Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TRDMT1 (tRNA aspartic acid methyltransferase 1)

Identity

Alias_namesDNMT2
DNA (cytosine-5-)-methyltransferase 2
Alias_symbol (synonym)RNMT1
Other aliasDMNT2
MHSAIIP
PUMET
HGNC (Hugo) TRDMT1
LocusID (NCBI) 1787
Atlas_Id 40348
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 17137336 and ends at 17202071 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TRDMT1 (10p13) / NID2 (14q22.1)TRDMT1 (10p13) / PANK1 (10q23.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TRDMT1   2977
Cards
Entrez_Gene (NCBI)TRDMT1  1787  tRNA aspartic acid methyltransferase 1
AliasesDMNT2; DNMT2; MHSAIIP; PUMET; 
RNMT1
GeneCards (Weizmann)TRDMT1
Ensembl hg19 (Hinxton)ENSG00000107614 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107614 [Gene_View]  ENSG00000107614 [Sequence]  chr10:17137336-17202071 [Contig_View]  TRDMT1 [Vega]
ICGC DataPortalENSG00000107614
TCGA cBioPortalTRDMT1
AceView (NCBI)TRDMT1
Genatlas (Paris)TRDMT1
WikiGenes1787
SOURCE (Princeton)TRDMT1
Genetics Home Reference (NIH)TRDMT1
Genomic and cartography
GoldenPath hg38 (UCSC)TRDMT1  -     chr10:17137336-17202071 -  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRDMT1  -     10p13   [Description]    (hg19-Feb_2009)
EnsemblTRDMT1 - 10p13 [CytoView hg19]  TRDMT1 - 10p13 [CytoView hg38]
Mapping of homologs : NCBITRDMT1 [Mapview hg19]  TRDMT1 [Mapview hg38]
OMIM602478   
Gene and transcription
Genbank (Entrez)AA399591 AF012128 AF045888 AF329940 AF329941
RefSeq transcript (Entrez)NM_001321006 NM_001321007 NM_001351219 NM_001351220 NM_001351221 NM_001351222 NM_001351223 NM_004412 NM_176081 NM_176083 NM_176084 NM_176085 NM_176086
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRDMT1
Cluster EST : UnigeneHs.733857 [ NCBI ]
CGAP (NCI)Hs.733857
Alternative Splicing GalleryENSG00000107614
Gene ExpressionTRDMT1 [ NCBI-GEO ]   TRDMT1 [ EBI - ARRAY_EXPRESS ]   TRDMT1 [ SEEK ]   TRDMT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TRDMT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1787
GTEX Portal (Tissue expression)TRDMT1
Human Protein AtlasENSG00000107614-TRDMT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14717   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14717  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14717
Splice isoforms : SwissVarO14717
Catalytic activity : Enzyme2.1.1.204 [ Enzyme-Expasy ]   2.1.1.2042.1.1.204 [ IntEnz-EBI ]   2.1.1.204 [ BRENDA ]   2.1.1.204 [ KEGG ]   
PhosPhoSitePlusO14717
Domaine pattern : Prosite (Expaxy)C5_MTASE_2 (PS00095)    SAM_MT_C5 (PS51679)   
Domains : Interpro (EBI)C5_MeTfrase    C5_meth_CS    SAM-dependent_MTases   
Domain families : Pfam (Sanger)DNA_methylase (PF00145)   
Domain families : Pfam (NCBI)pfam00145   
Conserved Domain (NCBI)TRDMT1
DMDM Disease mutations1787
Blocks (Seattle)TRDMT1
PDB (SRS)1G55   
PDB (PDBSum)1G55   
PDB (IMB)1G55   
PDB (RSDB)1G55   
Structural Biology KnowledgeBase1G55   
SCOP (Structural Classification of Proteins)1G55   
CATH (Classification of proteins structures)1G55   
SuperfamilyO14717
Human Protein Atlas [tissue]ENSG00000107614-TRDMT1 [tissue]
Peptide AtlasO14717
HPRD16001
IPIIPI00034003   IPI00219905   IPI00219906   IPI00219907   IPI00219908   IPI00221269   IPI00910354   IPI00643876   IPI00643658   IPI00478346   IPI00922351   
Protein Interaction databases
DIP (DOE-UCLA)O14717
IntAct (EBI)O14717
FunCoupENSG00000107614
BioGRIDTRDMT1
STRING (EMBL)TRDMT1
ZODIACTRDMT1
Ontologies - Pathways
QuickGOO14717
Ontology : AmiGOresponse to amphetamine  RNA binding  nucleoplasm  cytoplasm  tRNA modification  tRNA methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA methylation  
Ontology : EGO-EBIresponse to amphetamine  RNA binding  nucleoplasm  cytoplasm  tRNA modification  tRNA methyltransferase activity  tRNA (cytosine-5-)-methyltransferase activity  tRNA methylation  
NDEx NetworkTRDMT1
Atlas of Cancer Signalling NetworkTRDMT1
Wikipedia pathwaysTRDMT1
Orthology - Evolution
OrthoDB1787
GeneTree (enSembl)ENSG00000107614
Phylogenetic Trees/Animal Genes : TreeFamTRDMT1
HOVERGENO14717
HOGENOMO14717
Homologs : HomoloGeneTRDMT1
Homology/Alignments : Family Browser (UCSC)TRDMT1
Gene fusions - Rearrangements
Fusion : QuiverTRDMT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRDMT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRDMT1
dbVarTRDMT1
ClinVarTRDMT1
1000_GenomesTRDMT1 
Exome Variant ServerTRDMT1
ExAC (Exome Aggregation Consortium)ENSG00000107614
GNOMAD BrowserENSG00000107614
Varsome BrowserTRDMT1
Genetic variants : HAPMAP1787
Genomic Variants (DGV)TRDMT1 [DGVbeta]
DECIPHERTRDMT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRDMT1 
Mutations
ICGC Data PortalTRDMT1 
TCGA Data PortalTRDMT1 
Broad Tumor PortalTRDMT1
OASIS PortalTRDMT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRDMT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRDMT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRDMT1
DgiDB (Drug Gene Interaction Database)TRDMT1
DoCM (Curated mutations)TRDMT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRDMT1 (select a term)
intoGenTRDMT1
Cancer3DTRDMT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602478   
Orphanet
DisGeNETTRDMT1
MedgenTRDMT1
Genetic Testing Registry TRDMT1
NextProtO14717 [Medical]
TSGene1787
GENETestsTRDMT1
Target ValidationTRDMT1
Huge Navigator TRDMT1 [HugePedia]
snp3D : Map Gene to Disease1787
BioCentury BCIQTRDMT1
ClinGenTRDMT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1787
Chemical/Pharm GKB GenePA162406922
Clinical trialTRDMT1
Miscellaneous
canSAR (ICR)TRDMT1 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRDMT1
EVEXTRDMT1
GoPubMedTRDMT1
iHOPTRDMT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:46:39 CET 2018
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