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TRAF1 (TNF receptor associated factor 1)

Identity

Alias (NCBI)EBI6
MGC:10353
HGNC (Hugo) TRAF1
HGNC Alias symbEBI6
LocusID (NCBI) 7185
Atlas_Id 42686
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 120902393 and ends at 120926796 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF1 (9q33.2) / ALK (2p23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(2;9)(p23;q33) TRAF1/ALK
t(2;11)(p23;q12.3) EEF1G/ALK


External links

 

Nomenclature
HGNC (Hugo)TRAF1   12031
Cards
Entrez_Gene (NCBI)TRAF1    TNF receptor associated factor 1
AliasesEBI6; MGC:10353
GeneCards (Weizmann)TRAF1
Ensembl hg19 (Hinxton)ENSG00000056558 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000056558 [Gene_View]  ENSG00000056558 [Sequence]  chr9:120902393-120926796 [Contig_View]  TRAF1 [Vega]
ICGC DataPortalENSG00000056558
TCGA cBioPortalTRAF1
AceView (NCBI)TRAF1
Genatlas (Paris)TRAF1
SOURCE (Princeton)TRAF1
Genetics Home Reference (NIH)TRAF1
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF1  -     chr9:120902393-120926796 -  9q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF1  -     9q33.2   [Description]    (hg19-Feb_2009)
GoldenPathTRAF1 - 9q33.2 [CytoView hg19]  TRAF1 - 9q33.2 [CytoView hg38]
ImmunoBaseENSG00000056558
Genome Data Viewer NCBITRAF1 [Mapview hg19]  
OMIM601711   
Gene and transcription
Genbank (Entrez)AK090468 AK295959 AK315476 AL832989 AW014547
RefSeq transcript (Entrez)NM_001190945 NM_001190947 NM_005658
Consensus coding sequences : CCDS (NCBI)TRAF1
Gene ExpressionTRAF1 [ NCBI-GEO ]   TRAF1 [ EBI - ARRAY_EXPRESS ]   TRAF1 [ SEEK ]   TRAF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF1 [ Firebrowse - Broad ]
GenevisibleExpression of TRAF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7185
GTEX Portal (Tissue expression)TRAF1
Human Protein AtlasENSG00000056558-TRAF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13077
PhosPhoSitePlusQ13077
Domaine pattern : Prosite (Expaxy)MATH (PS50144)   
Domains : Interpro (EBI)MATH/TRAF_dom    TNF_rcpt-assoc_TRAF    TNF_rcpt-assoc_TRAF_met    TRAF-like    TRAF1    TRAF1_MATH    TRAF_BIRC3-bd   
Domain families : Pfam (Sanger)TRAF_BIRC3_bd (PF16673)   
Domain families : Pfam (NCBI)pfam16673   
Domain families : Smart (EMBL)MATH (SM00061)  
Conserved Domain (NCBI)TRAF1
PDB (RSDB)3M0D    5E1T    5H10   
PDB Europe3M0D    5E1T    5H10   
PDB (PDBSum)3M0D    5E1T    5H10   
PDB (IMB)3M0D    5E1T    5H10   
Structural Biology KnowledgeBase3M0D    5E1T    5H10   
SCOP (Structural Classification of Proteins)3M0D    5E1T    5H10   
CATH (Classification of proteins structures)3M0D    5E1T    5H10   
SuperfamilyQ13077
AlphaFold pdb e-kbQ13077   
Human Protein Atlas [tissue]ENSG00000056558-TRAF1 [tissue]
HPRD03418
Protein Interaction databases
DIP (DOE-UCLA)Q13077
IntAct (EBI)Q13077
BioGRIDTRAF1
STRING (EMBL)TRAF1
ZODIACTRAF1
Ontologies - Pathways
QuickGOQ13077
Ontology : AmiGOubiquitin-protein transferase activity  tumor necrosis factor receptor binding  tumor necrosis factor receptor binding  protein binding  cytoplasm  cytosol  apoptotic process  zinc ion binding  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  ubiquitin protein ligase binding  ubiquitin protein ligase binding  thioesterase binding  tumor necrosis factor-mediated signaling pathway  identical protein binding  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JNK cascade  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein-containing complex assembly  protein K63-linked ubiquitination  plasma membrane signaling receptor complex  regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIubiquitin-protein transferase activity  tumor necrosis factor receptor binding  tumor necrosis factor receptor binding  protein binding  cytoplasm  cytosol  apoptotic process  zinc ion binding  cytoplasmic side of plasma membrane  regulation of tumor necrosis factor-mediated signaling pathway  ubiquitin protein ligase binding  ubiquitin protein ligase binding  thioesterase binding  tumor necrosis factor-mediated signaling pathway  identical protein binding  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JNK cascade  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein-containing complex assembly  protein K63-linked ubiquitination  plasma membrane signaling receptor complex  regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAHIV-I Nef: negative effector of Fas and TNF [Genes]    TNFR2 Signaling Pathway [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    TNF signaling pathway    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Transcriptional misregulation in cancer    Viral carcinogenesis    Small cell lung cancer   
NDEx NetworkTRAF1
Atlas of Cancer Signalling NetworkTRAF1
Wikipedia pathwaysTRAF1
Orthology - Evolution
OrthoDB7185
GeneTree (enSembl)ENSG00000056558
Phylogenetic Trees/Animal Genes : TreeFamTRAF1
Homologs : HomoloGeneTRAF1
Homology/Alignments : Family Browser (UCSC)TRAF1
Gene fusions - Rearrangements
Fusion : MitelmanTRAF1/ALK [9q33.2/2p23.2]  
Fusion : QuiverTRAF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF1
dbVarTRAF1
ClinVarTRAF1
MonarchTRAF1
1000_GenomesTRAF1 
Exome Variant ServerTRAF1
GNOMAD BrowserENSG00000056558
Varsome BrowserTRAF1
ACMGTRAF1 variants
VarityQ13077
Genomic Variants (DGV)TRAF1 [DGVbeta]
DECIPHERTRAF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF1 
Mutations
ICGC Data PortalTRAF1 
TCGA Data PortalTRAF1 
Broad Tumor PortalTRAF1
OASIS PortalTRAF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRAF1
Mutations and Diseases : HGMDTRAF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRAF1
DgiDB (Drug Gene Interaction Database)TRAF1
DoCM (Curated mutations)TRAF1
CIViC (Clinical Interpretations of Variants in Cancer)TRAF1
Cancer3DTRAF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601711   
Orphanet
DisGeNETTRAF1
MedgenTRAF1
Genetic Testing Registry TRAF1
NextProtQ13077 [Medical]
GENETestsTRAF1
Target ValidationTRAF1
Huge Navigator TRAF1 [HugePedia]
ClinGenTRAF1
Clinical trials, drugs, therapy
MyCancerGenomeTRAF1
Protein Interactions : CTDTRAF1
Pharm GKB GenePA36708
PharosQ13077
Clinical trialTRAF1
Miscellaneous
canSAR (ICR)TRAF1
HarmonizomeTRAF1
DataMed IndexTRAF1
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRAF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:08 CEST 2021

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