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TPPP (tubulin polymerization promoting protein)

Identity

Alias_symbol (synonym)p25alpha
TPPP1
p25
TPPP/p25
Other aliasp24
HGNC (Hugo) TPPP
LocusID (NCBI) 11076
Atlas_Id 50011
Location 5p15.33  [Link to chromosome band 5p15]
Location_base_pair Starts at 659862 and ends at 693395 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CEP72 (5p15.33) / TPPP (5p15.33)FAM134B (5p15.1) / TPPP (5p15.33)CEP72 5p15.33 / TPPP 5p15.33
FAM134B 5p15.1 / TPPP 5p15.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPPP   24164
Cards
Entrez_Gene (NCBI)TPPP  11076  tubulin polymerization promoting protein
AliasesTPPP/p25; TPPP1; p24; p25; 
p25alpha
GeneCards (Weizmann)TPPP
Ensembl hg19 (Hinxton)ENSG00000171368 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171368 [Gene_View]  chr5:659862-693395 [Contig_View]  TPPP [Vega]
ICGC DataPortalENSG00000171368
TCGA cBioPortalTPPP
AceView (NCBI)TPPP
Genatlas (Paris)TPPP
WikiGenes11076
SOURCE (Princeton)TPPP
Genetics Home Reference (NIH)TPPP
Genomic and cartography
GoldenPath hg38 (UCSC)TPPP  -     chr5:659862-693395 -  5p15.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPPP  -     5p15.33   [Description]    (hg19-Feb_2009)
EnsemblTPPP - 5p15.33 [CytoView hg19]  TPPP - 5p15.33 [CytoView hg38]
Mapping of homologs : NCBITPPP [Mapview hg19]  TPPP [Mapview hg38]
OMIM608773   
Gene and transcription
Genbank (Entrez)AB017016 AI796918 AK054920 AK098392 AW955330
RefSeq transcript (Entrez)NM_007030
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPPP
Cluster EST : UnigeneHs.481466 [ NCBI ]
CGAP (NCI)Hs.481466
Alternative Splicing GalleryENSG00000171368
Gene ExpressionTPPP [ NCBI-GEO ]   TPPP [ EBI - ARRAY_EXPRESS ]   TPPP [ SEEK ]   TPPP [ MEM ]
Gene Expression Viewer (FireBrowse)TPPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11076
GTEX Portal (Tissue expression)TPPP
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94811   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94811  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94811
Splice isoforms : SwissVarO94811
PhosPhoSitePlusO94811
Domains : Interpro (EBI)EF-hand-dom_pair    P25-alpha    TPPP1   
Domain families : Pfam (Sanger)p25-alpha (PF05517)   
Domain families : Pfam (NCBI)pfam05517   
Conserved Domain (NCBI)TPPP
DMDM Disease mutations11076
Blocks (Seattle)TPPP
SuperfamilyO94811
Human Protein AtlasENSG00000171368
Peptide AtlasO94811
HPRD18522
IPIIPI00013043   
Protein Interaction databases
DIP (DOE-UCLA)O94811
IntAct (EBI)O94811
FunCoupENSG00000171368
BioGRIDTPPP
STRING (EMBL)TPPP
ZODIACTPPP
Ontologies - Pathways
QuickGOO94811
Ontology : AmiGOmicrotubule bundle formation  microtubule bundle formation  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  microtubule  microtubule binding  tubulin binding  tubulin binding  positive regulation of protein complex assembly  positive regulation of protein polymerization  myelin sheath  microtubule polymerization  microtubule polymerization  perinuclear region of cytoplasm  
Ontology : EGO-EBImicrotubule bundle formation  microtubule bundle formation  protein binding  nucleus  cytoplasm  mitochondrion  cytosol  microtubule  microtubule binding  tubulin binding  tubulin binding  positive regulation of protein complex assembly  positive regulation of protein polymerization  myelin sheath  microtubule polymerization  microtubule polymerization  perinuclear region of cytoplasm  
NDEx NetworkTPPP
Atlas of Cancer Signalling NetworkTPPP
Wikipedia pathwaysTPPP
Orthology - Evolution
OrthoDB11076
GeneTree (enSembl)ENSG00000171368
Phylogenetic Trees/Animal Genes : TreeFamTPPP
HOVERGENO94811
HOGENOMO94811
Homologs : HomoloGeneTPPP
Homology/Alignments : Family Browser (UCSC)TPPP
Gene fusions - Rearrangements
Fusion : MitelmanCEP72/TPPP [5p15.33/5p15.33]  [t(5;5)(p15;p15)]  
Fusion : MitelmanFAM134B/TPPP [5p15.1/5p15.33]  [t(5;5)(p15;p15)]  
Fusion: TCGACEP72 5p15.33 TPPP 5p15.33 LUAD
Fusion: TCGAFAM134B 5p15.1 TPPP 5p15.33 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPPP
dbVarTPPP
ClinVarTPPP
1000_GenomesTPPP 
Exome Variant ServerTPPP
ExAC (Exome Aggregation Consortium)TPPP (select the gene name)
Genetic variants : HAPMAP11076
Genomic Variants (DGV)TPPP [DGVbeta]
DECIPHERTPPP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPPP 
Mutations
ICGC Data PortalTPPP 
TCGA Data PortalTPPP 
Broad Tumor PortalTPPP
OASIS PortalTPPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPPP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPPP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPPP
DgiDB (Drug Gene Interaction Database)TPPP
DoCM (Curated mutations)TPPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPPP (select a term)
intoGenTPPP
Cancer3DTPPP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608773   
Orphanet
MedgenTPPP
Genetic Testing Registry TPPP
NextProtO94811 [Medical]
TSGene11076
GENETestsTPPP
Target ValidationTPPP
Huge Navigator TPPP [HugePedia]
snp3D : Map Gene to Disease11076
BioCentury BCIQTPPP
ClinGenTPPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11076
Chemical/Pharm GKB GenePA162406809
Clinical trialTPPP
Miscellaneous
canSAR (ICR)TPPP (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPPP
EVEXTPPP
GoPubMedTPPP
iHOPTPPP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:17:30 CEST 2017

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