Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TRAF5 (TNF receptor associated factor 5)

Identity

Alias_symbol (synonym)RNF84
Other aliasMGC:39780
HGNC (Hugo) TRAF5
LocusID (NCBI) 7188
Atlas_Id 42687
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 211346364 and ends at 211374944 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF5 (1q32.3) / RALGDS (9q34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  T-cell/histiocyte rich large B-cell lymphoma


External links

Nomenclature
HGNC (Hugo)TRAF5   12035
Cards
Entrez_Gene (NCBI)TRAF5  7188  TNF receptor associated factor 5
AliasesMGC:39780; RNF84
GeneCards (Weizmann)TRAF5
Ensembl hg19 (Hinxton)ENSG00000082512 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082512 [Gene_View]  ENSG00000082512 [Sequence]  chr1:211346364-211374944 [Contig_View]  TRAF5 [Vega]
ICGC DataPortalENSG00000082512
TCGA cBioPortalTRAF5
AceView (NCBI)TRAF5
Genatlas (Paris)TRAF5
WikiGenes7188
SOURCE (Princeton)TRAF5
Genetics Home Reference (NIH)TRAF5
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF5  -     chr1:211346364-211374944 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF5  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblTRAF5 - 17q11.2 [CytoView hg19]  TRAF5 - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBITRAF5 [Mapview hg19]  TRAF5 [Mapview hg38]
OMIM602356   
Gene and transcription
Genbank (Entrez)AB000509 AK126502 AK295766 AK303286 BC029600
RefSeq transcript (Entrez)NM_001033910 NM_001319207 NM_004619 NM_145759
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRAF5
Cluster EST : UnigeneHs.523930 [ NCBI ]
CGAP (NCI)Hs.523930
Alternative Splicing GalleryENSG00000082512
Gene ExpressionTRAF5 [ NCBI-GEO ]   TRAF5 [ EBI - ARRAY_EXPRESS ]   TRAF5 [ SEEK ]   TRAF5 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7188
GTEX Portal (Tissue expression)TRAF5
Human Protein AtlasENSG00000082512-TRAF5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00463   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00463  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00463
Splice isoforms : SwissVarO00463
PhosPhoSitePlusO00463
Domaine pattern : Prosite (Expaxy)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)MATH/TRAF_dom    TNF_rcpt--assoc_TRAF    TRAF-like    TRAF5    TRAF5_MATH    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domain families : Pfam (Sanger)zf-C3HC4 (PF00097)    zf-TRAF (PF02176)   
Domain families : Pfam (NCBI)pfam00097    pfam02176   
Domain families : Smart (EMBL)MATH (SM00061)  RING (SM00184)  
Conserved Domain (NCBI)TRAF5
DMDM Disease mutations7188
Blocks (Seattle)TRAF5
SuperfamilyO00463
Human Protein Atlas [tissue]ENSG00000082512-TRAF5 [tissue]
Peptide AtlasO00463
HPRD03834
IPIIPI00005760   IPI00982254   
Protein Interaction databases
DIP (DOE-UCLA)O00463
IntAct (EBI)O00463
FunCoupENSG00000082512
BioGRIDTRAF5
STRING (EMBL)TRAF5
ZODIACTRAF5
Ontologies - Pathways
QuickGOO00463
Ontology : AmiGOtumor necrosis factor receptor binding  protein binding  centrosome  cytosol  apoptotic process  signal transduction  zinc ion binding  cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  thioesterase binding  CD40 receptor complex  identical protein binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBItumor necrosis factor receptor binding  protein binding  centrosome  cytosol  apoptotic process  signal transduction  zinc ion binding  cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  thioesterase binding  CD40 receptor complex  identical protein binding  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  
Pathways : KEGGNF-kappa B signaling pathway    TNF signaling pathway    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Small cell lung cancer   
NDEx NetworkTRAF5
Atlas of Cancer Signalling NetworkTRAF5
Wikipedia pathwaysTRAF5
Orthology - Evolution
OrthoDB7188
GeneTree (enSembl)ENSG00000082512
Phylogenetic Trees/Animal Genes : TreeFamTRAF5
HOVERGENO00463
HOGENOMO00463
Homologs : HomoloGeneTRAF5
Homology/Alignments : Family Browser (UCSC)TRAF5
Gene fusions - Rearrangements
Fusion : QuiverTRAF5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF5
dbVarTRAF5
ClinVarTRAF5
1000_GenomesTRAF5 
Exome Variant ServerTRAF5
ExAC (Exome Aggregation Consortium)ENSG00000082512
GNOMAD BrowserENSG00000082512
Varsome BrowserTRAF5
Genetic variants : HAPMAP7188
Genomic Variants (DGV)TRAF5 [DGVbeta]
DECIPHERTRAF5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF5 
Mutations
ICGC Data PortalTRAF5 
TCGA Data PortalTRAF5 
Broad Tumor PortalTRAF5
OASIS PortalTRAF5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRAF5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRAF5
DgiDB (Drug Gene Interaction Database)TRAF5
DoCM (Curated mutations)TRAF5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRAF5 (select a term)
intoGenTRAF5
Cancer3DTRAF5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602356   
Orphanet
DisGeNETTRAF5
MedgenTRAF5
Genetic Testing Registry TRAF5
NextProtO00463 [Medical]
TSGene7188
GENETestsTRAF5
Target ValidationTRAF5
Huge Navigator TRAF5 [HugePedia]
snp3D : Map Gene to Disease7188
BioCentury BCIQTRAF5
ClinGenTRAF5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7188
Chemical/Pharm GKB GenePA36712
Clinical trialTRAF5
Miscellaneous
canSAR (ICR)TRAF5 (select the gene name)
Probes
Litterature
PubMed103 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRAF5
EVEXTRAF5
GoPubMedTRAF5
iHOPTRAF5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 11:38:38 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.