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TPK1 (thiamin pyrophosphokinase 1)

Identity

Alias (NCBI)HTPK1
PP20
THMD5
HGNC (Hugo) TPK1
HGNC Alias symbHTPK1
PP20
HGNC Alias nameplacental protein 20
 thiamine pyrophosphokinase 1
 thiamine kinase
 thiamine diphosphokinase
LocusID (NCBI) 27010
Atlas_Id 53831
Location 7q35  [Link to chromosome band 7q35]
Location_base_pair Starts at 144451941 and ends at 144836053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TPK1 (7q35) / CYCS (7p15.3)ZCCHC17 (1p35.2) / TPK1 (7q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPK1   17358
Cards
Entrez_Gene (NCBI)TPK1    thiamin pyrophosphokinase 1
AliasesHTPK1; PP20; THMD5
GeneCards (Weizmann)TPK1
Ensembl hg19 (Hinxton)ENSG00000196511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196511 [Gene_View]  ENSG00000196511 [Sequence]  chr7:144451941-144836053 [Contig_View]  TPK1 [Vega]
ICGC DataPortalENSG00000196511
TCGA cBioPortalTPK1
AceView (NCBI)TPK1
Genatlas (Paris)TPK1
SOURCE (Princeton)TPK1
Genetics Home Reference (NIH)TPK1
Genomic and cartography
GoldenPath hg38 (UCSC)TPK1  -     chr7:144451941-144836053 -  7q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPK1  -     7q35   [Description]    (hg19-Feb_2009)
GoldenPathTPK1 - 7q35 [CytoView hg19]  TPK1 - 7q35 [CytoView hg38]
ImmunoBaseENSG00000196511
Genome Data Viewer NCBITPK1 [Mapview hg19]  
OMIM606370   614458   
Gene and transcription
Genbank (Entrez)AB028138 AF297710 AK021810 AK026374 AK091736
RefSeq transcript (Entrez)NM_001042482 NM_001350879 NM_001350880 NM_001350881 NM_001350882 NM_001350883 NM_001350884 NM_001350885 NM_001350886 NM_001350887 NM_001350889 NM_001350893 NM_001350894 NM_001350895 NM_022445
Consensus coding sequences : CCDS (NCBI)TPK1
Gene ExpressionTPK1 [ NCBI-GEO ]   TPK1 [ EBI - ARRAY_EXPRESS ]   TPK1 [ SEEK ]   TPK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPK1 [ Firebrowse - Broad ]
GenevisibleExpression of TPK1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27010
GTEX Portal (Tissue expression)TPK1
Human Protein AtlasENSG00000196511-TPK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H3S4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H3S4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H3S4
Catalytic activity : Enzyme2.7.6.2 [ Enzyme-Expasy ]   2.7.6.22.7.6.2 [ IntEnz-EBI ]   2.7.6.2 [ BRENDA ]   2.7.6.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H3S4
Domains : Interpro (EBI)Thi_PPkinase    Thiamin_pyrophosphokinase_euk    Thiamin_PyroPKinase_B1-bd    TPK_B1-bd_sf    TPK_catalytic    TPK_catalytic_sf   
Domain families : Pfam (Sanger)TPK_B1_binding (PF04265)    TPK_catalytic (PF04263)   
Domain families : Pfam (NCBI)pfam04265    pfam04263   
Domain families : Smart (EMBL)TPK_B1_binding (SM00983)  
Conserved Domain (NCBI)TPK1
PDB (RSDB)1OLY    3S4Y   
PDB Europe1OLY    3S4Y   
PDB (PDBSum)1OLY    3S4Y   
PDB (IMB)1OLY    3S4Y   
Structural Biology KnowledgeBase1OLY    3S4Y   
SCOP (Structural Classification of Proteins)1OLY    3S4Y   
CATH (Classification of proteins structures)1OLY    3S4Y   
SuperfamilyQ9H3S4
AlphaFold pdb e-kbQ9H3S4   
Human Protein Atlas [tissue]ENSG00000196511-TPK1 [tissue]
HPRD06967
Protein Interaction databases
DIP (DOE-UCLA)Q9H3S4
IntAct (EBI)Q9H3S4
BioGRIDTPK1
STRING (EMBL)TPK1
ZODIACTPK1
Ontologies - Pathways
QuickGOQ9H3S4
Ontology : AmiGOthiamine diphosphokinase activity  protein binding  ATP binding  cytosol  thiamine metabolic process  thiamine diphosphate biosynthetic process  thiamine diphosphate biosynthetic process  kinase activity  phosphorylation  thiamine binding  thiamine-containing compound metabolic process  identical protein binding  
Ontology : EGO-EBIthiamine diphosphokinase activity  protein binding  ATP binding  cytosol  thiamine metabolic process  thiamine diphosphate biosynthetic process  thiamine diphosphate biosynthetic process  kinase activity  phosphorylation  thiamine binding  thiamine-containing compound metabolic process  identical protein binding  
Pathways : KEGGThiamine metabolism   
NDEx NetworkTPK1
Atlas of Cancer Signalling NetworkTPK1
Wikipedia pathwaysTPK1
Orthology - Evolution
OrthoDB27010
GeneTree (enSembl)ENSG00000196511
Phylogenetic Trees/Animal Genes : TreeFamTPK1
Homologs : HomoloGeneTPK1
Homology/Alignments : Family Browser (UCSC)TPK1
Gene fusions - Rearrangements
Fusion : QuiverTPK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPK1
dbVarTPK1
ClinVarTPK1
MonarchTPK1
1000_GenomesTPK1 
Exome Variant ServerTPK1
GNOMAD BrowserENSG00000196511
Varsome BrowserTPK1
ACMGTPK1 variants
VarityQ9H3S4
Genomic Variants (DGV)TPK1 [DGVbeta]
DECIPHERTPK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPK1 
Mutations
ICGC Data PortalTPK1 
TCGA Data PortalTPK1 
Broad Tumor PortalTPK1
OASIS PortalTPK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPK1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPK1
Mutations and Diseases : HGMDTPK1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPK1
DgiDB (Drug Gene Interaction Database)TPK1
DoCM (Curated mutations)TPK1
CIViC (Clinical Interpretations of Variants in Cancer)TPK1
Cancer3DTPK1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606370    614458   
Orphanet20894   
DisGeNETTPK1
MedgenTPK1
Genetic Testing Registry TPK1
NextProtQ9H3S4 [Medical]
GENETestsTPK1
Target ValidationTPK1
Huge Navigator TPK1 [HugePedia]
ClinGenTPK1
Clinical trials, drugs, therapy
MyCancerGenomeTPK1
Protein Interactions : CTDTPK1
Pharm GKB GenePA38235
PharosQ9H3S4
Clinical trialTPK1
Miscellaneous
canSAR (ICR)TPK1
HarmonizomeTPK1
DataMed IndexTPK1
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:01 CEST 2021

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