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TRHDE (thyrotropin releasing hormone degrading enzyme)

Identity

Alias_namesthyrotropin-releasing hormone degrading enzyme
Alias_symbol (synonym)PGPEP2
TRH-DE
PAP-II
Other alias
HGNC (Hugo) TRHDE
LocusID (NCBI) 29953
Atlas_Id 54722
Location 12q21.1  [Link to chromosome band 12q21]
Location_base_pair Starts at 72272749 and ends at 72665642 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH1 (16q22.1) / TRHDE (12q21.1)LIN7A (12q21.31) / TRHDE (12q21.1)NR6A1 (9q33.3) / TRHDE (12q21.1)
TRHDE (12q21.1) / LGR5 (12q21.1)CDH1 16q22.1 / TRHDE 12q21.1LIN7A 12q21.31 / TRHDE 12q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRHDE   30748
Cards
Entrez_Gene (NCBI)TRHDE  29953  thyrotropin releasing hormone degrading enzyme
AliasesPAP-II; PGPEP2; TRH-DE
GeneCards (Weizmann)TRHDE
Ensembl hg19 (Hinxton)ENSG00000072657 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072657 [Gene_View]  chr12:72272749-72665642 [Contig_View]  TRHDE [Vega]
ICGC DataPortalENSG00000072657
TCGA cBioPortalTRHDE
AceView (NCBI)TRHDE
Genatlas (Paris)TRHDE
WikiGenes29953
SOURCE (Princeton)TRHDE
Genetics Home Reference (NIH)TRHDE
Genomic and cartography
GoldenPath hg38 (UCSC)TRHDE  -     chr12:72272749-72665642 +  12q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRHDE  -     12q21.1   [Description]    (hg19-Feb_2009)
EnsemblTRHDE - 12q21.1 [CytoView hg19]  TRHDE - 12q21.1 [CytoView hg38]
Mapping of homologs : NCBITRHDE [Mapview hg19]  TRHDE [Mapview hg38]
OMIM606950   
Gene and transcription
Genbank (Entrez)AF126372 AK026034 AY358765 BC023230 BC142706
RefSeq transcript (Entrez)NM_013381
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRHDE
Cluster EST : UnigeneHs.199814 [ NCBI ]
CGAP (NCI)Hs.199814
Alternative Splicing GalleryENSG00000072657
Gene ExpressionTRHDE [ NCBI-GEO ]   TRHDE [ EBI - ARRAY_EXPRESS ]   TRHDE [ SEEK ]   TRHDE [ MEM ]
Gene Expression Viewer (FireBrowse)TRHDE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29953
GTEX Portal (Tissue expression)TRHDE
Human Protein AtlasENSG00000072657-TRHDE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKU6
Splice isoforms : SwissVarQ9UKU6
Catalytic activity : Enzyme3.4.19.6 [ Enzyme-Expasy ]   3.4.19.63.4.19.6 [ IntEnz-EBI ]   3.4.19.6 [ BRENDA ]   3.4.19.6 [ KEGG ]   
PhosPhoSitePlusQ9UKU6
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)ERAP1-like_C_dom    M1_APN-typ    Peptidase_M1    Peptidase_M1_N    TRH-DE   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)TRHDE
DMDM Disease mutations29953
Blocks (Seattle)TRHDE
SuperfamilyQ9UKU6
Human Protein Atlas [tissue]ENSG00000072657-TRHDE [tissue]
Peptide AtlasQ9UKU6
HPRD09506
IPIIPI00007798   IPI01020713   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKU6
IntAct (EBI)Q9UKU6
FunCoupENSG00000072657
BioGRIDTRHDE
STRING (EMBL)TRHDE
ZODIACTRHDE
Ontologies - Pathways
QuickGOQ9UKU6
Ontology : AmiGOaminopeptidase activity  cytoplasm  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  zinc ion binding  peptide binding  peptide catabolic process  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  cytoplasm  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  zinc ion binding  peptide binding  peptide catabolic process  metalloaminopeptidase activity  extracellular exosome  
NDEx NetworkTRHDE
Atlas of Cancer Signalling NetworkTRHDE
Wikipedia pathwaysTRHDE
Orthology - Evolution
OrthoDB29953
GeneTree (enSembl)ENSG00000072657
Phylogenetic Trees/Animal Genes : TreeFamTRHDE
HOVERGENQ9UKU6
HOGENOMQ9UKU6
Homologs : HomoloGeneTRHDE
Homology/Alignments : Family Browser (UCSC)TRHDE
Gene fusions - Rearrangements
Fusion : MitelmanCDH1/TRHDE [16q22.1/12q21.1]  [t(12;16)(q21;q22)]  
Fusion : MitelmanLIN7A/TRHDE [12q21.31/12q21.1]  [t(12;12)(q21;q21)]  
Fusion : MitelmanNR6A1/TRHDE [9q33.3/12q21.1]  [t(9;12)(q33;q21)]  
Fusion : MitelmanTRHDE/LGR5 [12q21.1/12q21.1]  [dup(12)(q21q21)]  
Fusion: TCGA_MDACCCDH1 16q22.1 TRHDE 12q21.1 PRAD
Fusion: TCGA_MDACCLIN7A 12q21.31 TRHDE 12q21.1 BRCA
Tumor Fusion PortalTRHDE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRHDE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRHDE
dbVarTRHDE
ClinVarTRHDE
1000_GenomesTRHDE 
Exome Variant ServerTRHDE
ExAC (Exome Aggregation Consortium)ENSG00000072657
GNOMAD BrowserENSG00000072657
Genetic variants : HAPMAP29953
Genomic Variants (DGV)TRHDE [DGVbeta]
DECIPHERTRHDE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRHDE 
Mutations
ICGC Data PortalTRHDE 
TCGA Data PortalTRHDE 
Broad Tumor PortalTRHDE
OASIS PortalTRHDE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRHDE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRHDE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRHDE
DgiDB (Drug Gene Interaction Database)TRHDE
DoCM (Curated mutations)TRHDE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRHDE (select a term)
intoGenTRHDE
Cancer3DTRHDE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606950   
Orphanet
DisGeNETTRHDE
MedgenTRHDE
Genetic Testing Registry TRHDE
NextProtQ9UKU6 [Medical]
TSGene29953
GENETestsTRHDE
Target ValidationTRHDE
Huge Navigator TRHDE [HugePedia]
snp3D : Map Gene to Disease29953
BioCentury BCIQTRHDE
ClinGenTRHDE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29953
Chemical/Pharm GKB GenePA142670702
Clinical trialTRHDE
Miscellaneous
canSAR (ICR)TRHDE (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRHDE
EVEXTRHDE
GoPubMedTRHDE
iHOPTRHDE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:39:38 CET 2017

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