TRAK1 (trafficking kinesin protein 1)

2009-03-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
DEE68,EIEE68,MILT1,OIP106
FUSION GENES

Other Information

Locus ID:

NCBI: 22906
MIM: 608112
HGNC: 29947
Ensembl: ENSG00000182606

Variants:

dbSNP: 22906
ClinVar: 22906
TCGA: ENSG00000182606
COSMIC: TRAK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182606ENST00000327628Q9UPV9
ENSG00000182606ENST00000327628A0A024R2M0
ENSG00000182606ENST00000341421Q9UPV9
ENSG00000182606ENST00000396175C9JC32
ENSG00000182606ENST00000418790F8WDH2
ENSG00000182606ENST00000427771H7C3T3
ENSG00000182606ENST00000449246Q9UPV9
ENSG00000182606ENST00000484786A0A0D9SGH2
ENSG00000182606ENST00000487159A0A0D9SFL5
ENSG00000182606ENST00000613405A0A087X0N0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373990732023Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.1
379492202023Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.2
373990732023Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.1
379492202023Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.2
331198382021TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.5
331198382021TRAK1-Mediated Abnormality of Mitochondrial Fission Increases Seizure Susceptibility in Temporal Lobe Epilepsy.5
325617402020Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.37
325617402020Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.37
289247452018Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.21
299929632018Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.37
289247452018Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.21
299929632018Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.37
283645492017Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.29
283645492017Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.29
256531022015Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons.15

Citation

Dessen P

TRAK1 (trafficking kinesin protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50704/trak1