TRA2B (transformer 2 beta homolog)

2009-03-01  

Identity

HGNC
LOCATION
3q27.2
LOCUSID
ALIAS
Htra2-beta,PPP1R156,SFRS10,SRFS10,TRA2-BETA,TRAN2B
FUSION GENES

Other Information

Locus ID:

NCBI: 6434
MIM: 602719
HGNC: 10781
Ensembl: ENSG00000136527

Variants:

dbSNP: 6434
ClinVar: 6434
TCGA: ENSG00000136527
COSMIC: TRA2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136527ENST00000259043H7BXF3
ENSG00000136527ENST00000342294P62995
ENSG00000136527ENST00000382191P62995
ENSG00000136527ENST00000414862H7C2L4
ENSG00000136527ENST00000453386P62995
ENSG00000136527ENST00000456380P62995

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145205602003Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1.53
218032912011Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis.51
126492792003Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta.39
209263942011Structural basis for the dual RNA-recognition modes of human Tra2-β RRM.30
248659682014HuR regulates alternative splicing of the TRA2β gene in human colon cancer cells under oxidative stress.25
253424682015Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA.24
252085762014Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons.17
125314732003Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer.15
232558072013Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA.15
237481752013Alterations in expression pattern of splicing factors in epithelial ovarian cancer and its clinical impact.14

Citation

Dessen P

TRA2B (transformer 2 beta homolog)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50699/tra2b