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TRAK2 (trafficking kinesin protein 2)

Identity

Alias (NCBI)ALS2CR3
CALS-C
GRIF-1
GRIF1
MILT2
OIP98
HGNC (Hugo) TRAK2
HGNC Alias symbCALS-C
KIAA0549
GRIF-1
OIP98
MILT2
HGNC Alias namegamma-aminobutyric acid(A) receptor-interacting factor
 milton homolog 2 (Drosophila)
 O-linked N-acetylglucosamine transferase interacting protein 98
HGNC Previous nameALS2CR3
HGNC Previous nameamyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3
 trafficking protein, kinesin binding 2
LocusID (NCBI) 66008
Atlas_Id 75103
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 201377207 and ends at 201451458 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRAK2 (2q33.1) / CD68 (17p13.1)TRAK2 (2q33.1) / GHRLOS (3p25.3)TRAK2 (2q33.1) / SPAG11B (8p23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRAK2   13206
Cards
Entrez_Gene (NCBI)TRAK2    trafficking kinesin protein 2
AliasesALS2CR3; CALS-C; GRIF-1; GRIF1; 
MILT2; OIP98
GeneCards (Weizmann)TRAK2
Ensembl hg19 (Hinxton)ENSG00000115993 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115993 [Gene_View]  ENSG00000115993 [Sequence]  chr2:201377207-201451458 [Contig_View]  TRAK2 [Vega]
ICGC DataPortalENSG00000115993
TCGA cBioPortalTRAK2
AceView (NCBI)TRAK2
Genatlas (Paris)TRAK2
SOURCE (Princeton)TRAK2
Genetics Home Reference (NIH)TRAK2
Genomic and cartography
GoldenPath hg38 (UCSC)TRAK2  -     chr2:201377207-201451458 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRAK2  -     2q33.1   [Description]    (hg19-Feb_2009)
GoldenPathTRAK2 - 2q33.1 [CytoView hg19]  TRAK2 - 2q33.1 [CytoView hg38]
ImmunoBaseENSG00000115993
Genome Data Viewer NCBITRAK2 [Mapview hg19]  
OMIM607334   
Gene and transcription
Genbank (Entrez)AB011121 AB038951 AK054763 AK314384 AL832573
RefSeq transcript (Entrez)NM_015049
Consensus coding sequences : CCDS (NCBI)TRAK2
Gene ExpressionTRAK2 [ NCBI-GEO ]   TRAK2 [ EBI - ARRAY_EXPRESS ]   TRAK2 [ SEEK ]   TRAK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRAK2 [ Firebrowse - Broad ]
GenevisibleExpression of TRAK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)66008
GTEX Portal (Tissue expression)TRAK2
Human Protein AtlasENSG00000115993-TRAK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60296   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60296  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60296
PhosPhoSitePlusO60296
Domains : Interpro (EBI)HAP1_N    TRAK1/2_C   
Domain families : Pfam (Sanger)HAP1_N (PF04849)    Milton (PF12448)   
Domain families : Pfam (NCBI)pfam04849    pfam12448   
Conserved Domain (NCBI)TRAK2
SuperfamilyO60296
AlphaFold pdb e-kbO60296   
Human Protein Atlas [tissue]ENSG00000115993-TRAK2 [tissue]
HPRD09547
Protein Interaction databases
DIP (DOE-UCLA)O60296
IntAct (EBI)O60296
BioGRIDTRAK2
STRING (EMBL)TRAK2
ZODIACTRAK2
Ontologies - Pathways
QuickGOO60296
Ontology : AmiGOsignaling receptor binding  signaling receptor binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  early endosome  plasma membrane  regulation of transcription by RNA polymerase II  protein O-linked glycosylation  protein targeting  endosome to lysosome transport  myosin binding  kinesin binding  enzyme binding  neurogenesis  dendrite  TPR domain binding  cytoplasmic vesicle  dendrite cytoplasm  neuronal cell body  axonal growth cone  vesicle transport along microtubule  mitochondrion distribution  dendrite morphogenesis  negative regulation of axonogenesis  GABA receptor binding  GABA receptor binding  anterograde axonal transport of mitochondrion  anterograde dendritic transport of mitochondrion  axon cytoplasm  
Ontology : EGO-EBIsignaling receptor binding  signaling receptor binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  early endosome  plasma membrane  regulation of transcription by RNA polymerase II  protein O-linked glycosylation  protein targeting  endosome to lysosome transport  myosin binding  kinesin binding  enzyme binding  neurogenesis  dendrite  TPR domain binding  cytoplasmic vesicle  dendrite cytoplasm  neuronal cell body  axonal growth cone  vesicle transport along microtubule  mitochondrion distribution  dendrite morphogenesis  negative regulation of axonogenesis  GABA receptor binding  GABA receptor binding  anterograde axonal transport of mitochondrion  anterograde dendritic transport of mitochondrion  axon cytoplasm  
NDEx NetworkTRAK2
Atlas of Cancer Signalling NetworkTRAK2
Wikipedia pathwaysTRAK2
Orthology - Evolution
OrthoDB66008
GeneTree (enSembl)ENSG00000115993
Phylogenetic Trees/Animal Genes : TreeFamTRAK2
Homologs : HomoloGeneTRAK2
Homology/Alignments : Family Browser (UCSC)TRAK2
Gene fusions - Rearrangements
Fusion : QuiverTRAK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRAK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRAK2
dbVarTRAK2
ClinVarTRAK2
MonarchTRAK2
1000_GenomesTRAK2 
Exome Variant ServerTRAK2
GNOMAD BrowserENSG00000115993
Varsome BrowserTRAK2
ACMGTRAK2 variants
VarityO60296
Genomic Variants (DGV)TRAK2 [DGVbeta]
DECIPHERTRAK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRAK2 
Mutations
ICGC Data PortalTRAK2 
TCGA Data PortalTRAK2 
Broad Tumor PortalTRAK2
OASIS PortalTRAK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRAK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRAK2
Mutations and Diseases : HGMDTRAK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRAK2
DgiDB (Drug Gene Interaction Database)TRAK2
DoCM (Curated mutations)TRAK2
CIViC (Clinical Interpretations of Variants in Cancer)TRAK2
Cancer3DTRAK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607334   
Orphanet
DisGeNETTRAK2
MedgenTRAK2
Genetic Testing Registry TRAK2
NextProtO60296 [Medical]
GENETestsTRAK2
Target ValidationTRAK2
Huge Navigator TRAK2 [HugePedia]
ClinGenTRAK2
Clinical trials, drugs, therapy
MyCancerGenomeTRAK2
Protein Interactions : CTDTRAK2
Pharm GKB GenePA24744
PharosO60296
Clinical trialTRAK2
Miscellaneous
canSAR (ICR)TRAK2
HarmonizomeTRAK2
DataMed IndexTRAK2
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRAK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:43 CEST 2021

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