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TRH (thyrotropin releasing hormone)

Identity

Alias (NCBI)Pro-TRH
TRF
HGNC (Hugo) TRH
HGNC Alias nameprothyroliberin
HGNC Previous namethyrotropin-releasing hormone
LocusID (NCBI) 7200
Atlas_Id 45882
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 129974720 and ends at 129977935 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNB1 (1p36.33) / TRH (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TRH   12298
Cards
Entrez_Gene (NCBI)TRH    thyrotropin releasing hormone
AliasesPro-TRH; TRF
GeneCards (Weizmann)TRH
Ensembl hg19 (Hinxton)ENSG00000170893 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170893 [Gene_View]  ENSG00000170893 [Sequence]  chr3:129974720-129977935 [Contig_View]  TRH [Vega]
ICGC DataPortalENSG00000170893
TCGA cBioPortalTRH
AceView (NCBI)TRH
Genatlas (Paris)TRH
SOURCE (Princeton)TRH
Genetics Home Reference (NIH)TRH
Genomic and cartography
GoldenPath hg38 (UCSC)TRH  -     chr3:129974720-129977935 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRH  -     3q22.1   [Description]    (hg19-Feb_2009)
GoldenPathTRH - 3q22.1 [CytoView hg19]  TRH - 3q22.1 [CytoView hg38]
ImmunoBaseENSG00000170893
genome Data Viewer NCBITRH [Mapview hg19]  
OMIM275120   613879   
Gene and transcription
Genbank (Entrez)AK313473 AW205952 BC069375 BC074888 BC074889
RefSeq transcript (Entrez)NM_007117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRH
Alternative Splicing GalleryENSG00000170893
Gene ExpressionTRH [ NCBI-GEO ]   TRH [ EBI - ARRAY_EXPRESS ]   TRH [ SEEK ]   TRH [ MEM ]
Gene Expression Viewer (FireBrowse)TRH [ Firebrowse - Broad ]
GenevisibleExpression of TRH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7200
GTEX Portal (Tissue expression)TRH
Human Protein AtlasENSG00000170893-TRH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20396   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20396
Splice isoforms : SwissVarP20396
PhosPhoSitePlusP20396
Domains : Interpro (EBI)TRH   
Domain families : Pfam (Sanger)TRH (PF05438)   
Domain families : Pfam (NCBI)pfam05438   
Conserved Domain (NCBI)TRH
Blocks (Seattle)TRH
SuperfamilyP20396
Human Protein Atlas [tissue]ENSG00000170893-TRH [tissue]
Peptide AtlasP20396
HPRD08944
IPIIPI00023604   IPI00967846   
Protein Interaction databases
DIP (DOE-UCLA)P20396
IntAct (EBI)P20396
BioGRIDTRH
STRING (EMBL)TRH
ZODIACTRH
Ontologies - Pathways
QuickGOP20396
Ontology : AmiGOresponse to hypoxia  histamine metabolic process  protein binding  extracellular region  nucleus  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  cell-cell signaling  thyrotropin-releasing hormone activity  response to cold  response to glucose  hormone-mediated signaling pathway  negative regulation of glutamate secretion  positive regulation of gamma-aminobutyric acid secretion  secretory granule  positive regulation of insulin secretion  eating behavior  response to ethanol  response to corticosterone  negative regulation of feeding behavior  
Ontology : EGO-EBIresponse to hypoxia  histamine metabolic process  protein binding  extracellular region  nucleus  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  cell-cell signaling  thyrotropin-releasing hormone activity  response to cold  response to glucose  hormone-mediated signaling pathway  negative regulation of glutamate secretion  positive regulation of gamma-aminobutyric acid secretion  secretory granule  positive regulation of insulin secretion  eating behavior  response to ethanol  response to corticosterone  negative regulation of feeding behavior  
NDEx NetworkTRH
Atlas of Cancer Signalling NetworkTRH
Wikipedia pathwaysTRH
Orthology - Evolution
OrthoDB7200
GeneTree (enSembl)ENSG00000170893
Phylogenetic Trees/Animal Genes : TreeFamTRH
HOGENOMP20396
Homologs : HomoloGeneTRH
Homology/Alignments : Family Browser (UCSC)TRH
Gene fusions - Rearrangements
Fusion : MitelmanGNB1/TRH [1p36.33/3q22.1]  
Fusion : QuiverTRH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRH [hg38]
dbVarTRH
ClinVarTRH
MonarchTRH
1000_GenomesTRH 
Exome Variant ServerTRH
GNOMAD BrowserENSG00000170893
Varsome BrowserTRH
Genomic Variants (DGV)TRH [DGVbeta]
DECIPHERTRH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRH 
Mutations
ICGC Data PortalTRH 
TCGA Data PortalTRH 
Broad Tumor PortalTRH
OASIS PortalTRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRH
Mutations and Diseases : HGMDTRH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRH
DgiDB (Drug Gene Interaction Database)TRH
DoCM (Curated mutations)TRH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRH (select a term)
intoGenTRH
Cancer3DTRH(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM275120    613879   
Orphanet19293   
DisGeNETTRH
MedgenTRH
Genetic Testing Registry TRH
NextProtP20396 [Medical]
GENETestsTRH
Target ValidationTRH
Huge Navigator TRH [HugePedia]
ClinGenTRH
Clinical trials, drugs, therapy
MyCancerGenomeTRH
Protein Interactions : CTD
Pharm GKB GenePA36978
PharosP20396
Clinical trialTRH
Miscellaneous
canSAR (ICR)TRH (select the gene name)
HarmonizomeTRH
DataMed IndexTRH
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:50:49 CET 2021

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