozen sections. Adapted from Hole and Stern, Br. J. Cancer (1988).
Expression TPBG is expressed by all types of trophoblasts by as early as 9 weeks of development. The gene is specific for trophoblastic cells except for amniotic epithelium. This has been demonstrated by immunoperoxidase staining of frozen sections. Expression is limited to few epithelial subtypes in adult tissue but is found to be widely expressed on a number of different carcinomas (Southall et al., 1990).
It has a molecular weight of 72 kD.
It is a glycoprotein with a 42-kDa core protein with extensive N-linked glycosylation.
It exists on the cell surface as a monomeric protein.
The mature protein is membrane bound and consists of 310 amino acid extracellular regions with 7 N-linked glycosylation sites and a short 44-amino acid cytoplasmic tails.
There are 7 leucine rich repeats in the extracellular portion.
The LRRs are believed to mediate protein-protein interactions (Carsberg et al., 1995).
Localisation Membrane, single-pass type I membrane protein.
Function - Cell adhesion
Transduction into cell lines enhances cell motility and decreases cell-to-cell contact, thereby playing a role in tumor invasion and metastases. This has been demonstarated in mouse fibroblasts (Carsberg et al., 1996).
- Chemotaxis
It has also been demonstrated that CXCR4-mediated chemotaxis is regulated by 5T4 as shown in mouse embryonic cells. CXCR4 mediates the migration of cells to tissues rich in CXCL12 (Southgate et al., 2010).
The 5T4 antigen has been shown to play an important role in the epithelial-to-mesenchymal transition. The EMT is a process that occurs in early embryonic cells as well as metastases of certain cancers. The main events that occur during this process are a switch from E cadherin to N cadherin, increased vimentin expression, up-regulation of E cadherin repressor molecules such as snail and slug proteins, increased matrix metalloproteinases such as MMP2 and MMP9, and cellular motility.
The role of 5T4 in the process of EMT has been demonstrated in experiments on embryonic stem cells (Ensembl).
- Pathways and interaction
There is 1 interacting protein for TPBG-GIPC1 (MINT).
Full expression of 5T4 is found to transform mouse mammary epithelial cells to dendritic morphology. This is accompanied by loss of actin/adherin junctions, down regulation of ecadherin and changes in the cytoskeleton. These changes do not occur in the absence of the cytoplasmic tail portion of 5T4. G1PC is a scaffolding protein that interacts with the cytoplasmic tail of 5T4 and it contains the PDZ protein (Lee et al., 2008). PDZ domains mediate protein-protein interactions.The interaction between GIPC1 and 5T4 was demonstrated in HeLa cells using the yeast two hybrid approach by Awan et al. (2002). This interaction indicates a role for 5T4 in mediating changes within the cytoskeleton and thereby it's role in invasion and metastases.
Homology Orthologs are present from 14 different species with the homology varying from 22% to 99%
The greatest homology was with Pan troglotydes species (chimpanzee) with 99,68% homology based on the nucleic acids and 99,52% homology based on amino acids comparison to the human gene (Ensembl).
There is 1 paralogue (Ensembl).


Note Summary of gene variation consequences (Ensembl)
There are a total of 921 variant sequences and 33 structural variations as summarized by the Ensembl data base.
This includes 6 frameshift mutations, 6 stop gained mutations, 3 inframe deletions, 153 misense variants, 2 splice region variants,111 synonymous variants,26 - 5 prime UTR variants,117- 3 prime UTR variants,22 intron variants, 179 upstream gene variants and 298 downstream gene variants.
Structural variations: there are 12 copy number variations, 2 insertions, 2 inversions, 4 tandem duplications and 13 intrachromosomal breakpoints.

Implicated in

Entity Gastric carcinoma
Note 5T4 antigen is expressed in up to 81% of gastric cancers. Starzynska et al. (1992) reported that the expression of 5T4 antigen in gastric cancer correlated with the presence of nodal involvement and distant metastases. Review of pathology showed a greater association of the 5T4 antigen with the diffuse variant of gastric cancer as opposed to the intestinal type or mixed pathology.
Entity Colorectal carcinoma
Note 5T4 antigen is expressed in up to 85% of colorectal cancers. Its presence is associated with poor prognosis. The antigen is found more commonly in tumors that present with nodal involvement or distant metastases. This has been demonstrated by IHC staining for the 5T4 antigen. According to a paper published by Mulder et al. (1997), the 5-year survival for tumors that were 5T4 positive was 22%, compared to 75% for tumors that were 5T4 negative. Median survival was 24 months for 5T4-positive tumors, compared to >90 months for 5T4 negative tumors. This indicates that 5T4 antigen expression can be used as an indicator of aggressive disease with earlier recurrence and suggests potential benefit from adjuvant chemotherapy as opposed to 5T4-negative tumors.

Drugs and compounds: TroVax
The first study of TroVax in colorectal cancer was in patients who had been previously treated with chemotherapy. In this dose-escalation study, TroVax was given to 22 colorectal cancer patients in an open-label phase I/II trial. Sixteen of 17 immunologically evaluable patients showed a 5T4-specific response. Fourteen patients demonstrated detectable antibody levels following vaccination. There was a positive association between the development of the antibody response and patient survival or time to disease progression (Mulryan et al., 2002).
TroVax has also been studied in combination with systemic chemotherapy in colorectal cancer patients. Two phase 2 studies have studied this combination. In the first study, 12 patients recieved a combination of 5T4 with 5-FU, folinic acid, and irinotecan. Six had a partial response, and 5 had stable disease. Ten patients had 5T4-specific antibody responses (Harrop et al., 2007).
The second study had a total of 11 patients who recived TroVax in combination with 5-FU/folinic acid and irinotecan. Six patients had either a complete response or stable disease, and 10 patients had 5-T4-specific antibody responses (Harrop et al., 2008).
TroVax has been studied as a single agent in patients scheduled for surgical resection of colon cancer. Sixteen patients were enrolled in this phase 2 study. They received 2 vaccinations prior to surgery and 2 vaccinations after surgery. Nine patients had no disease recurrence at 8.4 months, and 13 patients mounted a 5T4-specific antibody response (Elkord et al., 2008).

Entity Renal cell carcinoma
Note Griffiths et al. (2005) demonstrated the expression of 5T4 antigen in high levels in 20 cases of RCC. The sample was too small to make any conclusions regarding prognosis. The expression of 5T4 is on the membrane, making it a good candidate for targeted therapy in RCC. Phase 1 and 2 studies have demonstrated the safety and effectiveness of the TroVax vaccine in RCC. The TroVax vaccine is MVA-5T4, which is a modified virus carrying the 5T4 antigen and capable of eliciting an anti-5T4 antibody response.

Drugs and compounds: TroVax
Open-label phase1/2 trial of TroVax administration along with interferon alpha in 11 patients with metastatic RCC. All 11 patients mounted an antibody response to 5T4. The median time to progression was 9 months which was longer than that with interferon alone (Hawkins et al., 2009).
A second open-label, phase 2 trial involved 23 metatstatic RCC patients. TroVax was administered alone or in combination with IFN-alpha. In that study, 96% of patients mounted a 5T4-specific antibody response. One patient in the TroVax/IFN arm achieved a PR; 7 patients in the TroVax/interferon combination arm and 7 patients in the TroVax-alone arm achieved stable disease. The median PFS was 3.8 months, and the median OS was 12.1 months (Amato et al., 2009).
Another phase 2 trial looked at the combination of TroVax with low-dose IL-2 in metastatic RCC patients. Twenty-five patients were enrolled in that study, 21 of whom mounted 5T4-specific antibody response. Two patients demonstrated a complete reponse of >36 months, 1 patient demonstrated a PR of 12 months, and 6 patients demonstrated stable disease for between 6 and 21 months. Median PFS was 3.37 months, and median OS was 12.87 months (Amato et al., 2008b).
There has been only 1 phase 3 trial to date that has studied TroVax in metastatic RCC patients. Amato et al. (2010) enrolled 733 patients in a study to compare TroVax with sunitib, IFN, or IL-2. Immune response was assessed in 590 patients, 56% of whom had a positive 5T4-specific antibody response. A high 5T4 antibody response was associated with longer survival in the TroVax arm.

Entity Cervical carcinoma
Note It has been demonstrated that there is a relationship between the expression of 5T4 antigen and dysplastic conditions such as cervical intraepithelial neoplasia (CIN). Jones et al. (1990) showed a higher level of 5T4 expression in CIN grade 2 and 3 as well as invasive cervical cancer. It has been postulated that the expression of 5T4 may be directly related to the presence of the human papillomavirus. Jones et al. (1990) studied a total of 66 samples and demonstrated 100% expression of 5T4 in invasive cervical carcinoma. This indicates that 5T4 can be used as a potential tumor marker in cervical cancer.
Entity Non-small cell lung carcinoma
Note Damelin et al. (2011) demonstrated that 5T4 is expressed in tumor-initiating cells and is associated with a poor prognosis in NSCLC. Expression of 5T4 correlated with more undifferentiated histology, shorter time to recurrence, and worse overall survival. The expression of 5T4 correlated with markers of EMT. There were a total of 320 tumor samples in this study, 249 of which were positive for the expression of 5T4 antigen.
Entity Ovarian cancer
Note Wrigley et al. (1995) demonstrated that 71% of epithelial ovarian carcinomas expressed the 5T4 antigen (total sample of 72 tumors). There was a significant correlation between the expression of 5T4 antigen and advanced stage (i.e., FIGO stage 3 and 4) and an association with poorly differentiated tumors. Patients whose tumors expressed 5T4 had a worse overall survival, had shorter disease-free survival, and were less likely to respond to adjuvant therapy.
Entity Prostate cancer
Note Drugs and compounds: TroVax
Two phase 2 trials have studied TroVax in castration-resistant prostate cancer patients.
An open-label phase 2 trial by evaluated TroVax alone or in combination with GM-CSF in 27 patients with castration-resistant prostate cancer. All 24 immunologically evaluable patients mounted a 5T4 antibody response. Time to progression was significantly greater in those who mounted a 5T4-specific cellular response (5.6 vs. 2.3 months) (Amato et al., 2008a).
A second phase 2 randomized study enrolled 25 patients, 12 of whom were randomzied to receive TroVax plus docetaxel and 13 to receive docetaxel alone. Patients treated with TroVax plus docetaxel had a longer PFS (9.67 months) than those in the docetaxel-alone arm (5.10 months). Six of the 10 immunologically evaluable patients mounted a 5T4 antibody response (Harrop et al., 2013).
Entity Other diseases
Note Association with other diseases based on cell line studies: GEO Profiles.


Vaccination of prostate cancer patients with modified vaccinia ankara delivering the tumor antigen 5T4 (TroVax): a phase 2 trial.
Amato RJ, Drury N, Naylor S, Jac J, Saxena S, Cao A, Hernandez-McClain J, Harrop R.
J Immunother. 2008a Jul-Aug;31(6):577-85. doi: 10.1097/CJI.0b013e31817deafd.
PMID 18528296
Vaccination of metastatic renal cancer patients with MVA-5T4: a randomized, double-blind, placebo-controlled phase III study.
Amato RJ, Hawkins RE, Kaufman HL, Thompson JA, Tomczak P, Szczylik C, McDonald M, Eastty S, Shingler WH, de Belin J, Goonewardena M, Naylor S, Harrop R.
Clin Cancer Res. 2010 Nov 15;16(22):5539-47. doi: 10.1158/1078-0432.CCR-10-2082. Epub 2010 Sep 29.
PMID 20881001
Vaccination of renal cell cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) alone or administered in combination with interferon-alpha (IFN-alpha): a phase 2 trial.
Amato RJ, Shingler W, Goonewardena M, de Belin J, Naylor S, Jac J, Willis J, Saxena S, Hernandez-McClain J, Harrop R.
J Immunother. 2009 Sep;32(7):765-72. doi: 10.1097/CJI.0b013e3181ace876.
PMID 19561532
5T4 interacts with TIP-2/GIPC, a PDZ protein, with implications for metastasis.
Awan A, Lucic MR, Shaw DM, Sheppard F, Westwater C, Lyons SA, Stern PL.
Biochem Biophys Res Commun. 2002 Jan 25;290(3):1030-6.
PMID 11798178
Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells.
Carsberg CJ, Myers KA, Stern PL.
Int J Cancer. 1996 Sep 27;68(1):84-92.
PMID 8895545
CDC25B mediates rapamycin-induced oncogenic responses in cancer cells.
Chen RQ, Yang QK, Lu BW, Yi W, Cantin G, Chen YL, Fearns C, Yates JR 3rd, Lee JD.
Cancer Res. 2009 Mar 15;69(6):2663-8. doi: 10.1158/0008-5472.CAN-08-3222. Epub 2009 Mar 10.
PMID 19276368
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells.
Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, DiJoseph JF, Karnoub M, Huang S, Diesl V, Behrens C, Choe SE, Rios C, Gruzas J, Sridharan L, Dougher M, Kunz A, Hamann PR, Evans D, Armellino D, Khandke K, Marquette K, Tchistiakova L, Boghaert ER, Abraham RT, Wistuba II, Zhou BB.
Cancer Res. 2011 Jun 15;71(12):4236-46. doi: 10.1158/0008-5472.CAN-10-3919. Epub 2011 May 3.
PMID 21540235
Epithelial-mesenchymal transition events during human embryonic stem cell differentiation.
Eastham AM, Spencer H, Soncin F, Ritson S, Merry CL, Stern PL, Ward CM.
Cancer Res. 2007 Dec 1;67(23):11254-62.
PMID 18056451
An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases.
Elkord E, Dangoor A, Drury NL, Harrop R, Burt DJ, Drijfhout JW, Hamer C, Andrews D, Naylor S, Sherlock D, Hawkins RE, Stern PL.
J Immunother. 2008 Nov-Dec;31(9):820-9. doi: 10.1097/CJI.0b013e3181876ab3.
PMID 18833005
Expression of the 5T4 oncofoetal antigen in renal cell carcinoma: a potential target for T-cell-based immunotherapy.
Griffiths RW, Gilham DE, Dangoor A, Ramani V, Clarke NW, Stern PL, Hawkins RE.
Br J Cancer. 2005 Sep 19;93(6):670-7.
PMID 16222313
Vaccination of castration-resistant prostate cancer patients with TroVax (MVA-5T4) in combination with docetaxel: a randomized phase II trial.
Harrop R, Chu F, Gabrail N, Srinivas S, Blount D, Ferrari A.
Cancer Immunol Immunother. 2013 Sep;62(9):1511-20. doi: 10.1007/s00262-013-1457-z. Epub 2013 Jul 23.
PMID 23877659
Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.
Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Griffiths R, Steven N, Hawkins RE.
Cancer Immunol Immunother. 2008 Jul;57(7):977-86.
PMID 18060404
Vaccination of patients with metastatic renal cancer with modified vaccinia Ankara encoding the tumor antigen 5T4 (TroVax) given alongside interferon-alpha.
Hawkins RE, Macdermott C, Shablak A, Hamer C, Thistlethwaite F, Drury NL, Chikoti P, Shingler W, Naylor S, Harrop R.
J Immunother. 2009 May;32(4):424-9. doi: 10.1097/CJI.0b013e31819d297e.
PMID 19342962
A 72 kD trophoblast glycoprotein defined by a monoclonal antibody.
Hole N, Stern PL.
Br J Cancer. 1988 Mar;57(3):239-46.
PMID 3355761
Investigation of expression of 5T4 antigen in cervical cancer.
Jones H, Roberts G, Hole N, McDicken IW, Stern P.
Br J Cancer. 1990 Jan;61(1):96-100.
PMID 2404512
Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues.
King KW, Sheppard FC, Westwater C, Stern PL, Myers KA.
Biochim Biophys Acta. 1999 Jun 9;1445(3):257-70.
PMID 10366710
Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC.
Lee NY, Ray B, How T, Blobe GC.
J Biol Chem. 2008 Nov 21;283(47):32527-33. doi: 10.1074/jbc.M803059200. Epub 2008 Sep 5.
PMID 18775991
Low intercellular adhesion molecule 1 and high 5T4 expression on tumor cells correlate with reduced disease-free survival in colorectal carcinoma patients.
Mulder WM, Stern PL, Stukart MJ, de Windt E, Butzelaar RM, Meijer S, Ader HJ, Claessen AM, Vermorken JB, Meijer CJ, Wagstaff J, Scheper RJ, Bloemena E.
Clin Cancer Res. 1997 Nov;3(11):1923-30.
PMID 9815581
Attenuated recombinant vaccinia virus expressing oncofetal antigen (tumor-associated antigen) 5T4 induces active therapy of established tumors.
Mulryan K1, Ryan MG, Myers KA, Shaw D, Wang W, Kingsman SM, Stern PL, Carroll MW.
Mol Cancer Ther. 2002 Oct;1(12):1129-37.
PMID 12481437
Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein. An antigen associated with metastasis contains leucine-rich repeats.
Myers KA, Rahi-Saund V, Davison MD, Young JA, Cheater AJ, Stern PL.
J Biol Chem. 1994 Mar 25;269(12):9319-24.
PMID 8132670
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M.
Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475.
PMID 20068231
Immunohistological distribution of 5T4 antigen in normal and malignant tissues.
Southall PJ, Boxer GM, Bagshawe KD, Hole N, Bromley M, Stern PL.
Br J Cancer. 1990 Jan;61(1):89-95.
PMID 2404511
CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.
Southgate TD, McGinn OJ, Castro FV, Rutkowski AJ, Al-Muftah M, Marinov G, Smethurst GJ, Shaw D, Ward CM, Miller CJ, Stern PL.
PLoS One. 2010 Apr 1;5(4):e9982. doi: 10.1371/journal.pone.0009982.
PMID 20376365
The expression of 5T4 antigen in colorectal and gastric carcinoma.
Starzynska T, Rahi V, Stern PL.
Br J Cancer. 1992 Nov;66(5):867-9.
PMID 1419629
5T4 oncofetal antigen expression in ovarian carcinoma.
Wrigley E, McGown AT, Rennison J, Swindell R, Crowther D, Starzynska T, Stern PL.
Int J Gynecol Cancer. 1995 Jul;5(4):269-274.
PMID 11578488


This paper should be referenced as such :
Yadav, S ; Amato, RJ ; Mohlere, V
TPBG (trophoblast glycoprotein)
Atlas Genet Cytogenet Oncol Haematol. 2014;18(7):491-496.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)TPBG   12004
Entrez_Gene (NCBI)TPBG    trophoblast glycoprotein
Aliases5T4; 5T4AG; M6P1; WAIF1
GeneCards (Weizmann)TPBG
Ensembl hg19 (Hinxton)ENSG00000146242 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146242 [Gene_View]  ENSG00000146242 [Sequence]  chr6:82362983-82367416 [Contig_View]  TPBG [Vega]
ICGC DataPortalENSG00000146242
Genatlas (Paris)TPBG
SOURCE (Princeton)TPBG
Genetics Home Reference (NIH)TPBG
Genomic and cartography
GoldenPath hg38 (UCSC)TPBG  -     chr6:82362983-82367416 +  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPBG  -     6q14.1   [Description]    (hg19-Feb_2009)
GoldenPathTPBG - 6q14.1 [CytoView hg19]  TPBG - 6q14.1 [CytoView hg38]
Genome Data Viewer NCBITPBG [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AI342491 AI857997 AJ420536 AK074786 AK074790
RefSeq transcript (Entrez)NM_001166392 NM_001376922 NM_006670
Consensus coding sequences : CCDS (NCBI)TPBG
Gene ExpressionTPBG [ NCBI-GEO ]   TPBG [ EBI - ARRAY_EXPRESS ]   TPBG [ SEEK ]   TPBG [ MEM ]
Gene Expression Viewer (FireBrowse)TPBG [ Firebrowse - Broad ]
GenevisibleExpression of TPBG in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7162
GTEX Portal (Tissue expression)TPBG
Human Protein AtlasENSG00000146242-TPBG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13641   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13641  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13641
Domaine pattern : Prosite (Expaxy)LRR (PS51450)   
Domains : Interpro (EBI)Cys-rich_flank_reg_C    Leu-rich_rpt    Leu-rich_rpt_typical-subtyp    LRR_dom_sf    LRRNT   
Domain families : Pfam (Sanger)LRR_8 (PF13855)    LRRCT (PF01463)    LRRNT (PF01462)   
Domain families : Pfam (NCBI)pfam13855    pfam01463    pfam01462   
Domain families : Smart (EMBL)LRR_TYP (SM00369)  LRRCT (SM00082)  LRRNT (SM00013)  
Conserved Domain (NCBI)TPBG
PDB (RSDB)4CNC    4CNM    6HBY   
PDB Europe4CNC    4CNM    6HBY   
PDB (PDBSum)4CNC    4CNM    6HBY   
PDB (IMB)4CNC    4CNM    6HBY   
Structural Biology KnowledgeBase4CNC    4CNM    6HBY   
SCOP (Structural Classification of Proteins)4CNC    4CNM    6HBY   
CATH (Classification of proteins structures)4CNC    4CNM    6HBY   
AlphaFold pdb e-kbQ13641   
Human Protein Atlas [tissue]ENSG00000146242-TPBG [tissue]
Protein Interaction databases
IntAct (EBI)Q13641
Ontologies - Pathways
Ontology : AmiGOendoplasmic reticulum  plasma membrane  integral component of plasma membrane  cell adhesion  negative regulation of cell population proliferation  olfactory learning  cell surface  membrane  dendrite  axon terminus  positive regulation of chemotaxis  positive regulation of protein kinase B signaling  synaptic transmission, GABAergic  positive regulation of synapse assembly  cell chemotaxis  positive regulation of ERK1 and ERK2 cascade  protein localization to plasma membrane  negative regulation of canonical Wnt signaling pathway  mesenchymal cell migration  dendrite arborization  
Ontology : EGO-EBIendoplasmic reticulum  plasma membrane  integral component of plasma membrane  cell adhesion  negative regulation of cell population proliferation  olfactory learning  cell surface  membrane  dendrite  axon terminus  positive regulation of chemotaxis  positive regulation of protein kinase B signaling  synaptic transmission, GABAergic  positive regulation of synapse assembly  cell chemotaxis  positive regulation of ERK1 and ERK2 cascade  protein localization to plasma membrane  negative regulation of canonical Wnt signaling pathway  mesenchymal cell migration  dendrite arborization  
NDEx NetworkTPBG
Atlas of Cancer Signalling NetworkTPBG
Wikipedia pathwaysTPBG
Orthology - Evolution
GeneTree (enSembl)ENSG00000146242
Phylogenetic Trees/Animal Genes : TreeFamTPBG
Homologs : HomoloGeneTPBG
Homology/Alignments : Family Browser (UCSC)TPBG
Gene fusions - Rearrangements
Fusion : QuiverTPBG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPBG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPBG
Exome Variant ServerTPBG
GNOMAD BrowserENSG00000146242
Varsome BrowserTPBG
ACMGTPBG variants
Genomic Variants (DGV)TPBG [DGVbeta]
DECIPHERTPBG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPBG 
ICGC Data PortalTPBG 
TCGA Data PortalTPBG 
Broad Tumor PortalTPBG
OASIS PortalTPBG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPBG  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPBG
Mutations and Diseases : HGMDTPBG
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)TPBG
DoCM (Curated mutations)TPBG
CIViC (Clinical Interpretations of Variants in Cancer)TPBG
NCG (London)TPBG
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry TPBG
NextProtQ13641 [Medical]
Target ValidationTPBG
Huge Navigator TPBG [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDTPBG
Pharm GKB GenePA36685
Clinical trialTPBG
DataMed IndexTPBG
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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