Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TREX1 (three prime repair exonuclease 1)

Identity

Other namesAGS1
CRV
DRN3
HERNS
HGNC (Hugo) TREX1
LocusID (NCBI) 11277
Location 3p21.31
Location_base_pair Starts at 48506919 and ends at 48509044 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TREX1   12269
Cards
Entrez_Gene (NCBI)TREX1  11277  three prime repair exonuclease 1
GeneCards (Weizmann)TREX1
Ensembl (Hinxton)ENSG00000213689 [Gene_View]  chr3:48506919-48509044 [Contig_View]  TREX1 [Vega]
ICGC DataPortalENSG00000213689
cBioPortalTREX1
AceView (NCBI)TREX1
Genatlas (Paris)TREX1
WikiGenes11277
SOURCE (Princeton)NM_007248 NM_016381 NM_033627 NM_033628 NM_033629
Genomic and cartography
GoldenPath (UCSC)TREX1  -  3p21.31   chr3:48506919-48509044 +  3p21.31   [Description]    (hg19-Feb_2009)
EnsemblTREX1 - 3p21.31 [CytoView]
Mapping of homologs : NCBITREX1 [Mapview]
OMIM152700   192315   225750   606609   610448   
Gene and transcription
Genbank (Entrez)AF151105 AJ243797 AK315196 AL137745 BC019863
RefSeq transcript (Entrez)NM_007248 NM_016381 NM_033627 NM_033628 NM_033629
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_009820 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)TREX1
Cluster EST : UnigeneHs.744646 [ NCBI ]
CGAP (NCI)Hs.744646
Alternative Splicing : Fast-db (Paris)GSHG0020793
Alternative Splicing GalleryENSG00000213689
Gene ExpressionTREX1 [ NCBI-GEO ]     TREX1 [ SEEK ]   TREX1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NSU2 (Uniprot)
NextProtQ9NSU2  [Medical]
With graphics : InterProQ9NSU2
Splice isoforms : SwissVarQ9NSU2 (Swissvar)
Catalytic activity : Enzyme3.1.11.2 [ Enzyme-Expasy ]   3.1.11.23.1.11.2 [ IntEnz-EBI ]   3.1.11.2 [ BRENDA ]   3.1.11.2 [ KEGG ]   
Domains : Interpro (EBI)RNaseH-like_dom [organisation]  
Related proteins : CluSTrQ9NSU2
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
DMDM Disease mutations11277
Blocks (Seattle)Q9NSU2
Human Protein AtlasENSG00000213689 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9NSU2
HPRD09423
IPIIPI00220019   IPI00411455   IPI00085084   IPI00872616   
Protein Interaction databases
DIP (DOE-UCLA)Q9NSU2
IntAct (EBI)Q9NSU2
FunCoupENSG00000213689
BioGRIDTREX1
InParanoidQ9NSU2
Interologous Interaction database Q9NSU2
IntegromeDBTREX1
STRING (EMBL)TREX1
Ontologies - Pathways
Ontology : AmiGODNA catabolic process, exonucleolytic  DNA catabolic process, exonucleolytic  DNA catabolic process, exonucleolytic  double-stranded DNA binding  single-stranded DNA binding  nucleus  nuclear envelope  nucleolus  endoplasmic reticulum membrane  cytosol  DNA metabolic process  DNA replication  DNA repair  mismatch repair  DNA recombination  cell death  3'-5'-exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease III activity  MutLalpha complex binding  MutSalpha complex binding  regulation of type I interferon production  positive regulation of type I interferon production  adenyl deoxyribonucleotide binding  cellular response to interferon-beta  protein homodimerization activity  protein homodimerization activity  innate immune response  metal ion binding  metal ion binding  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
Ontology : EGO-EBIDNA catabolic process, exonucleolytic  DNA catabolic process, exonucleolytic  DNA catabolic process, exonucleolytic  double-stranded DNA binding  single-stranded DNA binding  nucleus  nuclear envelope  nucleolus  endoplasmic reticulum membrane  cytosol  DNA metabolic process  DNA replication  DNA repair  mismatch repair  DNA recombination  cell death  3'-5'-exodeoxyribonuclease activity  3'-5' exonuclease activity  3'-5' exonuclease activity  exodeoxyribonuclease III activity  MutLalpha complex binding  MutSalpha complex binding  regulation of type I interferon production  positive regulation of type I interferon production  adenyl deoxyribonucleotide binding  cellular response to interferon-beta  protein homodimerization activity  protein homodimerization activity  innate immune response  metal ion binding  metal ion binding  nucleic acid phosphodiester bond hydrolysis  nucleic acid phosphodiester bond hydrolysis  
Pathways : BIOCARTARole of BRCA1, BRCA2 and ATR in Cancer Susceptibility [Genes]   
Pathways : KEGGCytosolic DNA-sensing pathway   
Protein Interaction DatabaseTREX1
Wikipedia pathwaysTREX1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TREX1
snp3D : Map Gene to Disease11277
SNP (GeneSNP Utah)TREX1
SNP : HGBaseTREX1
Genetic variants : HAPMAPTREX1
Exome VariantTREX1
1000_GenomesTREX1 
ICGC programENSG00000213689 
Somatic Mutations in Cancer : COSMICTREX1 
CONAN: Copy Number AnalysisTREX1 
Mutations and Diseases : HGMDTREX1
Mutations and Diseases : intOGenTREX1
Genomic VariantsTREX1  TREX1 [DGVbeta]
dbVarTREX1
ClinVarTREX1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM152700    192315    225750    606609    610448   
MedgenTREX1
GENETestsTREX1
Disease Genetic AssociationTREX1
Huge Navigator TREX1 [HugePedia]  TREX1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTREX1
Homology/Alignments : Family Browser (UCSC)TREX1
Phylogenetic Trees/Animal Genes : TreeFamTREX1
Chemical/Protein Interactions : CTD11277
Chemical/Pharm GKB GenePA36949
Clinical trialTREX1
Cancer Resource (Charite)ENSG00000213689
Other databases
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
CoreMineTREX1
iHOPTREX1
OncoSearchTREX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 19:23:26 CEST 2014

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