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TRAF3IP1 (TRAF3 interacting protein 1)

Identity

Alias_namesTNF receptor-associated factor 3 interacting protein 1
Alias_symbol (synonym)MIP-T3
DKFZP434F124
MIPT3
IFT54
Other aliasSLSN9
HGNC (Hugo) TRAF3IP1
LocusID (NCBI) 26146
Atlas_Id 43538
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 238320544 and ends at 238400900 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASB1 (2q37.3) / TRAF3IP1 (2q37.3)CCT3 (1q22) / TRAF3IP1 (2q37.3)LYST (1q42.3) / TRAF3IP1 (2q37.3)
TRAF3IP1 (2q37.3) / GALNTL5 (7q36.1)ZBTB8B (1p35.1) / TRAF3IP1 (2q37.3)ASB1 2q37.3 / TRAF3IP1 2q37.3
TRAF3IP1 2q37.3 / GALNTL5 7q36.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TRAF3IP1   17861
Cards
Entrez_Gene (NCBI)TRAF3IP1  26146  TRAF3 interacting protein 1
AliasesIFT54; MIP-T3; MIPT3; SLSN9
GeneCards (Weizmann)TRAF3IP1
Ensembl hg19 (Hinxton)ENSG00000204104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204104 [Gene_View]  chr2:238320544-238400900 [Contig_View]  TRAF3IP1 [Vega]
ICGC DataPortalENSG00000204104
TCGA cBioPortalTRAF3IP1
AceView (NCBI)TRAF3IP1
Genatlas (Paris)TRAF3IP1
WikiGenes26146
SOURCE (Princeton)TRAF3IP1
Genetics Home Reference (NIH)TRAF3IP1
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF3IP1  -     chr2:238320544-238400900 +  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF3IP1  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblTRAF3IP1 - 2q37.3 [CytoView hg19]  TRAF3IP1 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBITRAF3IP1 [Mapview hg19]  TRAF3IP1 [Mapview hg38]
OMIM607380   616629   
Gene and transcription
Genbank (Entrez)AF230877 AF242456 AI356967 AL080153 BC059174
RefSeq transcript (Entrez)NM_001139490 NM_015650
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRAF3IP1
Cluster EST : UnigeneHs.631898 [ NCBI ]
CGAP (NCI)Hs.631898
Alternative Splicing GalleryENSG00000204104
Gene ExpressionTRAF3IP1 [ NCBI-GEO ]   TRAF3IP1 [ EBI - ARRAY_EXPRESS ]   TRAF3IP1 [ SEEK ]   TRAF3IP1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF3IP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : Davasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26146
GTEX Portal (Tissue expression)TRAF3IP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TDR0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TDR0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TDR0
Splice isoforms : SwissVarQ8TDR0
PhosPhoSitePlusQ8TDR0
Domains : Interpro (EBI)TRAF3IP1   
>a href=../extdef.html#PFAM TARGET=PFAM>Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TRAF3IP1
DMDM Disease mutations26146
Blocks (Seattle)TRAF3IP1
PDB (SRS)2EQO   
PDB (PDBSum)2EQO   
PDB (IMB)2EQO   
PDB (RSDB)2EQO   
Structural Biology KnowledgeBase2EQO   
SCOP (Structural Classification of Proteins)2EQO   
CATH (Classification of proteins structures)2EQO   
SuperfamilyQ8TDR0
Human Protein AtlasENSG00000204104
Peptide AtlasQ8TDR0
HPRD09571
IPIIPI00154813   IPI00855862   IPI00871328   IPI01015088   IPI00916235   
Protein Interaction databases
DIP (DOE-UCLA)Q8TDR0
IntAct (EBI)Q8TDR0
FunCoupENSG00000204104
BioGRIDTRAF3IP1
STRING (EMBL)TRAF3IP1
ZODIACTRAF3IP1
Ontologies - Pathways
QuickGOQ8TDR0
Ontology : AmiGOmorphogenesis of a polarized epithelium  kidney development  negative regulation of protein phosphorylation  protein binding  cytoplasm  centrosome  cilium  axoneme  microtubule binding  neural tube patterning  intraciliary transport particle B  intraciliary transport particle B  embryonic camera-type eye development  negative regulation of protein complex assembly  negative regulation of type I interferon production  negative regulation of interferon-beta production  embryonic heart tube development  intraciliary transport involved in cilium assembly  ciliary transition zone  ciliary basal body  post-anal tail morphogenesis  intraciliary transport  embryonic digit morphogenesis  negative regulation of defense response to virus  cilium assembly  regulation of microtubule cytoskeleton organization  ciliary tip  ciliary tip  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
Ontology : EGO-EBImorphogenesis of a polarized epithelium  kidney development  negative regulation of protein phosphorylation  protein binding  cytoplasm  centrosome  cilium  axoneme  microtubule binding  neural tube patterning  intraciliary transport particle B  intraciliary transport particle B  embryonic camera-type eye development  negative regulation of protein complex assembly  negative regulation of type I interferon production  negative regulation of interferon-beta production  embryonic heart tube development  intraciliary transport involved in cilium assembly  ciliary transition zone  ciliary basal body  post-anal tail morphogenesis  intraciliary transport  embryonic digit morphogenesis  negative regulation of defense response to virus  cilium assembly  regulation of microtubule cytoskeleton organization  ciliary tip  ciliary tip  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
NDEx NetworkTRAF3IP1
Atlas of Cancer Signalling NetworkTRAF3IP1
Wikipedia pathwaysTRAF3IP1
Orthology - Evolution
OrthoDB26146
GeneTree (enSembl)ENSG00000204104
Phylogenetic Trees/Animal Genes : TreeFamTRAF3IP1
HOVERGENQ8TDR0
HOGENOMQ8TDR0
Homologs : HomoloGeneTRAF3IP1
Homology/Alignments : Family Browser (UCSC)TRAF3IP1
Gene fusions - Rearrangements
Fusion : MitelmanASB1/TRAF3IP1 [2q37.3/2q37.3]  [t(2;2)(q37;q37)]  
Fusion : MitelmanTRAF3IP1/GALNTL5 [2q37.3/7q36.1]  [t(2;7)(q37;q36)]  
Fusion : MitelmanZBTB8B/TRAF3IP1 [1p35.1/2q37.3]  [t(1;2)(p35;q37)]  
Fusion: TCGAASB1 2q37.3 TRAF3IP1 2q37.3 BRCA
Fusion: TCGATRAF3IP1 2q37.3 GALNTL5 7q36.1 OV
Fusion Cancer (Beijing)LYST [1q42.3]  -  TRAF3IP1 [2q37.3]  [FUSC000014]  [FUSC000014]  [FUSC000014]  [FUSC000014]  [FUSC000014]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF3IP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF3IP1
dbVarTRAF3IP1
ClinVarTRAF3IP1
1000_GenomesTRAF3IP1 
Exome Variant ServerTRAF3IP1
ExAC (Exome Aggregation Consortium)TRAF3IP1 (select the gene name)
Genetic variants : HAPMAP26146
Genomic Variants (DGV)TRAF3IP1 [DGVbeta]
DECIPHERTRAF3IP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF3IP1 
Mutations
ICGC Data PortalTRAF3IP1 
TCGA Data PortalTRAF3IP1 
Broad Tumor PortalTRAF3IP1
OASIS PortalTRAF3IP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF3IP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRAF3IP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRAF3IP1
DgiDB (Drug Gene Interaction Database)TRAF3IP1
DoCM (Curated mutations)TRAF3IP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRAF3IP1 (select a term)
intoGenTRAF3IP1
Cancer3DTRAF3IP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607380    616629   
Orphanet2824   
MedgenTRAF3IP1
Genetic Testing Registry TRAF3IP1
NextProtQ8TDR0 [Medical]
TSGene26146
GENETestsTRAF3IP1
Target ValidationTRAF3IP1
Huge Navigator TRAF3IP1 [HugePedia]
snp3D : Map Gene to Disease26146
BioCentury BCIQTRAF3IP1
ClinGenTRAF3IP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26146
Chemical/Pharm GKB GenePA134943602
Clinical trialTRAF3IP1
Miscellaneous
canSAR (ICR)TRAF3IP1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRAF3IP1
EVEXTRAF3IP1
GoPubMedTRAF3IP1
iHOPTRAF3IP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:23 CEST 2017

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