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TRAF7 (TNF receptor-associated factor 7, E3 ubiquitin protein ligase)

Identity

Other namesRFWD1
RNF119
HGNC (Hugo) TRAF7
LocusID (NCBI) 84231
Location 16p13.3
Location_base_pair Starts at 2205799 and ends at 2228130 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRAF7   20456
Cards
Entrez_Gene (NCBI)TRAF7  84231  TNF receptor-associated factor 7, E3 ubiquitin protein ligase
GeneCards (Weizmann)TRAF7
Ensembl hg19 (Hinxton)ENSG00000131653 [Gene_View]  chr16:2205799-2228130 [Contig_View]  TRAF7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000131653 [Gene_View]  chr16:2205799-2228130 [Contig_View]  TRAF7 [Vega]
ICGC DataPortalENSG00000131653
cBioPortalTRAF7
AceView (NCBI)TRAF7
Genatlas (Paris)TRAF7
WikiGenes84231
SOURCE (Princeton)TRAF7
Genomic and cartography
GoldenPath hg19 (UCSC)TRAF7  -     chr16:2205799-2228130 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRAF7  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblTRAF7 - 16p13.3 [CytoView hg19]  TRAF7 - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBITRAF7 [Mapview hg19]  TRAF7 [Mapview hg38]
OMIM606692   
Gene and transcription
Genbank (Entrez)AK090624 AL136921 AW245178 AY569455 BC024267
RefSeq transcript (Entrez)NM_032271 NM_206835
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NT_010393 NW_001838339 NW_004929400
Consensus coding sequences : CCDS (NCBI)TRAF7
Cluster EST : UnigeneHs.713632 [ NCBI ]
CGAP (NCI)Hs.713632
Alternative Splicing : Fast-db (Paris)GSHG0010859
Alternative Splicing GalleryENSG00000131653
Gene ExpressionTRAF7 [ NCBI-GEO ]     TRAF7 [ SEEK ]   TRAF7 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Q0C0 (Uniprot)
NextProtQ6Q0C0  [Medical]
With graphics : InterProQ6Q0C0
Splice isoforms : SwissVarQ6Q0C0 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    SIAH-type    TRAF-like    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Related proteins : CluSTrQ6Q0C0
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)RING (SM00184)  WD40 (SM00320)  
DMDM Disease mutations84231
Blocks (Seattle)Q6Q0C0
Human Protein AtlasENSG00000131653
Peptide AtlasQ6Q0C0
HPRD06977
IPIIPI00395631   IPI00470778   
Protein Interaction databases
DIP (DOE-UCLA)Q6Q0C0
IntAct (EBI)Q6Q0C0
FunCoupENSG00000131653
BioGRIDTRAF7
IntegromeDBTRAF7
STRING (EMBL)TRAF7
Ontologies - Pathways
QuickGOQ6Q0C0
Ontology : AmiGOubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein transferase activity  protein binding  transcription, DNA-templated  regulation of transcription, DNA-templated  apoptotic process  zinc ion binding  cytoplasmic membrane-bounded vesicle  protein ubiquitination  protein ubiquitination  ligase activity  positive regulation of MAPK cascade  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein transferase activity  protein binding  transcription, DNA-templated  regulation of transcription, DNA-templated  apoptotic process  zinc ion binding  cytoplasmic membrane-bounded vesicle  protein ubiquitination  protein ubiquitination  ligase activity  positive regulation of MAPK cascade  positive regulation of apoptotic signaling pathway  
Protein Interaction DatabaseTRAF7
DoCM (Curated mutations)TRAF7
Wikipedia pathwaysTRAF7
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTRAF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF7
dbVarTRAF7
ClinVarTRAF7
1000_GenomesTRAF7 
Exome Variant ServerTRAF7
SNP (GeneSNP Utah)TRAF7
SNP : HGBaseTRAF7
Genetic variants : HAPMAPTRAF7
Genomic VariantsTRAF7  TRAF7 [DGVbeta]
Mutations
ICGC Data PortalENSG00000131653 
Cancer Gene: CensusTRAF7 
Somatic Mutations in Cancer : COSMICTRAF7 
CONAN: Copy Number AnalysisTRAF7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:2205799-2228130
Mutations and Diseases : HGMDTRAF7
OMIM606692   
MedgenTRAF7
NextProtQ6Q0C0 [Medical]
GENETestsTRAF7
Disease Genetic AssociationTRAF7
Huge Navigator TRAF7 [HugePedia]  TRAF7 [HugeCancerGEM]
snp3D : Map Gene to Disease84231
DGIdb (Drug Gene Interaction db)TRAF7
General knowledge
Homologs : HomoloGeneTRAF7
Homology/Alignments : Family Browser (UCSC)TRAF7
Phylogenetic Trees/Animal Genes : TreeFamTRAF7
Chemical/Protein Interactions : CTD84231
Chemical/Pharm GKB GenePA134917323
Clinical trialTRAF7
Cancer Resource (Charite)ENSG00000131653
Other databases
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
CoreMineTRAF7
GoPubMedTRAF7
iHOPTRAF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 02:03:28 CET 2014

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