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TRA2B (transformer 2 beta homolog)

Identity

Alias (NCBI)Htra2-beta
PPP1R156
SFRS10
SRFS10
TRA2-BETA
TRAN2B
HGNC (Hugo) TRA2B
HGNC Alias symbHtra2-beta
PPP1R156
HGNC Alias nameprotein phosphatase 1, regulatory subunit 156
HGNC Previous nameSFRS10
HGNC Previous namesplicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
 transformer 2 beta homolog (Drosophila)
LocusID (NCBI) 6434
Atlas_Id 50699
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 185914558 and ends at 185938014 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1G1 (15q22.31) / TRA2B (3q27.2)MALAT1 (11q13.1) / TRA2B (3q27.2)RMND5A (2p11.2) / TRA2B (3q27.2)
TRA2B (3q27.2) / GPX4 (19p13.3)TRA2B (3q27.2) / KIFC1 (6p21.32)TRA2B (3q27.2) / LOC100128164 (3q26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRA2B   10781
Cards
Entrez_Gene (NCBI)TRA2B    transformer 2 beta homolog
AliasesHtra2-beta; PPP1R156; SFRS10; SRFS10; 
TRA2-BETA; TRAN2B
GeneCards (Weizmann)TRA2B
Ensembl hg19 (Hinxton)ENSG00000136527 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136527 [Gene_View]  ENSG00000136527 [Sequence]  chr3:185914558-185938014 [Contig_View]  TRA2B [Vega]
ICGC DataPortalENSG00000136527
TCGA cBioPortalTRA2B
AceView (NCBI)TRA2B
Genatlas (Paris)TRA2B
SOURCE (Princeton)TRA2B
Genetics Home Reference (NIH)TRA2B
Genomic and cartography
GoldenPath hg38 (UCSC)TRA2B  -     chr3:185914558-185938014 -  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRA2B  -     3q27.2   [Description]    (hg19-Feb_2009)
GoldenPathTRA2B - 3q27.2 [CytoView hg19]  TRA2B - 3q27.2 [CytoView hg38]
ImmunoBaseENSG00000136527
Genome Data Viewer NCBITRA2B [Mapview hg19]  
OMIM602719   
Gene and transcription
Genbank (Entrez)AB209208 AK091863 AK094495 AK098191 AK125610
RefSeq transcript (Entrez)NM_001243879 NM_004593
Consensus coding sequences : CCDS (NCBI)TRA2B
Gene ExpressionTRA2B [ NCBI-GEO ]   TRA2B [ EBI - ARRAY_EXPRESS ]   TRA2B [ SEEK ]   TRA2B [ MEM ]
Gene Expression Viewer (FireBrowse)TRA2B [ Firebrowse - Broad ]
GenevisibleExpression of TRA2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6434
GTEX Portal (Tissue expression)TRA2B
Human Protein AtlasENSG00000136527-TRA2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62995
PhosPhoSitePlusP62995
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TRA2B
PDB (RSDB)2CQC    2KXN    2RRA    2RRB   
PDB Europe2CQC    2KXN    2RRA    2RRB   
PDB (PDBSum)2CQC    2KXN    2RRA    2RRB   
PDB (IMB)2CQC    2KXN    2RRA    2RRB   
Structural Biology KnowledgeBase2CQC    2KXN    2RRA    2RRB   
SCOP (Structural Classification of Proteins)2CQC    2KXN    2RRA    2RRB   
CATH (Classification of proteins structures)2CQC    2KXN    2RRA    2RRB   
SuperfamilyP62995
AlphaFold pdb e-kbP62995   
Human Protein Atlas [tissue]ENSG00000136527-TRA2B [tissue]
HPRD04097
Protein Interaction databases
DIP (DOE-UCLA)P62995
IntAct (EBI)P62995
BioGRIDTRA2B
STRING (EMBL)TRA2B
ZODIACTRA2B
Ontologies - Pathways
QuickGOP62995
Ontology : AmiGOresponse to reactive oxygen species  RNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleus  nuclear inner membrane  nucleoplasm  nucleoplasm  spliceosomal complex  spliceosomal complex  protein domain specific binding  cerebral cortex regionalization  protein-containing complex  pre-mRNA binding  identical protein binding  identical protein binding  regulation of RNA splicing  positive regulation of mRNA splicing, via spliceosome  positive regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  cellular response to glucose stimulus  embryonic brain development  
Ontology : EGO-EBIresponse to reactive oxygen species  RNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  RNA binding  mRNA binding  protein binding  nucleus  nucleus  nuclear inner membrane  nucleoplasm  nucleoplasm  spliceosomal complex  spliceosomal complex  protein domain specific binding  cerebral cortex regionalization  protein-containing complex  pre-mRNA binding  identical protein binding  identical protein binding  regulation of RNA splicing  positive regulation of mRNA splicing, via spliceosome  positive regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  cellular response to glucose stimulus  embryonic brain development  
Pathways : KEGGSpliceosome   
NDEx NetworkTRA2B
Atlas of Cancer Signalling NetworkTRA2B
Wikipedia pathwaysTRA2B
Orthology - Evolution
OrthoDB6434
GeneTree (enSembl)ENSG00000136527
Phylogenetic Trees/Animal Genes : TreeFamTRA2B
Homologs : HomoloGeneTRA2B
Homology/Alignments : Family Browser (UCSC)TRA2B
Gene fusions - Rearrangements
Fusion : QuiverTRA2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRA2B
dbVarTRA2B
ClinVarTRA2B
MonarchTRA2B
1000_GenomesTRA2B 
Exome Variant ServerTRA2B
GNOMAD BrowserENSG00000136527
Varsome BrowserTRA2B
ACMGTRA2B variants
VarityP62995
Genomic Variants (DGV)TRA2B [DGVbeta]
DECIPHERTRA2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRA2B 
Mutations
ICGC Data PortalTRA2B 
TCGA Data PortalTRA2B 
Broad Tumor PortalTRA2B
OASIS PortalTRA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRA2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRA2B
Mutations and Diseases : HGMDTRA2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRA2B
DgiDB (Drug Gene Interaction Database)TRA2B
DoCM (Curated mutations)TRA2B
CIViC (Clinical Interpretations of Variants in Cancer)TRA2B
Cancer3DTRA2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602719   
Orphanet
DisGeNETTRA2B
MedgenTRA2B
Genetic Testing Registry TRA2B
NextProtP62995 [Medical]
GENETestsTRA2B
Target ValidationTRA2B
Huge Navigator TRA2B [HugePedia]
ClinGenTRA2B
Clinical trials, drugs, therapy
MyCancerGenomeTRA2B
Protein Interactions : CTDTRA2B
Pharm GKB GenePA35697
PharosP62995
Clinical trialTRA2B
Miscellaneous
canSAR (ICR)TRA2B
HarmonizomeTRA2B
DataMed IndexTRA2B
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:08 CEST 2021

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