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TPT1 (tumor protein, translationally-controlled 1)

Identity

Alias_symbol (synonym)TCTP
fortilin
Other aliasHRF
p02
p23
HGNC (Hugo) TPT1
LocusID (NCBI) 7178
Atlas_Id 522
Location 13q14.13  [Link to chromosome band 13q14]
Location_base_pair Starts at 45333471 and ends at 45341284 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DUT (15q21.1) / TPT1 (13q14.13)ME3 (11q14.2) / TPT1 (13q14.13)P4HB (17q25.3) / TPT1 (13q14.13)
SFTPB (2p11.2) / TPT1 (13q14.13)TNS2 (12q13.13) / TPT1 (13q14.13)TPT1 (13q14.13) / ARFGEF2 (20q13.13)
TPT1 (13q14.13) / DUT (15q21.1)TPT1 (13q14.13) / LUC7L3 (17q21.33)TPT1 (13q14.13) / NCALD (8q22.3)
TPT1 (13q14.13) / SIAE (11q24.2)TPT1 (13q14.13) / TPT1 (13q14.13)TTR (18q12.1) / TPT1 (13q14.13)
P4HB 17q25.3 / TPT1 13q14.13TPT1 13q14.13 / ARFGEF2 20q13.13TPT1 13q14.13 / LUC7L3 17q21.33
TPT1 13q14.13 / NCALD 8q22.3TPT1 13q14.13 / SIAE 11q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13q) in chronic lymphocytic leukemia


External links

Nomenclature
HGNC (Hugo)TPT1   12022
Cards
Entrez_Gene (NCBI)TPT1  7178  tumor protein, translationally-controlled 1
AliasesHRF; TCTP; p02; p23
GeneCards (Weizmann)TPT1
Ensembl hg19 (Hinxton)ENSG00000133112 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133112 [Gene_View]  chr13:45333471-45341284 [Contig_View]  TPT1 [Vega]
ICGC DataPortalENSG00000133112
TCGA cBioPortalTPT1
AceView (NCBI)TPT1
Genatlas (Paris)TPT1
WikiGenes7178
SOURCE (Princeton)TPT1
Genetics Home Reference (NIH)TPT1
Genomic and cartography
GoldenPath hg38 (UCSC)TPT1  -     chr13:45333471-45341284 -  13q14.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPT1  -     13q14.13   [Description]    (hg19-Feb_2009)
EnsemblTPT1 - 13q14.13 [CytoView hg19]  TPT1 - 13q14.13 [CytoView hg38]
Mapping of homologs : NCBITPT1 [Mapview hg19]  TPT1 [Mapview hg38]
OMIM600763   
Gene and transcription
Genbank (Entrez)AF072098 AK130847 AK296587 AK296952 AK312951
RefSeq transcript (Entrez)NM_001286272 NM_001286273 NM_003295
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPT1
Cluster EST : UnigeneHs.717316 [ NCBI ]
CGAP (NCI)Hs.717316
Alternative Splicing GalleryENSG00000133112
Gene ExpressionTPT1 [ NCBI-GEO ]   TPT1 [ EBI - ARRAY_EXPRESS ]   TPT1 [ SEEK ]   TPT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TPT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7178
GTEX Portal (Tissue expression)TPT1
Human Protein AtlasENSG00000133112-TPT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13693   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13693  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13693
Splice isoforms : SwissVarP13693
PhosPhoSitePlusP13693
Domaine pattern : Prosite (Expaxy)TCTP_1 (PS01002)    TCTP_2 (PS01003)    TCTP_3 (PS51797)   
Domains : Interpro (EBI)Mss4-like    Mss4/transl-control_tumor    Translation_control_tumour_CS    Translational_control_tumour_p   
Domain families : Pfam (Sanger)TCTP (PF00838)   
Domain families : Pfam (NCBI)pfam00838   
Conserved Domain (NCBI)TPT1
DMDM Disease mutations7178
Blocks (Seattle)TPT1
PDB (SRS)1YZ1    2HR9    3EBM    4Z9V   
PDB (PDBSum)1YZ1    2HR9    3EBM    4Z9V   
PDB (IMB)1YZ1    2HR9    3EBM    4Z9V   
PDB (RSDB)1YZ1    2HR9    3EBM    4Z9V   
Structural Biology KnowledgeBase1YZ1    2HR9    3EBM    4Z9V   
SCOP (Structural Classification of Proteins)1YZ1    2HR9    3EBM    4Z9V   
CATH (Classification of proteins structures)1YZ1    2HR9    3EBM    4Z9V   
SuperfamilyP13693
Human Protein Atlas [tissue]ENSG00000133112-TPT1 [tissue]
Peptide AtlasP13693
HPRD15979
IPIIPI00550900   IPI00908553   IPI00643765   IPI00009943   IPI00979071   IPI01015706   IPI00978953   
Protein Interaction databases
DIP (DOE-UCLA)P13693
IntAct (EBI)P13693
FunCoupENSG00000133112
BioGRIDTPT1
STRING (EMBL)TPT1
ZODIACTPT1
Ontologies - Pathways
QuickGOP13693
Ontology : AmiGORNA binding  calcium ion binding  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  multivesicular body  cytosol  calcium ion transport  cellular calcium ion homeostasis  microtubule binding  response to virus  cell differentiation  regulation of apoptotic process  negative regulation of apoptotic process  tubulin complex  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
Ontology : EGO-EBIRNA binding  calcium ion binding  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  multivesicular body  cytosol  calcium ion transport  cellular calcium ion homeostasis  microtubule binding  response to virus  cell differentiation  regulation of apoptotic process  negative regulation of apoptotic process  tubulin complex  extracellular exosome  negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  
NDEx NetworkTPT1
Atlas of Cancer Signalling NetworkTPT1
Wikipedia pathwaysTPT1
Orthology - Evolution
OrthoDB7178
GeneTree (enSembl)ENSG00000133112
Phylogenetic Trees/Animal Genes : TreeFamTPT1
HOVERGENP13693
HOGENOMP13693
Homologs : HomoloGeneTPT1
Homology/Alignments : Family Browser (UCSC)TPT1
Gene fusions - Rearrangements
Fusion : MitelmanP4HB/TPT1 [17q25.3/13q14.13]  [t(13;17)(q14;q25)]  
Fusion : MitelmanTPT1/ARFGEF2 [13q14.13/20q13.13]  [t(13;20)(q14;q13)]  
Fusion : MitelmanTPT1/LUC7L3 [13q14.13/17q21.33]  [t(13;17)(q14;q21)]  
Fusion : MitelmanTPT1/NCALD [13q14.13/8q22.3]  [t(8;13)(q22;q14)]  
Fusion : MitelmanTPT1/SIAE [13q14.13/11q24.2]  [t(11;13)(q24;q14)]  
Fusion: TCGA_MDACCP4HB 17q25.3 TPT1 13q14.13 LUAD
Fusion: TCGA_MDACCTPT1 13q14.13 ARFGEF2 20q13.13 BRCA
Fusion: TCGA_MDACCTPT1 13q14.13 LUC7L3 17q21.33 BRCA
Fusion: TCGA_MDACCTPT1 13q14.13 NCALD 8q22.3 BRCA KIRC
Fusion: TCGA_MDACCTPT1 13q14.13 SIAE 11q24.2 THCA
Tumor Fusion PortalTPT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPT1
dbVarTPT1
ClinVarTPT1
1000_GenomesTPT1 
Exome Variant ServerTPT1
ExAC (Exome Aggregation Consortium)ENSG00000133112
GNOMAD BrowserENSG00000133112
Genetic variants : HAPMAP7178
Genomic Variants (DGV)TPT1 [DGVbeta]
DECIPHERTPT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPT1 
Mutations
ICGC Data PortalTPT1 
TCGA Data PortalTPT1 
Broad Tumor PortalTPT1
OASIS PortalTPT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTPT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPT1
DgiDB (Drug Gene Interaction Database)TPT1
DoCM (Curated mutations)TPT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPT1 (select a term)
intoGenTPT1
Cancer3DTPT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600763   
Orphanet
DisGeNETTPT1
MedgenTPT1
Genetic Testing Registry TPT1
NextProtP13693 [Medical]
TSGene7178
GENETestsTPT1
Target ValidationTPT1
Huge Navigator TPT1 [HugePedia]
snp3D : Map Gene to Disease7178
BioCentury BCIQTPT1
ClinGenTPT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7178
Chemical/Pharm GKB GenePA36701
Clinical trialTPT1
Miscellaneous
canSAR (ICR)TPT1 (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPT1
EVEXTPT1
GoPubMedTPT1
iHOPTPT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:39:27 CET 2017

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