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TRAF7 (TNF receptor associated factor 7)

Identity

Alias (NCBI)CAFDADD
RFWD1
RNF119
HGNC (Hugo) TRAF7
HGNC Alias symbRNF119
DKFZp586I021
MGC7807
HGNC Previous nameRFWD1
HGNC Previous namering finger and WD repeat domain 1
 TNF receptor-associated factor 7, E3 ubiquitin protein ligase
LocusID (NCBI) 84231
Atlas_Id 42094
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 2155782 and ends at 2178129 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAF7 (16p13.3) / EIF4A1 (17p13.1)TRAF7 (16p13.3) / WDR24 (16p13.3)TRAF7 16p13.3 / WDR24 16p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(16;16)(p13;p13) TRAF7/WDR24


External links

 

Nomenclature
HGNC (Hugo)TRAF7   20456
Cards
Entrez_Gene (NCBI)TRAF7    TNF receptor associated factor 7
AliasesCAFDADD; RFWD1; RNF119
GeneCards (Weizmann)TRAF7
Ensembl hg19 (Hinxton)ENSG00000131653 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000131653 [Gene_View]  ENSG00000131653 [Sequence]  chr16:2155782-2178129 [Contig_View]  TRAF7 [Vega]
ICGC DataPortalENSG00000131653
TCGA cBioPortalTRAF7
AceView (NCBI)TRAF7
Genatlas (Paris)TRAF7
SOURCE (Princeton)TRAF7
Genetics Home Reference (NIH)TRAF7
Genomic and cartography
GoldenPath hg38 (UCSC)TRAF7  -     chr16:2155782-2178129 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAF7  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTRAF7 - 16p13.3 [CytoView hg19]  TRAF7 - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000131653
Genome Data Viewer NCBITRAF7 [Mapview hg19]  
OMIM606692   618164   
Gene and transcription
Genbank (Entrez)AK090624 AL136921 AW245178 AY569455 BC024267
RefSeq transcript (Entrez)NM_032271 NM_206835
Consensus coding sequences : CCDS (NCBI)TRAF7
Gene ExpressionTRAF7 [ NCBI-GEO ]   TRAF7 [ EBI - ARRAY_EXPRESS ]   TRAF7 [ SEEK ]   TRAF7 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAF7 [ Firebrowse - Broad ]
GenevisibleExpression of TRAF7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84231
GTEX Portal (Tissue expression)TRAF7
Human Protein AtlasENSG00000131653-TRAF7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6Q0C0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6Q0C0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6Q0C0
Catalytic activity : Enzyme2.3.2.27 [ Enzyme-Expasy ]   2.3.2.272.3.2.27 [ IntEnz-EBI ]   2.3.2.27 [ BRENDA ]   2.3.2.27 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6Q0C0
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    TRAF-like    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf    Znf-RING_LisH    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS    Znf_TRAF   
Domain families : Pfam (Sanger)WD40 (PF00400)    zf-RING_UBOX (PF13445)   
Domain families : Pfam (NCBI)pfam00400    pfam13445   
Domain families : Smart (EMBL)RING (SM00184)  WD40 (SM00320)  
Conserved Domain (NCBI)TRAF7
SuperfamilyQ6Q0C0
AlphaFold pdb e-kbQ6Q0C0   
Human Protein Atlas [tissue]ENSG00000131653-TRAF7 [tissue]
HPRD06977
Protein Interaction databases
DIP (DOE-UCLA)Q6Q0C0
IntAct (EBI)Q6Q0C0
BioGRIDTRAF7
STRING (EMBL)TRAF7
ZODIACTRAF7
Ontologies - Pathways
QuickGOQ6Q0C0
Ontology : AmiGOribosomal large subunit assembly  ubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein transferase activity  protein binding  nucleolus  plasma membrane  apoptotic process  Notch signaling pathway  zinc ion binding  protein ubiquitination  protein ubiquitination  cytoplasmic vesicle  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  regulation of ERK1 and ERK2 cascade  positive regulation of apoptotic signaling pathway  
Ontology : EGO-EBIribosomal large subunit assembly  ubiquitin ligase complex  activation of MAPKKK activity  ubiquitin-protein transferase activity  protein binding  nucleolus  plasma membrane  apoptotic process  Notch signaling pathway  zinc ion binding  protein ubiquitination  protein ubiquitination  cytoplasmic vesicle  intracellular membrane-bounded organelle  positive regulation of MAPK cascade  regulation of ERK1 and ERK2 cascade  positive regulation of apoptotic signaling pathway  
NDEx NetworkTRAF7
Atlas of Cancer Signalling NetworkTRAF7
Wikipedia pathwaysTRAF7
Orthology - Evolution
OrthoDB84231
GeneTree (enSembl)ENSG00000131653
Phylogenetic Trees/Animal Genes : TreeFamTRAF7
Homologs : HomoloGeneTRAF7
Homology/Alignments : Family Browser (UCSC)TRAF7
Gene fusions - Rearrangements
Fusion : MitelmanTRAF7/WDR24 [16p13.3/16p13.3]  
Fusion : QuiverTRAF7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAF7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAF7
dbVarTRAF7
ClinVarTRAF7
MonarchTRAF7
1000_GenomesTRAF7 
Exome Variant ServerTRAF7
GNOMAD BrowserENSG00000131653
Varsome BrowserTRAF7
ACMGTRAF7 variants
VarityQ6Q0C0
Genomic Variants (DGV)TRAF7 [DGVbeta]
DECIPHERTRAF7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAF7 
Mutations
ICGC Data PortalTRAF7 
TCGA Data PortalTRAF7 
Broad Tumor PortalTRAF7
OASIS PortalTRAF7 [ Somatic mutations - Copy number]
Cancer Gene: CensusTRAF7 
Somatic Mutations in Cancer : COSMICTRAF7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRAF7
Mutations and Diseases : HGMDTRAF7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRAF7
DgiDB (Drug Gene Interaction Database)TRAF7
DoCM (Curated mutations)TRAF7
CIViC (Clinical Interpretations of Variants in Cancer)TRAF7
Cancer3DTRAF7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606692    618164   
Orphanet
DisGeNETTRAF7
MedgenTRAF7
Genetic Testing Registry TRAF7
NextProtQ6Q0C0 [Medical]
GENETestsTRAF7
Target ValidationTRAF7
Huge Navigator TRAF7 [HugePedia]
ClinGenTRAF7
Clinical trials, drugs, therapy
MyCancerGenomeTRAF7
Protein Interactions : CTDTRAF7
Pharm GKB GenePA134917323
PharosQ6Q0C0
Clinical trialTRAF7
Miscellaneous
canSAR (ICR)TRAF7
HarmonizomeTRAF7
DataMed IndexTRAF7
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRAF7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:10 CEST 2021

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