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TPP2 (tripeptidyl peptidase 2)

Identity

Alias_namestripeptidyl peptidase II
Alias_symbol (synonym)TPPII
Other aliasTPP-2
HGNC (Hugo) TPP2
LocusID (NCBI) 7174
Atlas_Id 50836
Location 13q33.1  [Link to chromosome band 13q33]
Location_base_pair Starts at 103249286 and ends at 103331523 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TPP2 (13q33.1) / MYO5B (18q21.1)TPP2 (13q33.1) / TPP2 (13q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPP2   12016
Cards
Entrez_Gene (NCBI)TPP2  7174  tripeptidyl peptidase 2
AliasesTPP-2; TPPII
GeneCards (Weizmann)TPP2
Ensembl hg19 (Hinxton)ENSG00000134900 [Gene_View]  chr13:103249286-103331523 [Contig_View]  TPP2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000134900 [Gene_View]  chr13:103249286-103331523 [Contig_View]  TPP2 [Vega]
ICGC DataPortalENSG00000134900
TCGA cBioPortalTPP2
AceView (NCBI)TPP2
Genatlas (Paris)TPP2
WikiGenes7174
SOURCE (Princeton)TPP2
Genetics Home Reference (NIH)TPP2
Genomic and cartography
GoldenPath hg19 (UCSC)TPP2  -     chr13:103249286-103331523 +  13q33.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TPP2  -     13q33.1   [Description]    (hg38-Dec_2013)
EnsemblTPP2 - 13q33.1 [CytoView hg19]  TPP2 - 13q33.1 [CytoView hg38]
Mapping of homologs : NCBITPP2 [Mapview hg19]  TPP2 [Mapview hg38]
OMIM190470   
Gene and transcription
Genbank (Entrez)AK097678 AK127549 AK304313 AU132468 BC024905
RefSeq transcript (Entrez)NM_003291
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_009952 NW_004929389
Consensus coding sequences : CCDS (NCBI)TPP2
Cluster EST : UnigeneHs.432424 [ NCBI ]
CGAP (NCI)Hs.432424
Alternative Splicing GalleryENSG00000134900
Gene ExpressionTPP2 [ NCBI-GEO ]   TPP2 [ EBI - ARRAY_EXPRESS ]   TPP2 [ SEEK ]   TPP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7174
GTEX Portal (Tissue expression)TPP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP29144   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP29144  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP29144
Splice isoforms : SwissVarP29144
Catalytic activity : Enzyme3.4.14.10 [ Enzyme-Expasy ]   3.4.14.103.4.14.10 [ IntEnz-EBI ]   3.4.14.10 [ BRENDA ]   3.4.14.10 [ KEGG ]   
PhosPhoSitePlusP29144
Domaine pattern : Prosite (Expaxy)SUBTILASE_HIS (PS00137)    SUBTILASE_SER (PS00138)   
Domains : Interpro (EBI)Peptidase_S8/S53_dom    Peptidase_S8_His-AS    Peptidase_S8_Ser-AS    Peptidase_S8_subtilisin-rel    Peptidase_S8A_TPPII   
Domain families : Pfam (Sanger)Peptidase_S8 (PF00082)    TPPII (PF12580)   
Domain families : Pfam (NCBI)pfam00082    pfam12580   
Conserved Domain (NCBI)TPP2
DMDM Disease mutations7174
Blocks (Seattle)TPP2
SuperfamilyP29144
Human Protein AtlasENSG00000134900
Peptide AtlasP29144
HPRD01834
IPIIPI00020416   IPI00640197   
Protein Interaction databases
DIP (DOE-UCLA)P29144
IntAct (EBI)P29144
FunCoupENSG00000134900
BioGRIDTPP2
STRING (EMBL)TPP2
ZODIACTPP2
Ontologies - Pathways
QuickGOP29144
Ontology : AmiGOprotein polyubiquitination  endopeptidase activity  aminopeptidase activity  serine-type endopeptidase activity  protein binding  nucleus  cytoplasm  cytosol  proteolysis  tripeptidyl-peptidase activity  peptide binding  
Ontology : EGO-EBIprotein polyubiquitination  endopeptidase activity  aminopeptidase activity  serine-type endopeptidase activity  protein binding  nucleus  cytoplasm  cytosol  proteolysis  tripeptidyl-peptidase activity  peptide binding  
NDEx NetworkTPP2
Atlas of Cancer Signalling NetworkTPP2
Wikipedia pathwaysTPP2
Orthology - Evolution
OrthoDB7174
GeneTree (enSembl)ENSG00000134900
Phylogenetic Trees/Animal Genes : TreeFamTPP2
HOVERGENP29144
HOGENOMP29144
Homologs : HomoloGeneTPP2
Homology/Alignments : Family Browser (UCSC)TPP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPP2
dbVarTPP2
ClinVarTPP2
1000_GenomesTPP2 
Exome Variant ServerTPP2
ExAC (Exome Aggregation Consortium)TPP2 (select the gene name)
Genetic variants : HAPMAP7174
Genomic Variants (DGV)TPP2 [DGVbeta]
DECIPHER (Syndromes)13:103249286-103331523  ENSG00000134900
CONAN: Copy Number AnalysisTPP2 
Mutations
ICGC Data PortalTPP2 
TCGA Data PortalTPP2 
Broad Tumor PortalTPP2
OASIS PortalTPP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPP2
DgiDB (Drug Gene Interaction Database)TPP2
DoCM (Curated mutations)TPP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPP2 (select a term)
intoGenTPP2
Cancer3DTPP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190470   
Orphanet23490   
MedgenTPP2
Genetic Testing Registry TPP2
NextProtP29144 [Medical]
TSGene7174
GENETestsTPP2
Huge Navigator TPP2 [HugePedia]
snp3D : Map Gene to Disease7174
BioCentury BCIQTPP2
ClinGenTPP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7174
Chemical/Pharm GKB GenePA36695
Clinical trialTPP2
Miscellaneous
canSAR (ICR)TPP2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPP2
EVEXTPP2
GoPubMedTPP2
iHOPTPP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:23:12 CEST 2017

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