TRAF1 (TNF receptor associated factor 1)

2003-05-01  

Identity

HGNC
TRAF1
LOCATION
9q33.2
LOCUSID
7185
ALIAS
EBI6,MGC:10353
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7185
MIM: 601711
HGNC: 12031
Ensembl: ENSG00000056558

Variants:

dbSNP: 7185
ClinVar: 7185
TCGA: ENSG00000056558
COSMIC: TRAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000056558ENST00000373887Q13077
ENSG00000056558ENST00000540010Q13077
ENSG00000056558ENST00000546084Q13077

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Small cell lung cancerKEGGko05222
ApoptosisKEGGhsa04210
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD23007924
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD23007924
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD23007924
PA449515etanerceptChemicalClinicalAnnotationassociatedPD23007924
PA452639infliximabChemicalClinicalAnnotationassociatedPD23007924

References

Pubmed IDYearTitleCitations
178048362007TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.333
178048362007TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.333
187948532008Common variants at CD40 and other loci confer risk of rheumatoid arthritis.199
190231252009A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.104
178802612007A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.87
178802612007A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.87
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191105362009Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.82
178273882007Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.67
203850932010Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.65

Citation

Dessen P

TRAF1 (TNF receptor associated factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42686/traf1