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TPO (thyroid peroxidase)

Identity

Alias_symbol (synonym)TPX
Other aliasMSA
TDH2A
HGNC (Hugo) TPO
LocusID (NCBI) 7173
Atlas_Id 42681
Location 2p25.3  [Link to chromosome band 2p25]
Location_base_pair Starts at 1413461 and ends at 1542727 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNPY3 (6p21.1) / TPO (2p25.3)TPO (2p25.3) / RAB11FIP3 (16p13.3)TPO (2p25.3) / TPO (2p25.3)
CNPY3 6p21.1 / TPO 2p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Myelofibrosis with Myeloid Metaplasia (MMM)::Idiopathic myelofibrosis::Agnogenic myeloid metaplasia
Polycythemia Vera (PV)
t(11;14)(p15;q22) AP2A2/NID2


External links

Nomenclature
HGNC (Hugo)TPO   12015
Cards
Entrez_Gene (NCBI)TPO  7173  thyroid peroxidase
AliasesMSA; TDH2A; TPX
GeneCards (Weizmann)TPO
Ensembl hg19 (Hinxton)ENSG00000115705 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115705 [Gene_View]  chr2:1413461-1542727 [Contig_View]  TPO [Vega]
ICGC DataPortalENSG00000115705
TCGA cBioPortalTPO
AceView (NCBI)TPO
Genatlas (Paris)TPO
WikiGenes7173
SOURCE (Princeton)TPO
Genetics Home Reference (NIH)TPO
Genomic and cartography
GoldenPath hg38 (UCSC)TPO  -     chr2:1413461-1542727 +  2p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPO  -     2p25.3   [Description]    (hg19-Feb_2009)
EnsemblTPO - 2p25.3 [CytoView hg19]  TPO - 2p25.3 [CytoView hg38]
Mapping of homologs : NCBITPO [Mapview hg19]  TPO [Mapview hg38]
OMIM274500   606765   
Gene and transcription
Genbank (Entrez)AB208960 AF439430 AF533528 AF533529 AF533530
RefSeq transcript (Entrez)NM_000547 NM_001206744 NM_001206745 NM_175719 NM_175720 NM_175721 NM_175722
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_011581 NT_187529
Consensus coding sequences : CCDS (NCBI)TPO
Cluster EST : UnigeneHs.467554 [ NCBI ]
CGAP (NCI)Hs.467554
Alternative Splicing GalleryENSG00000115705
Gene ExpressionTPO [ NCBI-GEO ]   TPO [ EBI - ARRAY_EXPRESS ]   TPO [ SEEK ]   TPO [ MEM ]
Gene Expression Viewer (FireBrowse)TPO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7173
GTEX Portal (Tissue expression)TPO
Human Protein AtlasENSG00000115705-TPO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07202   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07202  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07202
Splice isoforms : SwissVarP07202
PhosPhoSitePlusP07202
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    PEROXIDASE_1 (PS00435)    PEROXIDASE_3 (PS50292)    SUSHI (PS50923)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_CS    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Haem_peroxidase    Haem_peroxidase_animal    Sushi_SCR_CCP_dom    TPO   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EGF_CA (PF07645)    Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam03098    pfam07645    pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)TPO
DMDM Disease mutations7173
Blocks (Seattle)TPO
SuperfamilyP07202
Human Protein Atlas [tissue]ENSG00000115705-TPO [tissue]
Peptide AtlasP07202
HPRD06000
IPIIPI00289572   IPI00289573   IPI00335186   IPI00289575   IPI00289576   IPI00232922   IPI00232923   IPI00232924   IPI00953126   IPI00002367   IPI00440765   IPI00893232   IPI00952783   
Protein Interaction databases
DIP (DOE-UCLA)P07202
IntAct (EBI)P07202
FunCoupENSG00000115705
BioGRIDTPO
STRING (EMBL)TPO
ZODIACTPO
Ontologies - Pathways
QuickGOP07202
Ontology : AmiGOiodide peroxidase activity  peroxidase activity  peroxidase activity  calcium ion binding  extracellular space  mitochondrion  plasma membrane  integral component of plasma membrane  thyroid hormone generation  thyroid hormone generation  response to oxidative stress  cell surface  heme binding  embryonic hemopoiesis  hormone biosynthetic process  hydrogen peroxide catabolic process  oxidation-reduction process  cellular oxidant detoxification  
Ontology : EGO-EBIiodide peroxidase activity  peroxidase activity  peroxidase activity  calcium ion binding  extracellular space  mitochondrion  plasma membrane  integral component of plasma membrane  thyroid hormone generation  thyroid hormone generation  response to oxidative stress  cell surface  heme binding  embryonic hemopoiesis  hormone biosynthetic process  hydrogen peroxide catabolic process  oxidation-reduction process  cellular oxidant detoxification  
Pathways : KEGGTyrosine metabolism    Cytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Hematopoietic cell lineage    Thyroid hormone synthesis    Autoimmune thyroid disease   
NDEx NetworkTPO
Atlas of Cancer Signalling NetworkTPO
Wikipedia pathwaysTPO
Orthology - Evolution
OrthoDB7173
GeneTree (enSembl)ENSG00000115705
Phylogenetic Trees/Animal Genes : TreeFamTPO
HOVERGENP07202
HOGENOMP07202
Homologs : HomoloGeneTPO
Homology/Alignments : Family Browser (UCSC)TPO
Gene fusions - Rearrangements
Fusion : MitelmanCNPY3/TPO [6p21.1/2p25.3]  [t(2;6)(p25;p21)]  
Fusion: TCGA_MDACCCNPY3 6p21.1 TPO 2p25.3 THCA
Tumor Fusion PortalTPO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPO
dbVarTPO
ClinVarTPO
1000_GenomesTPO 
Exome Variant ServerTPO
ExAC (Exome Aggregation Consortium)ENSG00000115705
GNOMAD BrowserENSG00000115705
Genetic variants : HAPMAP7173
Genomic Variants (DGV)TPO [DGVbeta]
DECIPHERTPO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPO 
Mutations
ICGC Data PortalTPO 
TCGA Data PortalTPO 
Broad Tumor PortalTPO
OASIS PortalTPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPO  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPO
DgiDB (Drug Gene Interaction Database)TPO
DoCM (Curated mutations)TPO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPO (select a term)
intoGenTPO
Cancer3DTPO(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM274500    606765   
Orphanet12671   
DisGeNETTPO
MedgenTPO
Genetic Testing Registry TPO
NextProtP07202 [Medical]
TSGene7173
GENETestsTPO
Target ValidationTPO
Huge Navigator TPO [HugePedia]
snp3D : Map Gene to Disease7173
BioCentury BCIQTPO
ClinGenTPO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7173
Chemical/Pharm GKB GenePA36694
Clinical trialTPO
Miscellaneous
canSAR (ICR)TPO (select the gene name)
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPO
EVEXTPO
GoPubMedTPO
iHOPTPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:39:24 CET 2017

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