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TRD (T cell Receptor Delta)

Written2000-07Marie-Paule Lefranc
IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)TRD@ (T cell Receptor Delta)
HGNC Alias symbTCRDV1
HGNC Previous nameTCRD
HGNC Previous nameTCRD, TRD@
LocusID (NCBI) 6964
Atlas_Id 279
Location 14q11.2  [Link to chromosome band 14q11]
  for complete Figure, see: chromosome 14, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note The TRD locus is embedded in the TRA locus, between the TRAV and TRAJ genes. The orientation of the locus has been determined by the analysis of translocations, involving the TRD locus, in leukemia and lymphoma


V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: Pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRD IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
  • The human TRD locus at 14q11.2 comprises a cluster of one TRDV gene (TRDV2), three TRDD segments, and four TRDJ segments, upstream of the unique TRDC gene; another TRDV gene (TRDV3) is localized downstream of the TRDC gene, in inverted orientation of transcription.
  • This cluster spans 60 kb and is localized inside the TRA locus, between the TRAV genes and the TRAJ segments. One TRDV gene (TRDV1) is localized at 360 kb upstream of the TRDC gene, among the TRAV genes. Five variable genes have been found rearranged to both (D)J segments of the TRD locus and TRAJ segments, and can therefore be used for the synthesis of both delta and alpha chains. These genes are described as TRAV/DV.
  • The TRDV genes are unique members of different subgroups. All the TRD genes are functional, with the exception of one TRAV/DV, which has been found either functional or as a pseudogene.
  • Enhancer sequences have been described between the TRDJ3 and the TRDC gene.
  • List of the human TRD genes
  • Protein

  • Proteins encoded by the TRD locus are the T cell receptor delta chains. They result from the recombination (or rearrangement), at the DNA level, of three genes: TRDV, TRDD and TRDJ, with deletion of the intermediary DNA to create a rearranged TRDV-D-J gene. The rearranged TRDV-D-J gene is transcribed with the TRDC gene and translated into a T cell receptor delta chain.
  • Translation of the variable germline genes involved in the TRDV-D-J rearrangements are available at IMGT Repertoire Protein displays. TRD V-D-J rearrangements can be analysed using the IMGT/V-QUEST tool.
  • Mutations

    Note Mutations which correspond to allelic polymorphisms of the functional germline TRDV, TRDD, TRDJ and TRDC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRDV, TRDD or TRDJ recombination signals or isolated heptamer are frequently observed at the breakpoints.
    Entity ; involve TRD -TAL1 in 1p32
    Prognosis median survival > 5 yrs in children
    Entity ; involve TRD - MYC in 8q24
    Disease T-cell acute lymphocytic leukemia (ALL); rare
    Entity ; involve TRD - HOX11 in 10q24
    Disease T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
    Prognosis not unfavourable
    Entity ; involve TRD - RBTN2 in 11p13
    Disease T-cell acute lymphocytic leukemia (ALL)
    Entity ; involve TRD - RBTN1 in 11p15
    Disease T-cell Acute lymphocytic leukemia (ALL)
    Entity ; involve TRD - TCL1 in 14q32
    Disease and adult T cell leukemia/lymphoma
    Prognosis poor




    Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review)
    Lefranc MP
    The immunologist,. 2000.
    The T cell Receptor FactsBook (Review)
    Lefranc M-P and Lefranc G
    Academic Press, London, UK (398 pages), 2001. ISBN: 124413528


    This paper should be referenced as such :
    Lefranc, MP
    TRD (T cell receptor delta)
    Atlas Genet Cytogenet Oncol Haematol. 2000;4(3):121-122.
    Free journal version : [ pdf ]   [ DOI ]

    Other Leukemias implicated (Data extracted from papers in the Atlas) [ 28 ]
      t(10;14)(q24;q11) TLX1::TRD::t(7;10)(q34;q24) TRB::HOX11
    Hepatosplenic T-cell lymphoma (HSTCL)
    t(7;14)(q35;q32.1) TRB::TCL1A::inv(14)(q11q32.1) TRA-TRD::TCL1A::t(14;14)(q11;q32.1) TRA-TRD::TCL1A
    Pediatric T-Cell Acute Lymphoblastic Leukemia
    t(5;14)(q35;q11) RANBP17 (or TLX3)::TRD
    t(5;14)(q35;q11) TRD::NKX2-5
    t(5;14)(q35;q32.2) BCL11B::TLX3 and NKX2-5
    t(6;14)(p25.3;q11.2) TRA::IRF4
    t(7;12)(q34;p13) TRB::CCND2::t(12;14)(p13;q11) TRA or TRD::CCND2
    t(7;14)(p15;q11) TRD::HOXA10
    t(7;14)(q34;q11) TRA::TRB
    t(7;14)(q34;q11) TRA::TRB
    t(8;14)(q24;q11) TRA::MYC
    t(7;11)(q34;p15) TRB::LMO1::t(11;14)(p15;q11) TRD::LMO1
    t(14;14)(q11;q32) CEBPE::IGH::inv(14)(q11q32) CEBPE::IGH
    TAL1 (1p32) deletion in lymphoid malignancies
    T-lineage acute lymphoblastic leukemia (T-ALL)
    T-cell large granular lymphocyte leukaemia
    inv(14)(q11q32) BCL11B::TRD
    t(1;14)(p33;q11) TRD::TAL1
    t(5;14)(q35;q11) TRD::RANBP17
    t(5;14)(q35;q11) TRD::TLX3
    t(8;14)(q24;q11) TRD::PVT1
    t(9;14)(q21;q11) TRD::GNAQ
    t(10;14)(q24;q11) TLX1NB::TRD
    t(14;14)(q11;q13) NKX2-1-AS1::TRD

    External links

    HGNC (Hugo)TRD   12252
    Entrez_Gene (NCBI)TRD    T cell receptor delta locus
    AliasesTCRD; TCRDV1; TRD@
    GeneCards (Weizmann)TRD
    Ensembl hg19 (Hinxton) [Gene_View]
    Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  - [Contig_View]  TRD [Vega]
    TCGA cBioPortalTRD
    AceView (NCBI)TRD
    Genatlas (Paris)TRD
    SOURCE (Princeton)TRD
    Genetics Home Reference (NIH)TRD
    Genomic and cartography
    GoldenPath hg38 (UCSC)TRD  -  
    GoldenPath hg19 (UCSC)TRD  -  
    GoldenPathTRD - [CytoView hg19]  TRD - [CytoView hg38]
    Genome Data Viewer NCBITRD [Mapview hg19]  
    Gene and transcription
    Genbank (Entrez)-
    RefSeq transcript (Entrez)
    Consensus coding sequences : CCDS (NCBI)TRD
    Gene ExpressionTRD [ NCBI-GEO ]   TRD [ EBI - ARRAY_EXPRESS ]   TRD [ SEEK ]   TRD [ MEM ]
    Gene Expression Viewer (FireBrowse)TRD [ Firebrowse - Broad ]
    GenevisibleExpression of TRD in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)6964
    GTEX Portal (Tissue expression)TRD
    Protein : pattern, domain, 3D structure
    Domain families : Pfam (Sanger)
    Domain families : Pfam (NCBI)
    Conserved Domain (NCBI)TRD
    Protein Interaction databases
    Ontologies - Pathways
    PubMed58 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Fri Oct 8 21:29:13 CEST 2021

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