TRIB2 (tribbles pseudokinase 2)

2006-10-01  

Identity

HGNC
TRIB2
LOCATION
2p24.3
LOCUSID
28951
ALIAS
C5FW,GS3955,TRB2

Other Information

Locus ID:

NCBI: 28951
MIM: 609462
HGNC: 30809
Ensembl: ENSG00000071575

Variants:

dbSNP: 28951
ClinVar: 28951
TCGA: ENSG00000071575
COSMIC: TRIB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071575ENST00000155926Q92519
ENSG00000071575ENST00000381465F8WA18
ENSG00000071575ENST00000405331B5MCX4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448320allopurinolChemicalClinicalAnnotationassociatedPD30924126

References

Pubmed IDYearTitleCitations
201603492010Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.67
208053622010Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding.37
213996612011Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBPα.31
206148462010Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.29
230715392012miR-511 and miR-1297 inhibit human lung adenocarcinoma cell proliferation by targeting oncogene TRIB2.27
196567732009A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.25
202085622010Human TRIB2 is a repressor of FOXO that contributes to the malignant phenotype of melanoma cells.25
225897422012Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.24
206148472010Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy.23
235500392013Tribbles in acute leukemia.22

Citation

Dessen P

TRIB2 (tribbles pseudokinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43540/trib2