Identity
HGNC
LOCATION
10p13
LOCUSID
ALIAS
DMNT2,DNMT2,MHSAIIP,PUMET,RNMT1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1787
MIM: 602478
HGNC: 2977
Ensembl: ENSG00000107614
Variants:
dbSNP: 1787
ClinVar: 1787
TCGA: ENSG00000107614
COSMIC: TRDMT1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36273376 | 2023 | DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis. | 5 |
| 36273376 | 2023 | DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis. | 5 |
| 34100772 | 2021 | TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure. | 8 |
| 34139673 | 2021 | The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. | 18 |
| 34871455 | 2021 | Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2. | 8 |
| 34100772 | 2021 | TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure. | 8 |
| 34139673 | 2021 | The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence. | 18 |
| 34871455 | 2021 | Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2. | 8 |
| 33331537 | 2020 | Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation. | 0 |
| 33369458 | 2020 | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | 5 |
| 33331537 | 2020 | Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation. | 0 |
| 33369458 | 2020 | Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma. | 5 |
| 31570165 | 2019 | Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration. | 34 |
| 31570165 | 2019 | Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration. | 34 |
| 28476776 | 2017 | Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection. | 33 |
Citation
Dessen P
TRDMT1 (tRNA aspartic acid methyltransferase 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40348/trdmt1
