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TPM3 (tropomyosin 3)

Written2001-08Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)NEM1
HGNC (Hugo) TPM3
HGNC Alias symbTRK
HGNC Previous nameNEM1
LocusID (NCBI) 7170
Atlas_Id 225
Location 1q21.3  [Link to chromosome band 1q21]
Location_base_pair Starts at 154155308 and ends at 154183218 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TPM3.png]
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALK (2p23.2)::TPM3 (1q21.3)B4GALT3 (1q23.3)::TPM3 (1q21.3)EEF1A1 (6q13)::TPM3 (1q21.3)
JAK2 (9p24.1)::TPM3 (1q21.3)MTERF4 (2q37.3)::TPM3 (1q21.3)NTRK1 (1q23.1)::TPM3 (1q21.3)
SEC24D (4q26)::TPM3 (1q21.3)SH3BGRL3 (1p36.11)::TPM3 (1q21.3)TPM2 (9p13.3)::TPM3 (1q21.3)
TPM3 (1q21.3)::ALK (2p23.2)TPM3 (1q21.3)::C1orf43 (1q21.3)TPM3 (1q21.3)::JAK2 (9p24.1)
TPM3 (1q21.3)::NTRK1 (1q23.1)TPM3 (1q21.3)::PDGFRB (5q32)TPM3 (1q21.3)::ROS1 (6q22.1)
TPM3 (1q21.3)::SEC24D (4q26)TPM3 (1q21.3)::TPR (1q31.1)


Description spans at least 42 kb; 13 exons


Description by tissue-specific alternate splincing are produced 2 proteins: the tropomyosin alpha chain, skeletal muscle type, made of 284 amino acids (32 kDa), and the cytosqueletal type, made of 248 amino acids (29 kDa). Coiled-coil structure
Function Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown
Homology Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM4 located in 19p13.1

Implicated in

Entity rare cases of ALK+ anaplasic large cell lymphoma (ALCL) with
Disease ALCL presents as an aggressive lymphoma with systemic signs
Prognosis nonetheless, have a favourable prognosis
Hybrid/Mutated Gene 5' CLTC - 3' ALK
Abnormal Protein 104 kDa ; 221 N-term amino acids from TPM3 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis TPM3-ALK is contitutively activated
Entity cases of Inflammatory myofibroblastic tumors with
Disease rare soft tissue tumour found in children and young adults
Prognosis good prognosis
Hybrid/Mutated Gene 5' CLTC - 3' ALK
Abnormal Protein 104 kDa ; 221 N-term amino acids from TPM3 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis TPM3-ALK is contitutively activated
Entity papillary thyroid carcinoma
Disease represents about 60% of thyroid cancers; small, undetectable, chromosome 1q inversions have shown to produce a TPM3-NTRK1 hybrid gene in a very few cases of papillary thyroid carcinoma.
Prognosis prognosis of papillary thyroid carcinoma is excellent
Hybrid/Mutated Gene 5' TPM3 - 3' NTRK1
Abnormal Protein 221 N-term amino acids from PM3 fused to the C-term of NTRK1, including its tyrosine kinase domain



To be noted

ALK and TPM3 are therefore implicated in both anaplasic large cell lymphoma and inflammatory myofibroblastic tumours; this is a new concept, that 2 different types of tumour may result from the same chromosomal and genes rearrangement.


Deciphering the design of the tropomyosin molecule.
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501.
PMID 11438684
A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas.
Butti MG, Bongarzone I, Ferraresi G, Mondellini P, Borrello MG, Pierotti MA
Genomics. 1995 ; 28 (1) : 15-24.
PMID 7590742
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ
Cancer research. 1999 ; 59 (12) : 2776-2780.
PMID 10383129
Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms.
Ladanyi M
The American journal of pathology. 2000 ; 157 (2) : 341-345.
PMID 10934137
A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation.
Lamant L, Dastugue N, Pulford K, Delsol G, Mariamé B
Blood. 1999 ; 93 (9) : 3088-3095.
PMID 10216106
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors.
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA
The American journal of pathology. 2000 ; 157 (2) : 377-384.
PMID 10934142
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R
Journal of molecular biology. 2000 ; 302 (3) : 593-606.
PMID 10986121
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences.
Martin-Zanca D, Hughes SH, Barbacid M
Nature. 1986 ; 319 (6056) : 743-748.
PMID 2869410
Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma.
Siebert R, Gesk S, Harder L, Steinemann D, Grote W, Schlegelberger B, Tiemann M, Wlodarska I, Schemmel V
Blood. 1999 ; 94 (10) : 3614-3617.
PMID 10610119


This paper should be referenced as such :
Huret, JL
TPM3 (tropomyosin 3)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(4):271-272.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 9 ]
  Anaplastic large cell lymphoma (ALCL)
t(1;2)(q25;p23) TPM3::ALK
t(1;5)(q21;q32) PDE4DIP::PDGFRB::t(1;5)(q21-23;q32) TPM3::PDGFRB::t(1;5)(q21-23;q31-33)
t(2;11)(p23;q12.3) EEF1G::ALK
t(1;1)(q21;q23) B4GALT3::TPM3
t(1;5)(q21;q32) TPM3::PDGFRB
t(1;9)(q21;p24) JAK2::TPM3
t(1;9)(q21;p24) TPM3::JAK2

External links

HGNC (Hugo)TPM3   12012
LRG (Locus Reference Genomic)LRG_681
Atlas Explorer : (Salamanque)TPM3
Entrez_Gene (NCBI)TPM3    tropomyosin 3
AliasesCAPM1; CFTD; HEL-189; HEL-S-82p; 
NEM1; OK/SW-cl.5; TM-5; TM3; TM30; TM30nm; TM5; TPM3nu; TPMsk3; TRK; hscp30
GeneCards (Weizmann)TPM3
Ensembl hg19 (Hinxton)ENSG00000143549 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143549 [Gene_View]  ENSG00000143549 [Sequence]  chr1:154155308-154183218 [Contig_View]  TPM3 [Vega]
ICGC DataPortalENSG00000143549
TCGA cBioPortalTPM3
AceView (NCBI)TPM3
Genatlas (Paris)TPM3
SOURCE (Princeton)TPM3
Genetics Home Reference (NIH)TPM3
Genomic and cartography
GoldenPath hg38 (UCSC)TPM3  -     chr1:154155308-154183218 -  1q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPM3  -     1q21.3   [Description]    (hg19-Feb_2009)
GoldenPathTPM3 - 1q21.3 [CytoView hg19]  TPM3 - 1q21.3 [CytoView hg38]
Genome Data Viewer NCBITPM3 [Mapview hg19]  
OMIM191030   255310   609284   
Gene and transcription
Genbank (Entrez)AA429717 AA863064 AB062125 AF474157 AJ573307
RefSeq transcript (Entrez)NM_001043351 NM_001043352 NM_001043353 NM_001278188 NM_001278189 NM_001278190 NM_001278191 NM_001349679 NM_001364679 NM_001364680 NM_001364681 NM_001364682 NM_001364683 NM_152263 NM_153649
Consensus coding sequences : CCDS (NCBI)TPM3
Gene ExpressionTPM3 [ NCBI-GEO ]   TPM3 [ EBI - ARRAY_EXPRESS ]   TPM3 [ SEEK ]   TPM3 [ MEM ]
Gene Expression Viewer (FireBrowse)TPM3 [ Firebrowse - Broad ]
GenevisibleExpression of TPM3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7170
GTEX Portal (Tissue expression)TPM3
Human Protein AtlasENSG00000143549-TPM3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TPM3
Human Protein Atlas [tissue]ENSG00000143549-TPM3 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed202 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jan 17 15:43:13 CET 2022

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