Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRAF6 (TNF receptor associated factor 6)

Identity

Alias (NCBI)MGC:3310
RNF85
HGNC (Hugo) TRAF6
HGNC Alias symbRNF85
HGNC Previous nameTNF receptor-associated factor 6, E3 ubiquitin protein ligase
LocusID (NCBI) 7189
Atlas_Id 42688
Location 11p12  [Link to chromosome band 11p12]
Location_base_pair Starts at 36483771 and ends at 36510272 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF6 (11p12) / GANAB (11q12.3)TRAF6 (11p12) / TRAF6 (11p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(2;5)(p23;q35) SQSTM1/ALK
t(5;9)(q35;q34) SQSTM1/NUP214
t(14;19)(q32;q13) IGH/Various Partners

External links

 

Nomenclature
HGNC (Hugo)TRAF6   12036
Cards
Entrez_Gene (NCBI)TRAF6    TNF receptor associated factor 6
AliasesMGC:3310; RNF85
GeneCards (Weizmann)TRAF6
Ensembl hg19 (Hinxton)ENSG00000175104 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175104 [Gene_View]  ENSG00000175104 [Sequence]  chr11:36483771-36510272 [Contig_View]  TRAF6 [Vega]
ICGC DataPortalENSG00000175104
TCGA cBioPortalTRAF6
AceView (NCBI)TRAF6
Genatlas (Paris)TRAF6
SOURCE (Princeton)TRAF6
Genetics Home Reference (NIH)TRAF6
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF6  -     chr11:36483771-36510272 -  11p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF6  -     11p12   [Description]    (hg19-Feb_2009)
GoldenPathTRAF6 - 11p12 [CytoView hg19]  TRAF6 - 11p12 [CytoView hg38]
ImmunoBaseENSG00000175104
Genome Data Viewer NCBITRAF6 [Mapview hg19]  
OMIM602355   
Gene and transcription
Genbank (Entrez)AK128396 AK292978 BC031052 BI463192 BQ187062
RefSeq transcript (Entrez)NM_004620 NM_145803
Consensus coding sequences : CCDS (NCBI)TRAF6
Gene ExpressionTRAF6 [ NCBI-GEO ]   TRAF6 [ EBI - ARRAY_EXPRESS ]   TRAF6 [ SEEK ]   TRAF6 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF6 [ Firebrowse - Broad ]
GenevisibleExpression of TRAF6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7189
GTEX Portal (Tissue expression)TRAF6
Human Protein AtlasENSG00000175104-TRAF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4K3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4K3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4K3
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y4K3
Domaine pattern : Prosite (Expaxy)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)MATH/TRAF_dom    TNF_rcpt-assoc_TRAF    TNF_rcpt-assoc_TRAF_met    TRAF-like    TRAF6    TRAF6_MATH    TRAF6_Z2    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domain families : Pfam (Sanger)TRAF6_Z2 (PF18048)    zf-TRAF (PF02176)   
Domain families : Pfam (NCBI)pfam18048    pfam02176   
Domain families : Smart (EMBL)MATH (SM00061)  RING (SM00184)  
Conserved Domain (NCBI)TRAF6
PDB (RSDB)1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
PDB Europe1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
PDB (PDBSum)1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
PDB (IMB)1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
Structural Biology KnowledgeBase1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
SCOP (Structural Classification of Proteins)1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
CATH (Classification of proteins structures)1LB4    1LB5    1LB6    2ECI    2JMD    3HCS    3HCT    3HCU    4Z8M    5ZUJ    6A33   
SuperfamilyQ9Y4K3
AlphaFold pdb e-kbQ9Y4K3   
Human Protein Atlas [tissue]ENSG00000175104-TRAF6 [tissue]
HPRD03833
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4K3
IntAct (EBI)Q9Y4K3
BioGRIDTRAF6
STRING (EMBL)TRAF6
ZODIACTRAF6
Ontologies - Pathways
QuickGOQ9Y4K3
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  activation of MAPK activity  protein polyubiquitination  ossification  in utero embryonic development  neural tube closure  stimulatory C-type lectin receptor signaling pathway  toll-like receptor signaling pathway  regulation of immunoglobulin production  positive regulation of T cell cytokine production  cytoplasmic pattern recognition receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  tumor necrosis factor receptor binding  protein binding  nucleus  cytoplasm  lipid droplet  cytosol  plasma membrane  plasma membrane  cell cortex  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  JNK cascade  zinc ion binding  cytoplasmic side of plasma membrane  endosome membrane  protein deubiquitination  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein kinase binding  osteoclast differentiation  membrane protein intracellular domain proteolysis  positive regulation of protein ubiquitination  mitogen-activated protein kinase kinase kinase binding  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  positive regulation of lipopolysaccharide-mediated signaling pathway  thioesterase binding  activation of protein kinase activity  positive regulation of interleukin-12 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  protein-containing complex  tumor necrosis factor-mediated signaling pathway  toll-like receptor 9 signaling pathway  CD40 receptor complex  Fc-epsilon receptor signaling pathway  T-helper 1 type immune response  positive regulation of T cell proliferation  odontogenesis of dentin-containing tooth  identical protein binding  histone deacetylase binding  myeloid dendritic cell differentiation  positive regulation of apoptotic process  negative regulation of apoptotic process  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein kinase B binding  positive regulation of JUN kinase activity  positive regulation of JUN kinase activity  bone resorption  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of JNK cascade  protein N-terminus binding  cell development  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  protein autoubiquitination  protein autoubiquitination  ubiquitin protein ligase activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  response to interleukin-1  cellular response to lipopolysaccharide  cellular response to cytokine stimulus  interleukin-17-mediated signaling pathway  plasma membrane signaling receptor complex  positive regulation of NIK/NF-kappaB signaling  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  activation of MAPK activity  protein polyubiquitination  ossification  in utero embryonic development  neural tube closure  stimulatory C-type lectin receptor signaling pathway  toll-like receptor signaling pathway  regulation of immunoglobulin production  positive regulation of T cell cytokine production  cytoplasmic pattern recognition receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  tumor necrosis factor receptor binding  protein binding  nucleus  cytoplasm  lipid droplet  cytosol  plasma membrane  plasma membrane  cell cortex  cellular response to DNA damage stimulus  I-kappaB kinase/NF-kappaB signaling  activation of NF-kappaB-inducing kinase activity  JNK cascade  zinc ion binding  cytoplasmic side of plasma membrane  endosome membrane  protein deubiquitination  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein kinase binding  osteoclast differentiation  membrane protein intracellular domain proteolysis  positive regulation of protein ubiquitination  mitogen-activated protein kinase kinase kinase binding  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  positive regulation of lipopolysaccharide-mediated signaling pathway  thioesterase binding  activation of protein kinase activity  positive regulation of interleukin-12 production  positive regulation of interleukin-2 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  protein-containing complex  tumor necrosis factor-mediated signaling pathway  toll-like receptor 9 signaling pathway  CD40 receptor complex  Fc-epsilon receptor signaling pathway  T-helper 1 type immune response  positive regulation of T cell proliferation  odontogenesis of dentin-containing tooth  identical protein binding  histone deacetylase binding  myeloid dendritic cell differentiation  positive regulation of apoptotic process  negative regulation of apoptotic process  regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein kinase B binding  positive regulation of JUN kinase activity  positive regulation of JUN kinase activity  bone resorption  positive regulation of osteoclast differentiation  negative regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  positive regulation of JNK cascade  protein N-terminus binding  cell development  perinuclear region of cytoplasm  positive regulation of smooth muscle cell proliferation  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  protein autoubiquitination  protein autoubiquitination  protein autoubiquitination  ubiquitin protein ligase activity  nucleotide-binding oligomerization domain containing signaling pathway  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  response to interleukin-1  cellular response to lipopolysaccharide  cellular response to cytokine stimulus  interleukin-17-mediated signaling pathway  plasma membrane signaling receptor complex  positive regulation of NIK/NF-kappaB signaling  positive regulation of leukocyte adhesion to vascular endothelial cell  positive regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTASignal transduction through IL1R [Genes]    NF-kB Signaling Pathway [Genes]    Bone Remodelling [Genes]    TACI and BCMA stimulation of B cell immune responses. [Genes]    Toll-Like Receptor Pathway [Genes]    Acetylation and Deacetylation of RelA in The Nucleus [Genes]    CD40L Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Ubiquitin mediated proteolysis    Endocytosis    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    Neurotrophin signaling pathway    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Hepatitis C    Measles    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Small cell lung cancer   
NDEx NetworkTRAF6
Atlas of Cancer Signalling NetworkTRAF6
Wikipedia pathwaysTRAF6
Orthology - Evolution
OrthoDB7189
GeneTree (enSembl)ENSG00000175104
Phylogenetic Trees/Animal Genes : TreeFamTRAF6
Homologs : HomoloGeneTRAF6
Homology/Alignments : Family Browser (UCSC)TRAF6
Gene fusions - Rearrangements
Fusion : QuiverTRAF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF6
dbVarTRAF6
ClinVarTRAF6
MonarchTRAF6
1000_GenomesTRAF6 
Exome Variant ServerTRAF6
GNOMAD BrowserENSG00000175104
Varsome BrowserTRAF6
ACMGTRAF6 variants
VarityQ9Y4K3
Genomic Variants (DGV)TRAF6 [DGVbeta]
DECIPHERTRAF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF6 
Mutations
ICGC Data PortalTRAF6 
TCGA Data PortalTRAF6 
Broad Tumor PortalTRAF6
OASIS PortalTRAF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAF6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRAF6
Mutations and Diseases : HGMDTRAF6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRAF6
DgiDB (Drug Gene Interaction Database)TRAF6
DoCM (Curated mutations)TRAF6
CIViC (Clinical Interpretations of Variants in Cancer)TRAF6
Cancer3DTRAF6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602355   
Orphanet7027   
DisGeNETTRAF6
MedgenTRAF6
Genetic Testing Registry TRAF6
NextProtQ9Y4K3 [Medical]
GENETestsTRAF6
Target ValidationTRAF6
Huge Navigator TRAF6 [HugePedia]
ClinGenTRAF6
Clinical trials, drugs, therapy
MyCancerGenomeTRAF6
Protein Interactions : CTDTRAF6
Pharm GKB GenePA36713
PharosQ9Y4K3
Clinical trialTRAF6
Miscellaneous
canSAR (ICR)TRAF6
HarmonizomeTRAF6
DataMed IndexTRAF6
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRAF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:09 CEST 2021
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