TRADD (TNFRSF1A associated via death domain)

2003-08-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
Hs.89862
FUSION GENES

Other Information

Locus ID:

NCBI: 8717
MIM: 603500
HGNC: 12030
Ensembl: ENSG00000102871

Variants:

dbSNP: 8717
ClinVar: 8717
TCGA: ENSG00000102871
COSMIC: TRADD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102871ENST00000345057Q15628
ENSG00000102871ENST00000486556Q15628

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Adipocytokine signaling pathwayKEGGko04920
ApoptosisKEGGhsa04210
Adipocytokine signaling pathwayKEGGhsa04920
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
239551532013Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.75
166119922006Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1.44
239822052013Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.43
210681022011Association of STAT3 and TNFRSF1A with ankylosing spondylitis in Han Chinese.34
162276242005PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor.33
189907582008Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.26
257322262015MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.23
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
120451872002Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms.19
181989442008The viral oncoprotein LMP1 exploits TRADD for signaling by masking its apoptotic activity.19

Citation

Dessen P

TRADD (TNFRSF1A associated via death domain)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42685/tradd