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TPK1 (thiamin pyrophosphokinase 1)

Identity

Alias_symbol (synonym)HTPK1
PP20
Other aliasTHMD5
HGNC (Hugo) TPK1
LocusID (NCBI) 27010
Atlas_Id 53831
Location 7q35  [Link to chromosome band 7q35]
Location_base_pair Starts at 144149034 and ends at 144533146 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TPK1 (7q35) / CYCS (7p15.3)ZCCHC17 (1p35.2) / TPK1 (7q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPK1   17358
Cards
Entrez_Gene (NCBI)TPK1  27010  thiamin pyrophosphokinase 1
AliasesHTPK1; PP20; THMD5
GeneCards (Weizmann)TPK1
Ensembl hg19 (Hinxton)ENSG00000196511 [Gene_View]  chr7:144149034-144533146 [Contig_View]  TPK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196511 [Gene_View]  chr7:144149034-144533146 [Contig_View]  TPK1 [Vega]
ICGC DataPortalENSG00000196511
TCGA cBioPortalTPK1
AceView (NCBI)TPK1
Genatlas (Paris)TPK1
WikiGenes27010
SOURCE (Princeton)TPK1
Genetics Home Reference (NIH)TPK1
Genomic and cartography
GoldenPath hg19 (UCSC)TPK1  -     chr7:144149034-144533146 -  7q35   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TPK1  -     7q35   [Description]    (hg38-Dec_2013)
EnsemblTPK1 - 7q35 [CytoView hg19]  TPK1 - 7q35 [CytoView hg38]
Mapping of homologs : NCBITPK1 [Mapview hg19]  TPK1 [Mapview hg38]
OMIM606370   614458   
Gene and transcription
Genbank (Entrez)AB028138 AF297710 AK021810 AK026374 AK091736
RefSeq transcript (Entrez)NM_001042482 NM_022445
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_032112 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)TPK1
Cluster EST : UnigeneHs.660232 [ NCBI ]
CGAP (NCI)Hs.660232
Alternative Splicing GalleryENSG00000196511
Gene ExpressionTPK1 [ NCBI-GEO ]   TPK1 [ EBI - ARRAY_EXPRESS ]   TPK1 [ SEEK ]   TPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27010
GTEX Portal (Tissue expression)TPK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S4
Splice isoforms : SwissVarQ9H3S4
Catalytic activity : Enzyme2.7.6.2 [ Enzyme-Expasy ]   2.7.6.22.7.6.2 [ IntEnz-EBI ]   2.7.6.2 [ BRENDA ]   2.7.6.2 [ KEGG ]   
PhosPhoSitePlusQ9H3S4
Domains : Interpro (EBI)Thi_PPkinase    Thiamin_pyrophosphokinase_euk    Thiamin_PyroPKinase_B1-bd    TPK_catalytic   
Domain families : Pfam (Sanger)TPK_B1_binding (PF04265)    TPK_catalytic (PF04263)   
Domain families : Pfam (NCBI)pfam04265    pfam04263   
Domain families : Smart (EMBL)TPK_B1_binding (SM00983)  
Conserved Domain (NCBI)TPK1
DMDM Disease mutations27010
Blocks (Seattle)TPK1
PDB (SRS)1OLY    3S4Y   
PDB (PDBSum)1OLY    3S4Y   
PDB (IMB)1OLY    3S4Y   
PDB (RSDB)1OLY    3S4Y   
Structural Biology KnowledgeBase1OLY    3S4Y   
SCOP (Structural Classification of Proteins)1OLY    3S4Y   
CATH (Classification of proteins structures)1OLY    3S4Y   
SuperfamilyQ9H3S4
Human Protein AtlasENSG00000196511
Peptide AtlasQ9H3S4
HPRD06967
IPIIPI00072523   IPI00470947   IPI01012169   IPI01020981   IPI01023051   IPI01022605   IPI01022888   IPI00418733   
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S4
IntAct (EBI)Q9H3S4
FunCoupENSG00000196511
BioGRIDTPK1
STRING (EMBL)TPK1
ZODIACTPK1
Ontologies - Pathways
QuickGOQ9H3S4
Ontology : AmiGOthiamine diphosphokinase activity  thiamine diphosphokinase activity  ATP binding  cytosol  thiamine metabolic process  thiamine diphosphate biosynthetic process  thiamine diphosphate biosynthetic process  kinase activity  phosphorylation  thiamine binding  thiamine-containing compound metabolic process  
Ontology : EGO-EBIthiamine diphosphokinase activity  thiamine diphosphokinase activity  ATP binding  cytosol  thiamine metabolic process  thiamine diphosphate biosynthetic process  thiamine diphosphate biosynthetic process  kinase activity  phosphorylation  thiamine binding  thiamine-containing compound metabolic process  
Pathways : KEGGThiamine metabolism   
NDEx NetworkTPK1
Atlas of Cancer Signalling NetworkTPK1
Wikipedia pathwaysTPK1
Orthology - Evolution
OrthoDB27010
GeneTree (enSembl)ENSG00000196511
Phylogenetic Trees/Animal Genes : TreeFamTPK1
HOVERGENQ9H3S4
HOGENOMQ9H3S4
Homologs : HomoloGeneTPK1
Homology/Alignments : Family Browser (UCSC)TPK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPK1
dbVarTPK1
ClinVarTPK1
1000_GenomesTPK1 
Exome Variant ServerTPK1
ExAC (Exome Aggregation Consortium)TPK1 (select the gene name)
Genetic variants : HAPMAP27010
Genomic Variants (DGV)TPK1 [DGVbeta]
DECIPHER (Syndromes)7:144149034-144533146  ENSG00000196511
CONAN: Copy Number AnalysisTPK1 
Mutations
ICGC Data PortalTPK1 
TCGA Data PortalTPK1 
Broad Tumor PortalTPK1
OASIS PortalTPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TPK1
DgiDB (Drug Gene Interaction Database)TPK1
DoCM (Curated mutations)TPK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPK1 (select a term)
intoGenTPK1
Cancer3DTPK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606370    614458   
Orphanet20894   
MedgenTPK1
Genetic Testing Registry TPK1
NextProtQ9H3S4 [Medical]
TSGene27010
GENETestsTPK1
Huge Navigator TPK1 [HugePedia]
snp3D : Map Gene to Disease27010
BioCentury BCIQTPK1
ClinGenTPK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27010
Chemical/Pharm GKB GenePA38235
Clinical trialTPK1
Miscellaneous
canSAR (ICR)TPK1 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPK1
EVEXTPK1
GoPubMedTPK1
iHOPTPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:32:00 CET 2017

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