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TRIB3 (tribbles pseudokinase 3)

Identity

Alias_namesC20orf97
chromosome 20 open reading frame 97
tribbles homolog 3 (Drosophila)
Alias_symbol (synonym)dJ1103G7.3
TRB3
Other aliasNIPK
SINK
SKIP3
HGNC (Hugo) TRIB3
LocusID (NCBI) 57761
Atlas_Id 43541
Location 20p13  [Link to chromosome band 20p13]
Location_base_pair Starts at 361950 and ends at 378203 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BMP2 (20p12.3) / TRIB3 (20p13)TRIB3 (20p13) / DEFB125 (20p13)TRIB3 (20p13) / NADK2 (5p13.2)
TRIB3 (20p13) / WASF2 (1p36.11)BMP2 20p12.3 / TRIB3 20p13TRIB3 20p13 / DEFB125 20p13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TRIB3   16228
Cards
Entrez_Gene (NCBI)TRIB3  57761  tribbles pseudokinase 3
AliasesC20orf97; NIPK; SINK; SKIP3; 
TRB3
GeneCards (Weizmann)TRIB3
Ensembl hg19 (Hinxton)ENSG00000101255 [Gene_View]  chr20:361950-378203 [Contig_View]  TRIB3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101255 [Gene_View]  chr20:361950-378203 [Contig_View]  TRIB3 [Vega]
ICGC DataPortalENSG00000101255
TCGA cBioPortalTRIB3
AceView (NCBI)TRIB3
Genatlas (Paris)TRIB3
WikiGenes57761
SOURCE (Princeton)TRIB3
Genetics Home Reference (NIH)TRIB3
Genomic and cartography
GoldenPath hg19 (UCSC)TRIB3  -     chr20:361950-378203 +  20p13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TRIB3  -     20p13   [Description]    (hg38-Dec_2013)
EnsemblTRIB3 - 20p13 [CytoView hg19]  TRIB3 - 20p13 [CytoView hg38]
Mapping of homologs : NCBITRIB3 [Mapview hg19]  TRIB3 [Mapview hg38]
OMIM607898   
Gene and transcription
Genbank (Entrez)AF250311 AJ697936 AJ697937 AJ697938 AJ697939
RefSeq transcript (Entrez)NM_001301188 NM_001301190 NM_001301193 NM_001301196 NM_001301201 NM_021158
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011387 NW_004929416
Consensus coding sequences : CCDS (NCBI)TRIB3
Cluster EST : UnigeneHs.516826 [ NCBI ]
CGAP (NCI)Hs.516826
Alternative Splicing GalleryENSG00000101255
Gene ExpressionTRIB3 [ NCBI-GEO ]   TRIB3 [ EBI - ARRAY_EXPRESS ]   TRIB3 [ SEEK ]   TRIB3 [ MEM ]
Gene Expression Viewer (FireBrowse)TRIB3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57761
GTEX Portal (Tissue expression)TRIB3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RU7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RU7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RU7
Splice isoforms : SwissVarQ96RU7
PhosPhoSitePlusQ96RU7
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Tribbles/Ser_Thr_kinase_40    Tribbles_TRB3   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)TRIB3
DMDM Disease mutations57761
Blocks (Seattle)TRIB3
SuperfamilyQ96RU7
Human Protein AtlasENSG00000101255
Peptide AtlasQ96RU7
HPRD09836
IPIIPI00941370   IPI00290307   IPI00879713   
Protein Interaction databases
DIP (DOE-UCLA)Q96RU7
IntAct (EBI)Q96RU7
FunCoupENSG00000101255
BioGRIDTRIB3
STRING (EMBL)TRIB3
ZODIACTRIB3
Ontologies - Pathways
QuickGOQ96RU7
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  protein kinase inhibitor activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  protein phosphorylation  negative regulation of protein kinase activity  regulation of glucose transport  kinase activity  protein kinase binding  protein kinase binding  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  positive regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  cellular response to insulin stimulus  response to endoplasmic reticulum stress  regulation of MAP kinase activity  negative regulation of fat cell differentiation  negative regulation of fatty acid biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of ubiquitin-protein transferase activity  ubiquitin-protein transferase regulator activity  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  transcription corepressor activity  protein kinase inhibitor activity  protein binding  ATP binding  nucleus  nucleus  nucleoplasm  cytosol  plasma membrane  transcription, DNA-templated  protein phosphorylation  negative regulation of protein kinase activity  regulation of glucose transport  kinase activity  protein kinase binding  protein kinase binding  mitogen-activated protein kinase kinase binding  ubiquitin protein ligase binding  positive regulation of protein binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  cellular response to insulin stimulus  response to endoplasmic reticulum stress  regulation of MAP kinase activity  negative regulation of fat cell differentiation  negative regulation of fatty acid biosynthetic process  negative regulation of transcription, DNA-templated  positive regulation of ubiquitin-protein transferase activity  ubiquitin-protein transferase regulator activity  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  
NDEx NetworkTRIB3
Atlas of Cancer Signalling NetworkTRIB3
Wikipedia pathwaysTRIB3
Orthology - Evolution
OrthoDB57761
GeneTree (enSembl)ENSG00000101255
Phylogenetic Trees/Animal Genes : TreeFamTRIB3
HOVERGENQ96RU7
HOGENOMQ96RU7
Homologs : HomoloGeneTRIB3
Homology/Alignments : Family Browser (UCSC)TRIB3
Gene fusions - Rearrangements
Fusion : MitelmanBMP2/TRIB3 [20p12.3/20p13]  [t(20;20)(p12;p13)]  
Fusion: TCGABMP2 20p12.3 TRIB3 20p13 LGG
Fusion: TCGATRIB3 20p13 DEFB125 20p13 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTRIB3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TRIB3
dbVarTRIB3
ClinVarTRIB3
1000_GenomesTRIB3 
Exome Variant ServerTRIB3
ExAC (Exome Aggregation Consortium)TRIB3 (select the gene name)
Genetic variants : HAPMAP57761
Genomic Variants (DGV)TRIB3 [DGVbeta]
DECIPHER (Syndromes)20:361950-378203  ENSG00000101255
CONAN: Copy Number AnalysisTRIB3 
Mutations
ICGC Data PortalTRIB3 
TCGA Data PortalTRIB3 
Broad Tumor PortalTRIB3
OASIS PortalTRIB3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTRIB3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTRIB3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TRIB3
DgiDB (Drug Gene Interaction Database)TRIB3
DoCM (Curated mutations)TRIB3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TRIB3 (select a term)
intoGenTRIB3
Cancer3DTRIB3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607898   
Orphanet
MedgenTRIB3
Genetic Testing Registry TRIB3
NextProtQ96RU7 [Medical]
TSGene57761
GENETestsTRIB3
Huge Navigator TRIB3 [HugePedia]
snp3D : Map Gene to Disease57761
BioCentury BCIQTRIB3
ClinGenTRIB3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57761
Chemical/Pharm GKB GenePA25804
Clinical trialTRIB3
Miscellaneous
canSAR (ICR)TRIB3 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTRIB3
EVEXTRIB3
GoPubMedTRIB3
iHOPTRIB3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:23:24 CEST 2017

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