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TREM2 (triggering receptor expressed on myeloid cells 2)

Identity

Alias_namestriggering receptor expressed on myeloid cells 2a
Alias_symbol (synonym)TREM-2
Trem2a
Trem2b
Trem2c
Other alias
HGNC (Hugo) TREM2
LocusID (NCBI) 54209
Atlas_Id 55900
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41158506 and ends at 41163186 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TREM2   17761
LRG (Locus Reference Genomic)LRG_631
Cards
Entrez_Gene (NCBI)TREM2  54209  triggering receptor expressed on myeloid cells 2
AliasesTREM-2; Trem2a; Trem2b; Trem2c
GeneCards (Weizmann)TREM2
Ensembl hg19 (Hinxton)ENSG00000095970 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095970 [Gene_View]  ENSG00000095970 [Sequence]  chr6:41158506-41163186 [Contig_View]  TREM2 [Vega]
ICGC DataPortalENSG00000095970
TCGA cBioPortalTREM2
AceView (NCBI)TREM2
Genatlas (Paris)TREM2
WikiGenes54209
SOURCE (Princeton)TREM2
Genetics Home Reference (NIH)TREM2
Genomic and cartography
GoldenPath hg38 (UCSC)TREM2  -     chr6:41158506-41163186 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TREM2  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblTREM2 - 6p21.1 [CytoView hg19]  TREM2 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBITREM2 [Mapview hg19]  TREM2 [Mapview hg38]
OMIM221770   605086   
Gene and transcription
Genbank (Entrez)AB062787 AF213457 AK312215 BC018284 BC032362
RefSeq transcript (Entrez)NM_001271821 NM_018965
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TREM2
Cluster EST : UnigeneHs.435295 [ NCBI ]
CGAP (NCI)Hs.435295
Alternative Splicing GalleryENSG00000095970
Gene ExpressionTREM2 [ NCBI-GEO ]   TREM2 [ EBI - ARRAY_EXPRESS ]   TREM2 [ SEEK ]   TREM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TREM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54209
GTEX Portal (Tissue expression)TREM2
Human Protein AtlasENSG00000095970-TREM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZC2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZC2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZC2
Splice isoforms : SwissVarQ9NZC2
PhosPhoSitePlusQ9NZC2
Domains : Interpro (EBI)Ig-like_dom_sf    Ig-like_fold    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Conserved Domain (NCBI)TREM2
DMDM Disease mutations54209
Blocks (Seattle)TREM2
PDB (SRS)5ELI   
PDB (PDBSum)5ELI   
PDB (IMB)5ELI   
PDB (RSDB)5ELI   
Structural Biology KnowledgeBase5ELI   
SCOP (Structural Classification of Proteins)5ELI   
CATH (Classification of proteins structures)5ELI   
SuperfamilyQ9NZC2
Human Protein Atlas [tissue]ENSG00000095970-TREM2 [tissue]
Peptide AtlasQ9NZC2
HPRD05473
IPIIPI00103749   IPI00384361   IPI00429125   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZC2
IntAct (EBI)Q9NZC2
FunCoupENSG00000095970
BioGRIDTREM2
STRING (EMBL)TREM2
ZODIACTREM2
Ontologies - Pathways
QuickGOQ9NZC2
Ontology : AmiGOlipopolysaccharide binding  positive regulation of antigen processing and presentation of peptide antigen via MHC class II  phospholipid binding  extracellular region  plasma membrane  plasma membrane  phagocytosis, engulfment  humoral immune response  integral component of membrane  osteoclast differentiation  detection of lipopolysaccharide  detection of peptidoglycan  signaling receptor activity  peptidoglycan binding  innate immune response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  positive regulation of calcium-mediated signaling  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  detection of lipoteichoic acid  lipoteichoic acid binding  cellular response to lipoteichoic acid  cellular response to peptidoglycan  dendritic cell differentiation  scaffold protein binding  positive regulation of protein localization to plasma membrane  positive regulation of C-C chemokine receptor CCR7 signaling pathway  positive regulation of CD40 signaling pathway  
Ontology : EGO-EBIlipopolysaccharide binding  positive regulation of antigen processing and presentation of peptide antigen via MHC class II  phospholipid binding  extracellular region  plasma membrane  plasma membrane  phagocytosis, engulfment  humoral immune response  integral component of membrane  osteoclast differentiation  detection of lipopolysaccharide  detection of peptidoglycan  signaling receptor activity  peptidoglycan binding  innate immune response  positive regulation of peptidyl-tyrosine phosphorylation  regulation of immune response  positive regulation of calcium-mediated signaling  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  detection of lipoteichoic acid  lipoteichoic acid binding  cellular response to lipoteichoic acid  cellular response to peptidoglycan  dendritic cell differentiation  scaffold protein binding  positive regulation of protein localization to plasma membrane  positive regulation of C-C chemokine receptor CCR7 signaling pathway  positive regulation of CD40 signaling pathway  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkTREM2
Atlas of Cancer Signalling NetworkTREM2
Wikipedia pathwaysTREM2
Orthology - Evolution
OrthoDB54209
GeneTree (enSembl)ENSG00000095970
Phylogenetic Trees/Animal Genes : TreeFamTREM2
HOVERGENQ9NZC2
HOGENOMQ9NZC2
Homologs : HomoloGeneTREM2
Homology/Alignments : Family Browser (UCSC)TREM2
Gene fusions - Rearrangements
Fusion : QuiverTREM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTREM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TREM2
dbVarTREM2
ClinVarTREM2
1000_GenomesTREM2 
Exome Variant ServerTREM2
ExAC (Exome Aggregation Consortium)ENSG00000095970
GNOMAD BrowserENSG00000095970
Varsome BrowserTREM2
Genetic variants : HAPMAP54209
Genomic Variants (DGV)TREM2 [DGVbeta]
DECIPHERTREM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTREM2 
Mutations
ICGC Data PortalTREM2 
TCGA Data PortalTREM2 
Broad Tumor PortalTREM2
OASIS PortalTREM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTREM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTREM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TREM2
DgiDB (Drug Gene Interaction Database)TREM2
DoCM (Curated mutations)TREM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TREM2 (select a term)
intoGenTREM2
Cancer3DTREM2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM221770    605086   
Orphanet106    2523    20340    14642    14643   
DisGeNETTREM2
MedgenTREM2
Genetic Testing Registry TREM2
NextProtQ9NZC2 [Medical]
TSGene54209
GENETestsTREM2
Target ValidationTREM2
Huge Navigator TREM2 [HugePedia]
snp3D : Map Gene to Disease54209
BioCentury BCIQTREM2
ClinGenTREM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54209
Chemical/Pharm GKB GenePA38468
Clinical trialTREM2
Miscellaneous
canSAR (ICR)TREM2 (select the gene name)
Probes
Litterature
PubMed140 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTREM2
EVEXTREM2
GoPubMedTREM2
iHOPTREM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:46:41 CET 2018

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