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TPSAB1 (tryptase alpha/beta 1)

Identity

Alias_namesTPSB1
TPS1
TPS2
tryptase beta 1
Other alias
HGNC (Hugo) TPSAB1
LocusID (NCBI) 7177
Atlas_Id 45901
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 1240677 and ends at 1242554 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TPSAB1 (16p13.3) / MYADM (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPSAB1   12019
Cards
Entrez_Gene (NCBI)TPSAB1  7177  tryptase alpha/beta 1
AliasesTPS1; TPS2; TPSB1
GeneCards (Weizmann)TPSAB1
Ensembl hg19 (Hinxton)ENSG00000172236 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172236 [Gene_View]  chr16:1240677-1242554 [Contig_View]  TPSAB1 [Vega]
ICGC DataPortalENSG00000172236
TCGA cBioPortalTPSAB1
AceView (NCBI)TPSAB1
Genatlas (Paris)TPSAB1
WikiGenes7177
SOURCE (Princeton)TPSAB1
Genetics Home Reference (NIH)TPSAB1
Genomic and cartography
GoldenPath hg38 (UCSC)TPSAB1  -     chr16:1240677-1242554 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPSAB1  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblTPSAB1 - 16p13.3 [CytoView hg19]  TPSAB1 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBITPSAB1 [Mapview hg19]  TPSAB1 [Mapview hg38]
OMIM191080   
Gene and transcription
Genbank (Entrez)AF206665 AF206666 AF206667 BC038416 BC051852
RefSeq transcript (Entrez)NM_003294
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPSAB1
Cluster EST : UnigeneHs.592982 [ NCBI ]
CGAP (NCI)Hs.592982
Alternative Splicing GalleryENSG00000172236
Gene ExpressionTPSAB1 [ NCBI-GEO ]   TPSAB1 [ EBI - ARRAY_EXPRESS ]   TPSAB1 [ SEEK ]   TPSAB1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPSAB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7177
GTEX Portal (Tissue expression)TPSAB1
Human Protein AtlasENSG00000172236-TPSAB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15661
Splice isoforms : SwissVarQ15661
Catalytic activity : Enzyme3.4.21.59 [ Enzyme-Expasy ]   3.4.21.593.4.21.59 [ IntEnz-EBI ]   3.4.21.59 [ BRENDA ]   3.4.21.59 [ KEGG ]   
PhosPhoSitePlusQ15661
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)TPSAB1
DMDM Disease mutations7177
Blocks (Seattle)TPSAB1
PDB (SRS)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
PDB (PDBSum)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
PDB (IMB)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
PDB (RSDB)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
Structural Biology KnowledgeBase1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
SCOP (Structural Classification of Proteins)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
CATH (Classification of proteins structures)1LTO    2F9N    2F9O    2F9P    2ZEB    2ZEC    4A6L    4MPU    4MPV    4MPW    4MPX    4MQA    5F03   
SuperfamilyQ15661
Human Protein Atlas [tissue]ENSG00000172236-TPSAB1 [tissue]
Peptide AtlasQ15661
HPRD01848
IPIIPI00472739   IPI00010274   IPI01018188   IPI00946599   
Protein Interaction databases
DIP (DOE-UCLA)Q15661
IntAct (EBI)Q15661
FunCoupENSG00000172236
BioGRIDTPSAB1
STRING (EMBL)TPSAB1
ZODIACTPSAB1
Ontologies - Pathways
QuickGOQ15661
Ontology : AmiGOserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  defense response  serine-type peptidase activity  extracellular matrix disassembly  extracellular matrix  
Ontology : EGO-EBIserine-type endopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  defense response  serine-type peptidase activity  extracellular matrix disassembly  extracellular matrix  
NDEx NetworkTPSAB1
Atlas of Cancer Signalling NetworkTPSAB1
Wikipedia pathwaysTPSAB1
Orthology - Evolution
OrthoDB7177
GeneTree (enSembl)ENSG00000172236
Phylogenetic Trees/Animal Genes : TreeFamTPSAB1
HOVERGENQ15661
HOGENOMQ15661
Homologs : HomoloGeneTPSAB1
Homology/Alignments : Family Browser (UCSC)TPSAB1
Gene fusions - Rearrangements
Tumor Fusion PortalTPSAB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPSAB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPSAB1
dbVarTPSAB1
ClinVarTPSAB1
1000_GenomesTPSAB1 
Exome Variant ServerTPSAB1
ExAC (Exome Aggregation Consortium)ENSG00000172236
GNOMAD BrowserENSG00000172236
Genetic variants : HAPMAP7177
Genomic Variants (DGV)TPSAB1 [DGVbeta]
DECIPHERTPSAB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPSAB1 
Mutations
ICGC Data PortalTPSAB1 
TCGA Data PortalTPSAB1 
Broad Tumor PortalTPSAB1
OASIS PortalTPSAB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPSAB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPSAB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPSAB1
DgiDB (Drug Gene Interaction Database)TPSAB1
DoCM (Curated mutations)TPSAB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPSAB1 (select a term)
intoGenTPSAB1
Cancer3DTPSAB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191080   
Orphanet
DisGeNETTPSAB1
MedgenTPSAB1
Genetic Testing Registry TPSAB1
NextProtQ15661 [Medical]
TSGene7177
GENETestsTPSAB1
Target ValidationTPSAB1
Huge Navigator TPSAB1 [HugePedia]
snp3D : Map Gene to Disease7177
BioCentury BCIQTPSAB1
ClinGenTPSAB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7177
Chemical/Pharm GKB GenePA36698
Clinical trialTPSAB1
Miscellaneous
canSAR (ICR)TPSAB1 (select the gene name)
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPSAB1
EVEXTPSAB1
GoPubMedTPSAB1
iHOPTPSAB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:39:26 CET 2017

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