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TRIB2 (tribbles pseudokinase 2)

Identity

Alias_namestribbles homolog 2 (Drosophila)
Alias_symbol (synonym)TRB2
GS3955
Other aliasC5FW
HGNC (Hugo) TRIB2
LocusID (NCBI) 28951
Atlas_Id 43540
Location 2p24.3  [Link to chromosome band 2p24]
Location_base_pair Starts at 12716872 and ends at 12742732 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIB2   30809
Cards
Entrez_Gene (NCBI)TRIB2  28951  tribbles pseudokinase 2
AliasesC5FW; GS3955; TRB2
GeneCards (Weizmann)TRIB2
Ensembl hg19 (Hinxton)ENSG00000071575 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071575 [Gene_View]  ENSG00000071575 [Sequence]  chr2:12716872-12742732 [Contig_View]  TRIB2 [Vega]
ICGC DataPortalENSG00000071575
TCGA cBioPortalTRIB2
AceView (NCBI)TRIB2
Genatlas (Paris)TRIB2
WikiGenes28951
SOURCE (Princeton)TRIB2
Genetics Home Reference (NIH)TRIB2
Genomic and cartography
GoldenPath hg38 (UCSC)TRIB2  -     chr2:12716872-12742732 +  2p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TRIB2  -     2p24.3   [Description]    (hg19-Feb_2009)
GoldenPathTRIB2 - 2p24.3 [CytoView hg19]  TRIB2 - 2p24.3 [CytoView hg38]
ImmunoBaseENSG00000071575
Mapping of homologs : NCBITRIB2 [Mapview hg19]  TRIB2 [Mapview hg38]
OMIM609462   
Gene and transcription
Genbank (Entrez)AK129973 AK299146 AK313237 AY245544 BC002637
RefSeq transcript (Entrez)NM_021643
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TRIB2
Cluster EST : UnigeneHs.467751 [ NCBI ]
CGAP (NCI)Hs.467751
Alternative Splicing GalleryENSG00000071575
Gene ExpressionTRIB2 [ NCBI-GEO ]   TRIB2 [ EBI - ARRAY_EXPRESS ]   TRIB2 [ SEEK ]   TRIB2 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28951
GTEX Portal (Tissue expression)TRIB2
Human Protein AtlasENSG00000071575-TRIB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92519   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92519  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92519
Splice isoforms : SwissVarQ92519
PhosPhoSitePlusQ92519
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Tribbles/Ser_Thr_kinase_40   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)TRIB2
DMDM Disease mutations28951
Blocks (Seattle)TRIB2
SuperfamilyQ92519
Human Protein Atlas [tissue]ENSG00000071575-TRIB2 [tissue]
Peptide AtlasQ92519
HPRD18224
IPIIPI00012516   IPI00789581   IPI00892727   
Protein Interaction databases
DIP (DOE-UCLA)Q92519
IntAct (EBI)Q92519
FunCoupENSG00000071575
BioGRIDTRIB2
STRING (EMBL)TRIB2
ZODIACTRIB2
Ontologies - Pathways
QuickGOQ92519
Ontology : AmiGOnucleotide binding  protein kinase activity  protein kinase inhibitor activity  nucleus  cytoplasm  cytoskeleton  protein phosphorylation  negative regulation of protein kinase activity  transcription factor binding  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of MAP kinase activity  regulation of MAP kinase activity  negative regulation of interleukin-10 biosynthetic process  negative regulation of fat cell differentiation  ubiquitin-protein transferase regulator activity  
Ontology : EGO-EBInucleotide binding  protein kinase activity  protein kinase inhibitor activity  nucleus  cytoplasm  cytoskeleton  protein phosphorylation  negative regulation of protein kinase activity  transcription factor binding  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of MAP kinase activity  regulation of MAP kinase activity  negative regulation of interleukin-10 biosynthetic process  negative regulation of fat cell differentiation  ubiquitin-protein transferase regulator activity  
NDEx NetworkTRIB2
Atlas of Cancer Signalling NetworkTRIB2
Wikipedia pathwaysTRIB2
Orthology - Evolution
OrthoDB28951
GeneTree (enSembl)ENSG00000071575
Phylogenetic Trees/Animal Genes : TreeFamTRIB2
HOGENOMQ92519
Homologs : HomoloGeneTRIB2
Homology/Alignments : Family Browser (UCSC)TRIB2
Gene fusions - Rearrangements
Fusion : QuiverTRIB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIB2
dbVarTRIB2
ClinVarTRIB2
1000_GenomesTRIB2 
Exome Variant ServerTRIB2
ExAC (Exome Aggregation Consortium)ENSG00000071575
GNOMAD BrowserENSG00000071575
Varsome BrowserTRIB2
Genetic variants : HAPMAP28951
Genomic Variants (DGV)TRIB2 [DGVbeta]
DECIPHERTRIB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTRIB2 
Mutations
ICGC Data PortalTRIB2 
TCGA Data PortalTRIB2 
Broad Tumor PortalTRIB2
OASIS PortalTRIB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTRIB2
Mutations and Diseases : HGMDTRIB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIB2
DgiDB (Drug Gene Interaction Database)TRIB2
DoCM (Curated mutations)TRIB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIB2 (select a term)
intoGenTRIB2
Cancer3DTRIB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609462   
Orphanet
DisGeNETTRIB2
MedgenTRIB2
Genetic Testing Registry TRIB2
NextProtQ92519 [Medical]
TSGene28951
GENETestsTRIB2
Target ValidationTRIB2
Huge Navigator TRIB2 [HugePedia]
snp3D : Map Gene to Disease28951
BioCentury BCIQTRIB2
ClinGenTRIB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28951
Chemical/Pharm GKB GenePA128394647
Clinical trialTRIB2
Miscellaneous
canSAR (ICR)TRIB2 (select the gene name)
DataMed IndexTRIB2
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIB2
EVEXTRIB2
GoPubMedTRIB2
iHOPTRIB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:13:01 CET 2019

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