TRIM14 (tripartite motif containing 14)

2017-04-01  

Identity

HGNC
LOCATION
9q22.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 9830
MIM: 606556
HGNC: 16283
Ensembl: ENSG00000106785

Variants:

dbSNP: 9830
ClinVar: 9830
TCGA: ENSG00000106785
COSMIC: TRIM14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106785ENST00000341469Q14142
ENSG00000106785ENST00000341469A0A024R165
ENSG00000106785ENST00000342043Q14142
ENSG00000106785ENST00000342043A0A024R165
ENSG00000106785ENST00000375098Q14142
ENSG00000106785ENST00000375098A0A024R165
ENSG00000106785ENST00000475147F2Z2M2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243793732014TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response.41
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
267994202016Overexpression of TRIM14 promotes tongue squamous cell carcinoma aggressiveness by activating the NF-κB signaling pathway.20
275784252016TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein.20
290539562017Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling.19
292044462017miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14.16
282055342017TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway.15
259484742015Enhanced expression of trim14 gene suppressed Sindbis virus reproduction and modulated the transcription of a large number of genes of innate immunity.12
280590792017TRIM14 is a Putative Tumor Suppressor and Regulator of Innate Immune Response in Non-Small Cell Lung Cancer.11
283501382017miR-15b inhibits cancer-initiating cell phenotypes and chemoresistance of cisplatin by targeting TRIM14 in oral tongue squamous cell cancer.11

Citation

Dessen P

TRIM14 (tripartite motif containing 14)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56768/trim14