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TPO (thyroid peroxidase)

Identity

Alias (NCBI)MSA
TDH2A
TPX
HGNC (Hugo) TPO
HGNC Alias symbTPX
LocusID (NCBI) 7173
Atlas_Id 42681
Location 2p25.3  [Link to chromosome band 2p25]
Location_base_pair Starts at 1414408 and ends at 1542727 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNPY3 (6p21.1) / TPO (2p25.3)TPO (2p25.3) / RAB11FIP3 (16p13.3)TPO (2p25.3) / TPO (2p25.3)
CNPY3 6p21.1 / TPO 2p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  Myelofibrosis with Myeloid Metaplasia (MMM)::Idiopathic myelofibrosis::Agnogenic myeloid metaplasia
Polycythemia Vera (PV)
t(11;14)(p15;q22) AP2A2/NID2


External links

 

Nomenclature
HGNC (Hugo)TPO   12015
Cards
Entrez_Gene (NCBI)TPO    thyroid peroxidase
AliasesMSA; TDH2A; TPX
GeneCards (Weizmann)TPO
Ensembl hg19 (Hinxton)ENSG00000115705 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115705 [Gene_View]  ENSG00000115705 [Sequence]  chr2:1414408-1542727 [Contig_View]  TPO [Vega]
ICGC DataPortalENSG00000115705
TCGA cBioPortalTPO
AceView (NCBI)TPO
Genatlas (Paris)TPO
SOURCE (Princeton)TPO
Genetics Home Reference (NIH)TPO
Genomic and cartography
GoldenPath hg38 (UCSC)TPO  -     chr2:1414408-1542727 +  2p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPO  -     2p25.3   [Description]    (hg19-Feb_2009)
GoldenPathTPO - 2p25.3 [CytoView hg19]  TPO - 2p25.3 [CytoView hg38]
ImmunoBaseENSG00000115705
Genome Data Viewer NCBITPO [Mapview hg19]  
OMIM274500   606765   
Gene and transcription
Genbank (Entrez)AB208960 AF439430 AF533528 AF533529 AF533530
RefSeq transcript (Entrez)NM_000547 NM_001206744 NM_001206745 NM_175719 NM_175720 NM_175721 NM_175722
Consensus coding sequences : CCDS (NCBI)TPO
Gene ExpressionTPO [ NCBI-GEO ]   TPO [ EBI - ARRAY_EXPRESS ]   TPO [ SEEK ]   TPO [ MEM ]
Gene Expression Viewer (FireBrowse)TPO [ Firebrowse - Broad ]
GenevisibleExpression of TPO in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7173
GTEX Portal (Tissue expression)TPO
Human Protein AtlasENSG00000115705-TPO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07202   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07202  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07202
PhosPhoSitePlusP07202
Domaine pattern : Prosite (Expaxy)ASX_HYDROXYL (PS00010)    EGF_2 (PS01186)    EGF_3 (PS50026)    EGF_CA (PS01187)    PEROXIDASE_1 (PS00435)    PEROXIDASE_3 (PS50292)    SUSHI (PS50923)   
Domains : Interpro (EBI)EGF-like_Ca-bd_dom    EGF-like_dom    EGF-type_Asp/Asn_hydroxyl_site    EGF_Ca-bd_CS    Haem_peroxidase_animal    Haem_peroxidase_sf    Haem_peroxidase_sf_animal    Sushi/SCR/CCP_sf    Sushi_SCR_CCP_dom    TPO   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)    EGF_CA (PF07645)    Sushi (PF00084)   
Domain families : Pfam (NCBI)pfam03098    pfam07645    pfam00084   
Domain families : Smart (EMBL)CCP (SM00032)  EGF (SM00181)  EGF_CA (SM00179)  
Conserved Domain (NCBI)TPO
SuperfamilyP07202
AlphaFold pdb e-kbP07202   
Human Protein Atlas [tissue]ENSG00000115705-TPO [tissue]
HPRD06000
Protein Interaction databases
DIP (DOE-UCLA)P07202
IntAct (EBI)P07202
BioGRIDTPO
STRING (EMBL)TPO
ZODIACTPO
Ontologies - Pathways
QuickGOP07202
Ontology : AmiGOiodide peroxidase activity  peroxidase activity  calcium ion binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  thyroid hormone generation  thyroid hormone generation  response to oxidative stress  cell surface  heme binding  embryonic hemopoiesis  hormone biosynthetic process  hydrogen peroxide catabolic process  cellular oxidant detoxification  
Ontology : EGO-EBIiodide peroxidase activity  peroxidase activity  calcium ion binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  thyroid hormone generation  thyroid hormone generation  response to oxidative stress  cell surface  heme binding  embryonic hemopoiesis  hormone biosynthetic process  hydrogen peroxide catabolic process  cellular oxidant detoxification  
Pathways : KEGGTyrosine metabolism    Cytokine-cytokine receptor interaction    Jak-STAT signaling pathway    Hematopoietic cell lineage    Thyroid hormone synthesis    Autoimmune thyroid disease   
NDEx NetworkTPO
Atlas of Cancer Signalling NetworkTPO
Wikipedia pathwaysTPO
Orthology - Evolution
OrthoDB7173
GeneTree (enSembl)ENSG00000115705
Phylogenetic Trees/Animal Genes : TreeFamTPO
Homologs : HomoloGeneTPO
Homology/Alignments : Family Browser (UCSC)TPO
Gene fusions - Rearrangements
Fusion : MitelmanCNPY3/TPO [6p21.1/2p25.3]  
Fusion : QuiverTPO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPO
dbVarTPO
ClinVarTPO
MonarchTPO
1000_GenomesTPO 
Exome Variant ServerTPO
GNOMAD BrowserENSG00000115705
Varsome BrowserTPO
ACMGTPO variants
VarityP07202
Genomic Variants (DGV)TPO [DGVbeta]
DECIPHERTPO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPO 
Mutations
ICGC Data PortalTPO 
TCGA Data PortalTPO 
Broad Tumor PortalTPO
OASIS PortalTPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPO  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPO
Mutations and Diseases : HGMDTPO
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPO
DgiDB (Drug Gene Interaction Database)TPO
DoCM (Curated mutations)TPO
CIViC (Clinical Interpretations of Variants in Cancer)TPO
Cancer3DTPO
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM274500    606765   
Orphanet12671   
DisGeNETTPO
MedgenTPO
Genetic Testing Registry TPO
NextProtP07202 [Medical]
GENETestsTPO
Target ValidationTPO
Huge Navigator TPO [HugePedia]
ClinGenTPO
Clinical trials, drugs, therapy
MyCancerGenomeTPO
Protein Interactions : CTDTPO
Pharm GKB GenePA36694
PharosP07202
Clinical trialTPO
Miscellaneous
canSAR (ICR)TPO
HarmonizomeTPO
DataMed IndexTPO
Probes
Litterature
PubMed167 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:01 CEST 2021

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