TREML4 (triggering receptor expressed on myeloid cells like 4)

2014-11-01 Affiliation

Identity

HGNC

TREML4

LOCATION

6p21.1

LOCUSID

285852

ALIAS

TLT-4,TLT4

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 285852
MIM: 614664
HGNC: 30807
Ensembl: ENSG00000188056

Variants:

dbSNP: 285852
ClinVar: 285852
TCGA: ENSG00000188056
COSMIC: TREML4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000188056	ENST00000341495	Q6UXN2
ENSG00000188056	ENST00000448827	Q6UXN2
ENSG00000188056	ENST00000461240	H7C4X5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA10066	duloxetine	Chemical	ClinicalAnnotation	associated		PD	29407288
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated		PD	29407288

References

Pubmed ID	Year	Title	Citations
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
24975946	2014	Integrative DNA, RNA, and protein evidence connects TREML4 to coronary artery calcification.	0

Citation

Dessen P

TREML4 (triggering receptor expressed on myeloid cells like 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75135/treml4