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TRHDE (thyrotropin releasing hormone degrading enzyme)

Identity

Alias (NCBI)PAP-II
PGPEP2
TRH-DE
HGNC (Hugo) TRHDE
HGNC Alias symbPGPEP2
TRH-DE
PAP-II
HGNC Alias namepyroglutamyl-peptidase II
 pyroglutamyl aminopeptidase II
 TRH-specific aminopeptidase
HGNC Previous namethyrotropin-releasing hormone degrading enzyme
LocusID (NCBI) 29953
Atlas_Id 54722
Location 12q21.1  [Link to chromosome band 12q21]
Location_base_pair Starts at 72272749 and ends at 72665642 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDH1 (16q22.1) / TRHDE (12q21.1)LIN7A (12q21.31) / TRHDE (12q21.1)NR6A1 (9q33.3) / TRHDE (12q21.1)
TRHDE (12q21.1) / LGR5 (12q21.1)CDH1 16q22.1 / TRHDE 12q21.1LIN7A 12q21.31 / TRHDE 12q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TRHDE   30748
Cards
Entrez_Gene (NCBI)TRHDE    thyrotropin releasing hormone degrading enzyme
AliasesPAP-II; PGPEP2; TRH-DE
GeneCards (Weizmann)TRHDE
Ensembl hg19 (Hinxton)ENSG00000072657 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000072657 [Gene_View]  ENSG00000072657 [Sequence]  chr12:72272749-72665642 [Contig_View]  TRHDE [Vega]
ICGC DataPortalENSG00000072657
TCGA cBioPortalTRHDE
AceView (NCBI)TRHDE
Genatlas (Paris)TRHDE
SOURCE (Princeton)TRHDE
Genetics Home Reference (NIH)TRHDE
Genomic and cartography
GoldenPath hg38 (UCSC)TRHDE  -     chr12:72272749-72665642 +  12q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRHDE  -     12q21.1   [Description]    (hg19-Feb_2009)
GoldenPathTRHDE - 12q21.1 [CytoView hg19]  TRHDE - 12q21.1 [CytoView hg38]
ImmunoBaseENSG00000072657
Genome Data Viewer NCBITRHDE [Mapview hg19]  
OMIM606950   
Gene and transcription
Genbank (Entrez)AF126372 AK026034 AY358765 BC023230 BC142706
RefSeq transcript (Entrez)NM_013381
Consensus coding sequences : CCDS (NCBI)TRHDE
Gene ExpressionTRHDE [ NCBI-GEO ]   TRHDE [ EBI - ARRAY_EXPRESS ]   TRHDE [ SEEK ]   TRHDE [ MEM ]
Gene Expression Viewer (FireBrowse)TRHDE [ Firebrowse - Broad ]
GenevisibleExpression of TRHDE in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29953
GTEX Portal (Tissue expression)TRHDE
Human Protein AtlasENSG00000072657-TRHDE [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKU6
Catalytic activity : Enzyme3.4.19.6 [ Enzyme-Expasy ]   3.4.19.63.4.19.6 [ IntEnz-EBI ]   3.4.19.6 [ BRENDA ]   3.4.19.6 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UKU6
Domaine pattern : Prosite (Expaxy)ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Aminopeptidase_N-like_N    ERAP1-like_C_dom    M1_APN-typ    Peptidase_M1    Peptidase_M1_dom    TRH-DE   
Domain families : Pfam (Sanger)ERAP1_C (PF11838)    Peptidase_M1 (PF01433)   
Domain families : Pfam (NCBI)pfam11838    pfam01433   
Conserved Domain (NCBI)TRHDE
SuperfamilyQ9UKU6
AlphaFold pdb e-kbQ9UKU6   
Human Protein Atlas [tissue]ENSG00000072657-TRHDE [tissue]
HPRD09506
Protein Interaction databases
DIP (DOE-UCLA)Q9UKU6
IntAct (EBI)Q9UKU6
BioGRIDTRHDE
STRING (EMBL)TRHDE
ZODIACTRHDE
Ontologies - Pathways
QuickGOQ9UKU6
Ontology : AmiGOaminopeptidase activity  cytoplasm  plasma membrane  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  zinc ion binding  peptide binding  peptide catabolic process  metalloaminopeptidase activity  extracellular exosome  
Ontology : EGO-EBIaminopeptidase activity  cytoplasm  plasma membrane  integral component of plasma membrane  proteolysis  signal transduction  cell-cell signaling  regulation of blood pressure  zinc ion binding  peptide binding  peptide catabolic process  metalloaminopeptidase activity  extracellular exosome  
NDEx NetworkTRHDE
Atlas of Cancer Signalling NetworkTRHDE
Wikipedia pathwaysTRHDE
Orthology - Evolution
OrthoDB29953
GeneTree (enSembl)ENSG00000072657
Phylogenetic Trees/Animal Genes : TreeFamTRHDE
Homologs : HomoloGeneTRHDE
Homology/Alignments : Family Browser (UCSC)TRHDE
Gene fusions - Rearrangements
Fusion : MitelmanCDH1/TRHDE [16q22.1/12q21.1]  
Fusion : MitelmanLIN7A/TRHDE [12q21.31/12q21.1]  
Fusion : MitelmanNR6A1/TRHDE [9q33.3/12q21.1]  
Fusion : MitelmanTRHDE/LGR5 [12q21.1/12q21.1]  
Fusion : QuiverTRHDE
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRHDE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRHDE
dbVarTRHDE
ClinVarTRHDE
MonarchTRHDE
1000_GenomesTRHDE 
Exome Variant ServerTRHDE
GNOMAD BrowserENSG00000072657
Varsome BrowserTRHDE
ACMGTRHDE variants
VarityQ9UKU6
Genomic Variants (DGV)TRHDE [DGVbeta]
DECIPHERTRHDE [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRHDE 
Mutations
ICGC Data PortalTRHDE 
TCGA Data PortalTRHDE 
Broad Tumor PortalTRHDE
OASIS PortalTRHDE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRHDE  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRHDE
Mutations and Diseases : HGMDTRHDE
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTRHDE
DgiDB (Drug Gene Interaction Database)TRHDE
DoCM (Curated mutations)TRHDE
CIViC (Clinical Interpretations of Variants in Cancer)TRHDE
Cancer3DTRHDE
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606950   
Orphanet
DisGeNETTRHDE
MedgenTRHDE
Genetic Testing Registry TRHDE
NextProtQ9UKU6 [Medical]
GENETestsTRHDE
Target ValidationTRHDE
Huge Navigator TRHDE [HugePedia]
ClinGenTRHDE
Clinical trials, drugs, therapy
MyCancerGenomeTRHDE
Protein Interactions : CTDTRHDE
Pharm GKB GenePA142670702
PharosQ9UKU6
Clinical trialTRHDE
Miscellaneous
canSAR (ICR)TRHDE
HarmonizomeTRHDE
DataMed IndexTRHDE
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTRHDE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:16 CEST 2021

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