Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TREX1 (three prime repair exonuclease 1)

Identity

Other namesAGS1
CRV
DRN3
HERNS
HGNC (Hugo) TREX1
LocusID (NCBI) 11277
Atlas_Id 42696
Location 3p21.31
Location_base_pair Starts at 48506919 and ends at 48509044 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TREX1 (3p21.31) / TREX1 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TREX1   12269
Cards
Entrez_Gene (NCBI)TREX1  11277  three prime repair exonuclease 1
GeneCards (Weizmann)TREX1
Ensembl hg19 (Hinxton)ENSG00000213689 [Gene_View]  chr3:48506919-48509044 [Contig_View]  TREX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000213689 [Gene_View]  chr3:48506919-48509044 [Contig_View]  TREX1 [Vega]
ICGC DataPortalENSG00000213689
TCGA cBioPortalTREX1
AceView (NCBI)TREX1
Genatlas (Paris)TREX1
WikiGenes11277
SOURCE (Princeton)TREX1
Genomic and cartography
GoldenPath hg19 (UCSC)TREX1  -     chr3:48506919-48509044 +  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TREX1  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblTREX1 - 3p21.31 [CytoView hg19]  TREX1 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBITREX1 [Mapview hg19]  TREX1 [Mapview hg38]
OMIM152700   192315   225750   606609   610448   
Gene and transcription
Genbank (Entrez)AF151105 AJ243797 AK315196 AL137745 BC019863
RefSeq transcript (Entrez)NM_007248 NM_016381 NM_033627 NM_033628 NM_033629
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_009820 NG_041782 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TREX1
Cluster EST : UnigeneHs.744646 [ NCBI ]
CGAP (NCI)Hs.744646
Alternative Splicing : Fast-db (Paris)GSHG0020793
Alternative Splicing GalleryENSG00000213689
Gene ExpressionTREX1 [ NCBI-GEO ]   TREX1 [ EBI - ARRAY_EXPRESS ]   TREX1 [ SEEK ]   TREX1 [ MEM ]
Gene Expression Viewer (FireBrowse)TREX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)11277
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSU2 (Uniprot)
NextProtQ9NSU2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NSU2
Splice isoforms : SwissVarQ9NSU2 (Swissvar)
Catalytic activity : Enzyme3.1.11.2 [ Enzyme-Expasy ]   3.1.11.23.1.11.2 [ IntEnz-EBI ]   3.1.11.2 [ BRENDA ]   3.1.11.2 [ KEGG ]   
PhosPhoSitePlusQ9NSU2
Domains : Interpro (EBI)RNaseH-like_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations11277
Blocks (Seattle)TREX1
SuperfamilyQ9NSU2
Human Protein AtlasENSG00000213689
Peptide AtlasQ9NSU2
HPRD09423
IPIIPI00220019   IPI00411455   IPI00085084   IPI00872616   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSU2
IntAct (EBI)Q9NSU2
FunCoupENSG00000213689
BioGRIDTREX1
STRING (EMBL)TREX1
ZODIACTREX1
Ontologies - Pathways
QuickGOQ9NSU2
Ontology : AmiGOsingle-stranded DNA binding  protein binding  nuclear envelope  endoplasmic reticulum membrane  cytosol  DNA metabolic process  DNA replication  DNA repair  mismatch repair  DNA recombination  3'-5'-exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease III activity  MutLalpha complex binding  MutSalpha complex binding  regulation of type I interferon production  protein homodimerization activity  protein homodimerization activity  metal ion binding  metal ion binding  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIsingle-stranded DNA binding  protein binding  nuclear envelope  endoplasmic reticulum membrane  cytosol  DNA metabolic process  DNA replication  DNA repair  mismatch repair  DNA recombination  3'-5'-exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease III activity  MutLalpha complex binding  MutSalpha complex binding  regulation of type I interferon production  protein homodimerization activity  protein homodimerization activity  metal ion binding  metal ion binding  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
Pathways : KEGGCytosolic DNA-sensing pathway   
NDEx Network
Atlas of Cancer Signalling NetworkTREX1
Wikipedia pathwaysTREX1
Orthology - Evolution
OrthoDB11277
GeneTree (enSembl)ENSG00000213689
Phylogenetic Trees/Animal Genes : TreeFamTREX1
Homologs : HomoloGeneTREX1
Homology/Alignments : Family Browser (UCSC)TREX1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTREX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TREX1
dbVarTREX1
ClinVarTREX1
1000_GenomesTREX1 
Exome Variant ServerTREX1
ExAC (Exome Aggregation Consortium)TREX1 (select the gene name)
SNP (GeneSNP Utah)TREX1
SNP : HGBaseTREX1
Genetic variants : HAPMAPTREX1
Genomic Variants (DGV)TREX1 [DGVbeta]
Mutations
ICGC Data PortalTREX1 
TCGA Data PortalTREX1 
Broad Tumor PortalTREX1
OASIS PortalTREX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTREX1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch TREX1
DgiDB (Drug Gene Interaction Database)TREX1
DoCM (Curated mutations)TREX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TREX1 (select a term)
intoGenTREX1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)3:48506919-48509044
CONAN: Copy Number AnalysisTREX1 
Mutations and Diseases : HGMDTREX1
OMIM152700    192315    225750    606609    610448   
MedgenTREX1
Genetic Testing Registry TREX1
NextProtQ9NSU2 [Medical]
TSGene11277
GENETestsTREX1
Huge Navigator TREX1 [HugePedia]  TREX1 [HugeCancerGEM]
snp3D : Map Gene to Disease11277
BioCentury BCIQTREX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11277
Chemical/Pharm GKB GenePA36949
Clinical trialTREX1
Miscellaneous
canSAR (ICR)TREX1 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTREX1
GoPubMedTREX1
iHOPTREX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:08:18 CEST 2016

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