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TPTE (transmembrane phosphatase with tensin homology)

Identity

Alias_symbol (synonym)PTEN2
CT44
Other alias
HGNC (Hugo) TPTE
LocusID (NCBI) 7179
Atlas_Id 75089
Location 21p11.2  [Link to chromosome band 21p11]
Location_base_pair Starts at 10521514 and ends at 10606270 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TPTE   12023
Cards
Entrez_Gene (NCBI)TPTE  7179  transmembrane phosphatase with tensin homology
AliasesCT44; PTEN2
GeneCards (Weizmann)TPTE
Ensembl hg19 (Hinxton)ENSG00000274391 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000274391 [Gene_View]  chr21:10521514-10606270 [Contig_View]  TPTE [Vega]
ICGC DataPortalENSG00000274391
TCGA cBioPortalTPTE
AceView (NCBI)TPTE
Genatlas (Paris)TPTE
WikiGenes7179
SOURCE (Princeton)TPTE
Genetics Home Reference (NIH)TPTE
Genomic and cartography
GoldenPath hg38 (UCSC)TPTE  -     chr21:10521514-10606270 +  21p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPTE  -     21p11.2   [Description]    (hg19-Feb_2009)
EnsemblTPTE - 21p11.2 [CytoView hg19]  TPTE - 21p11.2 [CytoView hg38]
Mapping of homologs : NCBITPTE [Mapview hg19]  TPTE [Mapview hg38]
OMIM604336   
Gene and transcription
Genbank (Entrez)AF007118 AF495908 AI149736 AI200912 AK308254
RefSeq transcript (Entrez)NM_001290224 NM_199259 NM_199260 NM_199261
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TPTE
Cluster EST : UnigeneHs.122986 [ NCBI ]
CGAP (NCI)Hs.122986
Alternative Splicing GalleryENSG00000274391
Gene ExpressionTPTE [ NCBI-GEO ]   TPTE [ EBI - ARRAY_EXPRESS ]   TPTE [ SEEK ]   TPTE [ MEM ]
Gene Expression Viewer (FireBrowse)TPTE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7179
GTEX Portal (Tissue expression)TPTE
Human Protein AtlasENSG00000274391-TPTE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56180   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56180  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56180
Splice isoforms : SwissVarP56180
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusP56180
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)   
Domains : Interpro (EBI)C2_dom    Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tensin_C2-dom    Tensin_lipid_phosphatase_dom    Tyr_Pase_AS   
Domain families : Pfam (Sanger)DSPc (PF00782)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00782    pfam10409   
Domain families : Smart (EMBL)PTEN_C2 (SM01326)  
Conserved Domain (NCBI)TPTE
DMDM Disease mutations7179
Blocks (Seattle)TPTE
SuperfamilyP56180
Human Protein Atlas [tissue]ENSG00000274391-TPTE [tissue]
Peptide AtlasP56180
HPRD05064
IPIIPI00215913   IPI00413147   IPI00952568   IPI00414275   IPI00795780   IPI00926106   
Protein Interaction databases
DIP (DOE-UCLA)P56180
IntAct (EBI)P56180
FunCoupENSG00000274391
BioGRIDTPTE
STRING (EMBL)TPTE
ZODIACTPTE
Ontologies - Pathways
QuickGOP56180
Ontology : AmiGOprotein tyrosine phosphatase activity  protein dephosphorylation  signal transduction  protein tyrosine/serine/threonine phosphatase activity  integral component of membrane  peptidyl-tyrosine dephosphorylation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein dephosphorylation  signal transduction  protein tyrosine/serine/threonine phosphatase activity  integral component of membrane  peptidyl-tyrosine dephosphorylation  
NDEx NetworkTPTE
Atlas of Cancer Signalling NetworkTPTE
Wikipedia pathwaysTPTE
Orthology - Evolution
OrthoDB7179
GeneTree (enSembl)ENSG00000274391
Phylogenetic Trees/Animal Genes : TreeFamTPTE
HOVERGENP56180
HOGENOMP56180
Homologs : HomoloGeneTPTE
Homology/Alignments : Family Browser (UCSC)TPTE
Gene fusions - Rearrangements
Tumor Fusion PortalTPTE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPTE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPTE
dbVarTPTE
ClinVarTPTE
1000_GenomesTPTE 
Exome Variant ServerTPTE
ExAC (Exome Aggregation Consortium)ENSG00000274391
GNOMAD BrowserENSG00000274391
Genetic variants : HAPMAP7179
Genomic Variants (DGV)TPTE [DGVbeta]
DECIPHERTPTE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPTE 
Mutations
ICGC Data PortalTPTE 
TCGA Data PortalTPTE 
Broad Tumor PortalTPTE
OASIS PortalTPTE [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTPTE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TPTE
DgiDB (Drug Gene Interaction Database)TPTE
DoCM (Curated mutations)TPTE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TPTE (select a term)
intoGenTPTE
Cancer3DTPTE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604336   
Orphanet
DisGeNETTPTE
MedgenTPTE
Genetic Testing Registry TPTE
NextProtP56180 [Medical]
TSGene7179
GENETestsTPTE
Target ValidationTPTE
Huge Navigator TPTE [HugePedia]
snp3D : Map Gene to Disease7179
BioCentury BCIQTPTE
ClinGenTPTE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7179
Chemical/Pharm GKB GenePA36702
Clinical trialTPTE
Miscellaneous
canSAR (ICR)TPTE (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTPTE
EVEXTPTE
GoPubMedTPTE
iHOPTPTE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:43:19 CET 2017

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