TRDMT1 (tRNA aspartic acid methyltransferase 1)

2003-02-01  

Identity

HGNC
TRDMT1
LOCATION
10p13
LOCUSID
1787
ALIAS
DMNT2,DNMT2,MHSAIIP,PUMET,RNMT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1787
MIM: 602478
HGNC: 2977
Ensembl: ENSG00000107614

Variants:

dbSNP: 1787
ClinVar: 1787
TCGA: ENSG00000107614
COSMIC: TRDMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107614ENST00000313936H0Y2T8
ENSG00000107614ENST00000354631Q7Z3E4
ENSG00000107614ENST00000377799O14717
ENSG00000107614ENST00000377799Q6ICS7
ENSG00000107614ENST00000424636A0A0C4DG18
ENSG00000107614ENST00000436968H0Y4A2
ENSG00000107614ENST00000488990B7Z8H2
ENSG00000107614ENST00000495022O14717
ENSG00000107614ENST00000495022A0A0U1SZ86
ENSG00000107614ENST00000525762A0A0B4J214

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
164243442006Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2.278
127940652003The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity.52
201474122010Hepatitis B virus replication induces methylation of both host and viral DNA.38
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
196805562009Genetic variation in healthy oldest-old.20
208648162011The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.17
229427082012Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the Southern Chinese population.17
192465182009A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation.15
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Dessen P

TRDMT1 (tRNA aspartic acid methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40348/trdmt1