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TRH (thyrotropin releasing hormone)

Identity

Alias_namesthyrotropin-releasing hormone
Other aliasPro-TRH
TRF
HGNC (Hugo) TRH
LocusID (NCBI) 7200
Atlas_Id 45882
Location 3q22.1  [Link to chromosome band 3q22]
Location_base_pair Starts at 129974393 and ends at 129977938 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GNB1 (1p36.33) / TRH (3q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRH   12298
Cards
Entrez_Gene (NCBI)TRH  7200  thyrotropin releasing hormone
AliasesPro-TRH; TRF
GeneCards (Weizmann)TRH
Ensembl hg19 (Hinxton)ENSG00000170893 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170893 [Gene_View]  chr3:129974393-129977938 [Contig_View]  TRH [Vega]
ICGC DataPortalENSG00000170893
TCGA cBioPortalTRH
AceView (NCBI)TRH
Genatlas (Paris)TRH
WikiGenes7200
SOURCE (Princeton)TRH
Genetics Home Reference (NIH)TRH
Genomic and cartography
GoldenPath hg38 (UCSC)TRH  -     chr3:129974393-129977938 +  3q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRH  -     3q22.1   [Description]    (hg19-Feb_2009)
EnsemblTRH - 3q22.1 [CytoView hg19]  TRH - 3q22.1 [CytoView hg38]
Mapping of homologs : NCBITRH [Mapview hg19]  TRH [Mapview hg38]
OMIM275120   613879   
Gene and transcription
Genbank (Entrez)AK313473 AW205952 BC069375 BC074888 BC074889
RefSeq transcript (Entrez)NM_007117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRH
Cluster EST : UnigeneHs.732877 [ NCBI ]
CGAP (NCI)Hs.732877
Alternative Splicing GalleryENSG00000170893
Gene ExpressionTRH [ NCBI-GEO ]   TRH [ EBI - ARRAY_EXPRESS ]   TRH [ SEEK ]   TRH [ MEM ]
Gene Expression Viewer (FireBrowse)TRH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7200
GTEX Portal (Tissue expression)TRH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20396   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20396
Splice isoforms : SwissVarP20396
PhosPhoSitePlusP20396
Domains : Interpro (EBI)TRH   
Domain families : Pfam (Sanger)TRH (PF05438)   
Domain families : Pfam (NCBI)pfam05438   
Conserved Domain (NCBI)TRH
DMDM Disease mutations7200
Blocks (Seattle)TRH
SuperfamilyP20396
Human Protein AtlasENSG00000170893
Peptide AtlasP20396
HPRD08944
IPIIPI00023604   IPI00967846   
Protein Interaction databases
DIP (DOE-UCLA)P20396
IntAct (EBI)P20396
FunCoupENSG00000170893
BioGRIDTRH
STRING (EMBL)TRH
ZODIACTRH
Ontologies - Pathways
QuickGOP20396
Ontology : AmiGOresponse to hypoxia  histamine metabolic process  neuropeptide hormone activity  extracellular region  nucleus  plasma membrane  signal transduction  cell-cell signaling  adult walking behavior  thyrotropin-releasing hormone activity  response to cold  response to glucose  hormone-mediated signaling pathway  negative regulation of glutamate secretion  positive regulation of gamma-aminobutyric acid secretion  secretory granule  positive regulation of insulin secretion  eating behavior  response to ethanol  response to corticosterone  negative regulation of feeding behavior  
Ontology : EGO-EBIresponse to hypoxia  histamine metabolic process  neuropeptide hormone activity  extracellular region  nucleus  plasma membrane  signal transduction  cell-cell signaling  adult walking behavior  thyrotropin-releasing hormone activity  response to cold  response to glucose  hormone-mediated signaling pathway  negative regulation of glutamate secretion  positive regulation of gamma-aminobutyric acid secretion  secretory granule  positive regulation of insulin secretion  eating behavior  response to ethanol  response to corticosterone  negative regulation of feeding behavior  
NDEx NetworkTRH
Atlas of Cancer Signalling NetworkTRH
Wikipedia pathwaysTRH
Orthology - Evolution
OrthoDB7200
GeneTree (enSembl)ENSG00000170893
Phylogenetic Trees/Animal Genes : TreeFamTRH
HOVERGENP20396
HOGENOMP20396
Homologs : HomoloGeneTRH
Homology/Alignments : Family Browser (UCSC)TRH
Gene fusions - Rearrangements
Fusion : MitelmanGNB1/TRH [1p36.33/3q22.1]  [t(1;3)(p36;q22)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRH
dbVarTRH
ClinVarTRH
1000_GenomesTRH 
Exome Variant ServerTRH
ExAC (Exome Aggregation Consortium)TRH (select the gene name)
Genetic variants : HAPMAP7200
Genomic Variants (DGV)TRH [DGVbeta]
DECIPHERTRH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRH 
Mutations
ICGC Data PortalTRH 
TCGA Data PortalTRH 
Broad Tumor PortalTRH
OASIS PortalTRH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRH
DgiDB (Drug Gene Interaction Database)TRH
DoCM (Curated mutations)TRH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRH (select a term)
intoGenTRH
Cancer3DTRH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM275120    613879   
Orphanet19293   
MedgenTRH
Genetic Testing Registry TRH
NextProtP20396 [Medical]
TSGene7200
GENETestsTRH
Target ValidationTRH
Huge Navigator TRH [HugePedia]
snp3D : Map Gene to Disease7200
BioCentury BCIQTRH
ClinGenTRH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7200
Chemical/Pharm GKB GenePA36978
Clinical trialTRH
Miscellaneous
canSAR (ICR)TRH (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRH
EVEXTRH
GoPubMedTRH
iHOPTRH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:27 CEST 2017

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