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TRAF7 (TNF receptor-associated factor 7, E3 ubiquitin protein ligase)

Identity

Other namesRFWD1
RNF119
HGNC (Hugo) TRAF7
LocusID (NCBI) 84231
Location 16p13.3
Location_base_pair Starts at 2205799 and ends at 2228130 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRAF7   20456
Entrez_Gene (NCBI)TRAF7  84231  TNF receptor-associated factor 7, E3 ubiquitin protein ligase
Cards
GeneCards (Weizmann)TRAF7
Ensembl (Hinxton)ENSG00000131653 [Gene_View]  chr16:2205799-2228130 [Contig_View]  TRAF7 [Vega]
AceView (NCBI)TRAF7
Genatlas (Paris)TRAF7
SOURCE (Stanford)NM_032271 NM_206835
Genomic and cartography
GoldenPath (UCSC)TRAF7  -  16p13.3   chr16:2205799-2228130 +  16p13.3   [Description]    (hg19-Feb_2009)
EnsemblTRAF7 - 16p13.3 [CytoView]
Mapping of homologs : NCBITRAF7 [Mapview]
OMIM606692   
Gene and transcription
Genbank (Entrez)AK090624 AL136921 AW245178 AY569455 BC024267
RefSeq transcript (SRS)NM_032271 NM_206835
RefSeq transcript (Entrez)NM_032271 NM_206835
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NT_010393 NW_001838339 NW_004078085
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NT_010393 NW_001838339 NW_004078085
Consensus coding sequences : CCDS (NCBI)TRAF7
Cluster EST : UnigeneHs.713632 [ SRS ] Hs.713632 [ NCBI ]
CGAP (NCI)Hs.713632
Alternative Splicing : Fast-db (Paris)GSHG0010859
Alternative Splicing GalleryENSG00000131653
Gene ExpressionTRAF7 [ NCBI-GEO ]   TRAF7 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Q0C0 (SRS) Q6Q0C0 (Uniprot)
NextProtQ6Q0C0
With graphics : InterProQ6Q0C0
Splice isoforms : SwissVarQ6Q0C0(Swissvar)
Domaine pattern : Prosite (SRS)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (SRS)G-protein_beta_WD-40_rep    SIAH-type    TRAF-like    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    SIAH-type    TRAF-like    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    Znf_C3HC4_RING-type    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Related proteins : CluSTrQ6Q0C0
Domain families : Pfam (SRS)WD40 (PF00400)    zf-C3HC4 (PF00097)   
Domain families : Pfam (Sanger)WD40 (PF00400)    zf-C3HC4 (PF00097)   
Domain families : Pfam (NCBI)pfam00400    pfam00097   
Domain families : Smart (EMBL)RING (SM00184)  WD40 (SM00320)  
DMDM84231
Blocks (Seattle)Q6Q0C0
Human Protein AtlasENSG00000131653
HPRD06977
IPIIPI00395631   IPI00470778   
Protein Interaction databases
DIP (DOE-UCLA)Q6Q0C0
IntAct (EBI)Q6Q0C0
FunCoupENSG00000131653
REACTOMETRAF7
Protein Interaction Database84231
BioGRIDTRAF7
InParanoidQ6Q0C0
Interologous Interaction database Q6Q0C0
IntegromeDBTRAF7
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TRAF7
SNP (GeneSNP Utah)TRAF7
SNP : HGBaseTRAF7
Genetic variants : HAPMAPTRAF7
Somatic Mutations in Cancer : COSMICTRAF7 
CONAN: Copy Number AnalysisTRAF7 
Mutations and Diseases : HGMDTRAF7
OMIM606692   
GENETests606692   
Disease Genetic AssociationTRAF7
Huge Navigator TRAF7 [HugePedia]  TRAF7 [HugeCancerGEM]
Genomic VariantsTRAF7  TRAF7 [DGVbeta]
ClinVarTRAF7
snp3D : Map Gene to Disease84231
General knowledge
Homologs : HomoloGeneTRAF7
Homology/Alignments : Family Browser (UCSC)TRAF7
Phylogenetic Trees/Animal Genes : TreeFamTRAF7
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.- [ Enzyme-SRS ]   6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Chemical/Protein Interactions : CTD84231
Chemical/Pharm GKB GenePA134917323
Clinical trialTRAF7
Cancer Resource (Charite)ENSG00000131653
Ontology : AmiGOubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein ligase activity  protein binding  plasma membrane  transcription, DNA-dependent  regulation of transcription, DNA-dependent  apoptotic process  zinc ion binding  cytoplasmic membrane-bounded vesicle  protein ubiquitination  regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  
Ontology : EGO-EBIubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein ligase activity  protein binding  plasma membrane  transcription, DNA-dependent  regulation of transcription, DNA-dependent  apoptotic process  zinc ion binding  cytoplasmic membrane-bounded vesicle  protein ubiquitination  regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  
Pathways : KEGGTryptophan metabolism
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
PubGeneTRAF7
iHOPTRAF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:56:07 CEST 2013
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