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TRA2A (transformer 2 alpha homolog)

Identity

Alias (NCBI)AWMS1
HSU53209
HGNC (Hugo) TRA2A
HGNC Alias symbhtra-2-alpha
AWMS1
HGNC Previous nametransformer 2 alpha homolog (Drosophila)
LocusID (NCBI) 29896
Atlas_Id 52439
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 23504782 and ends at 23531981 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSN (9q33.2) / TRA2A (7p15.3)MPLKIP (7p14.1) / TRA2A (7p15.3)TRA2A (7p15.3) / CBX3 (7p15.2)
TRA2A (7p15.3) / CENPO (2p23.3)TRA2A (7p15.3) / DNAH11 (7p15.3)TRA2A (7p15.3) / EPDR1 (7p14.1)
TRA2A (7p15.3) / HECW1 (7p14.1)TRA2A (7p15.3) / HMGB2 (4q34.1)TRA2A (7p15.3) / THADA (2p21)
TRA2A (7p15.3) / TRA2A (7p15.3)C7orf11 TRA2A 7p15.3GSN 9q33.2 / TRA2A 7p15.3
TRA2A 7p15.3 / EPDR1 7p14.1TRA2A 7p15.3 / HECW1 7p14.1TRA2A 7p15.3 / THADA 2p21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(7;11)(p15;q24) UBASH3B/TRA2A


External links

 

Nomenclature
HGNC (Hugo)TRA2A   16645
Cards
Entrez_Gene (NCBI)TRA2A    transformer 2 alpha homolog
AliasesAWMS1; HSU53209
GeneCards (Weizmann)TRA2A
Ensembl hg19 (Hinxton)ENSG00000164548 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164548 [Gene_View]  ENSG00000164548 [Sequence]  chr7:23504782-23531981 [Contig_View]  TRA2A [Vega]
ICGC DataPortalENSG00000164548
TCGA cBioPortalTRA2A
AceView (NCBI)TRA2A
Genatlas (Paris)TRA2A
SOURCE (Princeton)TRA2A
Genetics Home Reference (NIH)TRA2A
Genomic and cartography
GoldenPath hg38 (UCSC)TRA2A  -     chr7:23504782-23531981 -  7p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRA2A  -     7p15.3   [Description]    (hg19-Feb_2009)
GoldenPathTRA2A - 7p15.3 [CytoView hg19]  TRA2A - 7p15.3 [CytoView hg38]
ImmunoBaseENSG00000164548
Genome Data Viewer NCBITRA2A [Mapview hg19]  
OMIM602718   
Gene and transcription
Genbank (Entrez)AB052759 AB097048 AK298815 AK300565 AK300741
RefSeq transcript (Entrez)NM_001282757 NM_001282758 NM_001282759 NM_001362759 NM_001362760 NM_001362761 NM_013293
Consensus coding sequences : CCDS (NCBI)TRA2A
Gene ExpressionTRA2A [ NCBI-GEO ]   TRA2A [ EBI - ARRAY_EXPRESS ]   TRA2A [ SEEK ]   TRA2A [ MEM ]
Gene Expression Viewer (FireBrowse)TRA2A [ Firebrowse - Broad ]
GenevisibleExpression of TRA2A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29896
GTEX Portal (Tissue expression)TRA2A
Human Protein AtlasENSG00000164548-TRA2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13595   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13595  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13595
PhosPhoSitePlusQ13595
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TRA2A
SuperfamilyQ13595
AlphaFold pdb e-kbQ13595   
Human Protein Atlas [tissue]ENSG00000164548-TRA2A [tissue]
HPRD04096
Protein Interaction databases
DIP (DOE-UCLA)Q13595
IntAct (EBI)Q13595
BioGRIDTRA2A
STRING (EMBL)TRA2A
ZODIACTRA2A
Ontologies - Pathways
QuickGOQ13595
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  spliceosomal complex  nucleolus  intracellular membrane-bounded organelle  positive regulation of mRNA splicing, via spliceosome  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  spliceosomal complex  nucleolus  intracellular membrane-bounded organelle  positive regulation of mRNA splicing, via spliceosome  
Pathways : KEGGSpliceosome   
NDEx NetworkTRA2A
Atlas of Cancer Signalling NetworkTRA2A
Wikipedia pathwaysTRA2A
Orthology - Evolution
OrthoDB29896
GeneTree (enSembl)ENSG00000164548
Phylogenetic Trees/Animal Genes : TreeFamTRA2A
Homologs : HomoloGeneTRA2A
Homology/Alignments : Family Browser (UCSC)TRA2A
Gene fusions - Rearrangements
Fusion : MitelmanGSN/TRA2A [9q33.2/7p15.3]  
Fusion : MitelmanMPLKIP/TRA2A [7p14.1/7p15.3]  
Fusion : MitelmanTRA2A/EPDR1 [7p15.3/7p14.1]  
Fusion : MitelmanTRA2A/HECW1 [7p15.3/7p14.1]  
Fusion : MitelmanTRA2A/THADA [7p15.3/2p21]  
Fusion : QuiverTRA2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRA2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRA2A
dbVarTRA2A
ClinVarTRA2A
MonarchTRA2A
1000_GenomesTRA2A 
Exome Variant ServerTRA2A
GNOMAD BrowserENSG00000164548
Varsome BrowserTRA2A
ACMGTRA2A variants
VarityQ13595
Genomic Variants (DGV)TRA2A [DGVbeta]
DECIPHERTRA2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRA2A 
Mutations
ICGC Data PortalTRA2A 
TCGA Data PortalTRA2A 
Broad Tumor PortalTRA2A
OASIS PortalTRA2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRA2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRA2A
Mutations and Diseases : HGMDTRA2A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRA2A
DgiDB (Drug Gene Interaction Database)TRA2A
DoCM (Curated mutations)TRA2A
CIViC (Clinical Interpretations of Variants in Cancer)TRA2A
Cancer3DTRA2A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602718   
Orphanet
DisGeNETTRA2A
MedgenTRA2A
Genetic Testing Registry TRA2A
NextProtQ13595 [Medical]
GENETestsTRA2A
Target ValidationTRA2A
Huge Navigator TRA2A [HugePedia]
ClinGenTRA2A
Clinical trials, drugs, therapy
MyCancerGenomeTRA2A
Protein Interactions : CTDTRA2A
Pharm GKB GenePA164726707
PharosQ13595
Clinical trialTRA2A
Miscellaneous
canSAR (ICR)TRA2A
HarmonizomeTRA2A
DataMed IndexTRA2A
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRA2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:07 CEST 2021

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