Written | 2001-08 | Jean-Loup Huret |
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France |
Identity |
HGNC (Hugo) | TPM4 |
LocusID (NCBI) | 7171 |
Atlas_Id | 359 |
Location | 19p13.12 [Link to chromosome band 19p13] |
Location_base_pair | Starts at 16076495 and ends at 16103002 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping TPM4.png] |
Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
ALK (2p23.2) / TPM4 (19p13.12) | AVL9 (7p14.3) / TPM4 (19p13.12) | EPS15L1 (19p13.11) / TPM4 (19p13.12) | |
FAM32A (19p13.11) / TPM4 (19p13.12) | FAM32A (19p13.12) / TPM4 (19p13.12) | GSE1 (16q24.1) / TPM4 (19p13.12) | |
NEK6 (9q33.3) / TPM4 (19p13.12) | TPM4 (19p13.12) / ALK (2p23.2) | TPM4 (19p13.12) / CNNM2 (10q24.32) | |
TPM4 (19p13.12) / INAFM1 (19q13.32) | TPM4 (19p13.12) / METRNL (17q25.3) | TPM4 (19p13.12) / PROM1 (4p15.32) | |
TPM4 (19p13.12) / SEC62 (3q26.2) | TPM4 (19p13.12) / TBL1XR1 (3q26.32) | TPM4 (19p13.12) / WHAMM (15q25.2) | |
DNA/RNA |
Transcription | alternate transcripts |
Protein |
Description | 248 amino acids, 29 kDa. Coiled-coil structure |
Function | Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown |
Homology | Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25 |
Implicated in |
Note | |
Entity | Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1) |
Disease | rare soft tissue tumour found in children and young adults |
Prognosis | good prognosis |
Hybrid/Mutated Gene | 5' CLTC - 3' ALK |
Abnormal Protein | 221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein. |
Oncogenesis | TPM4-ALK is contitutively activated |
Bibliography |
Deciphering the design of the tropomyosin molecule. |
Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C |
Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501. |
PMID 11438684 |
Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. |
Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ |
Cancer research. 1999 ; 59 (12) : 2776-2780. |
PMID 10383129 |
Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. |
Ladanyi M |
The American journal of pathology. 2000 ; 157 (2) : 341-345. |
PMID 10934137 |
TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. |
Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA |
The American journal of pathology. 2000 ; 157 (2) : 377-384. |
PMID 10934142 |
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. |
Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R |
Journal of molecular biology. 2000 ; 302 (3) : 593-606. |
PMID 10986121 |
Citation |
This paper should be referenced as such : |
Huret, JL |
TPM4 (tropomyosin ) |
Atlas Genet Cytogenet Oncol Haematol. 2001;5(4):273-273. |
Free journal version : [ pdf ] [ DOI ] |
Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ] |
t(2;19)(p23;p13) TPM4/ALK
t(17;19)(q25;p13) TPM4/METRNL |
Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ] |
External links |
REVIEW articles | automatic search in PubMed |
Last year publications | automatic search in PubMed |
© Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Fri Feb 19 18:02:04 CET 2021 |
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