Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TPP1 (tripeptidyl peptidase 1)

Identity

Alias (NCBI)CLN2
GIG1
LPIC
SCAR7
TPP-1
HGNC (Hugo) TPP1
HGNC Alias symbLPIC
TPP-1
HGNC Alias nameTPP I
 lysosomal pepstatin-insensitive carboxypeptidase
HGNC Previous nameCLN2
 SCAR7
HGNC Previous nameceroid-lipofuscinosis, neuronal 2, late infantile (Jansky-Bielschowsky disease)
 spinocerebellar ataxia, autosomal recessive 7
 tripeptidyl peptidase I
LocusID (NCBI) 1200
Atlas_Id 46412
Location 11p15.4  [Link to chromosome band 11p15]
Location_base_pair Starts at 6612770 and ends at 6619422 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD74 (5q32) / TPP1 (11p15.4)DNAJB9 (7q31.1) / TPP1 (11p15.4)LZTS3 (20p13) / TPP1 (11p15.4)
MALAT1 (11q13.1) / TPP1 (11p15.4)PEX11B (1q21.1) / TPP1 (11p15.4)PRAF2 (Xp11.23) / TPP1 (11p15.4)
RNF213 (17q25.3) / TPP1 (11p15.4)TPP1 (11p15.4) / PRKAR1A (17q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPP1   2073
LRG (Locus Reference Genomic)LRG_830
Cards
Entrez_Gene (NCBI)TPP1    tripeptidyl peptidase 1
AliasesCLN2; GIG1; LPIC; SCAR7; 
TPP-1
GeneCards (Weizmann)TPP1
Ensembl hg19 (Hinxton)ENSG00000166340 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166340 [Gene_View]  ENSG00000166340 [Sequence]  chr11:6612770-6619422 [Contig_View]  TPP1 [Vega]
ICGC DataPortalENSG00000166340
TCGA cBioPortalTPP1
AceView (NCBI)TPP1
Genatlas (Paris)TPP1
SOURCE (Princeton)TPP1
Genetics Home Reference (NIH)TPP1
Genomic and cartography
GoldenPath hg38 (UCSC)TPP1  -     chr11:6612770-6619422 -  11p15.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPP1  -     11p15.4   [Description]    (hg19-Feb_2009)
GoldenPathTPP1 - 11p15.4 [CytoView hg19]  TPP1 - 11p15.4 [CytoView hg38]
ImmunoBaseENSG00000166340
Genome Data Viewer NCBITPP1 [Mapview hg19]  
OMIM204500   607998   609270   
Gene and transcription
Genbank (Entrez)AF017456 AI023962 AK222499 AK222538 AK293518
RefSeq transcript (Entrez)NM_000391
Consensus coding sequences : CCDS (NCBI)TPP1
Gene ExpressionTPP1 [ NCBI-GEO ]   TPP1 [ EBI - ARRAY_EXPRESS ]   TPP1 [ SEEK ]   TPP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPP1 [ Firebrowse - Broad ]
GenevisibleExpression of TPP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1200
GTEX Portal (Tissue expression)TPP1
Human Protein AtlasENSG00000166340-TPP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14773   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14773  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14773
PhosPhoSitePlusO14773
Domaine pattern : Prosite (Expaxy)SEDOLISIN (PS51695)   
Domains : Interpro (EBI)Peptidase_S8/S53_dom    Peptidase_S8/S53_dom_sf    S53_propep    Sedolisin_dom   
Domain families : Pfam (Sanger)Peptidase_S8 (PF00082)    Pro-kuma_activ (PF09286)   
Domain families : Pfam (NCBI)pfam00082    pfam09286   
Domain families : Smart (EMBL)Pro-kuma_activ (SM00944)  
Conserved Domain (NCBI)TPP1
PDB (RSDB)1R60    3EDY    3EE6   
PDB Europe1R60    3EDY    3EE6   
PDB (PDBSum)1R60    3EDY    3EE6   
PDB (IMB)1R60    3EDY    3EE6   
Structural Biology KnowledgeBase1R60    3EDY    3EE6   
SCOP (Structural Classification of Proteins)1R60    3EDY    3EE6   
CATH (Classification of proteins structures)1R60    3EDY    3EE6   
SuperfamilyO14773
AlphaFold pdb e-kbO14773   
Human Protein Atlas [tissue]ENSG00000166340-TPP1 [tissue]
HPRD06415
Protein Interaction databases
DIP (DOE-UCLA)O14773
IntAct (EBI)O14773
BioGRIDTPP1
STRING (EMBL)TPP1
ZODIACTPP1
Ontologies - Pathways
QuickGOO14773
Ontology : AmiGOendopeptidase activity  endopeptidase activity  endopeptidase activity  serine-type endopeptidase activity  protein binding  lysosome  lysosome  Golgi apparatus  proteolysis  proteolysis  lipid metabolic process  lysosome organization  nervous system development  central nervous system development  peptidase activity  serine-type peptidase activity  tripeptidyl-peptidase activity  tripeptidyl-peptidase activity  tripeptidyl-peptidase activity  protein catabolic process  epithelial cell differentiation  lysophosphatidic acid binding  IRE1-mediated unfolded protein response  peptide binding  melanosome  peptide catabolic process  lysosomal lumen  membrane raft  bone resorption  metal ion binding  neuromuscular process controlling balance  recycling endosome  extracellular exosome  protein localization to chromosome, telomeric region  sulfatide binding  lysosomal protein catabolic process  
Ontology : EGO-EBIendopeptidase activity  endopeptidase activity  endopeptidase activity  serine-type endopeptidase activity  protein binding  lysosome  lysosome  Golgi apparatus  proteolysis  proteolysis  lipid metabolic process  lysosome organization  nervous system development  central nervous system development  peptidase activity  serine-type peptidase activity  tripeptidyl-peptidase activity  tripeptidyl-peptidase activity  tripeptidyl-peptidase activity  protein catabolic process  epithelial cell differentiation  lysophosphatidic acid binding  IRE1-mediated unfolded protein response  peptide binding  melanosome  peptide catabolic process  lysosomal lumen  membrane raft  bone resorption  metal ion binding  neuromuscular process controlling balance  recycling endosome  extracellular exosome  protein localization to chromosome, telomeric region  sulfatide binding  lysosomal protein catabolic process  
Pathways : KEGGLysosome   
NDEx NetworkTPP1
Atlas of Cancer Signalling NetworkTPP1
Wikipedia pathwaysTPP1
Orthology - Evolution
OrthoDB1200
GeneTree (enSembl)ENSG00000166340
Phylogenetic Trees/Animal Genes : TreeFamTPP1
Homologs : HomoloGeneTPP1
Homology/Alignments : Family Browser (UCSC)TPP1
Gene fusions - Rearrangements
Fusion : QuiverTPP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPP1
dbVarTPP1
ClinVarTPP1
MonarchTPP1
1000_GenomesTPP1 
Exome Variant ServerTPP1
GNOMAD BrowserENSG00000166340
Varsome BrowserTPP1
ACMGTPP1 variants
VarityO14773
Genomic Variants (DGV)TPP1 [DGVbeta]
DECIPHERTPP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPP1 
Mutations
ICGC Data PortalTPP1 
TCGA Data PortalTPP1 
Broad Tumor PortalTPP1
OASIS PortalTPP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPP1
Mutations and Diseases : HGMDTPP1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPP1
DgiDB (Drug Gene Interaction Database)TPP1
DoCM (Curated mutations)TPP1
CIViC (Clinical Interpretations of Variants in Cancer)TPP1
Cancer3DTPP1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM204500    607998    609270   
Orphanet19110    20595   
DisGeNETTPP1
MedgenTPP1
Genetic Testing Registry TPP1
NextProtO14773 [Medical]
GENETestsTPP1
Target ValidationTPP1
Huge Navigator TPP1 [HugePedia]
ClinGenTPP1
Clinical trials, drugs, therapy
MyCancerGenomeTPP1
Protein Interactions : CTDTPP1
Pharm GKB GenePA26600
PharosO14773
Clinical trialTPP1
Miscellaneous
canSAR (ICR)TPP1
HarmonizomeTPP1
DataMed IndexTPP1
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:02 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.