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TPT1 (tumor protein, translationally-controlled 1)

Identity

Alias (NCBI)HRF
TCTP
p02
p23
HGNC (Hugo) TPT1
HGNC Alias symbTCTP
fortilin
LocusID (NCBI) 7178
Atlas_Id 522
Location 13q14.13  [Link to chromosome band 13q14]
Location_base_pair Starts at 45333471 and ends at 45341183 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUT (15q21.1) / TPT1 (13q14.13)ME3 (11q14.2) / TPT1 (13q14.13)P4HB (17q25.3) / TPT1 (13q14.13)
SFTPB (2p11.2) / TPT1 (13q14.13)TNS2 (12q13.13) / TPT1 (13q14.13)TPT1 (13q14.13) / ARFGEF2 (20q13.13)
TPT1 (13q14.13) / DUT (15q21.1)TPT1 (13q14.13) / LUC7L3 (17q21.33)TPT1 (13q14.13) / NCALD (8q22.3)
TPT1 (13q14.13) / SIAE (11q24.2)TPT1 (13q14.13) / TPT1 (13q14.13)TTR (18q12.1) / TPT1 (13q14.13)
P4HB 17q25.3 / TPT1 13q14.13TPT1 13q14.13 / ARFGEF2 20q13.13TPT1 13q14.13 / LUC7L3 17q21.33
TPT1 13q14.13 / NCALD 8q22.3TPT1 13q14.13 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13q) in chronic lymphocytic leukemia


External links

Nomenclature
HGNC (Hugo)TPT1   12022
Cards
Entrez_Gene (NCBI)TPT1    tumor protein, translationally-controlled 1
AliasesHRF; TCTP; p02; p23
GeneCards (Weizmann)TPT1
Ensembl hg19 (Hinxton)ENSG00000133112 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133112 [Gene_View]  ENSG00000133112 [Sequence]  chr13:45333471-45341183 [Contig_View]  TPT1 [Vega]
ICGC DataPortalENSG00000133112
TCGA cBioPortalTPT1
AceView (NCBI)TPT1
Genatlas (Paris)TPT1
SOURCE (Princeton)TPT1
Genetics Home Reference (NIH)TPT1
Genomic and cartography
GoldenPath hg38 (UCSC)TPT1  -     chr13:45333471-45341183 -  13q14.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPT1  -     13q14.13   [Description]    (hg19-Feb_2009)
GoldenPathTPT1 - 13q14.13 [CytoView hg19]  TPT1 - 13q14.13 [CytoView hg38]
ImmunoBaseENSG00000133112
genome Data Viewer NCBITPT1 [Mapview hg19]  
OMIM600763   
Gene and transcription
Genbank (Entrez)AF072098 AK130847 AK296587 AK296952 AK312951
RefSeq transcript (Entrez)NM_001286272 NM_001286273 NM_003295
Consensus coding sequences : CCDS (NCBI)TPT1
Alternative Splicing GalleryENSG00000133112
Gene ExpressionTPT1 [ NCBI-GEO ]   TPT1 [ EBI - ARRAY_EXPRESS ]   TPT1 [ SEEK ]   TPT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPT1 [ Firebrowse - Broad ]
GenevisibleExpression of TPT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7178
GTEX Portal (Tissue expression)TPT1
Human Protein AtlasENSG00000133112-TPT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13693   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13693  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13693
PhosPhoSitePlusP13693
Domaine pattern : Prosite (Expaxy)TCTP_1 (PS01002)    TCTP_2 (PS01003)    TCTP_3 (PS51797)   
Domains : Interpro (EBI)Mss4-like_sf    Mss4/transl-control_tumour    TCTP    Translation_control_tumour_CS    Translational_control_tumour_p   
Domain families : Pfam (Sanger)TCTP (PF00838)   
Domain families : Pfam (NCBI)pfam00838   
Conserved Domain (NCBI)TPT1
PDB (RSDB)1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
PDB Europe1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
PDB (PDBSum)1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
PDB (IMB)1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
Structural Biology KnowledgeBase1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
SCOP (Structural Classification of Proteins)1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
CATH (Classification of proteins structures)1YZ1    2HR9    3EBM    4Z9V    5O9L    5O9M    6IZB    6IZE   
SuperfamilyP13693
AlphaFold pdb e-kbP13693   
Human Protein Atlas [tissue]ENSG00000133112-TPT1 [tissue]
HPRD15979
Protein Interaction databases
DIP (DOE-UCLA)P13693
IntAct (EBI)P13693
BioGRIDTPT1
STRING (EMBL)TPT1
ZODIACTPT1
Ontologies - Pathways
QuickGOP13693
Ontology : AmiGOspindle pole  RNA binding  calcium ion binding  calcium ion binding  protein binding  extracellular space  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  multivesicular body  cytosol  cytoplasmic microtubule  calcium ion transport  cellular calcium ion homeostasis  response to virus  stem cell population maintenance  regulation of apoptotic process  negative regulation of apoptotic process  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of ectoderm development  
Ontology : EGO-EBIspindle pole  RNA binding  calcium ion binding  calcium ion binding  protein binding  extracellular space  nucleus  nucleoplasm  cytoplasm  cytoplasm  cytoplasm  multivesicular body  cytosol  cytoplasmic microtubule  calcium ion transport  cellular calcium ion homeostasis  response to virus  stem cell population maintenance  regulation of apoptotic process  negative regulation of apoptotic process  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  negative regulation of ectoderm development  
NDEx NetworkTPT1
Atlas of Cancer Signalling NetworkTPT1
Wikipedia pathwaysTPT1
Orthology - Evolution
OrthoDB7178
GeneTree (enSembl)ENSG00000133112
Phylogenetic Trees/Animal Genes : TreeFamTPT1
Homologs : HomoloGeneTPT1
Homology/Alignments : Family Browser (UCSC)TPT1
Gene fusions - Rearrangements
Fusion : MitelmanP4HB/TPT1 [17q25.3/13q14.13]  
Fusion : MitelmanTPT1/ARFGEF2 [13q14.13/20q13.13]  
Fusion : MitelmanTPT1/LUC7L3 [13q14.13/17q21.33]  
Fusion : MitelmanTPT1/NCALD [13q14.13/8q22.3]  
Fusion : MitelmanTPT1/SIAE [13q14.13/11q24.2]  
Fusion PortalP4HB 17q25.3 TPT1 13q14.13 LUAD
Fusion PortalTPT1 13q14.13 ARFGEF2 20q13.13 BRCA
Fusion PortalTPT1 13q14.13 LUC7L3 17q21.33 BRCA
Fusion PortalTPT1 13q14.13 NCALD 8q22.3 BRCA KIRC
Fusion PortalTPT1 13q14.13 SIAE 11q24.2 THCA
Fusion : QuiverTPT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPT1
dbVarTPT1
ClinVarTPT1
MonarchTPT1
1000_GenomesTPT1 
Exome Variant ServerTPT1
GNOMAD BrowserENSG00000133112
Varsome BrowserTPT1
Genomic Variants (DGV)TPT1 [DGVbeta]
DECIPHERTPT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPT1 
Mutations
ICGC Data PortalTPT1 
TCGA Data PortalTPT1 
Broad Tumor PortalTPT1
OASIS PortalTPT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPT1
Mutations and Diseases : HGMDTPT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch TPT1
DgiDB (Drug Gene Interaction Database)TPT1
DoCM (Curated mutations)TPT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPT1 (select a term)
Cancer3DTPT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600763   
Orphanet
DisGeNETTPT1
MedgenTPT1
Genetic Testing Registry TPT1
NextProtP13693 [Medical]
GENETestsTPT1
Target ValidationTPT1
Huge Navigator TPT1 [HugePedia]
ClinGenTPT1
Clinical trials, drugs, therapy
MyCancerGenomeTPT1
Protein Interactions : CTDTPT1
Pharm GKB GenePA36701
PharosP13693
Clinical trialTPT1
Miscellaneous
canSAR (ICR)TPT1
HarmonizomeTPT1
DataMed IndexTPT1
Probes
Litterature
PubMed161 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Sep 15 22:41:40 CEST 2021

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