TRAPPC3 (trafficking protein particle complex subunit 3)

2016-10-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
BET3
FUSION GENES

Other Information

Locus ID:

NCBI: 27095
MIM: 610955
HGNC: 19942
Ensembl: ENSG00000054116

Variants:

dbSNP: 27095
ClinVar: 27095
TCGA: ENSG00000054116
COSMIC: TRAPPC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054116ENST00000373159A6NKE1
ENSG00000054116ENST00000373162O43617
ENSG00000054116ENST00000373163O43617
ENSG00000054116ENST00000373166O43617
ENSG00000054116ENST00000616074A0A087WYS5
ENSG00000054116ENST00000616395A0A087WWM0
ENSG00000054116ENST00000617904O43617

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168802712006mBet3p is required for homotypic COPII vesicle tethering in mammalian cells.39
156925642005Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization.16
157282492005Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus.16
169088482006Unique self-palmitoylation activity of the transport protein particle component Bet3: a mechanism required for protein stability.11
168287972006Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.10
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.0

Citation

Dessen P

TRAPPC3 (trafficking protein particle complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56508/trappc3