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TPGS2 (tubulin polyglutamylase complex subunit 2)

Identity

Alias (NCBI)C18orf10
HMFN0601
L17
PGs2
HGNC (Hugo) TPGS2
HGNC Alias symbDKFZP586M1523
HsT3006
HGNC Previous nameC18orf10
HGNC Previous namechromosome 18 open reading frame 10
LocusID (NCBI) 25941
Atlas_Id 54718
Location 18q12.2  [Link to chromosome band 18q12]
Location_base_pair Starts at 36794108 and ends at 36829002 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP5 (14q12) / TPGS2 (18q12.2)PDCD1LG2 (9p24.1) / TPGS2 (18q12.2)TPGS2 (18q12.2) / MCM4 (8q11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPGS2   24561
Cards
Entrez_Gene (NCBI)TPGS2    tubulin polyglutamylase complex subunit 2
AliasesC18orf10; HMFN0601; L17; PGs2
GeneCards (Weizmann)TPGS2
Ensembl hg19 (Hinxton)ENSG00000134779 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134779 [Gene_View]  ENSG00000134779 [Sequence]  chr18:36794108-36829002 [Contig_View]  TPGS2 [Vega]
ICGC DataPortalENSG00000134779
TCGA cBioPortalTPGS2
AceView (NCBI)TPGS2
Genatlas (Paris)TPGS2
SOURCE (Princeton)TPGS2
Genetics Home Reference (NIH)TPGS2
Genomic and cartography
GoldenPath hg38 (UCSC)TPGS2  -     chr18:36794108-36829002 -  18q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPGS2  -     18q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTPGS2 - 18q12.2 [CytoView hg19]  TPGS2 - 18q12.2 [CytoView hg38]
ImmunoBaseENSG00000134779
Genome Data Viewer NCBITPGS2 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA677381 AB073382 AK000543 AK295817 AL050225
RefSeq transcript (Entrez)NM_001271949 NM_001271950 NM_001271951 NM_001271952 NM_001271953 NM_001271954 NM_001271955 NM_001271956 NM_001330572 NM_015476
Consensus coding sequences : CCDS (NCBI)TPGS2
Gene ExpressionTPGS2 [ NCBI-GEO ]   TPGS2 [ EBI - ARRAY_EXPRESS ]   TPGS2 [ SEEK ]   TPGS2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPGS2 [ Firebrowse - Broad ]
GenevisibleExpression of TPGS2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25941
GTEX Portal (Tissue expression)TPGS2
Human Protein AtlasENSG00000134779-TPGS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68CL5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68CL5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68CL5
PhosPhoSitePlusQ68CL5
Domains : Interpro (EBI)Knr4/Smi1-like_dom    TPGS2   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)SMI1_KNR4 (SM00860)  
Conserved Domain (NCBI)TPGS2
SuperfamilyQ68CL5
AlphaFold pdb e-kbQ68CL5   
Human Protein Atlas [tissue]ENSG00000134779-TPGS2 [tissue]
HPRD12684
Protein Interaction databases
DIP (DOE-UCLA)Q68CL5
IntAct (EBI)Q68CL5
BioGRIDTPGS2
STRING (EMBL)TPGS2
ZODIACTPGS2
Ontologies - Pathways
QuickGOQ68CL5
Ontology : AmiGOprotein binding  cytoplasm  microtubule  protein polyglutamylation  
Ontology : EGO-EBIprotein binding  cytoplasm  microtubule  protein polyglutamylation  
NDEx NetworkTPGS2
Atlas of Cancer Signalling NetworkTPGS2
Wikipedia pathwaysTPGS2
Orthology - Evolution
OrthoDB25941
GeneTree (enSembl)ENSG00000134779
Phylogenetic Trees/Animal Genes : TreeFamTPGS2
Homologs : HomoloGeneTPGS2
Homology/Alignments : Family Browser (UCSC)TPGS2
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP5/TPGS2 [14q12/18q12.2]  
Fusion : MitelmanPDCD1LG2/TPGS2 [9p24.1/18q12.2]  
Fusion : QuiverTPGS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPGS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPGS2
dbVarTPGS2
ClinVarTPGS2
MonarchTPGS2
1000_GenomesTPGS2 
Exome Variant ServerTPGS2
GNOMAD BrowserENSG00000134779
Varsome BrowserTPGS2
ACMGTPGS2 variants
VarityQ68CL5
Genomic Variants (DGV)TPGS2 [DGVbeta]
DECIPHERTPGS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPGS2 
Mutations
ICGC Data PortalTPGS2 
TCGA Data PortalTPGS2 
Broad Tumor PortalTPGS2
OASIS PortalTPGS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPGS2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPGS2
Mutations and Diseases : HGMDTPGS2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPGS2
DgiDB (Drug Gene Interaction Database)TPGS2
DoCM (Curated mutations)TPGS2
CIViC (Clinical Interpretations of Variants in Cancer)TPGS2
Cancer3DTPGS2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTPGS2
MedgenTPGS2
Genetic Testing Registry TPGS2
NextProtQ68CL5 [Medical]
GENETestsTPGS2
Target ValidationTPGS2
Huge Navigator TPGS2 [HugePedia]
ClinGenTPGS2
Clinical trials, drugs, therapy
MyCancerGenomeTPGS2
Protein Interactions : CTDTPGS2
Pharm GKB GenePA128394637
PharosQ68CL5
Clinical trialTPGS2
Miscellaneous
canSAR (ICR)TPGS2
HarmonizomeTPGS2
DataMed IndexTPGS2
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPGS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:00 CEST 2021

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