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TRA2B (transformer 2 beta homolog)

Identity

Alias_namesregulatory subunit 156
SFRS10
Alias_symbol (synonym)Htra2-beta
PPP1R156
Other aliasSRFS10
TRA2-BETA
TRAN2B
HGNC (Hugo) TRA2B
LocusID (NCBI) 6434
Atlas_Id 50699
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 185914570 and ends at 185938136 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1G1 (15q22.31) / TRA2B (3q27.2)MALAT1 (11q13.1) / TRA2B (3q27.2)RMND5A (2p11.2) / TRA2B (3q27.2)
TRA2B (3q27.2) / GPX4 (19p13.3)TRA2B (3q27.2) / KIFC1 (6p21.32)TRA2B (3q27.2) / LOC100128164 (3q26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRA2B   10781
Cards
Entrez_Gene (NCBI)TRA2B  6434  transformer 2 beta homolog
AliasesHtra2-beta; PPP1R156; SFRS10; SRFS10; 
TRA2-BETA; TRAN2B
GeneCards (Weizmann)TRA2B
Ensembl hg19 (Hinxton)ENSG00000136527 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136527 [Gene_View]  chr3:185914570-185938136 [Contig_View]  TRA2B [Vega]
ICGC DataPortalENSG00000136527
TCGA cBioPortalTRA2B
AceView (NCBI)TRA2B
Genatlas (Paris)TRA2B
WikiGenes6434
SOURCE (Princeton)TRA2B
Genetics Home Reference (NIH)TRA2B
Genomic and cartography
GoldenPath hg38 (UCSC)TRA2B  -     chr3:185914570-185938136 -  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRA2B  -     3q27.2   [Description]    (hg19-Feb_2009)
EnsemblTRA2B - 3q27.2 [CytoView hg19]  TRA2B - 3q27.2 [CytoView hg38]
Mapping of homologs : NCBITRA2B [Mapview hg19]  TRA2B [Mapview hg38]
OMIM602719   
Gene and transcription
Genbank (Entrez)AB209208 AK091863 AK094495 AK098191 AK125610
RefSeq transcript (Entrez)NM_001243879 NM_004593
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRA2B
Cluster EST : UnigeneHs.533122 [ NCBI ]
CGAP (NCI)Hs.533122
Alternative Splicing GalleryENSG00000136527
Gene ExpressionTRA2B [ NCBI-GEO ]   TRA2B [ EBI - ARRAY_EXPRESS ]   TRA2B [ SEEK ]   TRA2B [ MEM ]
Gene Expression Viewer (FireBrowse)TRA2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6434
GTEX Portal (Tissue expression)TRA2B
Human Protein AtlasENSG00000136527-TRA2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62995   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62995  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62995
Splice isoforms : SwissVarP62995
PhosPhoSitePlusP62995
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TRA2B
DMDM Disease mutations6434
Blocks (Seattle)TRA2B
PDB (SRS)2CQC    2KXN    2RRA    2RRB   
PDB (PDBSum)2CQC    2KXN    2RRA    2RRB   
PDB (IMB)2CQC    2KXN    2RRA    2RRB   
PDB (RSDB)2CQC    2KXN    2RRA    2RRB   
Structural Biology KnowledgeBase2CQC    2KXN    2RRA    2RRB   
SCOP (Structural Classification of Proteins)2CQC    2KXN    2RRA    2RRB   
CATH (Classification of proteins structures)2CQC    2KXN    2RRA    2RRB   
SuperfamilyP62995
Human Protein Atlas [tissue]ENSG00000136527-TRA2B [tissue]
Peptide AtlasP62995
HPRD04097
IPIIPI00301503   IPI00220938   IPI00472633   IPI00555647   IPI00927271   IPI00927262   
Protein Interaction databases
DIP (DOE-UCLA)P62995
IntAct (EBI)P62995
FunCoupENSG00000136527
BioGRIDTRA2B
STRING (EMBL)TRA2B
ZODIACTRA2B
Ontologies - Pathways
QuickGOP62995
Ontology : AmiGOresponse to reactive oxygen species  RNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  mRNA binding  protein binding  nucleus  nuclear inner membrane  nucleoplasm  nucleoplasm  spliceosomal complex  cerebral cortex regionalization  pre-mRNA binding  negative regulation of mRNA splicing, via spliceosome  positive regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  poly-purine tract binding  cellular response to glucose stimulus  embryonic brain development  
Ontology : EGO-EBIresponse to reactive oxygen species  RNA splicing, via transesterification reactions  regulation of alternative mRNA splicing, via spliceosome  regulation of alternative mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  RNA binding  mRNA binding  protein binding  nucleus  nuclear inner membrane  nucleoplasm  nucleoplasm  spliceosomal complex  cerebral cortex regionalization  pre-mRNA binding  negative regulation of mRNA splicing, via spliceosome  positive regulation of mRNA splicing, via spliceosome  perinuclear region of cytoplasm  poly-purine tract binding  cellular response to glucose stimulus  embryonic brain development  
Pathways : KEGGSpliceosome   
NDEx NetworkTRA2B
Atlas of Cancer Signalling NetworkTRA2B
Wikipedia pathwaysTRA2B
Orthology - Evolution
OrthoDB6434
GeneTree (enSembl)ENSG00000136527
Phylogenetic Trees/Animal Genes : TreeFamTRA2B
HOVERGENP62995
HOGENOMP62995
Homologs : HomoloGeneTRA2B
Homology/Alignments : Family Browser (UCSC)TRA2B
Gene fusions - Rearrangements
Tumor Fusion PortalTRA2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRA2B
dbVarTRA2B
ClinVarTRA2B
1000_GenomesTRA2B 
Exome Variant ServerTRA2B
ExAC (Exome Aggregation Consortium)ENSG00000136527
GNOMAD BrowserENSG00000136527
Genetic variants : HAPMAP6434
Genomic Variants (DGV)TRA2B [DGVbeta]
DECIPHERTRA2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRA2B 
Mutations
ICGC Data PortalTRA2B 
TCGA Data PortalTRA2B 
Broad Tumor PortalTRA2B
OASIS PortalTRA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRA2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRA2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRA2B
DgiDB (Drug Gene Interaction Database)TRA2B
DoCM (Curated mutations)TRA2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRA2B (select a term)
intoGenTRA2B
Cancer3DTRA2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602719   
Orphanet
DisGeNETTRA2B
MedgenTRA2B
Genetic Testing Registry TRA2B
NextProtP62995 [Medical]
TSGene6434
GENETestsTRA2B
Target ValidationTRA2B
Huge Navigator TRA2B [HugePedia]
snp3D : Map Gene to Disease6434
BioCentury BCIQTRA2B
ClinGenTRA2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6434
Chemical/Pharm GKB GenePA35697
Clinical trialTRA2B
Miscellaneous
canSAR (ICR)TRA2B (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRA2B
EVEXTRA2B
GoPubMedTRA2B
iHOPTRA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:39:30 CET 2017

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