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TPSAB1 (tryptase alpha/beta 1)

Identity

Alias (NCBI)TPS1
TPS2
TPSB1
TPSB2
Tryptase-2
HGNC (Hugo) TPSAB1
HGNC Alias nametryptase alpha II
 tryptase beta I
 tryptase-I
 tryptase-II
 tryptase-III
HGNC Previous nameTPSB1
 TPS1
 TPS2
HGNC Previous nametryptase beta 1
LocusID (NCBI) 7177
Atlas_Id 45901
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1240705 and ends at 1242554 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TPSAB1 (16p13.3) / MYADM (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPSAB1   12019
Cards
Entrez_Gene (NCBI)TPSAB1    tryptase alpha/beta 1
AliasesTPS1; TPS2; TPSB1; TPSB2; 
Tryptase-2
GeneCards (Weizmann)TPSAB1
Ensembl hg19 (Hinxton)ENSG00000172236 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172236 [Gene_View]  ENSG00000172236 [Sequence]  chr16:1240705-1242554 [Contig_View]  TPSAB1 [Vega]
ICGC DataPortalENSG00000172236
TCGA cBioPortalTPSAB1
AceView (NCBI)TPSAB1
Genatlas (Paris)TPSAB1
SOURCE (Princeton)TPSAB1
Genetics Home Reference (NIH)TPSAB1
Genomic and cartography
GoldenPath hg38 (UCSC)TPSAB1  -     chr16:1240705-1242554 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPSAB1  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTPSAB1 - 16p13.3 [CytoView hg19]  TPSAB1 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000172236
Genome Data Viewer NCBITPSAB1 [Mapview hg19]  
OMIM191080   
Gene and transcription
Genbank (Entrez)AF206665 AF206666 AF206667 BC038416 BC051852
RefSeq transcript (Entrez)NM_003294
Consensus coding sequences : CCDS (NCBI)TPSAB1
Gene ExpressionTPSAB1 [ NCBI-GEO ]   TPSAB1 [ EBI - ARRAY_EXPRESS ]   TPSAB1 [ SEEK ]   TPSAB1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPSAB1 [ Firebrowse - Broad ]
GenevisibleExpression of TPSAB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7177
GTEX Portal (Tissue expression)TPSAB1
Human Protein AtlasENSG00000172236-TPSAB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15661
Catalytic activity : Enzyme3.4.21.59 [ Enzyme-Expasy ]   3.4.21.593.4.21.59 [ IntEnz-EBI ]   3.4.21.59 [ BRENDA ]   3.4.21.59 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15661
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1_PA_chymotrypsin    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TPSAB1
PDB (RSDB)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
PDB Europe1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
PDB (PDBSum)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
PDB (IMB)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
Structural Biology KnowledgeBase1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
SCOP (Structural Classification of Proteins)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
CATH (Classification of proteins structures)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03    5WI6    6O1F    6P0P   
SuperfamilyQ15661
AlphaFold pdb e-kbQ15661   
Human Protein Atlas [tissue]ENSG00000172236-TPSAB1 [tissue]
HPRD01848
Protein Interaction databases
DIP (DOE-UCLA)Q15661
IntAct (EBI)Q15661
BioGRIDTPSAB1
STRING (EMBL)TPSAB1
ZODIACTPSAB1
Ontologies - Pathways
QuickGOQ15661
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  proteolysis  defense response  serine-type peptidase activity  extracellular matrix disassembly  extracellular matrix disassembly  identical protein binding  collagen-containing extracellular matrix  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  proteolysis  defense response  serine-type peptidase activity  extracellular matrix disassembly  extracellular matrix disassembly  identical protein binding  collagen-containing extracellular matrix  
NDEx NetworkTPSAB1
Atlas of Cancer Signalling NetworkTPSAB1
Wikipedia pathwaysTPSAB1
Orthology - Evolution
OrthoDB7177
GeneTree (enSembl)ENSG00000172236
Phylogenetic Trees/Animal Genes : TreeFamTPSAB1
Homologs : HomoloGeneTPSAB1
Homology/Alignments : Family Browser (UCSC)TPSAB1
Gene fusions - Rearrangements
Fusion : QuiverTPSAB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPSAB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPSAB1
dbVarTPSAB1
ClinVarTPSAB1
MonarchTPSAB1
1000_GenomesTPSAB1 
Exome Variant ServerTPSAB1
GNOMAD BrowserENSG00000172236
Varsome BrowserTPSAB1
ACMGTPSAB1 variants
VarityQ15661
Genomic Variants (DGV)TPSAB1 [DGVbeta]
DECIPHERTPSAB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPSAB1 
Mutations
ICGC Data PortalTPSAB1 
TCGA Data PortalTPSAB1 
Broad Tumor PortalTPSAB1
OASIS PortalTPSAB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPSAB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPSAB1
Mutations and Diseases : HGMDTPSAB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPSAB1
DgiDB (Drug Gene Interaction Database)TPSAB1
DoCM (Curated mutations)TPSAB1
CIViC (Clinical Interpretations of Variants in Cancer)TPSAB1
Cancer3DTPSAB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191080   
Orphanet
DisGeNETTPSAB1
MedgenTPSAB1
Genetic Testing Registry TPSAB1
NextProtQ15661 [Medical]
GENETestsTPSAB1
Target ValidationTPSAB1
Huge Navigator TPSAB1 [HugePedia]
ClinGenTPSAB1
Clinical trials, drugs, therapy
MyCancerGenomeTPSAB1
Protein Interactions : CTDTPSAB1
Pharm GKB GenePA36698
PharosQ15661
Clinical trialTPSAB1
Miscellaneous
canSAR (ICR)TPSAB1
HarmonizomeTPSAB1
DataMed IndexTPSAB1
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPSAB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:03 CEST 2021

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