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TPI1 (triosephosphate isomerase 1)

Identity

Other aliasHEL-S-49
TIM
TPI
TPID
HGNC (Hugo) TPI1
LocusID (NCBI) 7167
Atlas_Id 46334
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6868114 and ends at 6870946 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPNS1 (19q13.12) / TPI1 (12p13.31)CHD2 (15q26.1) / TPI1 (12p13.31)RPL28 (19q13.42) / TPI1 (12p13.31)
SERPINH1 (11q13.5) / TPI1 (12p13.31)TPI1 (12p13.31) / ILF3 (19p13.2)TPI1 (12p13.31) / MAPK14 (6p21.31)
TPI1 (12p13.31) / PFKL (21q22.3)TPI1 (12p13.31) / TOP2B (3p24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TPI1   12009
LRG (Locus Reference Genomic)LRG_1126
Cards
Entrez_Gene (NCBI)TPI1  7167  triosephosphate isomerase 1
AliasesHEL-S-49; TIM; TPI; TPID
GeneCards (Weizmann)TPI1
Ensembl hg19 (Hinxton)ENSG00000111669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111669 [Gene_View]  ENSG00000111669 [Sequence]  chr12:6868114-6870946 [Contig_View]  TPI1 [Vega]
ICGC DataPortalENSG00000111669
TCGA cBioPortalTPI1
AceView (NCBI)TPI1
Genatlas (Paris)TPI1
WikiGenes7167
SOURCE (Princeton)TPI1
Genetics Home Reference (NIH)TPI1
Genomic and cartography
GoldenPath hg38 (UCSC)TPI1  -     chr12:6868114-6870946 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPI1  -     12p13.31   [Description]    (hg19-Feb_2009)
EnsemblTPI1 - 12p13.31 [CytoView hg19]  TPI1 - 12p13.31 [CytoView hg38]
Mapping of homologs : NCBITPI1 [Mapview hg19]  TPI1 [Mapview hg38]
OMIM190450   615512   
Gene and transcription
Genbank (Entrez)AK129488 AK222638 AK298809 AK300661 AK313282
RefSeq transcript (Entrez)NM_000365 NM_001159287 NM_001258026
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPI1
Cluster EST : UnigeneHs.524219 [ NCBI ]
CGAP (NCI)Hs.524219
Alternative Splicing GalleryENSG00000111669
Gene ExpressionTPI1 [ NCBI-GEO ]   TPI1 [ EBI - ARRAY_EXPRESS ]   TPI1 [ SEEK ]   TPI1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7167
GTEX Portal (Tissue expression)TPI1
Human Protein AtlasENSG00000111669-TPI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60174   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60174  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60174
Splice isoforms : SwissVarP60174
Catalytic activity : Enzyme5.3.1.1 [ Enzyme-Expasy ]   5.3.1.15.3.1.1 [ IntEnz-EBI ]   5.3.1.1 [ BRENDA ]   5.3.1.1 [ KEGG ]   
PhosPhoSitePlusP60174
Domaine pattern : Prosite (Expaxy)TIM_1 (PS00171)    TIM_2 (PS51440)   
Domains : Interpro (EBI)Aldolase_TIM    TIM_sf    TrioseP_Isoase_bac/euk    Triosephosphate_isomerase    Triosephosphate_isomerase_AS   
Domain families : Pfam (Sanger)TIM (PF00121)   
Domain families : Pfam (NCBI)pfam00121   
Conserved Domain (NCBI)TPI1
DMDM Disease mutations7167
Blocks (Seattle)TPI1
PDB (SRS)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
PDB (PDBSum)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
PDB (IMB)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
PDB (RSDB)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
Structural Biology KnowledgeBase1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
SCOP (Structural Classification of Proteins)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
CATH (Classification of proteins structures)1HTI    1KLG    1KLU    1WYI    2IAM    2IAN    2JK2    2VOM    4BR1    4E41    4POC    4POD    4UNK    4UNL    4ZVJ   
SuperfamilyP60174
Human Protein Atlas [tissue]ENSG00000111669-TPI1 [tissue]
Peptide AtlasP60174
HPRD01833
Protein Interaction databases
DIP (DOE-UCLA)P60174
IntAct (EBI)P60174
FunCoupENSG00000111669
BioGRIDTPI1
STRING (EMBL)TPI1
ZODIACTPI1
Ontologies - Pathways
QuickGOP60174
Ontology : AmiGOtriose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  protein binding  extracellular space  nucleus  cytosol  cytosol  gluconeogenesis  gluconeogenesis  gluconeogenesis  glycolytic process  methylglyoxal synthase activity  methylglyoxal biosynthetic process  glycerol catabolic process  ubiquitin protein ligase binding  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  glyceraldehyde-3-phosphate biosynthetic process  canonical glycolysis  extracellular exosome  
Ontology : EGO-EBItriose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  triose-phosphate isomerase activity  protein binding  extracellular space  nucleus  cytosol  cytosol  gluconeogenesis  gluconeogenesis  gluconeogenesis  glycolytic process  methylglyoxal synthase activity  methylglyoxal biosynthetic process  glycerol catabolic process  ubiquitin protein ligase binding  protein homodimerization activity  glyceraldehyde-3-phosphate biosynthetic process  glyceraldehyde-3-phosphate biosynthetic process  canonical glycolysis  extracellular exosome  
Pathways : KEGGGlycolysis / Gluconeogenesis    Fructose and mannose metabolism    Inositol phosphate metabolism   
NDEx NetworkTPI1
Atlas of Cancer Signalling NetworkTPI1
Wikipedia pathwaysTPI1
Orthology - Evolution
OrthoDB7167
GeneTree (enSembl)ENSG00000111669
Phylogenetic Trees/Animal Genes : TreeFamTPI1
HOGENOMP60174
Homologs : HomoloGeneTPI1
Homology/Alignments : Family Browser (UCSC)TPI1
Gene fusions - Rearrangements
Fusion : QuiverTPI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPI1
dbVarTPI1
ClinVarTPI1
1000_GenomesTPI1 
Exome Variant ServerTPI1
ExAC (Exome Aggregation Consortium)ENSG00000111669
GNOMAD BrowserENSG00000111669
Varsome BrowserTPI1
Genetic variants : HAPMAP7167
Genomic Variants (DGV)TPI1 [DGVbeta]
DECIPHERTPI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPI1 
Mutations
ICGC Data PortalTPI1 
TCGA Data PortalTPI1 
Broad Tumor PortalTPI1
OASIS PortalTPI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPI1
DgiDB (Drug Gene Interaction Database)TPI1
DoCM (Curated mutations)TPI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPI1 (select a term)
intoGenTPI1
Cancer3DTPI1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190450    615512   
Orphanet325   
DisGeNETTPI1
MedgenTPI1
Genetic Testing Registry TPI1
NextProtP60174 [Medical]
TSGene7167
GENETestsTPI1
Target ValidationTPI1
Huge Navigator TPI1 [HugePedia]
snp3D : Map Gene to Disease7167
BioCentury BCIQTPI1
ClinGenTPI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7167
Chemical/Pharm GKB GenePA36689
Clinical trialTPI1
Miscellaneous
canSAR (ICR)TPI1 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPI1
EVEXTPI1
GoPubMedTPI1
iHOPTPI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Dec 21 15:58:56 CET 2018
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