TRAPPC6A (trafficking protein particle complex subunit 6A)

2014-11-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
TRS33
FUSION GENES

Other Information

Locus ID:

NCBI: 79090
MIM: 610396
HGNC: 23069
Ensembl: ENSG00000007255

Variants:

dbSNP: 79090
ClinVar: 79090
TCGA: ENSG00000007255
COSMIC: TRAPPC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007255ENST00000006275O75865
ENSG00000007255ENST00000585934O75865
ENSG00000007255ENST00000585934B7TZ90
ENSG00000007255ENST00000588062O75865
ENSG00000007255ENST00000592647O75865

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
166975532006A mouse TRAPP-related protein is involved in pigmentation.14
277954292017Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking.14
293915792018A missense mutation in TRAPPC6A leads to build-up of the protein, in patients with a neurodevelopmental syndrome and dysmorphic features.7

Citation

Dessen P

TRAPPC6A (trafficking protein particle complex subunit 6A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75115/trappc6a