TPPP (tubulin polymerization promoting protein)

2007-02-01  

Identity

HGNC
TPPP
LOCATION
5p15.33
LOCUSID
11076
ALIAS
TPPP/p25,TPPP1,p24,p25,p25alpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11076
MIM: 608773
HGNC: 24164
Ensembl: ENSG00000171368

Variants:

dbSNP: 11076
ClinVar: 11076
TCGA: ENSG00000171368
COSMIC: TPPP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171368ENST00000360578O94811
ENSG00000171368ENST00000360578Q4L233

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
183111572008The role of GSK-3 in synaptic plasticity.85
246556512014Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry.73
182044892008Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.71
220831402011Inhibition of GSK3 by Wnt signalling--two contrasting models.70
178232882007p25alpha relocalizes in oligodendroglia from myelin to cytoplasmic inclusions in multiple system atrophy.52
218320492011Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.45
155906522005p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.42
203080652010TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.33
180258012007Gain of 5p15.33 is associated with progression of bladder cancer.30
180289082007The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.22

Citation

Dessen P

TPPP (tubulin polymerization promoting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50011/tppp