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TPPP2 (tubulin polymerization promoting protein family member 2)

Identity

Alias (NCBI)C14orf8
CT152
P18
p25beta
HGNC (Hugo) TPPP2
HGNC Alias symbp25beta
p18
CT152
HGNC Previous nameC14orf8
HGNC Previous namechromosome 14 open reading frame 8
LocusID (NCBI) 122664
Atlas_Id 75078
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21030217 and ends at 21032815 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPPP2   19293
Cards
Entrez_Gene (NCBI)TPPP2    tubulin polymerization promoting protein family member 2
AliasesC14orf8; CT152; P18; p25beta
GeneCards (Weizmann)TPPP2
Ensembl hg19 (Hinxton)ENSG00000179636 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000179636 [Gene_View]  ENSG00000179636 [Sequence]  chr14:21030217-21032815 [Contig_View]  TPPP2 [Vega]
ICGC DataPortalENSG00000179636
TCGA cBioPortalTPPP2
AceView (NCBI)TPPP2
Genatlas (Paris)TPPP2
SOURCE (Princeton)TPPP2
Genetics Home Reference (NIH)TPPP2
Genomic and cartography
GoldenPath hg38 (UCSC)TPPP2  -     chr14:21030217-21032815 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPPP2  -     14q11.2   [Description]    (hg19-Feb_2009)
GoldenPathTPPP2 - 14q11.2 [CytoView hg19]  TPPP2 - 14q11.2 [CytoView hg38]
ImmunoBaseENSG00000179636
Genome Data Viewer NCBITPPP2 [Mapview hg19]  
OMIM616956   
Gene and transcription
Genbank (Entrez)AK093070 AK098680 AW135537 AY072034 AY173946
RefSeq transcript (Entrez)NM_173846
Consensus coding sequences : CCDS (NCBI)TPPP2
Gene ExpressionTPPP2 [ NCBI-GEO ]   TPPP2 [ EBI - ARRAY_EXPRESS ]   TPPP2 [ SEEK ]   TPPP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPPP2 [ Firebrowse - Broad ]
GenevisibleExpression of TPPP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)122664
GTEX Portal (Tissue expression)TPPP2
Human Protein AtlasENSG00000179636-TPPP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP59282   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP59282  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP59282
PhosPhoSitePlusP59282
Domains : Interpro (EBI)EF-hand-dom_pair    P25-alpha    TPPP2   
Domain families : Pfam (Sanger)p25-alpha (PF05517)   
Domain families : Pfam (NCBI)pfam05517   
Conserved Domain (NCBI)TPPP2
SuperfamilyP59282
AlphaFold pdb e-kbP59282   
Human Protein Atlas [tissue]ENSG00000179636-TPPP2 [tissue]
HPRD12657
Protein Interaction databases
DIP (DOE-UCLA)P59282
IntAct (EBI)P59282
BioGRIDTPPP2
STRING (EMBL)TPPP2
ZODIACTPPP2
Ontologies - Pathways
QuickGOP59282
Ontology : AmiGOmicrotubule bundle formation  cytosol  microtubule  spermatogenesis  tubulin binding  tubulin binding  cell differentiation  positive regulation of protein polymerization  sperm flagellum  microtubule polymerization  regulation of flagellated sperm motility  regulation of flagellated sperm motility  
Ontology : EGO-EBImicrotubule bundle formation  cytosol  microtubule  spermatogenesis  tubulin binding  tubulin binding  cell differentiation  positive regulation of protein polymerization  sperm flagellum  microtubule polymerization  regulation of flagellated sperm motility  regulation of flagellated sperm motility  
NDEx NetworkTPPP2
Atlas of Cancer Signalling NetworkTPPP2
Wikipedia pathwaysTPPP2
Orthology - Evolution
OrthoDB122664
GeneTree (enSembl)ENSG00000179636
Phylogenetic Trees/Animal Genes : TreeFamTPPP2
Homologs : HomoloGeneTPPP2
Homology/Alignments : Family Browser (UCSC)TPPP2
Gene fusions - Rearrangements
Fusion : QuiverTPPP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPPP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPPP2
dbVarTPPP2
ClinVarTPPP2
MonarchTPPP2
1000_GenomesTPPP2 
Exome Variant ServerTPPP2
GNOMAD BrowserENSG00000179636
Varsome BrowserTPPP2
ACMGTPPP2 variants
VarityP59282
Genomic Variants (DGV)TPPP2 [DGVbeta]
DECIPHERTPPP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPPP2 
Mutations
ICGC Data PortalTPPP2 
TCGA Data PortalTPPP2 
Broad Tumor PortalTPPP2
OASIS PortalTPPP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPPP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPPP2
Mutations and Diseases : HGMDTPPP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPPP2
DgiDB (Drug Gene Interaction Database)TPPP2
DoCM (Curated mutations)TPPP2
CIViC (Clinical Interpretations of Variants in Cancer)TPPP2
Cancer3DTPPP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616956   
Orphanet
DisGeNETTPPP2
MedgenTPPP2
Genetic Testing Registry TPPP2
NextProtP59282 [Medical]
GENETestsTPPP2
Target ValidationTPPP2
Huge Navigator TPPP2 [HugePedia]
ClinGenTPPP2
Clinical trials, drugs, therapy
MyCancerGenomeTPPP2
Protein Interactions : CTDTPPP2
Pharm GKB GenePA162406822
PharosP59282
Clinical trialTPPP2
Miscellaneous
canSAR (ICR)TPPP2
HarmonizomeTPPP2
DataMed IndexTPPP2
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPPP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:37 CEST 2021

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