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TPM1 (tropomyosin 1 (alpha))

Identity

Other namesC15orf13
CMD1Y
CMH3
HTM-alpha
LVNC9
TMSA
HGNC (Hugo) TPM1
LocusID (NCBI) 7168
Location 15q22.2
Location_base_pair Starts at 63334838 and ends at 63358292 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TPM1   12010
Cards
Entrez_Gene (NCBI)TPM1  7168  tropomyosin 1 (alpha)
GeneCards (Weizmann)TPM1
Ensembl hg19 (Hinxton)ENSG00000140416 [Gene_View]  chr15:63334838-63358292 [Contig_View]  TPM1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140416 [Gene_View]  chr15:63334838-63358292 [Contig_View]  TPM1 [Vega]
ICGC DataPortalENSG00000140416
cBioPortalTPM1
AceView (NCBI)TPM1
Genatlas (Paris)TPM1
WikiGenes7168
SOURCE (Princeton)TPM1
Genomic and cartography
GoldenPath hg19 (UCSC)TPM1  -     chr15:63334838-63358292 +  15q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TPM1  -     15q22.2   [Description]    (hg38-Dec_2013)
EnsemblTPM1 - 15q22.2 [CytoView hg19]  TPM1 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBITPM1 [Mapview hg19]  TPM1 [Mapview hg38]
OMIM115196   191010   611878   
Gene and transcription
Genbank (Entrez)AB209041 AF474156 AJ000147 AJ001055 AK055197
RefSeq transcript (Entrez)NM_000366 NM_001018004 NM_001018005 NM_001018006 NM_001018007 NM_001018008 NM_001018020
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_007557 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)TPM1
Cluster EST : UnigeneHs.602995 [ NCBI ]
CGAP (NCI)Hs.602995
Alternative Splicing : Fast-db (Paris)GSHG0009920
Alternative Splicing GalleryENSG00000140416
Gene ExpressionTPM1 [ NCBI-GEO ]     TPM1 [ SEEK ]   TPM1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09493 (Uniprot)
NextProtP09493  [Medical]
With graphics : InterProP09493
Splice isoforms : SwissVarP09493 (Swissvar)
Domaine pattern : Prosite (Expaxy)TROPOMYOSIN (PS00326)   
Domains : Interpro (EBI)Tropomyosin   
Related proteins : CluSTrP09493
Domain families : Pfam (Sanger)Tropomyosin (PF00261)   
Domain families : Pfam (NCBI)pfam00261   
DMDM Disease mutations7168
Blocks (Seattle)P09493
Human Protein AtlasENSG00000140416
Peptide AtlasP09493
HPRD01839
IPIIPI00014581   IPI00745267   IPI00216135   IPI00296039   IPI01012191   IPI00915324   IPI00921977   IPI00442894   IPI01018017   IPI00018853   IPI00384369   IPI00940084   IPI00940343   IPI00604537   IPI00000230   IPI00216134   IPI00970818   
Protein Interaction databases
DIP (DOE-UCLA)P09493
IntAct (EBI)P09493
FunCoupENSG00000140416
BioGRIDTPM1
IntegromeDBTPM1
STRING (EMBL)TPM1
Ontologies - Pathways
QuickGOP09493
Ontology : AmiGOin utero embryonic development  stress fiber  positive regulation of heart rate by epinephrine  actin binding  structural constituent of cytoskeleton  cytosol  cytoskeleton  muscle thin filament tropomyosin  cellular component movement  muscle contraction  regulation of muscle contraction  cytoskeleton organization  regulation of heart contraction  cytoskeletal protein binding  structural constituent of muscle  sarcomere  muscle filament sliding  muscle filament sliding  negative regulation of cell migration  ruffle organization  filamentous actin  bleb  ruffle membrane  positive regulation of ATPase activity  cellular response to reactive oxygen species  wound healing  sarcomere organization  positive regulation of cell adhesion  positive regulation of stress fiber assembly  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Ontology : EGO-EBIin utero embryonic development  stress fiber  positive regulation of heart rate by epinephrine  actin binding  structural constituent of cytoskeleton  cytosol  cytoskeleton  muscle thin filament tropomyosin  cellular component movement  muscle contraction  regulation of muscle contraction  cytoskeleton organization  regulation of heart contraction  cytoskeletal protein binding  structural constituent of muscle  sarcomere  muscle filament sliding  muscle filament sliding  negative regulation of cell migration  ruffle organization  filamentous actin  bleb  ruffle membrane  positive regulation of ATPase activity  cellular response to reactive oxygen species  wound healing  sarcomere organization  positive regulation of cell adhesion  positive regulation of stress fiber assembly  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    MicroRNAs in cancer    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
Protein Interaction DatabaseTPM1
DoCM (Curated mutations)TPM1
Wikipedia pathwaysTPM1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTPM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPM1
dbVarTPM1
ClinVarTPM1
1000_GenomesTPM1 
Exome Variant ServerTPM1
SNP (GeneSNP Utah)TPM1
SNP : HGBaseTPM1
Genetic variants : HAPMAPTPM1
Genomic VariantsTPM1  TPM1 [DGVbeta]
Mutations
ICGC Data PortalENSG00000140416 
Somatic Mutations in Cancer : COSMICTPM1 
CONAN: Copy Number AnalysisTPM1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:63334838-63358292
Mutations and Diseases : HGMDTPM1
OMIM115196    191010    611878   
MedgenTPM1
NextProtP09493 [Medical]
GENETestsTPM1
Disease Genetic AssociationTPM1
Huge Navigator TPM1 [HugePedia]  TPM1 [HugeCancerGEM]
snp3D : Map Gene to Disease7168
DGIdb (Drug Gene Interaction db)TPM1
General knowledge
Homologs : HomoloGeneTPM1
Homology/Alignments : Family Browser (UCSC)TPM1
Phylogenetic Trees/Animal Genes : TreeFamTPM1
Chemical/Protein Interactions : CTD7168
Chemical/Pharm GKB GenePA36690
Clinical trialTPM1
Cancer Resource (Charite)ENSG00000140416
Other databases
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
CoreMineTPM1
GoPubMedTPM1
iHOPTPM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 02:02:37 CET 2014

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