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TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2)

Identity

Alias (NCBI)TPIP
HGNC (Hugo) TPTE2
HGNC Alias symbTPIP
LocusID (NCBI) 93492
Atlas_Id 53335
Location 13q12.11  [Link to chromosome band 13q12]
Location_base_pair Starts at 19422879 and ends at 19536763 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DNMBP (10q24.2) / TPTE2 (13q12.11)DNMBP 10q24.2 / TPTE2 13q12.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TPTE2   17299
Cards
Entrez_Gene (NCBI)TPTE2    transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
AliasesTPIP
GeneCards (Weizmann)TPTE2
Ensembl hg19 (Hinxton)ENSG00000132958 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132958 [Gene_View]  ENSG00000132958 [Sequence]  chr13:19422879-19536763 [Contig_View]  TPTE2 [Vega]
ICGC DataPortalENSG00000132958
TCGA cBioPortalTPTE2
AceView (NCBI)TPTE2
Genatlas (Paris)TPTE2
SOURCE (Princeton)TPTE2
Genetics Home Reference (NIH)TPTE2
Genomic and cartography
GoldenPath hg38 (UCSC)TPTE2  -     chr13:19422879-19536763 -  13q12.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TPTE2  -     13q12.11   [Description]    (hg19-Feb_2009)
GoldenPathTPTE2 - 13q12.11 [CytoView hg19]  TPTE2 - 13q12.11 [CytoView hg38]
ImmunoBaseENSG00000132958
Genome Data Viewer NCBITPTE2 [Mapview hg19]  
OMIM606791   
Gene and transcription
Genbank (Entrez)AJ421032 AJ421033 AK301741 AL079582 AY219890
RefSeq transcript (Entrez)NM_001141968 NM_001271850 NM_130785 NM_199254 NM_199255
Consensus coding sequences : CCDS (NCBI)TPTE2
Gene ExpressionTPTE2 [ NCBI-GEO ]   TPTE2 [ EBI - ARRAY_EXPRESS ]   TPTE2 [ SEEK ]   TPTE2 [ MEM ]
Gene Expression Viewer (FireBrowse)TPTE2 [ Firebrowse - Broad ]
GenevisibleExpression of TPTE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)93492
GTEX Portal (Tissue expression)TPTE2
Human Protein AtlasENSG00000132958-TPTE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6XPS3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6XPS3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6XPS3
PhosPhoSitePlusQ6XPS3
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)   
Domains : Interpro (EBI)Dual-sp_phosphatase_cat-dom    Prot-tyrosine_phosphatase-like    Tensin_C2-dom    Tensin_phosphatase    Tyr_Pase_AS    Volt_channel_dom_sf   
Domain families : Pfam (Sanger)DSPc (PF00782)    PTEN_C2 (PF10409)   
Domain families : Pfam (NCBI)pfam00782    pfam10409   
Domain families : Smart (EMBL)PTEN_C2 (SM01326)  
Conserved Domain (NCBI)TPTE2
SuperfamilyQ6XPS3
AlphaFold pdb e-kbQ6XPS3   
Human Protein Atlas [tissue]ENSG00000132958-TPTE2 [tissue]
HPRD06003
Protein Interaction databases
DIP (DOE-UCLA)Q6XPS3
IntAct (EBI)Q6XPS3
BioGRIDTPTE2
STRING (EMBL)TPTE2
ZODIACTPTE2
Ontologies - Pathways
QuickGOQ6XPS3
Ontology : AmiGOGolgi membrane  protein tyrosine phosphatase activity  nucleus  endoplasmic reticulum membrane  cytosol  plasma membrane  protein dephosphorylation  phosphatidylinositol biosynthetic process  negative regulation of cell population proliferation  phosphatidylinositol 3-kinase signaling  integral component of membrane  dephosphorylation  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  peptidyl-tyrosine dephosphorylation  cell projection  phosphatidylinositol dephosphorylation  cell motility  regulation of protein kinase B signaling  
Ontology : EGO-EBIGolgi membrane  protein tyrosine phosphatase activity  nucleus  endoplasmic reticulum membrane  cytosol  plasma membrane  protein dephosphorylation  phosphatidylinositol biosynthetic process  negative regulation of cell population proliferation  phosphatidylinositol 3-kinase signaling  integral component of membrane  dephosphorylation  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity  peptidyl-tyrosine dephosphorylation  cell projection  phosphatidylinositol dephosphorylation  cell motility  regulation of protein kinase B signaling  
NDEx NetworkTPTE2
Atlas of Cancer Signalling NetworkTPTE2
Wikipedia pathwaysTPTE2
Orthology - Evolution
OrthoDB93492
GeneTree (enSembl)ENSG00000132958
Phylogenetic Trees/Animal Genes : TreeFamTPTE2
Homologs : HomoloGeneTPTE2
Homology/Alignments : Family Browser (UCSC)TPTE2
Gene fusions - Rearrangements
Fusion : MitelmanDNMBP/TPTE2 [10q24.2/13q12.11]  
Fusion : QuiverTPTE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTPTE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TPTE2
dbVarTPTE2
ClinVarTPTE2
MonarchTPTE2
1000_GenomesTPTE2 
Exome Variant ServerTPTE2
GNOMAD BrowserENSG00000132958
Varsome BrowserTPTE2
ACMGTPTE2 variants
VarityQ6XPS3
Genomic Variants (DGV)TPTE2 [DGVbeta]
DECIPHERTPTE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTPTE2 
Mutations
ICGC Data PortalTPTE2 
TCGA Data PortalTPTE2 
Broad Tumor PortalTPTE2
OASIS PortalTPTE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTPTE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTPTE2
Mutations and Diseases : HGMDTPTE2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTPTE2
DgiDB (Drug Gene Interaction Database)TPTE2
DoCM (Curated mutations)TPTE2
CIViC (Clinical Interpretations of Variants in Cancer)TPTE2
Cancer3DTPTE2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606791   
Orphanet
DisGeNETTPTE2
MedgenTPTE2
Genetic Testing Registry TPTE2
NextProtQ6XPS3 [Medical]
GENETestsTPTE2
Target ValidationTPTE2
Huge Navigator TPTE2 [HugePedia]
ClinGenTPTE2
Clinical trials, drugs, therapy
MyCancerGenomeTPTE2
Protein Interactions : CTDTPTE2
Pharm GKB GenePA134917664
PharosQ6XPS3
Clinical trialTPTE2
Miscellaneous
canSAR (ICR)TPTE2
HarmonizomeTPTE2
DataMed IndexTPTE2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTPTE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:07 CEST 2021

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