TRIM17 (tripartite motif containing 17)

2016-10-01  

Identity

HGNC
TRIM17
LOCATION
1q42.13
LOCUSID
51127
ALIAS
RBCC,RNF16,terf

Other Information

Locus ID:

NCBI: 51127
MIM: 606123
HGNC: 13430
Ensembl: ENSG00000162931

Variants:

dbSNP: 51127
ClinVar: 51127
TCGA: ENSG00000162931
COSMIC: TRIM17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162931ENST00000295033Q9Y577
ENSG00000162931ENST00000295033A0A024R3T1
ENSG00000162931ENST00000355586J3KNZ3
ENSG00000162931ENST00000366697Q9Y577
ENSG00000162931ENST00000366697A0A024R3T1
ENSG00000162931ENST00000366698Q9Y577
ENSG00000162931ENST00000366698A0A024R3T1
ENSG00000162931ENST00000456946Q9Y577
ENSG00000162931ENST00000457345J3KQG0
ENSG00000162931ENST00000479800E5RJW6
ENSG00000162931ENST00000520264E5RI62

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
220238002012Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.20
193588232009TRIM44 interacts with and stabilizes terf, a TRIM ubiquitin E3 ligase.16
275620682016TRIM17 contributes to autophagy of midbodies while actively sparing other targets from degradation.11
252159462015Control of neuronal apoptosis by reciprocal regulation of NFATc3 and Trim17.9
194729182008Candidate-gene testing for orphan limb-girdle muscular dystrophies.4
304858142018The E3 Ubiquitin Ligases TRIM17 and TRIM41 Modulate α-Synuclein Expression by Regulating ZSCAN21.2
314098982019LSD1 suppresses invasion, migration and metastasis of luminal breast cancer cells via activation of GATA3 and repression of TRIM37 expression.1

Citation

Dessen P

TRIM17 (tripartite motif containing 17)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56316/trim17