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TPH1 (tryptophan hydroxylase 1)

Identity

Alias_namesTPRH
TPH
tryptophan hydroxylase (tryptophan 5-monooxygenase)
Other aliasTRPH
HGNC (Hugo) TPH1
LocusID (NCBI) 7166
Atlas_Id 51272
Location 11p15.1  [Link to chromosome band 11p15]
Location_base_pair Starts at 18020537 and ends at 18040788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TPH1 (11p15.1) / ARL6IP5 (3p14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPH1   12008
Cards
Entrez_Gene (NCBI)TPH1  7166  tryptophan hydroxylase 1
AliasesTPRH; TRPH
GeneCards (Weizmann)TPH1
Ensembl hg19 (Hinxton)ENSG00000129167 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129167 [Gene_View]  chr11:18020537-18040788 [Contig_View]  TPH1 [Vega]
ICGC DataPortalENSG00000129167
TCGA cBioPortalTPH1
AceView (NCBI)TPH1
Genatlas (Paris)TPH1
WikiGenes7166
SOURCE (Princeton)TPH1
Genetics Home Reference (NIH)TPH1
Genomic and cartography
GoldenPath hg38 (UCSC)TPH1  -     chr11:18020537-18040788 -  11p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPH1  -     11p15.1   [Description]    (hg19-Feb_2009)
EnsemblTPH1 - 11p15.1 [CytoView hg19]  TPH1 - 11p15.1 [CytoView hg38]
Mapping of homologs : NCBITPH1 [Mapview hg19]  TPH1 [Mapview hg38]
OMIM191060   
Gene and transcription
Genbank (Entrez)AH012638 AH012638 AY196346 BC106739 BC106740
RefSeq transcript (Entrez)NM_004179
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPH1
Cluster EST : UnigeneHs.591999 [ NCBI ]
CGAP (NCI)Hs.591999
Alternative Splicing GalleryENSG00000129167
Gene ExpressionTPH1 [ NCBI-GEO ]   TPH1 [ EBI - ARRAY_EXPRESS ]   TPH1 [ SEEK ]   TPH1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPH1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7166
GTEX Portal (Tissue expression)TPH1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17752   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17752  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17752
Splice isoforms : SwissVarP17752
Catalytic activity : Enzyme1.14.16.4 [ Enzyme-Expasy ]   1.14.16.41.14.16.4 [ IntEnz-EBI ]   1.14.16.4 [ BRENDA ]   1.14.16.4 [ KEGG ]   
PhosPhoSitePlusP17752
Domaine pattern : Prosite (Expaxy)ACT (PS51671)    BH4_AAA_HYDROXYL_1 (PS00367)    BH4_AAA_HYDROXYL_2 (PS51410)   
Domains : Interpro (EBI)ACT_dom    ArAA_hydroxylase    ArAA_hydroxylase_Fe/CU_BS    Aromatic-AA_hydroxylase_C    Trp_5_mOase    Tyrosine_3-monooxygenase-like   
Domain families : Pfam (Sanger)Biopterin_H (PF00351)   
Domain families : Pfam (NCBI)pfam00351   
Conserved Domain (NCBI)TPH1
DMDM Disease mutations7166
Blocks (Seattle)TPH1
PDB (SRS)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
PDB (PDBSum)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
PDB (IMB)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
PDB (RSDB)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
Structural Biology KnowledgeBase1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
SCOP (Structural Classification of Proteins)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
CATH (Classification of proteins structures)1IN9    1MLW    3HF6    3HF8    3HFB    5J6D    5L01    5TPG   
SuperfamilyP17752
Human Protein AtlasENSG00000129167
Peptide AtlasP17752
HPRD01846
IPIIPI00016810   IPI00216828   IPI00794674   IPI00979783   
Protein Interaction databases
DIP (DOE-UCLA)P17752
IntAct (EBI)P17752
FunCoupENSG00000129167
BioGRIDTPH1
STRING (EMBL)TPH1
ZODIACTPH1
Ontologies - Pathways
QuickGOP17752
Ontology : AmiGOtryptophan 5-monooxygenase activity  iron ion binding  cytosol  circadian rhythm  aromatic amino acid family metabolic process  amino acid binding  negative regulation of ossification  response to immobilization stress  serotonin biosynthetic process  neuron projection  positive regulation of fat cell differentiation  indolalkylamine biosynthetic process  bone remodeling  oxidation-reduction process  mammary gland alveolus development  
Ontology : EGO-EBItryptophan 5-monooxygenase activity  iron ion binding  cytosol  circadian rhythm  aromatic amino acid family metabolic process  amino acid binding  negative regulation of ossification  response to immobilization stress  serotonin biosynthetic process  neuron projection  positive regulation of fat cell differentiation  indolalkylamine biosynthetic process  bone remodeling  oxidation-reduction process  mammary gland alveolus development  
Pathways : KEGGTryptophan metabolism    Serotonergic synapse   
NDEx NetworkTPH1
Atlas of Cancer Signalling NetworkTPH1
Wikipedia pathwaysTPH1
Orthology - Evolution
OrthoDB7166
GeneTree (enSembl)ENSG00000129167
Phylogenetic Trees/Animal Genes : TreeFamTPH1
HOVERGENP17752
HOGENOMP17752
Homologs : HomoloGeneTPH1
Homology/Alignments : Family Browser (UCSC)TPH1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPH1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPH1
dbVarTPH1
ClinVarTPH1
1000_GenomesTPH1 
Exome Variant ServerTPH1
ExAC (Exome Aggregation Consortium)TPH1 (select the gene name)
Genetic variants : HAPMAP7166
Genomic Variants (DGV)TPH1 [DGVbeta]
DECIPHERTPH1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPH1 
Mutations
ICGC Data PortalTPH1 
TCGA Data PortalTPH1 
Broad Tumor PortalTPH1
OASIS PortalTPH1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPH1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPH1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPH1
DgiDB (Drug Gene Interaction Database)TPH1
DoCM (Curated mutations)TPH1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPH1 (select a term)
intoGenTPH1
Cancer3DTPH1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191060   
Orphanet
MedgenTPH1
Genetic Testing Registry TPH1
NextProtP17752 [Medical]
TSGene7166
GENETestsTPH1
Target ValidationTPH1
Huge Navigator TPH1 [HugePedia]
snp3D : Map Gene to Disease7166
BioCentury BCIQTPH1
ClinGenTPH1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7166
Chemical/Pharm GKB GenePA355
Clinical trialTPH1
Miscellaneous
canSAR (ICR)TPH1 (select the gene name)
Probes
Litterature
PubMed213 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPH1
EVEXTPH1
GoPubMedTPH1
iHOPTPH1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:17:29 CEST 2017

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