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TPM1 (tropomyosin 1 (alpha))

Identity

Alias_namesC15orf13
CMH3
chromosome 15 open reading frame 13
cardiomyopathy, hypertrophic 3
HGNC (Hugo) TPM1
LocusID (NCBI) 7168
Atlas_Id 42679
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 63334838 and ends at 63358292 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MALAT1 (11q13.1) / TPM1 (15q22.2)MIR6723 (1p36.33) / TPM1 (15q22.2)TNC (9q33.1) / TPM1 (15q22.2)
TPM1 (15q22.2) / ALK (2p23.2)TPM1 (15q22.2) / GK (Xp21.2)TPM1 (15q22.2) / HOPX (4q12)
TPM1 (15q22.2) / NMNAT1 (1p36.22)TPM1 (15q22.2) / PTMS (12p13.31)TPM1 (15q22.2) / TPM1 (15q22.2)
TPM1 (15q22.2) / TPM2 (9p13.3)TPM1 15q22.2 / ALK 2p23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPM1   12010
LRG (Locus Reference Genomic)LRG_387
Cards
Entrez_Gene (NCBI)TPM1  7168  tropomyosin 1 (alpha)
AliasesC15orf13; CMD1Y; CMH3; HEL-S-265; 
HTM-alpha; LVNC9; TMSA
GeneCards (Weizmann)TPM1
Ensembl hg19 (Hinxton)ENSG00000140416 [Gene_View]  chr15:63334838-63358292 [Contig_View]  TPM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140416 [Gene_View]  chr15:63334838-63358292 [Contig_View]  TPM1 [Vega]
ICGC DataPortalENSG00000140416
TCGA cBioPortalTPM1
AceView (NCBI)TPM1
Genatlas (Paris)TPM1
WikiGenes7168
SOURCE (Princeton)TPM1
Genetics Home Reference (NIH)TPM1
Genomic and cartography
GoldenPath hg19 (UCSC)TPM1  -     chr15:63334838-63358292 +  15q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TPM1  -     15q22.2   [Description]    (hg38-Dec_2013)
EnsemblTPM1 - 15q22.2 [CytoView hg19]  TPM1 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBITPM1 [Mapview hg19]  TPM1 [Mapview hg38]
OMIM115196   191010   611878   
Gene and transcription
Genbank (Entrez)AB209041 AF474156 AJ000147 AJ001055 AK055197
RefSeq transcript (Entrez)NM_000366 NM_001018004 NM_001018005 NM_001018006 NM_001018007 NM_001018008 NM_001018020 NM_001301244 NM_001301289
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_007557 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)TPM1
Cluster EST : UnigeneHs.602995 [ NCBI ]
CGAP (NCI)Hs.602995
Alternative Splicing GalleryENSG00000140416
Gene ExpressionTPM1 [ NCBI-GEO ]   TPM1 [ EBI - ARRAY_EXPRESS ]   TPM1 [ SEEK ]   TPM1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7168
GTEX Portal (Tissue expression)TPM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09493   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09493  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09493
Splice isoforms : SwissVarP09493
PhosPhoSitePlusP09493
Domaine pattern : Prosite (Expaxy)TROPOMYOSIN (PS00326)   
Domains : Interpro (EBI)Tropomyosin   
Domain families : Pfam (Sanger)Tropomyosin (PF00261)   
Domain families : Pfam (NCBI)pfam00261   
Conserved Domain (NCBI)TPM1
DMDM Disease mutations7168
Blocks (Seattle)TPM1
SuperfamilyP09493
Human Protein AtlasENSG00000140416
Peptide AtlasP09493
HPRD01839
IPIIPI00014581   IPI00745267   IPI00216135   IPI00296039   IPI01012191   IPI00915324   IPI00921977   IPI00442894   IPI01018017   IPI00018853   IPI00384369   IPI00940084   IPI00940343   IPI00604537   IPI00000230   IPI00216134   IPI00970818   
Protein Interaction databases
DIP (DOE-UCLA)P09493
IntAct (EBI)P09493
FunCoupENSG00000140416
BioGRIDTPM1
STRING (EMBL)TPM1
ZODIACTPM1
Ontologies - Pathways
QuickGOP09493
Ontology : AmiGOin utero embryonic development  stress fiber  positive regulation of heart rate by epinephrine  actin binding  structural constituent of cytoskeleton  protein binding  cytosol  cytoskeleton  muscle thin filament tropomyosin  movement of cell or subcellular component  muscle contraction  regulation of muscle contraction  cytoskeleton organization  regulation of heart contraction  cytoskeletal protein binding  structural constituent of muscle  regulation of cell shape  sarcomere  muscle filament sliding  muscle filament sliding  negative regulation of cell migration  ruffle organization  filamentous actin  bleb  ruffle membrane  positive regulation of ATPase activity  cellular response to reactive oxygen species  wound healing  sarcomere organization  positive regulation of cell adhesion  positive regulation of stress fiber assembly  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  negative regulation of vascular smooth muscle cell proliferation  negative regulation of vascular associated smooth muscle cell migration  
Ontology : EGO-EBIin utero embryonic development  stress fiber  positive regulation of heart rate by epinephrine  actin binding  structural constituent of cytoskeleton  protein binding  cytosol  cytoskeleton  muscle thin filament tropomyosin  movement of cell or subcellular component  muscle contraction  regulation of muscle contraction  cytoskeleton organization  regulation of heart contraction  cytoskeletal protein binding  structural constituent of muscle  regulation of cell shape  sarcomere  muscle filament sliding  muscle filament sliding  negative regulation of cell migration  ruffle organization  filamentous actin  bleb  ruffle membrane  positive regulation of ATPase activity  cellular response to reactive oxygen species  wound healing  sarcomere organization  positive regulation of cell adhesion  positive regulation of stress fiber assembly  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  negative regulation of vascular smooth muscle cell proliferation  negative regulation of vascular associated smooth muscle cell migration  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    MicroRNAs in cancer    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
NDEx NetworkTPM1
Atlas of Cancer Signalling NetworkTPM1
Wikipedia pathwaysTPM1
Orthology - Evolution
OrthoDB7168
GeneTree (enSembl)ENSG00000140416
Phylogenetic Trees/Animal Genes : TreeFamTPM1
HOVERGENP09493
HOGENOMP09493
Homologs : HomoloGeneTPM1
Homology/Alignments : Family Browser (UCSC)TPM1
Gene fusions - Rearrangements
Fusion : MitelmanTPM1/ALK [15q22.2/2p23.2]  
Fusion: TCGATPM1 15q22.2 ALK 2p23.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPM1
dbVarTPM1
ClinVarTPM1
1000_GenomesTPM1 
Exome Variant ServerTPM1
ExAC (Exome Aggregation Consortium)TPM1 (select the gene name)
Genetic variants : HAPMAP7168
Genomic Variants (DGV)TPM1 [DGVbeta]
DECIPHER (Syndromes)15:63334838-63358292  ENSG00000140416
CONAN: Copy Number AnalysisTPM1 
Mutations
ICGC Data PortalTPM1 
TCGA Data PortalTPM1 
Broad Tumor PortalTPM1
OASIS PortalTPM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TPM1
DgiDB (Drug Gene Interaction Database)TPM1
DoCM (Curated mutations)TPM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPM1 (select a term)
intoGenTPM1
Cancer3DTPM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM115196    191010    611878   
Orphanet635    10750   
MedgenTPM1
Genetic Testing Registry TPM1
NextProtP09493 [Medical]
TSGene7168
GENETestsTPM1
Huge Navigator TPM1 [HugePedia]
snp3D : Map Gene to Disease7168
BioCentury BCIQTPM1
ClinGenTPM1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7168
Chemical/Pharm GKB GenePA36690
Clinical trialTPM1
Miscellaneous
canSAR (ICR)TPM1 (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPM1
EVEXTPM1
GoPubMedTPM1
iHOPTPM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Nov 18 19:54:21 CET 2016

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