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TREM2 (triggering receptor expressed on myeloid cells 2)

Identity

Alias (NCBI)PLOSL2
TREM-2
Trem2a
Trem2b
Trem2c
HGNC (Hugo) TREM2
HGNC Alias symbTREM-2
Trem2a
Trem2b
Trem2c
HGNC Previous nametriggering receptor expressed on myeloid cells 2a
LocusID (NCBI) 54209
Atlas_Id 55900
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41158508 and ends at 41163116 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TREM2   17761
LRG (Locus Reference Genomic)LRG_631
Cards
Entrez_Gene (NCBI)TREM2    triggering receptor expressed on myeloid cells 2
AliasesPLOSL2; TREM-2; Trem2a; Trem2b; 
Trem2c
GeneCards (Weizmann)TREM2
Ensembl hg19 (Hinxton)ENSG00000095970 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095970 [Gene_View]  ENSG00000095970 [Sequence]  chr6:41158508-41163116 [Contig_View]  TREM2 [Vega]
ICGC DataPortalENSG00000095970
TCGA cBioPortalTREM2
AceView (NCBI)TREM2
Genatlas (Paris)TREM2
SOURCE (Princeton)TREM2
Genetics Home Reference (NIH)TREM2
Genomic and cartography
GoldenPath hg38 (UCSC)TREM2  -     chr6:41158508-41163116 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TREM2  -     6p21.1   [Description]    (hg19-Feb_2009)
GoldenPathTREM2 - 6p21.1 [CytoView hg19]  TREM2 - 6p21.1 [CytoView hg38]
ImmunoBaseENSG00000095970
Genome Data Viewer NCBITREM2 [Mapview hg19]  
OMIM605086   618193   
Gene and transcription
Genbank (Entrez)AB062787 AF213457 AK312215 BC018284 BC032362
RefSeq transcript (Entrez)NM_001271821 NM_018965
Consensus coding sequences : CCDS (NCBI)TREM2
Gene ExpressionTREM2 [ NCBI-GEO ]   TREM2 [ EBI - ARRAY_EXPRESS ]   TREM2 [ SEEK ]   TREM2 [ MEM ]
Gene Expression Viewer (FireBrowse)TREM2 [ Firebrowse - Broad ]
GenevisibleExpression of TREM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54209
GTEX Portal (Tissue expression)TREM2
Human Protein AtlasENSG00000095970-TREM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZC2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZC2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZC2
PhosPhoSitePlusQ9NZC2
Domains : Interpro (EBI)Ig-like_dom_sf    Ig-like_fold    Ig_V-set   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Conserved Domain (NCBI)TREM2
PDB (RSDB)5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
PDB Europe5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
PDB (PDBSum)5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
PDB (IMB)5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
Structural Biology KnowledgeBase5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
SCOP (Structural Classification of Proteins)5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
CATH (Classification of proteins structures)5ELI    5UD7    5UD8    6B8O    6Z0G    6Z0H    6Z0I   
SuperfamilyQ9NZC2
AlphaFold pdb e-kbQ9NZC2   
Human Protein Atlas [tissue]ENSG00000095970-TREM2 [tissue]
HPRD05473
Protein Interaction databases
DIP (DOE-UCLA)Q9NZC2
IntAct (EBI)Q9NZC2
BioGRIDTREM2
STRING (EMBL)TREM2
ZODIACTREM2
Ontologies - Pathways
QuickGOQ9NZC2
Ontology : AmiGOlipopolysaccharide binding  amyloid-beta binding  microglial cell activation  phosphatidylserine binding  positive regulation of protein phosphorylation  microglial cell activation involved in immune response  positive regulation of antigen processing and presentation of peptide antigen via MHC class II  negative regulation of inflammatory response to antigenic stimulus  response to ischemia  transmembrane signaling receptor activity  protein binding  phospholipid binding  extracellular region  plasma membrane  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  phagocytosis, engulfment  humoral immune response  memory  memory  high-density lipoprotein particle binding  lipid binding  phosphatidylethanolamine binding  regulation of gene expression  negative regulation of autophagy  positive regulation of gene expression  positive regulation of mitochondrion organization  positive regulation of cholesterol efflux  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  positive regulation of high-density lipoprotein particle clearance  negative regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  kinase activator activity  low-density lipoprotein particle binding  osteoclast differentiation  osteoclast differentiation  intrinsic component of plasma membrane  regulation of TOR signaling  positive regulation of TOR signaling  detection of lipopolysaccharide  detection of peptidoglycan  regulation of interleukin-6 production  negative regulation of interleukin-1 beta production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  positive regulation of kinase activity  negative regulation of toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 4 signaling pathway  regulation of toll-like receptor 6 signaling pathway  apolipoprotein binding  apolipoprotein A-I binding  very-low-density lipoprotein particle binding  positive regulation of macrophage fusion  negative regulation of glial cell apoptotic process  social behavior  signaling receptor activity  CXCL12-activated CXCR4 signaling pathway  peptidoglycan binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  apoptotic cell clearance  plasma membrane raft  protein-containing complex binding  innate immune response  regulation of innate immune response  positive regulation of osteoclast differentiation  respiratory burst after phagocytosis  positive regulation of complement activation, classical pathway  astrocyte activation  response to axon injury  response to axon injury  positive regulation of protein secretion  regulation of peptidyl-tyrosine phosphorylation  regulation of peptidyl-tyrosine phosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  positive regulation of phagocytosis  regulation of immune response  defense response to Gram-negative bacterium  positive regulation of calcium-mediated signaling  positive regulation of calcium-mediated signaling  negative regulation of cell activation  positive regulation of chemotaxis  lipid homeostasis  regulation of resting membrane potential  positive regulation of phagocytosis, engulfment  positive regulation of phagocytosis, engulfment  positive regulation of phagocytosis, engulfment  microglial cell proliferation  negative regulation of astrocyte activation  pyroptosis  negative regulation of fat cell proliferation  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  detection of lipoteichoic acid  lipoteichoic acid binding  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to glucose stimulus  cellular response to hypoxia  regulation of macrophage inflammatory protein 1 alpha production  lipoprotein particle binding  dendritic cell differentiation  dendritic spine maintenance  scaffold protein binding  import into cell  regulation of hippocampal neuron apoptotic process  regulation of plasma membrane bounded cell projection organization  regulation of plasma membrane bounded cell projection organization  regulation of plasma membrane bounded cell projection organization  sulfatide binding  cellular response to oxidised low-density lipoprotein particle stimulus  complement-mediated synapse pruning  neuroinflammatory response  negative regulation of neuroinflammatory response  amyloid-beta clearance by cellular catabolic process  amyloid-beta clearance by cellular catabolic process  regulation of cytokine production involved in inflammatory response  negative regulation of cytokine production involved in inflammatory response  positive regulation of amyloid-beta clearance  positive regulation of amyloid-beta clearance  negative regulation of NLRP3 inflammasome complex assembly  positive regulation of engulfment of apoptotic cell  positive regulation of NIK/NF-kappaB signaling  positive regulation of proteasomal protein catabolic process  positive regulation of inward rectifier potassium channel activity  negative regulation of macrophage colony-stimulating factor signaling pathway  regulation of intracellular signal transduction  positive regulation of protein localization to plasma membrane  positive regulation of C-C chemokine receptor CCR7 signaling pathway  regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of p38MAPK cascade  positive regulation of microglial cell activation  positive regulation of microglial cell activation  positive regulation of microglial cell activation  negative regulation of autophagic cell death  positive regulation of microglial cell migration  positive regulation of microglial cell migration  cellular response to amyloid-beta  positive regulation of establishment of protein localization  positive regulation of CAMKK-AMPK signaling cascade  positive regulation of low-density lipoprotein particle clearance  excitatory synapse pruning  positive regulation of synapse pruning  negative regulation of amyloid fibril formation  protein tyrosine kinase binding  positive regulation of CD40 signaling pathway  positive regulation of ATP biosynthetic process  
Ontology : EGO-EBIlipopolysaccharide binding  amyloid-beta binding  microglial cell activation  phosphatidylserine binding  positive regulation of protein phosphorylation  microglial cell activation involved in immune response  positive regulation of antigen processing and presentation of peptide antigen via MHC class II  negative regulation of inflammatory response to antigenic stimulus  response to ischemia  transmembrane signaling receptor activity  protein binding  phospholipid binding  extracellular region  plasma membrane  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  phagocytosis, engulfment  humoral immune response  memory  memory  high-density lipoprotein particle binding  lipid binding  phosphatidylethanolamine binding  regulation of gene expression  negative regulation of autophagy  positive regulation of gene expression  positive regulation of mitochondrion organization  positive regulation of cholesterol efflux  negative regulation of cholesterol storage  negative regulation of sequestering of triglyceride  positive regulation of high-density lipoprotein particle clearance  negative regulation of phosphatidylinositol 3-kinase signaling  positive regulation of phosphatidylinositol 3-kinase signaling  integral component of membrane  kinase activator activity  low-density lipoprotein particle binding  osteoclast differentiation  osteoclast differentiation  intrinsic component of plasma membrane  regulation of TOR signaling  positive regulation of TOR signaling  detection of lipopolysaccharide  detection of peptidoglycan  regulation of interleukin-6 production  negative regulation of interleukin-1 beta production  negative regulation of tumor necrosis factor production  positive regulation of interleukin-10 production  positive regulation of kinase activity  negative regulation of toll-like receptor 2 signaling pathway  negative regulation of toll-like receptor 4 signaling pathway  regulation of toll-like receptor 6 signaling pathway  apolipoprotein binding  apolipoprotein A-I binding  very-low-density lipoprotein particle binding  positive regulation of macrophage fusion  negative regulation of glial cell apoptotic process  social behavior  signaling receptor activity  CXCL12-activated CXCR4 signaling pathway  peptidoglycan binding  negative regulation of I-kappaB kinase/NF-kappaB signaling  apoptotic cell clearance  plasma membrane raft  protein-containing complex binding  innate immune response  regulation of innate immune response  positive regulation of osteoclast differentiation  respiratory burst after phagocytosis  positive regulation of complement activation, classical pathway  astrocyte activation  response to axon injury  response to axon injury  positive regulation of protein secretion  regulation of peptidyl-tyrosine phosphorylation  regulation of peptidyl-tyrosine phosphorylation  positive regulation of peptidyl-tyrosine phosphorylation  positive regulation of phagocytosis  positive regulation of phagocytosis  regulation of immune response  defense response to Gram-negative bacterium  positive regulation of calcium-mediated signaling  positive regulation of calcium-mediated signaling  negative regulation of cell activation  positive regulation of chemotaxis  lipid homeostasis  regulation of resting membrane potential  positive regulation of phagocytosis, engulfment  positive regulation of phagocytosis, engulfment  positive regulation of phagocytosis, engulfment  microglial cell proliferation  negative regulation of astrocyte activation  pyroptosis  negative regulation of fat cell proliferation  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  detection of lipoteichoic acid  lipoteichoic acid binding  cellular response to lipoteichoic acid  cellular response to peptidoglycan  cellular response to glucose stimulus  cellular response to hypoxia  regulation of macrophage inflammatory protein 1 alpha production  lipoprotein particle binding  dendritic cell differentiation  dendritic spine maintenance  scaffold protein binding  import into cell  regulation of hippocampal neuron apoptotic process  regulation of plasma membrane bounded cell projection organization  regulation of plasma membrane bounded cell projection organization  regulation of plasma membrane bounded cell projection organization  sulfatide binding  cellular response to oxidised low-density lipoprotein particle stimulus  complement-mediated synapse pruning  neuroinflammatory response  negative regulation of neuroinflammatory response  amyloid-beta clearance by cellular catabolic process  amyloid-beta clearance by cellular catabolic process  regulation of cytokine production involved in inflammatory response  negative regulation of cytokine production involved in inflammatory response  positive regulation of amyloid-beta clearance  positive regulation of amyloid-beta clearance  negative regulation of NLRP3 inflammasome complex assembly  positive regulation of engulfment of apoptotic cell  positive regulation of NIK/NF-kappaB signaling  positive regulation of proteasomal protein catabolic process  positive regulation of inward rectifier potassium channel activity  negative regulation of macrophage colony-stimulating factor signaling pathway  regulation of intracellular signal transduction  positive regulation of protein localization to plasma membrane  positive regulation of C-C chemokine receptor CCR7 signaling pathway  regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of p38MAPK cascade  positive regulation of microglial cell activation  positive regulation of microglial cell activation  positive regulation of microglial cell activation  negative regulation of autophagic cell death  positive regulation of microglial cell migration  positive regulation of microglial cell migration  cellular response to amyloid-beta  positive regulation of establishment of protein localization  positive regulation of CAMKK-AMPK signaling cascade  positive regulation of low-density lipoprotein particle clearance  excitatory synapse pruning  positive regulation of synapse pruning  negative regulation of amyloid fibril formation  protein tyrosine kinase binding  positive regulation of CD40 signaling pathway  positive regulation of ATP biosynthetic process  
Pathways : KEGGOsteoclast differentiation   
NDEx NetworkTREM2
Atlas of Cancer Signalling NetworkTREM2
Wikipedia pathwaysTREM2
Orthology - Evolution
OrthoDB54209
GeneTree (enSembl)ENSG00000095970
Phylogenetic Trees/Animal Genes : TreeFamTREM2
Homologs : HomoloGeneTREM2
Homology/Alignments : Family Browser (UCSC)TREM2
Gene fusions - Rearrangements
Fusion : QuiverTREM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTREM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TREM2
dbVarTREM2
ClinVarTREM2
MonarchTREM2
1000_GenomesTREM2 
Exome Variant ServerTREM2
GNOMAD BrowserENSG00000095970
Varsome BrowserTREM2
ACMGTREM2 variants
VarityQ9NZC2
Genomic Variants (DGV)TREM2 [DGVbeta]
DECIPHERTREM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTREM2 
Mutations
ICGC Data PortalTREM2 
TCGA Data PortalTREM2 
Broad Tumor PortalTREM2
OASIS PortalTREM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTREM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTREM2
Mutations and Diseases : HGMDTREM2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTREM2
DgiDB (Drug Gene Interaction Database)TREM2
DoCM (Curated mutations)TREM2
CIViC (Clinical Interpretations of Variants in Cancer)TREM2
Cancer3DTREM2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605086    618193   
Orphanet106    2523    20340    14642    14643   
DisGeNETTREM2
MedgenTREM2
Genetic Testing Registry TREM2
NextProtQ9NZC2 [Medical]
GENETestsTREM2
Target ValidationTREM2
Huge Navigator TREM2 [HugePedia]
ClinGenTREM2
Clinical trials, drugs, therapy
MyCancerGenomeTREM2
Protein Interactions : CTDTREM2
Pharm GKB GenePA38468
PharosQ9NZC2
Clinical trialTREM2
Miscellaneous
canSAR (ICR)TREM2
HarmonizomeTREM2
DataMed IndexTREM2
Probes
Litterature
PubMed218 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTREM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:14 CEST 2021

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